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CDC Public Access

CDC Stacks Public Health Publications

Items in this collection are manuscripts and articles written by CDC or CDC-funded authors, and published in scholarly journals outside CDC. These items are available in compliance with the 2024 update of CDC-GA-2013-01 CDC Public Access to CDC-Funded Publications, available at: https://stacks.cdc.gov/view/cdc/159734.

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Showing 25061 - 25080 of 27881 results
  • Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin Interactions
    Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin Interactions
    Dixon, Jesse R. ;
    Selvaraj, Siddarth
    Apr 11 2012 | Nature. 485(7398):376-380.
    The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct chromosome territories, and numerous models have been proposed for how chromosomes fold withi ...
    Supporting Files
  • HospitalBased Mortality in Federal Capital Territory HospitalsNigeria 2005 2008
    Hospital-Based Mortality in Federal Capital Territory Hospitals-Nigeria, 2005 - 2008
    Preacely, Nykiconia ;
    Biya, Oladayo
    Apr 11 2012 | Pan Afr Med J. 2012; 11.
    BackgroundCause-specific mortality data are important to monitor trends in mortality over time. Medical records provide reliable documentation of the causes of deaths occurring in hospitals. This study describes all causes of mortality reported at hospitals in the Federal Capital Territory (FCT) of Nigeria.MethodsDeaths reported in 15 secondary and ...
    Supporting Files Public Domain
  • An Analysis of 332 Fatalities Infected with Pandemic 2009 Influenza A H1N1 in Argentina
    An Analysis of 332 Fatalities Infected with Pandemic 2009 Influenza A (H1N1) in Argentina
    Balanzat, Ana M. ;
    Hertlein, Christian
    Apr 10 2012 | PLoS One. 2012; 7(4).
    BackgroundThe apparent high number of deaths in Argentina during the 2009 pandemic led to concern that the influenza A H1N1pdm disease was different there. We report the characteristics and risk factors for influenza A H1N1pdm fatalities.MethodsWe identified laboratory-confirmed influenza A H1N1pdm fatalities occurring during June-July 2009. Physic ...
    Supporting Files Public Domain
  • Factoringin Agglomeration of Carbon Nanotubes and Nanofibers for Better Prediction of Their Toxicity Versus Asbestos
    Factoring-in Agglomeration of Carbon Nanotubes and Nanofibers for Better Prediction of Their Toxicity Versus Asbestos
    Fadeel, Bengt ;
    Kagan, Valerian E.
    2012/04/10 | Part Fibre Toxicol 2012 Apr; 9:10 | National Institute for Occupational Safety and Health (NIOSH)
    Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurring asbestos fibers which are known to be extremely pathogenic. While the toxicity and hazardous outcomes elicited by airborne exposure to sin ...
    Supporting Files
  • Exposures to fine particulate air pollution and respiratory outcomes in adults using two national datasets a crosssectional study
    Exposures to fine particulate air pollution and respiratory outcomes in adults using two national datasets: a cross-sectional study
    Nachman, Keeve E. ;
    Parker, Jennifer D.
    Apr 10 2012 | Environ Health. 2012; 11:25.
    BackgroundRelationships between chronic exposures to air pollution and respiratory health outcomes have yet to be clearly articulated for adults. Recent data from nationally representative surveys suggest increasing disparity by race/ethnicity regarding asthma-related morbidity and mortality. The objectives of this study are to evaluate the relatio ...
    Supporting Files Public Domain
  • Elucidating the Role of the Complement Control Protein in Monkeypox Pathogenicity
    Elucidating the Role of the Complement Control Protein in Monkeypox Pathogenicity
    Hudson, Paul N. ;
    Self, Joshua
    4 9 2012 | PLoS One. 2012; 7(4)
    Monkeypox virus (MPXV) causes a smallpox-like disease in humans. Clinical and epidemiological studies provide evidence of pathogenicity differences between two geographically distinct monkeypox virus clades: the West African and Congo Basin. Genomic analysis of strains from both clades identified a ∼10 kbp deletion in the less virulent West African ...
    Supporting Files
  • Mechanisms of carbon nanotubeinduced toxicity Focus on oxidative stress
    Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress
    Shvedova, Anna A. ;
    Pietroiusti, Antonio
    Apr 06 2012 | Toxicol Appl Pharmacol. 261(2):121-133.
    Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a comm ...
    Supporting Files
  • Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
    Mutation Accumulation May Be a Minor Force in Shaping Life History Traits
    Dańko, Maciej Jan ;
    Kozłowski, Jan
    Apr 06 2012 | PLoS One. 2012; 7(4).
    Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-strings to capture different age-specific mutational patter ...
    Supporting Files Public Domain
  • Selection Bias in PopulationBased Cancer CaseControl Studies Due to Incomplete Sampling Frame Coverage
    Selection Bias in Population-Based Cancer Case–Control Studies Due to Incomplete Sampling Frame Coverage
    Walsh, Matthew C. ;
    Trentham-Dietz, Amy
    Apr 06 2012 | Cancer Epidemiol Biomarkers Prev. 2012; 21(6):881-886.
    BackgroundIncreasing numbers of individuals are choosing to opt out of population-based sampling frames due to privacy concerns. This is especially a problem in the selection of controls for case–control studies, as the cases often arise from relatively complete population-based registries, whereas control selection requires a sampling frame. If op ...
    Supporting Files
  • Ross Macdonald and a Theory for the Dynamics and Control of MosquitoTransmitted Pathogens
    Ross, Macdonald, and a Theory for the Dynamics and Control of Mosquito-Transmitted Pathogens
    Smith, David L. ;
    Battle, Katherine E.
    Apr 05 2012 | PLoS Pathog. 2012; 8(4).
    Ronald Ross and George Macdonald are credited with developing a mathematical model of mosquito-borne pathogen transmission. A systematic historical review suggests that several mathematicians and scientists contributed to development of the Ross-Macdonald model over a period of 70 years. Ross developed two different mathematical models, Macdonald a ...
