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Showing 821 - 840 of 1969 results

Investigating Heterogeneous Effects of An Expanded Methadone Access Policy With Opioid Treatment Program Retention: a Rhode Island Population-based Retrospective Cohort Study.

Allen, Bennett ;

Krawczyk, Noa

May 2025 | American Journal of Epidemiology, 2025, v. 194, no. 9

Following federal regulatory changes during the COVID-19 pandemic, Rhode Island expanded methadone access for opioid treatment programs (OTPs) in March 2020. The policy, which permitted take-home dosing for patients, contrasted with longstanding restrictions on methadone. This study used patient-level OTP admission and discharge records to compare ...

10/09/2026

Supporting Files

Title : Investigating Heterogeneous Effects of An Expanded Methadone Access Policy With Opioid Treatment Program Retention: a Rhode Island Population-based Retrospective Cohort Study. Personal Author(s) : Allen, Bennett;Krawczyk, Noa;Basaraba, Cale;Jent, Victoria A.;Yedinak, Jesse L.;Goedel, William C.;Krieger, Maxwell;Pratty, Claire;Macmadu, Alexandria;Samuels, Elizabeth A.;Marshall, Brandon D. L.;Neill, Daniel B.;Cerdá, Magdalena; Published Date : May 2025 Pages in Document : 2744-2754 (24 pdf pages) Source : American Journal of Epidemiology, 2025, v. 194, no. 9 DOI : https://doi.org/10.1093/aje/kwaf092 Journal Title : American Journal of Epidemiology
Allen, B., Krawczyk, N., Basaraba, C., Jent, V. A., Yedinak, J. L., Goedel, W. C., Krieger, M., Pratty, C., Macmadu, A., Samuels, E. A., Marshall, B. D. L., Neill, D. B., & Cerdá, M. (2025). Investigating Heterogeneous Effects of An Expanded Methadone Access Policy With Opioid Treatment Program Retention: a Rhode Island Population-based Retrospective Cohort Study. American Journal of Epidemiology, 194(9). https://doi.org/10.1093/aje/kwaf092

Allen, Bennett, Noa Krawczyk, Cale Basaraba, Victoria A. Jent, Jesse L. Yedinak, William C. Goedel, and Maxwell Krieger, et al.. "Investigating Heterogeneous Effects of An Expanded Methadone Access Policy With Opioid Treatment Program Retention: a Rhode Island Population-based Retrospective Cohort Study." American Journal of Epidemiology 194, no. 9 (2025). https://doi.org/10.1093/aje/kwaf092.

Allen, Bennett, et al. "Investigating Heterogeneous Effects of An Expanded Methadone Access Policy With Opioid Treatment Program Retention: a Rhode Island Population-based Retrospective Cohort Study." American Journal of Epidemiology, vol. 194, no. 9, 2025. Stacks. https://doi.org/10.1093/aje/kwaf092.
Export RIS Citation Information. TY - Journal Article AU - Allen, Bennett AU - Krawczyk, Noa AU - Basaraba, Cale AU - Jent, Victoria A. AU - Yedinak, Jesse L. AU - Goedel, William C. AU - Krieger, Maxwell AU - Pratty, Claire AU - Macmadu, Alexandria AU - Samuels, Elizabeth A. AU - Marshall, Brandon D. L. AU - Neill, Daniel B. AU - Cerdá, Magdalena AB - Following federal regulatory changes during the COVID-19 pandemic, Rhode Island expanded methadone access for opioid treatment programs (OTPs) in March 2020. The policy, which permitted take-home dosing for patients, contrasted with longstanding restrictions on methadone. This study used patient-level OTP admission and discharge records to compare six-month retention before and after the policy change. We conducted a retrospective cohort study of 1248 patients newly admitted to OTPs between March 18 and June 30 of 2019 (pre-policy) and 2020 (post-policy). We used logistic regression to estimate associations with retention before and after the policy and used a machine learning approach, the heterogeneous treatment effect (HTE)-Scan, to explore heterogeneity in retention across subgroups. Overall, we found no change in retention following the policy, with an adjusted OR of 1.08 (95% CI, 0.80, 1.45) and adjusted RR of 1.03 (0.90-1.18). Using HTE-Scan, we identified two subgroups with significantly increased retention above the overall cohort: (1) patients with below high-school education and past-month arrest and (2) male, non-Hispanic white or Hispanic/Latino patients reporting heroin or fentanyl use with past-month arrest. We identified no subgroups with significantly decreased retention. Collectively, findings suggest that expanded methadone access may benefit vulnerable populations without harming overall retention. AB - Author manuscript AN - cdc:261442 C4 - PMC12409131 DO - https://doi.org/10.1093/aje/kwaf092 IS - 9 J2 - American Journal of Epidemiology KW - Retrospective Studies KW - Methadone KW - Analgesics, Opioid KW - Female KW - Male KW - Middle Aged KW - Humans KW - Health Services Accessibility KW - COVID-19 KW - Opioid-Related Disorders KW - Adult KW - Opiate Substitution Treatment KW - treatment retention KW - methadone KW - COVID-19 KW - heterogeneous treatment effects KW - machine learning KW - Rhode Island KW - HTE-scan KW - Humans KW - Methadone KW - Retrospective Studies KW - Male KW - Female KW - Opiate Substitution Treatment KW - Opioid-Related Disorders KW - Adult KW - Middle Aged KW - Analgesics, Opioid KW - COVID-19 KW - Health Services Accessibility LA - eng PY - 2025 T2 - American Journal of Epidemiology T2 - American Journal of Epidemiology, 2025, v. 194, no. 9 TI - Investigating Heterogeneous Effects of An Expanded Methadone Access Policy With Opioid Treatment Program Retention: a Rhode Island Population-based Retrospective Cohort Study. VL - 194 UR - https://stacks.cdc.gov/view/cdc/261442 ER -
Mesoporous Pd@Pt Nanoparticle Label/Lateral Flow Immunoassay Integrated With a 3D-Printed Smartphone Reader For Detection of Wood Smoke Biomarkers.

