Progenitor "Mycobacterium canettii" Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Blouin, Yann ; Cazajous, Géraldine ; Dehan, Céline ; Soler, Charles ; Vong, Rithy ; Hassan, Mohamed Osman ; Hauck, Yolande ; Boulais, Christian ; Andriamanantena, Dina ; Martinaud, Christophe ; Martin, Émilie ; Pourcel, Christine ; Vergnaud, Gilles
  More +
• Description:
  "Mycobacterium canettii," an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.
• Subjects:
  • Research
  • Adolescent
  • Adult
  • Biosynthetic Pathways
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Female
  • Genome, Bacterial
  More +
• Source:
  Emerg Infect Dis. 20(1):21-28.
• Document Type:
  Journal Article
• Place as Subject:
  Djibouti
• Location:
  Africa
• Volume:
  20
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/21664/cdc_21664_DS1.pdf
• File Type:
  [PDF - 492.20 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:adbe234a1497415ac8a1b1553d46647fce9921a8a6cf450ca30be45010b5879553a7c762bb3d7298e7cd8c2aec5df111215b55f1b6607e6b21722cdc3200d32d