25265504

PMC4201626

Limiting energy-dense foods, fast foods, and sugary drinks that promote weight gain is a cancer prevention recommendation, but no studies have evaluated intake in relation to breast cancer risk in African American (AA) women. In a case-control study with 1692 AA women (803 cases and 889 controls) and 1456 European American (EA) women (755 cases and 701 controls), odds ratios (OR) and 95% confidence intervals (CI) for risk were computed, stratifying for menopausal and estrogen receptor (ER) status. Among postmenopausal EA women, breast cancer risk was associated with frequent consumption of energy-dense foods (OR = 2.95; 95% CI: 1.66-5.22), fast foods (OR = 2.35; 95% CI: 1.38-4.00), and sugary drinks (OR = 2.05; 95% CI: 1.13-3.70). Elevated risk of ER+ tumors in EA women was associated with energy-dense (OR = 1.75; 95% CI: 1.14-2.69) and fast foods (OR = 1.84; 95% CI: 1.22-2.77). Among AA women, frequent fast food consumption was related to premenopausal breast cancer risk (OR = 1.97; 95% CI: 1.13-3.43), and with ER+ tumors. Energy adjustment attenuated risk estimates in AA women, while strengthening them among EA women. Frequent consumption of energy-dense and fast foods that have poor nutritive value appeared to increase breast cancer risk in AA and EA women, with differences by menopausal status and ER status.

CDC Public Access

1US58DP003931-01/DP/NCCDPHP CDC HHS/United States
K22 CA138563/CA/NCI NIH HHS/United States
K22 CA138563/CA/NCI NIH HHS/United States
N01PC-2010-00027/PC/NCI NIH HHS/United States
P01 CA151135/CA/NCI NIH HHS/United States
P01 CA151135/CA/NCI NIH HHS/United States
P30CA072720/CA/NCI NIH HHS/United States
R01 CA100598/CA/NCI NIH HHS/United States
R01 CA100598/CA/NCI NIH HHS/United States