Yang, Zhansen ;

Li, Xinyi

May 2025 | ACS Applied Materials & Interfaces, 2025, v. 17, no. 19

Wood smoke exposure poses significant health risks, particularly in occupations such as firefighting, where short-term exposure to high levels of pollutants is common. The biomonitoring of wood smoke-associated biomarkers is crucial for assessing human exposure. S-phenylmercapturic acid (S-PMA), a key metabolite of benzene, has been widely used as ...

10/09/2026

Supporting Files

Title : Mesoporous Pd@Pt Nanoparticle Label/Lateral Flow Immunoassay Integrated With a 3D-Printed Smartphone Reader For Detection of Wood Smoke Biomarkers. Personal Author(s) : Yang, Zhansen;Li, Xinyi;Fu, Yonghao;Song, Yang;Simpson, Christopher D.;Naeher, Luke P.;Lin, Yuehe;Du, Dan; Published Date : May 2025 Pages in Document : 28523-28531 (20 pdf pages) Source : ACS Applied Materials & Interfaces, 2025, v. 17, no. 19 DOI : https://doi.org/10.1021/acsami.5c02147 Journal Title : ACS Applied Materials & Interfaces
Yang, Z., Li, X., Fu, Y., Song, Y., Simpson, C. D., Naeher, L. P., Lin, Y., & Du, D. (2025). Mesoporous Pd@Pt Nanoparticle Label/Lateral Flow Immunoassay Integrated With a 3D-Printed Smartphone Reader For Detection of Wood Smoke Biomarkers. ACS Applied Materials & Interfaces, 17(19). https://doi.org/10.1021/acsami.5c02147

Yang, Zhansen, Xinyi Li, Yonghao Fu, Yang Song, Christopher D. Simpson, Luke P. Naeher, Yuehe Lin, and Dan Du. "Mesoporous Pd@Pt Nanoparticle Label/Lateral Flow Immunoassay Integrated With a 3D-Printed Smartphone Reader For Detection of Wood Smoke Biomarkers." ACS Applied Materials & Interfaces 17, no. 19 (2025). https://doi.org/10.1021/acsami.5c02147.

Yang, Zhansen, et al. "Mesoporous Pd@Pt Nanoparticle Label/Lateral Flow Immunoassay Integrated With a 3D-Printed Smartphone Reader For Detection of Wood Smoke Biomarkers." ACS Applied Materials & Interfaces, vol. 17, no. 19, 2025. Stacks. https://doi.org/10.1021/acsami.5c02147.
Export RIS Citation Information. TY - Journal Article AU - Yang, Zhansen AU - Li, Xinyi AU - Fu, Yonghao AU - Song, Yang AU - Simpson, Christopher D. AU - Naeher, Luke P. AU - Lin, Yuehe AU - Du, Dan AB - Wood smoke exposure poses significant health risks, particularly in occupations such as firefighting, where short-term exposure to high levels of pollutants is common. The biomonitoring of wood smoke-associated biomarkers is crucial for assessing human exposure. S-phenylmercapturic acid (S-PMA), a key metabolite of benzene, has been widely used as a reliable biomarker for this purpose. However, current S-PMA detection methods lack the speed, portability, and user-friendliness required for widespread, on-site applications. In this study, we propose a novel detection system that integrates mesoporous Pd@Pt nanoparticle-mediated lateral flow immunoassay (LFIA) with a 3D-printed smartphone-based reader for detecting S-PMA. Performance testing with S-PMA in phosphate-buffered saline and spiked urine samples yielded limits of detection of 0.5 ng/mL and 2.5 ng/mL, respectively. The use of mesoporous Pd@Pt nanoparticles as signal amplifiers for LFIA, along with the integration of a 3D-printed device for accurate image acquisition, significantly enhanced the system's sensitivity, achieving detection limits well below the threshold recommended by the American Conference of Governmental and Industrial Hygienists. With remarkable stability and reproducibility, our method provides a noninvasive, highly sensitive, rapid, portable, low-cost, and user-friendly solution for the on-site assessment of wood smoke exposure in occupational settings, laying the foundation for future innovations in real-time environmental exposure monitoring. AB - Author manuscript AN - cdc:261441 C4 - PMC13079441 DO - https://doi.org/10.1021/acsami.5c02147 IS - 19 J2 - ACS Applied Materials & Interfaces KW - Biomarkers KW - Limit of Detection KW - Wood KW - Metal Nanoparticles KW - Smartphone KW - Platinum KW - Smoke KW - Immunoassay KW - Printing, Three-Dimensional KW - Humans KW - Palladium KW - Porosity KW - mesoporous Pd@Pt nanoparticles KW - lateral flow immunoassays KW - 3Dprinting KW - smartphone readers KW - wood smoke biomarkers KW - Wood KW - Printing, Three-Dimensional KW - Smartphone KW - Smoke KW - Immunoassay KW - Humans KW - Biomarkers KW - Metal Nanoparticles KW - Palladium KW - Porosity KW - Platinum KW - Limit of Detection LA - eng PY - 2025 T2 - ACS Applied Materials & Interfaces T2 - ACS Applied Materials & Interfaces, 2025, v. 17, no. 19 TI - Mesoporous Pd@Pt Nanoparticle Label/Lateral Flow Immunoassay Integrated With a 3D-Printed Smartphone Reader For Detection of Wood Smoke Biomarkers. VL - 17 UR - https://stacks.cdc.gov/view/cdc/261441 ER -
Acceptability, Feasibility, and Effectiveness of Caregiver-assisted HIV Self-testing Among Children Using an Oral Mucosal Test in Uganda and Zambia: a Prospective Interventional Study.

Gross, Jessica ;

Tumwesigye, Nazarius M

May 2025 | The Lancet. HIV, 2025, v. 12, no. 5

During the COVID-19 pandemic, the US President's Emergency Plan for AIDS Relief supported oral caregiver-assisted HIV self-testing (CG-HIVST) to address the gap in HIV diagnosis of children. We aimed to investigate caregiver uptake, results return, acceptability, and potential social harms of CG-HIVST.This prospective, interventional, study was don ...

