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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

CITE Title : Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex Personal Author(s) : Konermann, Silvana;Brigham, Mark D.;Trevino, Alexandro E.;Joung, Julia;Abudayyeh, Omar O.;Barcena, Clea;Hsu, Patrick D.;Habib, Naomi;Gootenberg, Jonathan S.;Nishimasu, Hiroshi;Nureki, Osamu;Zhang, Feng; Published Date : Dec 10 2014 Source : Nature. 517(7536):583-588. URL : https://stacks.cdc.gov/view/cdc/30833 Konermann, Silvana et al. (2014). Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. 517(7536). Konermann, Silvana et al. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" 517, no. 7536 (2014) Konermann, Silvana et al. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" vol. 517, no. 7536, 2014 Export RIS Citation Information.

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Konermann, Silvana ;

Brigham, Mark D.

Dec 10 2014 | Nature. 517(7536):583-588.

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Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe struc...
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

CITE Title : In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy Personal Author(s) : Nelson, Christopher E.;Hakim, Chady H.;Ousterout, David G.;Thakore, Pratiksha I.;Moreb, Eirik A.;Rivera, Ruth M. Castellanos;Madhavan, Sarina;Pan, Xiufang;Ran, F. Ann;Yan, Winston X.;Asokan, Aravind;Zhang, Feng;Duan, Dongsheng;Gersbach, Charles A.; Published Date : Dec 31 2015 Source : Science. 351(6271):403-407. URL : https://stacks.cdc.gov/view/cdc/39629 Nelson, Christopher E. et al. (2015). In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. 351(6271). Nelson, Christopher E. et al. "In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy" 351, no. 6271 (2015) Nelson, Christopher E. et al. "In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy" vol. 351, no. 6271, 2015 Export RIS Citation Information.

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Nelson, Christopher E. ;

Hakim, Chady H.

Dec 31 2015 | Science. 351(6271):403-407.

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Duchenne muscular dystrophy (DMD) is a devastating disease affecting about 1 out of 5000 male births and caused by mutations in the dystrophin gene. G...
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

CITE Title : A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus Personal Author(s) : Flint, Mike;Chatterjee, Payel;Lin, David L.;McMullan, Laura K.;Shrivastava-Ranjan, Punya;Bergeron, Éric;Lo, Michael K.;Welch, Stephen R.;Nichol, Stuart T.;Tai, Andrew W.;Spiropoulou, Christina F.; Published Date : January 17 2019 Source : Nat Commun. 10 URL : https://stacks.cdc.gov/view/cdc/75846 Flint, Mike et al. (2019). A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. 10 Flint, Mike et al. "A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus" 10 (2019) Flint, Mike et al. "A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus" vol. 10, 2019 Export RIS Citation Information.

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Flint, Mike ;

Chatterjee, Payel

January 17 2019 | Nat Commun. 10

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There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Eb...
Genome engineering using the CRISPR-Cas9 system

CITE Title : Genome engineering using the CRISPR-Cas9 system Personal Author(s) : Ran, F. Ann;Hsu, Patrick D.;Wright, Jason;Agarwala, Vineeta;Scott, David A.;Zhang, Feng; Published Date : Oct 24 2013 Source : Nat Protoc. 2013; 8(11):2281-2308. URL : https://stacks.cdc.gov/view/cdc/29900 Ran, F. Ann et al. (2013). Genome engineering using the CRISPR-Cas9 system. 8(11). Ran, F. Ann et al. "Genome engineering using the CRISPR-Cas9 system" 8, no. 11 (2013) Ran, F. Ann et al. "Genome engineering using the CRISPR-Cas9 system" vol. 8, no. 11, 2013 Export RIS Citation Information.

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Ran, F. Ann ;

Hsu, Patrick D.

Oct 24 2013 | Nat Protoc. 2013; 8(11):2281-2308.

