Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Details

• Alternative Title:
  Front Med (Lausanne)
• Personal Author:
  Fusco, Dahlene N. ; Ganova-Raeva, Lilia ; Khudyakov, Yury ; Punkova, Lili ; Mohamed, Aisha ; Cheon, Scarlett Se Yun ; Koirala, Prapti ; Andersson, Karin L. ; Jourdain, Gonzague ; Sureau, Camille ; Chung, Raymond T. ; Lauer, Georg
• Description:
  A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.
• Subjects:
  HBV Vaccine Escape Mutant HCV Hepatitis B Virus Medicine PreS2 Deletion Surface Antibody Escape Mutant
• Source:
  Front Med (Lausanne). 2018; 5.
• Pubmed ID:
  29761102
• Pubmed Central ID:
  PMC5936758
• Document Type:
  Journal Article
• Volume:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e1014aab5b7359794316c0ce628071ad04b49b442c2e61e621ca951379d0ad52
• Download URL:
  https://stacks.cdc.gov/view/cdc/55634/cdc_55634_DS1.pdf
• File Type:
  [PDF - 229.43 KB ]