Alcohol Consumption Does Not Modify the Polygenic Risk Score-Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study.

Details

• Alternative Title:
  Cancer Prevention Research (Philadelphia, Pa.), 2025, v. 18, no. 2: Alcohol Consumption Does Not Modify the Polygenic Risk Score-Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study.
• Journal Article:
  Cancer Prevention Research (Philadelphia, Pa.)
• Personal Author:
  Zhang, Minghui ; Ru, Meng ; Zhang, Jingning ; Wang, Ziqiao ; Lu, Jiayun ; Butler, Kenneth R. ; Chatterjee, Nilanjan ; Couper, David J. ; Prizment, Anna E. ; Soori, Mehrnoosh M. ; Visvanathan, Kala ; Zahnow, Cynthia A. ; Joshu, Corinne E. ; Platz, Elizabeth A.
• Description:
  High genetic risk and alcohol consumption ≥1 drink/day are associated with increased breast cancer risk. However, the interaction between alcohol and genetics on breast cancer risk is poorly understood, including in populations not enriched with daily drinkers. We prospectively studied 5,651 White and Black postmenopausal women in the Atherosclerosis Risk in Communities study. Alcohol intake was assessed by a food frequency questionnaire. The 313-SNP polygenic risk score (PRS) was calculated. Breast cancer cases were ascertained primarily by cancer registry linkage through 2015. Multivariable Cox regression was used to estimate HRs and 95% confidence intervals (CI) for the association of PRS and current ethanol intake with breast cancer, and their interaction. Of these individuals, 50.6% were current drinkers, and of them, 50.8% drank <1 drink/week and 12.8% drank >7 drinks/week. A higher PRS was associated with a higher breast cancer risk among White (HR1-SD, 1.48; 95% CI, 1.34-1.65) and Black (HR1-SD, 1.15; 95% CI, 0.96-1.38) women. Positive associations were not observed between current ethanol intake and breast cancer risk (White: HR13 g/week, 1.00; 95% CI, 0.98-1.03; Black: HR, 0.83; 95% CI, 0.69-1.00). Among both White and Black women, PRS generally seemed to be positively associated with risk in drinkers and nondrinkers. There was no evidence of a PRS-ethanol intake interaction among White or Black women. Patterns in Black women were similar when using an 89-SNP PRS developed among African ancestry women. In conclusion, in a prospective analysis of White and Black postmenopausal women in a study population not enriched with daily drinkers, our findings suggest that alcohol drinking does not modify the PRS-based genetic risk of breast cancer. Prevention Relevance: Although our findings suggest that alcohol drinking does not modify the PRS-based genetic risk of breast cancer among White and Black women with lower alcohol intake, nevertheless, women should consider limiting alcohol consumption as a general cancer prevention strategy, as indicated in dietary guidelines.
• Content Notes:
  Author manuscript
• Subjects:
  • Aged
  • Female
  • Humans
  • Middle Aged
  • Alcohol Drinking
  • Atherosclerosis
  • Black or African American
  • Breast Neoplasms
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  More +
• Keywords:
  • Breast cancer
  • alcohol
  • polygenetic risk score
  • gene-environment interaction
  • risk
• Source:
  Cancer Prevention Research (Philadelphia, Pa.), 2025, v. 18, no. 2
• DOI:
  https://doi.org/10.1158/1940-6207.CAPR-24-0208
• ISSN:
  1940-6207 ; 1940-6215
• Pubmed ID:
  39676351
• Pubmed Central ID:
  PMC11790378
• Document Type:
  Text
• Funding:
  R01 HL086694/HL/NHLBI NIH HHSUnited States/ ; U01 HG004402/HG/NHGRI NIH HHSUnited States/ ; Johns Hopkins University (JHU)/ ; NU58DP007114/Centers for Disease Control and Prevention (CDC)/ ; 75N92022D00003/HL/NHLBI NIH HHSUnited States/ ; 75N92022D00005/HL/NHLBI NIH HHSUnited States/ ; K99 HG013674/HG/NHGRI NIH HHSUnited States/ ; R01 HL087641/HL/NHLBI NIH HHSUnited States/ ; U01 CA164975/CA/NCI NIH HHSUnited States/ ; 75N92022D00001/HL/NHLBI NIH HHSUnited States/ ; R01HL087641/National Institutes of Health (NIH)/ ; UL1 RR025005/RR/NCRR NIH HHSUnited States/ ; 75N92022D00002/HL/NHLBI NIH HHSUnited States/ ; 75N92022D00004/HL/NHLBI NIH HHSUnited States/ ; U01HG004402/National Human Genome Research Institute (NHGRI)/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  73-83 (22 pdf pages)
• Volume:
  18
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261854/cdc_261854_DS1.pdf
• File Type:
  [PDF - 711.17 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:562b83b780c53dc129efb5649433a98d867e496c2ffe9e201b5daf3e039f4d5499176390255aec49125818a90282814df827b55e0beb1b4000f01753a1c5fc74