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Targeted nucleases are powerful tools for mediating genome alteration with high precision. The RNA-guided Cas9 nuclease from the microbial clustered r...
In vivo gene editing in dystrophic mouse muscle and muscle stem cells#

CITE Title : In vivo gene editing in dystrophic mouse muscle and muscle stem cells# Personal Author(s) : Tabebordbar, Mohammadsharif;Zhu, Kexian;Cheng, Jason K.W.;Chew, Wei Leong;Widrick, Jeffrey J.;Yan, Winston X.;Maesner, Claire;Wu, Elizabeth Y.;Xiao, Ru;Ran, F. Ann;Cong, Le;Zhang, Feng;Vandenberghe, Luk H.;Church, George M.;Wagers, Amy J.; Published Date : Dec 31 2015 Source : Science. 351(6271):407-411. URL : https://stacks.cdc.gov/view/cdc/40098 Tabebordbar, Mohammadsharif et al. (2015). In vivo gene editing in dystrophic mouse muscle and muscle stem cells#. 351(6271). Tabebordbar, Mohammadsharif et al. "In vivo gene editing in dystrophic mouse muscle and muscle stem cells#" 351, no. 6271 (2015) Tabebordbar, Mohammadsharif et al. "In vivo gene editing in dystrophic mouse muscle and muscle stem cells#" vol. 351, no. 6271, 2015 Export RIS Citation Information.

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Tabebordbar, Mohammadsharif ;

Zhu, Kexian

Dec 31 2015 | Science. 351(6271):407-411.

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Frame-disrupting mutations in the DMD gene, encoding dystrophin, compromise myofiber integrity and drive muscle deterioration in Duchenne muscular dys...
Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair

CITE Title : Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair Personal Author(s) : Findlay, Gregory M.;Boyle, Evan A.;Hause, Ronald J.;Klein, Jason;Shendure, Jay; Published Date : Sep 4 2014 Source : Nature. 513(7516):120-123. URL : https://stacks.cdc.gov/view/cdc/28566 Findlay, Gregory M. et al. (2014). Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair. 513(7516). Findlay, Gregory M. et al. "Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair" 513, no. 7516 (2014) Findlay, Gregory M. et al. "Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair" vol. 513, no. 7516, 2014 Export RIS Citation Information.

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Findlay, Gregory M. ;

Boyle, Evan A.

Sep 4 2014 | Nature. 513(7516):120-123.

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Saturation mutagenesis--coupled to an appropriate biological assay--represents a fundamental means of achieving a high-resolution understanding of reg...
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

CITE Title : BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Personal Author(s) : Canver, Matthew C.;Smith, Elenoe C.;Sher, Falak;Pinello, Luca;Sanjana, Neville E.;Shalem, Ophir;Chen, Diane D.;Schupp, Patrick G.;Vinjamur, Divya S.;Garcia, Sara P.;Luc, Sidinh;Kurita, Ryo;Nakamura, Yukio;Fujiwara, Yuko;Maeda, Takahiro;Yuan, Guo-Cheng;Feng, Zhang;Orkin, Stuart H.;Bauer, Daniel E.; Published Date : Sep 16 2015 Source : Nature. 527(7577):192-197. URL : https://stacks.cdc.gov/view/cdc/36479 Canver, Matthew C. et al. (2015). BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. 527(7577). Canver, Matthew C. et al. "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis" 527, no. 7577 (2015) Canver, Matthew C. et al. "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis" vol. 527, no. 7577, 2015 Export RIS Citation Information.

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Canver, Matthew C. ;

Smith, Elenoe C.

Sep 16 2015 | Nature. 527(7577):192-197.

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Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although...
Engineered CRISPR-Cas9 nucleases with altered PAM specificities

CITE Title : Engineered CRISPR-Cas9 nucleases with altered PAM specificities Personal Author(s) : Kleinstiver, Benjamin P.;Prew, Michelle S.;Tsai, Shengdar Q.;Topkar, Ved;Nguyen, Nhu T.;Zheng, Zongli;Gonzales, Andrew P.W.;Li, Zhuyun;Peterson, Randall T.;Yeh, Jing-Ruey Joanna;Aryee, Martin J.;Joung, J. Keith; Published Date : Jun 22 2015 Source : Nature. 523(7561):481-485. URL : https://stacks.cdc.gov/view/cdc/32948 Kleinstiver, Benjamin P. et al. (2015). Engineered CRISPR-Cas9 nucleases with altered PAM specificities. 523(7561). Kleinstiver, Benjamin P. et al. "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" 523, no. 7561 (2015) Kleinstiver, Benjamin P. et al. "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" vol. 523, no. 7561, 2015 Export RIS Citation Information.

