Using Data to Guide Policy: Next Steps for Preventing Perinatal Hepatitis B Virus Transmission in Cambodia

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Soeung, Sann Chan ; Thiep, Chanthon ; Duncan, Richard ; Patel, Minal ; Hennessey, Karen
• Description:
  Cambodia is highly endemic for hepatitis B virus (HBV) infection. Preventing perinatal HBV transmission should be prioritized in health facilities by providing hepatitis B vaccination to all infants within 24 h of birth (timely birth dose coverage).|Teams assessed birth dose policy, practices and coverage in hospitals and health facilities in 10 provinces in Cambodia.|Fifty-one sites were assessed. Median (interquartile range) timely birth dose coverage was 66% (48-92%); coverage was 88% (range=60-96%) in facilities vaccinating on-site and 48% (range=20-52%) in those referring off-site (p<0.0001). Overall, 5 (29%) of 16 hospitals that referred vaccination off-site did not tell mothers vaccination should take place within 24 h of birth, and 6 (35%) discharged mothers when no vaccination services were available for infants to receive the birth dose.|Newborns can miss a time-sensitive opportunity to be protected against perinatal HBV infection when they are referred for vaccination off-site rather than being vaccinated in the delivery facility. These data support the case to strengthen policies and practices to provide hepatitis B birth dose vaccination in the delivery facility.
• Subjects:
  Cambodia Female Hepatitis B Hepatitis B Virus Humans Infant, Newborn Infectious Disease Transmission, Vertical Male Pregnancy Pregnancy Complications, Infectious
• Keywords:
  Birth Dose Hepatitis B Virus Perinatal Transmission Vaccination
• Source:
  Vaccine. 31(1):149-153
• Pubmed ID:
  23127515
• Pubmed Central ID:
  PMC4663666
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  31
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:79c8783367ed07587ae72971fb11776c7cbea52ec676b2abaf62cf235d44e26c
• Download URL:
  https://stacks.cdc.gov/view/cdc/36712/cdc_36712_DS1.pdf
• File Type:
  [PDF - 105.86 KB ]