High Intention to Vaccinate Against Tuberculosis During Pregnancy and Lactation: Understanding Vaccine-specific Maternal Immunization Acceptance in Amhara, Ethiopia.

Details

• Alternative Title:
  The Pediatric Infectious Disease Journal, 2025, v. 44, no. 2: High Intention to Vaccinate Against Tuberculosis During Pregnancy and Lactation: Understanding Vaccine-specific Maternal Immunization Acceptance in Amhara, Ethiopia.
• Journal Article:
  The Pediatric Infectious Disease Journal
• Personal Author:
  Quincer, Elizabeth M. ; Gobezayehu, Abebe Gebremariam ; Belew, Mulusew Lijalem ; Endalamaw, Lamesgin Alamineh ; Tesfaye, Yihenew Alemu ; Shiferaw, Meseret ; Hussen, Sophia Ahmed ; Cranmer, John N. ; Omer, Saad B. ; Cranmer, Lisa Marie
• Description:
  Tuberculosis (TB) disease during pregnancy results in adverse maternal and infant outcomes. The development of a TB vaccine with potential for administration during pregnancy or lactation is a priority identified by the World Health Organization. We assessed the acceptability of vaccines currently administered during pregnancy tetanus, diphtheria and COVID-19 and willingness to receive a new TB vaccine during pregnancy and/or lactation among Ethiopian women.
  
  From January to February 2022, we conducted surveys among pregnant women receiving antenatal care at 20 hospitals in Amhara, Ethiopia. We evaluated uptake of available vaccines (diphtheria), acceptance of new and future vaccines (COVID-19 and TB) during pregnancy and lactation, and knowledge, attitudes and beliefs associated with vaccine-specific acceptance.
  
  Among 200 participants, we found high intention to receive a TB vaccine during pregnancy (90%) and lactation (92%) and low COVID-19 vaccine acceptance during pregnancy (40%) and lactation (47%). Most participants believed TB vaccination would protect their child from disease (82.5%) and have societal benefits (81.5%), while few women perceived the COVID-19 vaccine to offer protection (35.5%) or have societal benefits (42.5%). Intention to receive TB vaccination during pregnancy was associated with the belief that a future maternal TB vaccine would prevent TB among infants (adjusted prevalence ratio 1.37, 95% CI: 1.10-1.70). Most participants reported high acceptability of educational interventions to increase uptake of maternal immunization.
  
  We found high intention to receive a new TB vaccine during pregnancy and lactation among Ethiopian women. Our findings support vaccine-specific educational interventions to strengthen maternal immunization programs in Ethiopia.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Pregnancy
  • Adult
  • Patient Acceptance of Health Care
  • Health Knowledge, Attitudes, Practice
  • Tuberculosis
  • Young Adult
  • Tuberculosis Vaccines
  • Vaccination
  More +
• Keywords:
  • vaccination during pregnancy
  • lactation
  • tuberculosis
  • COVID-19
  • tetanus
  • maternal child health
• Source:
  The Pediatric Infectious Disease Journal, 2025, v. 44, no. 2
• DOI:
  https://doi.org/10.1097/INF.0000000000004699
• ISSN:
  0891-3668 ; 1532-0987
• Pubmed ID:
  39951091
• Pubmed Central ID:
  PMC11839159
• Document Type:
  Text
• Funding:
  K23 AI143479/AI/NIAID NIH HHSUnited States/ ; T32 AI074492/AI/NIAID NIH HHSUnited States/ ; UL1 TR002378/TR/NCATS NIH HHSUnited States/ ; P30 AI168386/AI/NIAID NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Ethiopia
• Pages in Document:
  S135-S140 (12 pdf pages)
• Volume:
  44
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261682/cdc_261682_DS1.pdf
• File Type:
  [PDF - 323.33 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0ab121dec1d0ae9cf3028814fa32e7a74791d1d55a305b91b620a482d441a30e2dec0421967034b6bd2d31485f59930fde0cc0a495472409fdccb7450aa11e41