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Kleinstiver, Benjamin P. ;

Prew, Michelle S.

Jun 22 2015 | Nature. 523(7561):481-485.

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Although CRISPR-Cas9 nucleases are widely used for genome editing, the range of sequences that Cas9 can recognize is constrained by the need for a spe...
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

CITE Title : Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells Personal Author(s) : Shalem, Ophir;Sanjana, Neville E.;Hartenian, Ella;Shi, Xi;Scott, David A.;Mikkelson, Tarjei;Heckl, Dirk;Ebert, Benjamin L.;Root, David E.;Doench, John G.;Zhang, Feng; Published Date : Dec 12 2013 Source : Science. 343(6166):84-87. URL : https://stacks.cdc.gov/view/cdc/30029 Shalem, Ophir et al. (2013). Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells. 343(6166). Shalem, Ophir et al. "Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells" 343, no. 6166 (2013) Shalem, Ophir et al. "Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells" vol. 343, no. 6166, 2013 Export RIS Citation Information.

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Shalem, Ophir ;

Sanjana, Neville E.

Dec 12 2013 | Science. 343(6166):84-87.

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The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9 to modify specific genom...
Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons

CITE Title : Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons Personal Author(s) : Heman-Ackah, Sabrina Mahalia;Bassett, Andrew Roger;Wood, Matthew John Andrew; Published Date : Jun 24 2016 Source : Sci Rep. 2016; 6. URL : https://stacks.cdc.gov/view/cdc/40475 Heman-Ackah, Sabrina Mahalia et al. (2016). Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons. 6 Heman-Ackah, Sabrina Mahalia and Bassett, Andrew Roger and Wood, Matthew John Andrew "Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons" 6 (2016) Heman-Ackah, Sabrina Mahalia et al. "Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons" vol. 6, 2016 Export RIS Citation Information.

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Heman-Ackah, Sabrina Mahalia ;

Bassett, Andrew Roger

Jun 24 2016 | Sci Rep. 2016; 6.

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The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differe...
Silencing Integrated SIV Proviral DNA with TAR-specific CRISPR Tools

CITE Title : Silencing Integrated SIV Proviral DNA with TAR-specific CRISPR Tools Personal Author(s) : Smith, Lisa M.;Hodara, Vida L.;Parodi, Laura M.;Callery, Jessica;Giavedoni, Luis D.; Published Date : 10 2020 Source : J Med Primatol. 49(5):269-279 URL : https://stacks.cdc.gov/view/cdc/102582 Smith, Lisa M. et al. (2020). Silencing Integrated SIV Proviral DNA with TAR-specific CRISPR Tools. 49(5). Smith, Lisa M. et al. "Silencing Integrated SIV Proviral DNA with TAR-specific CRISPR Tools" 49, no. 5 (2020) Smith, Lisa M. et al. "Silencing Integrated SIV Proviral DNA with TAR-specific CRISPR Tools" vol. 49, no. 5, 2020 Export RIS Citation Information.

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Smith, Lisa M. ;

Hodara, Vida L.

10 2020 | J Med Primatol. 49(5):269-279

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BackgroundOne approach for a functional HIV cure is to prevent transcription from integrated proviral DNA. A critical step in HIV transcription is the...
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

CITE Title : Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing Personal Author(s) : Tsai, Shengdar Q.;Wyvekens, Nicolas;Khayter, Cyd;Foden, Jennifer A.;Thapar, Vishal;Reyon, Deepak;Goodwin, Mathew J.;Aryee, Martin J.;Joung, J. Keith; Published Date : Apr 25 2014 Source : Nat Biotechnol. 32(6):569-576. URL : https://stacks.cdc.gov/view/cdc/27889 Tsai, Shengdar Q. et al. (2014). Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. 32(6). Tsai, Shengdar Q. et al. "Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing" 32, no. 6 (2014) Tsai, Shengdar Q. et al. "Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing" vol. 32, no. 6, 2014 Export RIS Citation Information.

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Tsai, Shengdar Q. ;

Wyvekens, Nicolas

Apr 25 2014 | Nat Biotechnol. 32(6):569-576.