    Supporting Files
  • Decision analysis economic evaluation and newborn screening challenges and opportunities
    Decision analysis, economic evaluation, and newborn screening: challenges and opportunities
    Prosser, Lisa A. ;
    Grosse, Scott D.
    Apr 05 2012 | Genet Med. 14(8):703-712
    The number of conditions included in newborn screening panels has increased rapidly in the United States during the past decade, and many more conditions are under consideration for addition to state panels. The rare nature of candidate conditions for newborn screening makes their evaluation challenging. The scarcity of data on the costs of screeni ...
    Supporting Files
  • Hand breakaway strength model Effects of glove use and handle shapes on a persons hand strength to hold onto handles to prevent fall from elevation
    Hand breakaway strength model – Effects of glove use and handle shapes on a person’s hand strength to hold onto handles to prevent fall from elevation
    Hur, Pilwon ;
    Motawar, Binal
    4 05 2012 | J Biomech. 45(6):958-964
    This study developed biomechanical models for hand breakaway strength that account for not only grip force but also hand-handle frictional coupling in generation of breakaway strength. Specifically, models for predicting breakaway strength for two commonly-used handle shapes (circular and rectangular handles) and varying coefficients of friction (C ...
    Supporting Files
  • Digitoxin and its analogs as novel cancer therapeutics
    Digitoxin and its analogs as novel cancer therapeutics
    Elbaz, Hosam A ;
    Stueckle, Todd A
    Apr 05 2012 | Exp Hematol Oncol. 2012; 1:4.
    A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to syntheti ...
    Supporting Files Public Domain
  • Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats
    Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats
    Shoykhet, Michael ;
    Simons, Daniel J.
    Apr 4 2012 | J Neurosci. 32(14):4972-4981.
    Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. Previous studies of global brain hypoxia-ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. Susceptible neuronal populations also include inhibitory neurons in the thalamic reticular nucleus. We therefore investigated the imp ...
    Supporting Files
  • Variants in the vitamin D pathway serum levels of vitamin D and estrogen receptor negative breast cancer among AfricanAmerican women a casecontrol study
    Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study
    Yao, Song ;
    Zirpoli, Gary
    Apr 04 2012 | Breast Cancer Res. 2012; 14(2):R58.
    IntroductionAmerican women of African ancestry (AA) are more likely than European Americans (EA) to have estrogen receptor (ER)-negative breast cancer. 25-hydroxyvitamin D (25OHD) is low in AAs, and was associated with ER-negative tumors in EAs. We hypothesized that racial differences in 25OHD levels, as well as in inherited genetic variations, may ...
    Supporting Files
  • Resveratrol Inhibits ParaquatInduced Oxidative Stress and Fibrogenic Response by Activating the Nuclear Factor Erythroid 2Related Factor 2 Pathway
    Resveratrol Inhibits Paraquat-Induced Oxidative Stress and Fibrogenic Response by Activating the Nuclear Factor Erythroid 2-Related Factor 2 Pathway
    He, Xiaoqing ;
    Wang, Liping
    Apr 04 2012 | J Pharmacol Exp Ther. 342(1):81-90
    Nuclear factor erythroid 2-related factor 2 (Nrf2) is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular defense against oxidative and inflammatory lesions. Resveratrol (Res) is a natural phytoalexin that exhibits multiple therapeutic potentials, including antioxidative and anti-inflammatory effe ...
    Supporting Files
  • NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
    NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
    Pryor, Shona ;
    McCaffrey, Gretchen
    Apr 04 2012 | PLoS One. 2012; 7(4).
    Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition. Although the nerve growth factor (NGF) receptors, TrkA and p75(NTR) collaborate with each other at t ...
    Supporting Files
  • Patterns of arthritis medication use in a community sample
    Patterns of arthritis medication use in a community sample
    Rosenwald, Kent ;
    Ertl, Kristyn
    Apr 04 2012 | J Prim Care Community Health. 3(4):272-277.
    BACKGROUNDAlthough arthritis is disabling, highly prevalent, and often treated without health professional input, little is known about the treatments selected by affected individuals. Such information is important because of the toxicity associated with some arthritis treatments.OBJECTIVETo describe the pattern of drug treatment use in a sample of ...
    Supporting Files
  • Towards Elimination of MothertoChild Transmission of HIV The Impact of a Rapid Results Initiative in Nyanza Province Kenya
    Towards Elimination of Mother-to-Child Transmission of HIV: The Impact of a Rapid Results Initiative in Nyanza Province, Kenya
    Dillabaugh, Lisa L. ;
    Lewis Kulzer, Jayne
    Apr 04 2012 | AIDS Res Treat. 2012; 2012.
    Many HIV-positive pregnant women and infants are still not receiving optimal services, preventing the goal of eliminating mother-to-child transmission (MTCT) and improving maternal child health overall. A Rapid Results Initiative (RRI) approach was utilized to address key challenges in delivery of prevention of MTCT (PMTCT) services including highl ...
    Supporting Files
  • A NonVH169 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
    A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
    De Marco, Donata ;
    Clementi, Nicola
    April 04 2012 | PLoS One. 2012; 7(4)
    Influenza viruses are among the most important human pathogens and are responsible for annual epidemics and sporadic, potentially devastating pandemics. The humoral immune response plays an important role in the defense against these viruses, providing protection mainly by producing antibodies directed against the hemagglutinin (HA) glycoprotein. H ...
    Supporting Files Public Domain
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