10/09/2026

Supporting Files

Title : Acceptability, Feasibility, and Effectiveness of Caregiver-assisted HIV Self-testing Among Children Using an Oral Mucosal Test in Uganda and Zambia: a Prospective Interventional Study. Personal Author(s) : Gross, Jessica;Tumwesigye, Nazarius M;Mutembo, Simon;Moyo, Nkumbula;Mukose, Aggrey;Chilyabanyama, Obvious;Matoba, Japhet;Parris, KaeAnne;Lee, Brianna;Churchill, Taralyn;Williamson, Dhelia;Pals, Sherri;Biribawa, Claire;Kagaayi, Joseph;Ndubani, Phillimon;Okello, Francis;Zyambo, Zude;Taasi, Geoffrey;Magongo, Eleanor N;Munthali, Gloria;Mwiya, Mwiya;Nazziwa, Esther;Awor, Anna C;Itoh, Megumi;Boyd, Adetinuke Mary;Macleod, David;Rivadeneira, Emilia;Oliver, Daniel;Ferrand, Rashida A;Stecker, Carl; Published Date : May 2025 Pages in Document : e325-e337 (24 pdf pages) Source : The Lancet. HIV, 2025, v. 12, no. 5 DOI : https://doi.org/10.1016/S2352-3018(25)00005-0 Journal Title : The Lancet. HIV
Gross, J., Tumwesigye, N. M., Mutembo, S., Moyo, N., Mukose, A., Chilyabanyama, O., Matoba, J., Parris, K., Lee, B., Churchill, T., Williamson, D., Pals, S., Biribawa, C., Kagaayi, J., Ndubani, P., Okello, F., Zyambo, Z., Taasi, G., Magongo, E. N., ... Stecker, C. (2025). Acceptability, Feasibility, and Effectiveness of Caregiver-assisted HIV Self-testing Among Children Using an Oral Mucosal Test in Uganda and Zambia: a Prospective Interventional Study. The Lancet. HIV, 12(5). https://doi.org/10.1016/S2352-3018(25)00005-0

Gross, Jessica, Nazarius M Tumwesigye, Simon Mutembo, Nkumbula Moyo, Aggrey Mukose, Obvious Chilyabanyama, and Japhet Matoba, et al.. "Acceptability, Feasibility, and Effectiveness of Caregiver-assisted HIV Self-testing Among Children Using an Oral Mucosal Test in Uganda and Zambia: a Prospective Interventional Study." The Lancet. HIV 12, no. 5 (2025). https://doi.org/10.1016/S2352-3018(25)00005-0.

Gross, Jessica, et al. "Acceptability, Feasibility, and Effectiveness of Caregiver-assisted HIV Self-testing Among Children Using an Oral Mucosal Test in Uganda and Zambia: a Prospective Interventional Study." The Lancet. HIV, vol. 12, no. 5, 2025. Stacks. https://doi.org/10.1016/S2352-3018(25)00005-0.
Export RIS Citation Information. TY - Journal Article AU - Gross, Jessica AU - Tumwesigye, Nazarius M AU - Mutembo, Simon AU - Moyo, Nkumbula AU - Mukose, Aggrey AU - Chilyabanyama, Obvious AU - Matoba, Japhet AU - Parris, KaeAnne AU - Lee, Brianna AU - Churchill, Taralyn AU - Williamson, Dhelia AU - Pals, Sherri AU - Biribawa, Claire AU - Kagaayi, Joseph AU - Ndubani, Phillimon AU - Okello, Francis AU - Zyambo, Zude AU - Taasi, Geoffrey AU - Magongo, Eleanor N AU - Munthali, Gloria AU - Mwiya, Mwiya AU - Nazziwa, Esther AU - Awor, Anna C AU - Itoh, Megumi AU - Boyd, Adetinuke Mary AU - Macleod, David AU - Rivadeneira, Emilia AU - Oliver, Daniel AU - Ferrand, Rashida A AU - Stecker, Carl AB - During the COVID-19 pandemic, the US President's Emergency Plan for AIDS Relief supported oral caregiver-assisted HIV self-testing (CG-HIVST) to address the gap in HIV diagnosis of children. We aimed to investigate caregiver uptake, results return, acceptability, and potential social harms of CG-HIVST. AB - This prospective, interventional, study was done at 32 health facilities in Uganda and 15 health facilities in Zambia. Caregivers aged 18 years and older (plus emancipated minors aged 15-17 years in Uganda) living with HIV who were currently accessing HIV care and considered index cases, with no positive responses to an intimate partner violence screen, and with one or more children aged 18 months to 14 years with unknown HIV status were eligible to participate. Eligible caregivers were offered oral HIVST kits to screen their children and primary outcomes were described by caregiver and child characteristics. Following HIVST kit administration, caregivers were surveyed using a standardised questionnaire to document their perceptions, adverse events, and social harm. Primary outcomes were the uptake of HIVST and the number and proportion of returned screening test results, reactive results, reactive screens with confirmatory HIV testing, confirmatory testing with a positive result, and children who were confirmed HIV-positive who were linked to treatment. This study was registered with ClinicalTrials.gov, NCT04774666 and NCT04754386, and is completed. AB - From Feb 1 to Oct 31, 2021, 12 998 interested caregivers were screened for eligibility, 4023 of whom were eligible. 3903 (97·0%) accepted HIVST kits to screen their child for HIV (1609 [41·2%] in Zambia and 2294 [58·8%] in Uganda). Among caregivers, 3094 (79·3%) of 3903 were female, and 809 (20·7%) were male. 7601 children were enrolled (3779 [49·7%] were female and 3822 [50·3%] were male). 4766 (97·9%) of 4866 test results were returned in Uganda and 2647 (96·8%) of 2735 in Zambia. 119 (1·6%) of 7413 children had reactive HIVST results, requiring confirmatory testing. Of 116 children with confirmatory testing, 43 were confirmed HIV-positive (HIV prevalence 0·7% [n=32] in Uganda and 0·4% [n=11] in Zambia) and 100% were linked to antiretroviral therapy. Adverse events were rare (11 [0·4%] of 2720) and minor, and there were no reports of social harm or violence. Caregivers surveyed reported the HIVST kit was easy to use (2637 [97·0%] of 2718), they would use it again (2650 [99·1%] of 2674), and they would recommend it to other parents (2615 [97·8%] of 2674). AB - Our findings suggest that oral CG-HIVST is acceptable, feasible, and safe, with no reports of social harm, and has the potential to expand access to HIV testing for children while reducing the service delivery burden on health facilities. AB - US President's Emergency Plan for AIDS Relief and Wellcome Trust. AB - Author manuscript AN - cdc:261440 C4 - PMC12993861 DO - https://doi.org/10.1016/S2352-3018(25)00005-0 IS - 5 J2 - The Lancet. HIV KW - Adolescent KW - Female KW - Mass Screening KW - Feasibility Studies KW - Prospective Studies KW - Caregivers KW - Mouth Mucosa KW - Self-Testing KW - Patient Acceptance of Health Care KW - Child KW - Infant KW - Male KW - Humans KW - Middle Aged KW - Child, Preschool KW - Adult KW - HIV Infections KW - Adolescent KW - Adult KW - Child KW - Child, Preschool KW - Female KW - Humans KW - Infant KW - Male KW - Middle Aged KW - Caregivers KW - Feasibility Studies KW - HIV Infections KW - Mass Screening KW - Mouth Mucosa KW - Patient Acceptance of Health Care KW - Prospective Studies KW - Self-Testing LA - eng PY - 2025 T2 - The Lancet. HIV T2 - The Lancet. HIV, 2025, v. 12, no. 5 TI - Acceptability, Feasibility, and Effectiveness of Caregiver-assisted HIV Self-testing Among Children Using an Oral Mucosal Test in Uganda and Zambia: a Prospective Interventional Study. VL - 12 UR - https://stacks.cdc.gov/view/cdc/261440 ER -
Kinetics of SARS-CoV-2 Shedding in Nursing Home Residents and Staff.