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Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here w...
CRISPR RNA-guided activation of endogenous human genes

CITE Title : CRISPR RNA-guided activation of endogenous human genes Personal Author(s) : Maeder, Morgan L;Linder, Samantha J;Cascio, Vincent M;Fu, Yanfang;Ho, Quan H;Joung, J Keith; Published Date : Jul 25 2013 Source : Nat Methods. 10(10):977-979. URL : https://stacks.cdc.gov/view/cdc/22527 Maeder, Morgan L et al. (2013). CRISPR RNA-guided activation of endogenous human genes. 10(10). Maeder, Morgan L et al. "CRISPR RNA-guided activation of endogenous human genes" 10, no. 10 (2013) Maeder, Morgan L et al. "CRISPR RNA-guided activation of endogenous human genes" vol. 10, no. 10, 2013 Export RIS Citation Information.

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Maeder, Morgan L ;

Linder, Samantha J

Jul 25 2013 | Nat Methods. 10(10):977-979.

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Short guide RNAs (gRNAs) can direct catalytically inactive CRISPR-associated 9 nuclease (dCas9) to repress endogenous genes in bacteria and human cell...
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

CITE Title : CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling Personal Author(s) : Platt, Randall J.;Chen, Sidi;Zhou, Yang;Yim, Michael J.;Swiech, Lukasz;Kempton, Hannah R.;Dahlman, James E.;Parnas, Oren;Eisenhaure, Thomas M.;Jovanovic, Marko;Graham, Daniel B.;Jhunjhunwala, Siddharth;Xavier, Ramnik J.;Langer, Robert;Anderson, Daniel G.;Hacohen, Nir;Regev, Aviv;Feng, Guoping;Sharp, Phillip A.;Zhang, Feng; Published Date : 10 9 2014;10-9-; Source : Cell. 2014; 159(2):440-455 URL : https://stacks.cdc.gov/view/cdc/30201 Platt, Randall J. et al. (2014). CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. 159(2). Platt, Randall J. et al. "CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling" 159, no. 2 (2014) Platt, Randall J. et al. "CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling" vol. 159, no. 2, 2014 Export RIS Citation Information.

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Platt, Randall J. ;

Chen, Sidi

10 9 2014 | Cell. 2014; 159(2):440-455

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CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo...
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

CITE Title : In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9 Personal Author(s) : Swiech, Lukasz;Heidenreich, Matthias;Banerjee, Abhishek;Habib, Naomi;Li, Yinqing;Trombetta, John;Sur, Mriganka;Zhang, Feng; Published Date : 1 2015;1-2015; Source : Nat Biotechnol. 2014; 33(1):102-106 URL : https://stacks.cdc.gov/view/cdc/32021 Swiech, Lukasz et al. (2015). In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. 33(1). Swiech, Lukasz et al. "In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9" 33, no. 1 (2015) Swiech, Lukasz et al. "In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9" vol. 33, no. 1, 2015 Export RIS Citation Information.

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Swiech, Lukasz ;

Heidenreich, Matthias

1 2015 | Nat Biotechnol. 2014; 33(1):102-106

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Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularl...
Applications of CRISPR-Cas systems in neuroscience

CITE Title : Applications of CRISPR-Cas systems in neuroscience Personal Author(s) : Heidenreich, Matthias;Zhang, Feng; Published Date : Dec 10 2015 Source : Nat Rev Neurosci. 17(1):36-44. URL : https://stacks.cdc.gov/view/cdc/39857 Heidenreich, Matthias and Zhang, Feng (2015). Applications of CRISPR-Cas systems in neuroscience. 17(1). Heidenreich, Matthias and Zhang, Feng "Applications of CRISPR-Cas systems in neuroscience" 17, no. 1 (2015) Heidenreich, Matthias and Zhang, Feng "Applications of CRISPR-Cas systems in neuroscience" vol. 17, no. 1, 2015 Export RIS Citation Information.

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Heidenreich, Matthias ;

Zhang, Feng

Dec 10 2015 | Nat Rev Neurosci. 17(1):36-44.

