Applications of CRISPR-Cas systems in neuroscience

Details

• Alternative Title:
  Nat Rev Neurosci
• Personal Author:
  Heidenreich, Matthias ; Zhang, Feng
• Description:
  Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal models and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.
• Subjects:
  Animals Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Cas Systems Genetic Engineering Humans Neurosciences Translational Medical Research
• Source:
  Nat Rev Neurosci. 17(1):36-44.
• Pubmed ID:
  26656253
• Pubmed Central ID:
  PMC4899966
• Document Type:
  Journal Article
• Funding:
  1R01-MH110049/MH/NIMH NIH HHS/United States ; 5DP1-MH100706/DP/NCCDPHP CDC HHS/United States ; 5R01DK097768-03/DK/NIDDK NIH HHS/United States ; DP1 MH100706/MH/NIMH NIH HHS/United States ; R01 MH110049/MH/NIMH NIH HHS/United States
• Volume:
  17
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:83326fd9014ce03310f2671a8289363e9d82b0507e967b28f68bc7676cb47d1b
• Download URL:
  https://stacks.cdc.gov/view/cdc/39857/cdc_39857_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]