Katz, Morgan J. ;

Reeves, Majerle

July 2025 | Journal of the American Geriatrics Society, 2025, v. 73, no. 7

Nursing homes (NHs) were disproportionately affected by the COVID-19 pandemic. However, little is known regarding the kinetics of SARS-CoV-2 shedding in NH residents and staff, which could inform treatment and infection prevention.We enrolled NH residents and staff in eight US states from April to November 2023 and analyzed the kinetics of SARS-CoV ...

10/09/2026

Supporting Files

Title : Kinetics of SARS-CoV-2 Shedding in Nursing Home Residents and Staff. Personal Author(s) : Katz, Morgan J.;Reeves, Majerle;Harris, Tiffany G.;Duque, Jazmin;Fridkin, Scott K.;Rebolledo, Paulina A.;Furuno, Jon P.;Short, Emily K.;Canaday, David H.;Abul, Yasin;Gravenstein, Stefan;Cosgrove, Sara E.;Mody, Lona;Meddings, Jennifer;Nace, David A.;Handler, Steven;Crnich, Christopher J.;Meece, Jennifer;Webby, Richard J.;Fabrizio, Tom P.;Harcourt, Jennifer L.;Healy, Jessica M.;Lipsitch, Marc;Lutgring, Joseph D.;Paul, Prabasaj;Zipfel, Casey M.;Hernandez-Romieu, Alfonso C.;Reddy, Sujan C.;Slayton, Rachel B.; Published Date : July 2025 Pages in Document : 2127-2136 (18 pdf pages) Source : Journal of the American Geriatrics Society, 2025, v. 73, no. 7 DOI : https://doi.org/10.1111/jgs.19499 Journal Title : Journal of the American Geriatrics Society
Katz, M. J., Reeves, M., Harris, T. G., Duque, J., Fridkin, S. K., Rebolledo, P. A., Furuno, J. P., Short, E. K., Canaday, D. H., Abul, Y., Gravenstein, S., Cosgrove, S. E., Mody, L., Meddings, J., Nace, D. A., Handler, S., Crnich, C. J., Meece, J., Webby, R. J., ... Slayton, R. B. (2025). Kinetics of SARS-CoV-2 Shedding in Nursing Home Residents and Staff. Journal of the American Geriatrics Society, 73(7). https://doi.org/10.1111/jgs.19499

Katz, Morgan J., Majerle Reeves, Tiffany G. Harris, Jazmin Duque, Scott K. Fridkin, Paulina A. Rebolledo, and Jon P. Furuno, et al.. "Kinetics of SARS-CoV-2 Shedding in Nursing Home Residents and Staff." Journal of the American Geriatrics Society 73, no. 7 (2025). https://doi.org/10.1111/jgs.19499.

Katz, Morgan J., et al. "Kinetics of SARS-CoV-2 Shedding in Nursing Home Residents and Staff." Journal of the American Geriatrics Society, vol. 73, no. 7, 2025. Stacks. https://doi.org/10.1111/jgs.19499.
Export RIS Citation Information. TY - Journal Article AU - Katz, Morgan J. AU - Reeves, Majerle AU - Harris, Tiffany G. AU - Duque, Jazmin AU - Fridkin, Scott K. AU - Rebolledo, Paulina A. AU - Furuno, Jon P. AU - Short, Emily K. AU - Canaday, David H. AU - Abul, Yasin AU - Gravenstein, Stefan AU - Cosgrove, Sara E. AU - Mody, Lona AU - Meddings, Jennifer AU - Nace, David A. AU - Handler, Steven AU - Crnich, Christopher J. AU - Meece, Jennifer AU - Webby, Richard J. AU - Fabrizio, Tom P. AU - Harcourt, Jennifer L. AU - Healy, Jessica M. AU - Lipsitch, Marc AU - Lutgring, Joseph D. AU - Paul, Prabasaj AU - Zipfel, Casey M. AU - Hernandez-Romieu, Alfonso C. AU - Reddy, Sujan C. AU - Slayton, Rachel B. AB - Nursing homes (NHs) were disproportionately affected by the COVID-19 pandemic. However, little is known regarding the kinetics of SARS-CoV-2 shedding in NH residents and staff, which could inform treatment and infection prevention. AB - We enrolled NH residents and staff in eight US states from April to November 2023 and analyzed the kinetics of SARS-CoV-2 using serial antigen and molecular (RT-PCR) tests, whole genome sequencing, and viral culture (VC). Symptoms, vaccination, and treatment were collected via interviews and chart review. Viral load trajectories were modeled with gamma distribution functional forms. Antigen and VC test positivity over time were assessed using a Chi-squared test. AB - Of the 587 enrolled participants, 86 tested positive and 73 underwent testing for ≥ 10 days; most residents (78%) and staff (87%) had ≥ 3 COVID-19 vaccine doses. The modeled SARS-CoV-2 proliferation period (period prior to reaching peak viral load) had ended for 48% (14/29) of residents and 56% (9/16) of staff when they took the initial RT-PCR test. Both antigen and VC showed higher positivity rates early in the course of disease (Days 0-5 vs. Days ≥ 6) (antigen: p < 0·001, VC: p < 0·001). VC positivity was 15% after Day 5 (14/96); two participants were VC positive after Day 10. AB - Peak viral load occurs early in the disease, suggesting asymptomatic and presymptomatic transmission may be a significant driver of transmission. Only two participants had a positive VC after Day 10, supporting current isolation and return to work recommendations. AB - Author manuscript AN - cdc:261439 C4 - PMC12303745 DO - https://doi.org/10.1111/jgs.19499 IS - 7 J2 - Journal of the American Geriatrics Society KW - Aged, 80 and over KW - Female KW - Nursing Homes KW - Virus Shedding KW - COVID-19 Vaccines KW - SARS-CoV-2 KW - Aged KW - Male KW - Middle Aged KW - Humans KW - COVID-19 KW - Viral Load KW - COVID-19 KW - kinetics KW - nursing home KW - SARS-CoV-2 KW - shedding KW - Humans KW - Nursing Homes KW - COVID-19 KW - Virus Shedding KW - SARS-CoV-2 KW - Male KW - Female KW - Aged KW - Viral Load KW - Aged, 80 and over KW - Middle Aged KW - COVID-19 Vaccines LA - eng PY - 2025 T2 - Journal of the American Geriatrics Society T2 - Journal of the American Geriatrics Society, 2025, v. 73, no. 7 TI - Kinetics of SARS-CoV-2 Shedding in Nursing Home Residents and Staff. VL - 73 UR - https://stacks.cdc.gov/view/cdc/261439 ER -
A Workplace Violence Policies Influence on the Occurrence of Violence.