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Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated...
Fatal Necrotizing Enterocolitis in Neonate Caused by Cronobacter sakazakii Sequence Type 64 Strain of CRISPR Sublineage b

CITE Title : Fatal Necrotizing Enterocolitis in Neonate Caused by Cronobacter sakazakii Sequence Type 64 Strain of CRISPR Sublineage b Personal Author(s) : Zeng, Haiyan;Li, Chengsi;Zhang, Jumei;Liang, Bingshao;Mei, Hanjie;Wu, Qingping; Published Date : 9 2023 Source : Emerg Infect Dis. 2023; 29(9):1917-1920 URL : https://stacks.cdc.gov/view/cdc/133593 Zeng, Haiyan et al. (2023). Fatal Necrotizing Enterocolitis in Neonate Caused by Cronobacter sakazakii Sequence Type 64 Strain of CRISPR Sublineage b. 29(9). Zeng, Haiyan et al. "Fatal Necrotizing Enterocolitis in Neonate Caused by Cronobacter sakazakii Sequence Type 64 Strain of CRISPR Sublineage b" 29, no. 9 (2023) Zeng, Haiyan et al. "Fatal Necrotizing Enterocolitis in Neonate Caused by Cronobacter sakazakii Sequence Type 64 Strain of CRISPR Sublineage b" vol. 29, no. 9, 2023 Export RIS Citation Information.

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Zeng, Haiyan ;

Li, Chengsi

9 2023 | Emerg Infect Dis. 2023; 29(9):1917-1920

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We report fatal neonatal necrotizing enterocolitis in China caused by Cronobacter sakazakii capsular profile K1:CA1, sequence type 64, and CRISPR type...
Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti

CITE Title : Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti Personal Author(s) : Blouin, Yann;Cazajous, Géraldine;Dehan, Céline;Soler, Charles;Vong, Rithy;Hassan, Mohamed Osman;Hauck, Yolande;Boulais, Christian;Andriamanantena, Dina;Martinaud, Christophe;Martin, Émilie;Pourcel, Christine;Vergnaud, Gilles; Published Date : Jan 2014 Source : Emerg Infect Dis. 20(1):21-28. URL : https://stacks.cdc.gov/view/cdc/21664 Blouin, Yann et al. (2014). Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti. 20(1). Blouin, Yann et al. "Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti" 20, no. 1 (2014) Blouin, Yann et al. "Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti" vol. 20, no. 1, 2014 Export RIS Citation Information.

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Blouin, Yann ;

Cazajous, Géraldine

Jan 2014 | Emerg Infect Dis. 20(1):21-28.

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"Mycobacterium canettii," an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacte...
High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets

CITE Title : High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets Personal Author(s) : Kleinstiver, Benjamin P.;Pattanayak, Vikram;Prew, Michelle S.;Tsai, Shengdar Q.;Nguyen, Nhu;Zheng, Zongli;Joung, J. Keith; Published Date : Jan 06 2016 Source : Nature. 529(7587):490-495. URL : https://stacks.cdc.gov/view/cdc/39163 Kleinstiver, Benjamin P. et al. (2016). High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets. 529(7587). Kleinstiver, Benjamin P. et al. "High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets" 529, no. 7587 (2016) Kleinstiver, Benjamin P. et al. "High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets" vol. 529, no. 7587, 2016 Export RIS Citation Information.

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Kleinstiver, Benjamin P. ;

Pattanayak, Vikram

Jan 06 2016 | Nature. 529(7587):490-495.

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CRISPR-Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide of...
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

CITE Title : C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector Personal Author(s) : Abudayyeh, Omar O.;Gootenberg, Jonathan S.;Konermann, Silvana;Joung, Julia;Slaymaker, Ian M.;Cox, David B.T.;Shmakov, Sergey;Makarova, Kira S.;Semenova, Ekaterina;Minakhin, Leonid;Severinov, Konstantin;Regev, Aviv;Lander, Eric S.;Koonin, Eugene V.;Zhang, Feng; Published Date : Jun 02 2016 Source : Science. 353(6299):aaf5573. URL : https://stacks.cdc.gov/view/cdc/42943 Abudayyeh, Omar O. et al. (2016). C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. 353(6299). Abudayyeh, Omar O. et al. "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector" 353, no. 6299 (2016) Abudayyeh, Omar O. et al. "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector" vol. 353, no. 6299, 2016 Export RIS Citation Information.

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Abudayyeh, Omar O. ;

Gootenberg, Jonathan S.

Jun 02 2016 | Science. 353(6299):aaf5573.

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The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against fo...