Incident Cardiovascular Disease Risk Among Older Asian, Native Hawaiian and Pacific Islander Breast Cancer Survivors

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Hashibe, Mia ; Wei, Mei ; Lee, Catherine J. ; Tao, Randa ; Koric, Alzina ; Wang, Jing ; Daud, Anees ; Tay, Djin ; Shen, Jincheng ; Lee, Yuan-chin A. ; Chang, Chun-Pin E.
• Description:
  Background.
  
  Cardiotoxicity among breast cancer survivors is associated with chemotherapy and radiation therapy. The risk of cardiovascular disease (CVD) among Asian, Native Hawaiian and Pacific Islander (ANHPI) breast cancer survivors in the US is unknown.
  
  Methods.
  
  We used the SEER-Medicare linked database to estimate the risk of CVD among older breast cancer survivors. ICD diagnosis codes were used to identify incident CVD outcomes. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) comparing ANHPI to Non-Hispanic White (NHW) breast cancer patients for CVD, and among ANHPI race and ethnicity groups.
  
  Results.
  
  A total of 7,122 ANHPI breast cancer survivors and 21,365 NHW breast cancer survivors were identified. The risks of incident heart failure and ischemic heart disease were lower among ANHPI compared to NHW breast cancer survivors (HRheart failure=0.72, 95%CI=0.61, 0.84; HRheart disease=0.74, 95%CI=0.63, 0.88). Compared to Japanese breast cancer patients, Filipino, Asian Indian and Pakistani, and Native Hawaiian breast cancer survivors had higher risks of heart failure. ischemic heart disease and death. Among ANHPI breast cancer survivors, risk factors for heart failure included older age, higher comorbidity score, distant cancer stage and chemotherapy.
  
  Conclusions.
  
  Our results support heterogeneity in CVD outcomes among breast cancer survivors among ANHPI race and ethnicity groups. Further research is needed to elucidate the disparities experienced among ANHPI breast cancer survivors.
  
  Impact.
  
  Filipino, Asian Indian and Pakistani, and Native Hawaiian breast cancer patients had higher risks of heart failure, ischemic heart disease and death among ANHPI breast cancer patients.
  
  
• Subjects:
  Aged Breast Neoplasms Cancer Survivors Cardiovascular Diseases Female Heart Failure Humans Medicare Myocardial Ischemia Native Hawaiian Or Other Pacific Islander United States

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 33(1):126-135
• Pubmed ID:
  37843411
• Pubmed Central ID:
  PMC10842246
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; R01 CA244326/CA/NCI NIH HHSUnited States/
• Volume:
  33
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ba08b2bf0be11fd131ad5902ed6c1378ea2fbfcf2590cc40d21d2210590efebf254a90a2175f865264e818e8b1f9f47291cdb90699eeb077c7b29301210a55ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/147719/cdc_147719_DS1.pdf
• File Type:
  [PDF - 442.47 KB ]