Bellacov, Ryan ;

Obariase, Efosa

October 8, 2025 | Home Healthcare Now, 2025, v. 43, no. 3

There is a lack of research on the quality of workplace violence (WPV) policies in home care. This study conducted a blinded review of WPV policies from home care agencies in Ohio, Oregon, and Texas, evaluating them based on five key criteria: WPV reporting, WPV training, WPV policy, workplace conduct, and policy review. Seven agencies participated ...

10/09/2026

Supporting Files

Title : A Workplace Violence Policies Influence on the Occurrence of Violence. Personal Author(s) : Bellacov, Ryan;Obariase, Efosa;Gillespie, Gordon;Davis, Kermit; Published Date : October 8, 2025 Pages in Document : 144-149 (9 pdf pages) Source : Home Healthcare Now, 2025, v. 43, no. 3 DOI : https://doi.org/10.1097/NHH.0000000000001338 Journal Title : Home Healthcare Now
Bellacov, R., Obariase, E., Gillespie, G., & Davis, K. (2025). A Workplace Violence Policies Influence on the Occurrence of Violence. Home Healthcare Now, 43(3). https://doi.org/10.1097/NHH.0000000000001338

Bellacov, Ryan, Efosa Obariase, Gordon Gillespie, and Kermit Davis. "A Workplace Violence Policies Influence on the Occurrence of Violence." Home Healthcare Now 43, no. 3 (2025). https://doi.org/10.1097/NHH.0000000000001338.

Bellacov, Ryan, et al. "A Workplace Violence Policies Influence on the Occurrence of Violence." Home Healthcare Now, vol. 43, no. 3, 2025. Stacks. https://doi.org/10.1097/NHH.0000000000001338.
Export RIS Citation Information. TY - Journal Article AU - Bellacov, Ryan AU - Obariase, Efosa AU - Gillespie, Gordon AU - Davis, Kermit AB - There is a lack of research on the quality of workplace violence (WPV) policies in home care. This study conducted a blinded review of WPV policies from home care agencies in Ohio, Oregon, and Texas, evaluating them based on five key criteria: WPV reporting, WPV training, WPV policy, workplace conduct, and policy review. Seven agencies participated, but only one met more than 50% of the criteria. Major deficiencies included a lack of WPV prevention methods, formal training, and protective strategies for home visits. While the study examined a small sample, the findings highlight that most WPV policies were incomplete, lacking essential procedures and training to safeguard home care providers. If these findings reflect broader industry trends, home care agencies must prioritize employee safety by implementing more comprehensive WPV policies. AB - Author manuscript AN - cdc:261437 C4 - PMC12505418 DO - https://doi.org/10.1097/NHH.0000000000001338 IS - 3 J2 - Home Healthcare Now KW - Organizational Policy KW - Humans KW - Workplace Violence KW - Occupational Health KW - Workplace KW - Home Care Agencies KW - Humans KW - Workplace Violence KW - Organizational Policy KW - Home Care Agencies KW - Occupational Health KW - Workplace LA - eng PY - 2025 T2 - Home Healthcare Now T2 - Home Healthcare Now, 2025, v. 43, no. 3 TI - A Workplace Violence Policies Influence on the Occurrence of Violence. VL - 43 UR - https://stacks.cdc.gov/view/cdc/261437 ER -
Can Allostatic Load Cross Over? Short-term Work and Nonwork Stressor Pile-up on Parent and Adolescent Diurnal Cortisol, Physical Symptoms, and Sleep.

French, Kimberly A. ;

Smith, Claire E.

October 2025 | The Journal of Applied Psychology, 2025, v. 110, no. 10

Grounded in and expanding upon the allostatic load model, the present study examined how repeated exposure to work and nonwork stressors (i.e., stressor pile-up) across an 8-day study period relates to daily strain-related outcomes-diurnal cortisol, physical symptoms, and sleep quantity and quality-in both parents and their adolescent children. Non ...

