Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Blouin, Yann ; Cazajous, Géraldine ; Dehan, Céline ; Soler, Charles ; Vong, Rithy ; Hassan, Mohamed Osman ; Hauck, Yolande ; Boulais, Christian ; Andriamanantena, Dina ; Martinaud, Christophe ; Martin, Émilie ; Pourcel, Christine ; Vergnaud, Gilles
• Description:
  "Mycobacterium canettii," an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.
• Subjects:
  Adolescent Adult Biosynthetic Pathways Child Child, Preschool Cluster Analysis Clustered Regularly Interspaced Short Palindromic Repeats Female Genome, Bacterial Humans Infant Male Middle Aged Mycobacterium/classification Mycobacterium/genetics Mycobacterium/metabolism Phylogeny Polymorphism, Single Nucleotide Research Tuberculosis, Lymph Node/epidemiology Tuberculosis, Lymph Node/microbiology Vitamin B 12/biosynthesis Young Adult

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• Source:
  Emerg Infect Dis. 20(1):21-28.
• Document Type:
  Journal Article
• Place as Subject:
  Djibouti
• Location:
  Africa
• Volume:
  20
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:31d430c89528b4c5ebdb294a9da766b5a5c7369b0f80fb7037ee087582ed4396
• Download URL:
  https://stacks.cdc.gov/view/cdc/21664/cdc_21664_DS1.pdf
• File Type:
  [PDF - 492.20 KB ]