Epidemiology of Hepatitis B Virus Infection and Impact of Vaccination on Disease

Details

• Alternative Title:
  Clin Liver Dis
• Personal Author:
  Nelson, Noele P. ; Easterbrook, Philippa J. ; McMahon, Brian J.
• Description:
  Integration of hepatitis B vaccination into national immunization programs has resulted in substantial reductions of hepatitis B virus (HBV) transmission in previously high endemic countries. The key strategy for control of the HBV epidemic is birth dose and infant vaccination. Additional measures include use of hepatitis B immunoglobulin (HBIG) and diagnosis of mothers at high risk of transmitting HBV and use of antiviral agents during pregnancy to decrease maternal DNA concentrations to undetectable concentrations. Despite the substantial decrease in HBV cases since vaccination introduction, implementation of birth dose vaccination in low-income and middle-income countries and vaccination of high-risk adults remain challenging.
• Subjects:
  • Global Health
  • Hepatitis B
  • Hepatitis B Antigens
  • Hepatitis B Vaccines
  • Hepatitis B virus
  • Humans
  • Incidence
  • Vaccination
• Keywords:
  • Hepatitis B virus
  • Hepatitis B vaccine
  • Birth dose
  • Perinatal transmission
  • Vaccine impact
• Source:
  Clin Liver Dis. 20(4):607-628
• Pubmed ID:
  27742003
• Pubmed Central ID:
  PMC5582972
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  20
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/48002/cdc_48002_DS1.pdf
• File Type:
  [PDF - 564.64 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:79c970c2a0e51132dbbafc627b78c0d5932fb8ccfa8dbff3578be6d9b5d74808