10/09/2026

Supporting Files

Title : Can Allostatic Load Cross Over? Short-term Work and Nonwork Stressor Pile-up on Parent and Adolescent Diurnal Cortisol, Physical Symptoms, and Sleep. Personal Author(s) : French, Kimberly A.;Smith, Claire E.;Lee, Soomi;Chen, Zheng; Published Date : October 2025 Pages in Document : 1350-1370 (44 pdf pages) Source : The Journal of Applied Psychology, 2025, v. 110, no. 10 DOI : https://doi.org/10.1037/apl0001284 Journal Title : The Journal of Applied Psychology
French, K. A., Smith, C. E., Lee, S., & Chen, Z. (2025). Can Allostatic Load Cross Over? Short-term Work and Nonwork Stressor Pile-up on Parent and Adolescent Diurnal Cortisol, Physical Symptoms, and Sleep. The Journal of Applied Psychology, 110(10). https://doi.org/10.1037/apl0001284

French, Kimberly A., Claire E. Smith, Soomi Lee, and Zheng Chen. "Can Allostatic Load Cross Over? Short-term Work and Nonwork Stressor Pile-up on Parent and Adolescent Diurnal Cortisol, Physical Symptoms, and Sleep." The Journal of Applied Psychology 110, no. 10 (2025). https://doi.org/10.1037/apl0001284.

French, Kimberly A., et al. "Can Allostatic Load Cross Over? Short-term Work and Nonwork Stressor Pile-up on Parent and Adolescent Diurnal Cortisol, Physical Symptoms, and Sleep." The Journal of Applied Psychology, vol. 110, no. 10, 2025. Stacks. https://doi.org/10.1037/apl0001284.
Export RIS Citation Information. TY - Journal Article AU - French, Kimberly A. AU - Smith, Claire E. AU - Lee, Soomi AU - Chen, Zheng AB - Grounded in and expanding upon the allostatic load model, the present study examined how repeated exposure to work and nonwork stressors (i.e., stressor pile-up) across an 8-day study period relates to daily strain-related outcomes-diurnal cortisol, physical symptoms, and sleep quantity and quality-in both parents and their adolescent children. Nonlinear associations between daily stressor pile-up and daily strain were explored. Data from the Work, Family, and Health Network study ( AB - = 131 parent-child dyads, AB - = 1,014 daily survey observations, AB - = 465 daily observations with cortisol) were used to test the study hypotheses. Parent work stressor pile-up and adolescent stressor pile-up were associated with increased daily physical symptom likelihood in parents and adolescents, respectively. Counter to expectations, parent nonwork stressor pile-up was associated with steeper daily cortisol slopes. Additionally, we found curvilinear crossover effects for sleep quantity, such that parent nonwork stressor pile-up and adolescent stressor pile-up were associated with shorter sleep duration among adolescents and parents (respectively), but this relationship plateaued and reversed as daily pile-up increased to more extreme levels. Our article explores conceptual and operational pile-up definitions (level of analysis, length of time window, inclusion of the current-day stressor events). Individual-level analyses supported more consistent, positive linear relationships between stressor pile-up and strains. Time window had little consequences for conclusions, but inclusion of the current day yields some alternative conclusions. We discuss implications for understanding stressor pile-up across domains and across parent-child dyads as it relates to daily strain within the family system. (PsycInfo Database Record (c) 2025 APA, all rights reserved). AB - Author manuscript AN - cdc:261435 C4 - PMC12353331 DO - https://doi.org/10.1037/apl0001284 IS - 10 J2 - The Journal of Applied Psychology KW - Sleep KW - Adolescent KW - Allostasis KW - Female KW - Hydrocortisone KW - Parents KW - Male KW - Middle Aged KW - Humans KW - Employment KW - Stress, Psychological KW - Adult KW - allostatic load KW - crossover KW - cortisol KW - physical symptoms KW - sleep KW - Humans KW - Hydrocortisone KW - Female KW - Male KW - Allostasis KW - Adolescent KW - Adult KW - Parents KW - Stress, Psychological KW - Sleep KW - Employment KW - Middle Aged LA - eng PY - 2025 T2 - The Journal of Applied Psychology T2 - The Journal of Applied Psychology, 2025, v. 110, no. 10 TI - Can Allostatic Load Cross Over? Short-term Work and Nonwork Stressor Pile-up on Parent and Adolescent Diurnal Cortisol, Physical Symptoms, and Sleep. VL - 110 UR - https://stacks.cdc.gov/view/cdc/261435 ER -
Estimating the Population Need For Preexposure Prophylaxis For HIV in the United States.

Kourtis, Athena P. ;

Wiener, Jeffrey

June 2025 | Annals of Epidemiology, 2025, v. 106

Preexposure prophylaxis (PrEP) is highly effective in preventing HIV infections and is recommended for people without HIV who are at ongoing risk of HIV acquisition. In 2019, the U.S. launched the "Ending the HIV Epidemic in the U.S." initiative, which aims to reduce by 90 % the number of annual new HIV infections. To monitor progress towards this ...

10/09/2026

Supporting Files

Title : Estimating the Population Need For Preexposure Prophylaxis For HIV in the United States. Personal Author(s) : Kourtis, Athena P.;Wiener, Jeffrey;Zhu, Weiming;Rönn, Minttu M.;Salomon, Joshua;Huang, Ya-Lin A.;Lyles, Cynthia;Patel, Rupa R.;Hoover, Karen W.;Fanfair, Robyn Neblett;Mermin, Jonathan; Published Date : June 2025 Pages in Document : 48-54 (16 pdf pages) Source : Annals of Epidemiology, 2025, v. 106 DOI : https://doi.org/10.1016/j.annepidem.2025.04.017 Journal Title : Annals of Epidemiology
Kourtis, A. P., Wiener, J., Zhu, W., Rönn, M. M., Salomon, J., Huang, Y. L. A., Lyles, C., Patel, R. R., Hoover, K. W., Fanfair, R. N., & Mermin, J. (2025). Estimating the Population Need For Preexposure Prophylaxis For HIV in the United States. Annals of Epidemiology, 106. https://doi.org/10.1016/j.annepidem.2025.04.017

Kourtis, Athena P., Jeffrey Wiener, Weiming Zhu, Minttu M. Rönn, Joshua Salomon, Ya-Lin A. Huang, and Cynthia Lyles, et al.. "Estimating the Population Need For Preexposure Prophylaxis For HIV in the United States." Annals of Epidemiology 106 (2025). https://doi.org/10.1016/j.annepidem.2025.04.017.

Kourtis, Athena P., et al. "Estimating the Population Need For Preexposure Prophylaxis For HIV in the United States." Annals of Epidemiology, vol. 106, 2025. Stacks. https://doi.org/10.1016/j.annepidem.2025.04.017.
Export RIS Citation Information. TY - Journal Article AU - Kourtis, Athena P. AU - Wiener, Jeffrey AU - Zhu, Weiming AU - Rönn, Minttu M. AU - Salomon, Joshua AU - Huang, Ya-Lin A. AU - Lyles, Cynthia AU - Patel, Rupa R. AU - Hoover, Karen W. AU - Fanfair, Robyn Neblett AU - Mermin, Jonathan AB - Preexposure prophylaxis (PrEP) is highly effective in preventing HIV infections and is recommended for people without HIV who are at ongoing risk of HIV acquisition. In 2019, the U.S. launched the "Ending the HIV Epidemic in the U.S." initiative, which aims to reduce by 90 % the number of annual new HIV infections. To monitor progress towards this goal, several national indicators have been established, one of which is PrEP coverage. Several ways to monitor PrEP use have been developed, each with its own advantages and disadvantages. We developed a method to estimate PrEP "need" in the U.S. that could be used as a denominator to estimate PrEP coverage. The "population need for PrEP" (PPN) is estimated based on the number of people needed to treat (NNT) with PrEP to prevent an additional HIV infection in subpopulations whose annual HIV incidence is ≥ 1 %. This is done in three steps: 1) calculating NNT for each transmission group using 1 % incidence threshold and clinical trial-and cohort-generated evidence of the degree of PrEP effectiveness in each transmission group, 2) estimating the proportion of new HIV infections in subpopulations with incidence at least 1 % from epidemiologic data, 3) multiplying estimates from steps 1 and 2 with the number of new HIV infections for each transmission group from Surveillance. The estimates for each transmission group are then added together, and the number of current PrEP users is finally added to this estimate to produce PPN. This method is relatively easy to calculate and can provide public health authorities at the national, state, or local level with pragmatic estimates of PrEP "need" among different demographic or transmission groups, which can help with planning, resource allocation, and monitoring progress. AB - Author manuscript AN - cdc:261434 C4 - PMC13479374 DO - https://doi.org/10.1016/j.annepidem.2025.04.017 J2 - Annals of Epidemiology KW - Female KW - Anti-HIV Agents KW - Incidence KW - Male KW - Humans KW - United States KW - HIV Infections KW - Pre-Exposure Prophylaxis KW - Hiv KW - PrEP KW - Need KW - United States KW - Method KW - Humans KW - HIV Infections KW - Pre-Exposure Prophylaxis KW - United States KW - Anti-HIV Agents KW - Incidence KW - Male KW - Female LA - eng PY - 2025 T2 - Annals of Epidemiology T2 - Annals of Epidemiology, 2025, v. 106 TI - Estimating the Population Need For Preexposure Prophylaxis For HIV in the United States. VL - 106 UR - https://stacks.cdc.gov/view/cdc/261434 ER -
An Overdose Forecasting Dashboard For Local Harm-Reduction Response.

Krieger, Maxwell ;

Yedinak, Jesse

May 6, 2025 | Health Promotion Practice, May 2025

As the United States grapples with an ongoing overdose crisis, states and jurisdictions are adopting novel approaches to reduce overdose mortality. In one novel approach, public health researchers and leaders in Rhode Island leveraged the state's robust surveillance data and collaborations between government, academic, and community-based organizat ...

10/09/2026

Supporting Files

Title : An Overdose Forecasting Dashboard For Local Harm-Reduction Response. Personal Author(s) : Krieger, Maxwell;Yedinak, Jesse;Duong, Ellen;Macmadu, Alexandria;Skinner, Alexandra;Allen, Bennett;Pratty, Claire;Ahern, Jennifer;Cerdá, Magdalena;Marshall, Brandon D. L.; Published Date : May 6, 2025 Pages in Document : 9 pdf pages Source : Health Promotion Practice, May 2025 DOI : https://doi.org/10.1177/15248399251335620 Journal Title : Health Promotion Practice
Krieger, M., Yedinak, J., Duong, E., Macmadu, A., Skinner, A., Allen, B., Pratty, C., Ahern, J., Cerdá, M., & Marshall, B. D. L. (2025). An Overdose Forecasting Dashboard For Local Harm-Reduction Response. Health Promotion Practice. https://doi.org/10.1177/15248399251335620

Krieger, Maxwell, Jesse Yedinak, Ellen Duong, Alexandria Macmadu, Alexandra Skinner, Bennett Allen, Claire Pratty, Jennifer Ahern, Magdalena Cerdá, and Brandon D. L. Marshall. "An Overdose Forecasting Dashboard For Local Harm-Reduction Response." Health Promotion Practice (2025). https://doi.org/10.1177/15248399251335620.

Krieger, Maxwell, et al. "An Overdose Forecasting Dashboard For Local Harm-Reduction Response." Health Promotion Practice, 2025. Stacks. https://doi.org/10.1177/15248399251335620.
Export RIS Citation Information. TY - Journal Article AU - Krieger, Maxwell AU - Yedinak, Jesse AU - Duong, Ellen AU - Macmadu, Alexandria AU - Skinner, Alexandra AU - Allen, Bennett AU - Pratty, Claire AU - Ahern, Jennifer AU - Cerdá, Magdalena AU - Marshall, Brandon D. L. AB - As the United States grapples with an ongoing overdose crisis, states and jurisdictions are adopting novel approaches to reduce overdose mortality. In one novel approach, public health researchers and leaders in Rhode Island leveraged the state's robust surveillance data and collaborations between government, academic, and community-based organizations (CBOs) to launch the PROVIDENT (PReventing OVerdose using Information and Data from the EnvironmeNT) project, a population-based randomized controlled research trial (NCT05096429) in December 2019. The PROVIDENT trial utilizes machine learning (ML) methods to identify neighborhoods at risk of future overdose deaths at the census-block-group level to inform community-level overdose prevention resource distribution. To disseminate the ML model predictions, our research team developed an interactive, online mapping dashboard in close collaboration with three statewide CBOs. We measured whether these organizations utilized the PROVIDENT dashboard to allocate harm-reduction services based on ML model predictions and collected information about their data-driven decision-making processes. This case study describes how we assembled and piloted this overdose forecasting dashboard for use by CBOs between November 2021 and August 2024. By measuring dashboard logins, completed surveys, and engagement with ongoing training, we illustrate how organizations utilized ML and surveillance data to inform their outreach efforts and generate valuable insights at a neighborhood level. AB - Author manuscript AN - cdc:261433 C4 - PMC12651787 DO - https://doi.org/10.1177/15248399251335620 J2 - Health Promotion Practice KW - Public Health KW - Community Health Services KW - Drug Overdose KW - Machine Learning KW - overdose prevention KW - machine learning KW - forecasting KW - predictive analytics KW - data dashboard KW - data visualization KW - GIS KW - neighborhood KW - community organizations KW - Drug Overdose KW - Public Health KW - Community Health Services KW - Machine Learning LA - eng PY - 2025 T2 - Health Promotion Practice T2 - Health Promotion Practice, May 2025 TI - An Overdose Forecasting Dashboard For Local Harm-Reduction Response. UR - https://stacks.cdc.gov/view/cdc/261433 ER -
Estimated Health Outcomes of Breast Cancer Screening in the National Breast and Cervical Cancer Early Detection Program by Race/ethnicity.

Ekwueme, Donatus U. ;

Reagan, Kelly A.

October 2025 | Cancer Causes & Control : CCC, 2025, v. 36, no. 10

To estimate the number of screenings received, life-years (LYs) saved, and number of screenings per LY saved per woman who participated in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) (Program) compared with those who did not participate (no Program).We developed a time-to-event simulation model to compare the outcomes ...

10/09/2026

Supporting Files

Title : Estimated Health Outcomes of Breast Cancer Screening in the National Breast and Cervical Cancer Early Detection Program by Race/ethnicity. Personal Author(s) : Ekwueme, Donatus U.;Reagan, Kelly A.;Kao, Szu-Yu;Dasari, Sabitha;Kenney, Kristy M.;Wu, Manxia;Thompson, Trevor D.;Miller, Jacqueline W.; Published Date : October 2025 Pages in Document : 1079-1092 (23 pdf pages) Source : Cancer Causes & Control : CCC, 2025, v. 36, no. 10 DOI : https://doi.org/10.1007/s10552-025-02006-2 Journal Title : Cancer Causes & Control : CCC
Ekwueme, D. U., Reagan, K. A., Kao, S. Y., Dasari, S., Kenney, K. M., Wu, M., Thompson, T. D., & Miller, J. W. (2025). Estimated Health Outcomes of Breast Cancer Screening in the National Breast and Cervical Cancer Early Detection Program by Race/ethnicity. Cancer Causes & Control : CCC, 36(10). https://doi.org/10.1007/s10552-025-02006-2

Ekwueme, Donatus U., Kelly A. Reagan, Szu-Yu Kao, Sabitha Dasari, Kristy M. Kenney, Manxia Wu, Trevor D. Thompson, and Jacqueline W. Miller. "Estimated Health Outcomes of Breast Cancer Screening in the National Breast and Cervical Cancer Early Detection Program by Race/ethnicity." Cancer Causes & Control : CCC 36, no. 10 (2025). https://doi.org/10.1007/s10552-025-02006-2.

Ekwueme, Donatus U., et al. "Estimated Health Outcomes of Breast Cancer Screening in the National Breast and Cervical Cancer Early Detection Program by Race/ethnicity." Cancer Causes & Control : CCC, vol. 36, no. 10, 2025. Stacks. https://doi.org/10.1007/s10552-025-02006-2.
Export RIS Citation Information. TY - Journal Article AU - Ekwueme, Donatus U. AU - Reagan, Kelly A. AU - Kao, Szu-Yu AU - Dasari, Sabitha AU - Kenney, Kristy M. AU - Wu, Manxia AU - Thompson, Trevor D. AU - Miller, Jacqueline W. AB - To estimate the number of screenings received, life-years (LYs) saved, and number of screenings per LY saved per woman who participated in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) (Program) compared with those who did not participate (no Program). AB - We developed a time-to-event simulation model to compare the outcomes of women participating in the Program vs. no Program, categorized by race/ethnicity. Model input parameters included data from the Program's minimum data elements, United States Cancer Statistics, National Health Interview Survey, and published literature. The Program's impact was calculated as the difference in LYs between the Program and no Program using data from 2010 to 2019. AB - Among 1 million women of all races/ethnicities who participated in the NBCCEDP in the last 10 years, 457,152 (standard deviation [SD]: 848) received more screenings than those who did not participate. These participants saved an average of 0.027 LYs per woman screened. In addition, we estimated that about 17 screenings would be required to save an additional 1 LY per woman screened in the Program compared with no Program. Per woman screened by race/ethnicity, non-Hispanic Black women had the highest estimated 0.075 LYs saved, followed by Hispanic women with 0.025 LYs, non-Hispanic White with 0.014 LYs, and non-Hispanic American Indian/Alaska Native and Asian/Pacific Islander had the least health outcome with 0.011 LYs. AB - The reported findings underscore the importance of providing preventive health services to populations that might not otherwise have access to these services. AB - Author manuscript AN - cdc:261432 C4 - PMC12246945 DO - https://doi.org/10.1007/s10552-025-02006-2 IS - 10 J2 - Cancer Causes & Control : CCC KW - Female KW - Ethnicity KW - Mass Screening KW - Racial Groups KW - Aged KW - Middle Aged KW - Humans KW - Early Detection of Cancer KW - Breast Neoplasms KW - Uterine Cervical Neoplasms KW - Adult KW - Breast cancer KW - Cancer prevention KW - Breast cancer screening KW - NBCCEDP KW - Cancer in subpopulations KW - Adult KW - Aged KW - Female KW - Humans KW - Middle Aged KW - Breast Neoplasms KW - Early Detection of Cancer KW - Ethnicity KW - Mass Screening KW - Racial Groups KW - Uterine Cervical Neoplasms LA - eng PY - 2025 T2 - Cancer Causes & Control : CCC T2 - Cancer Causes & Control : CCC, 2025, v. 36, no. 10 TI - Estimated Health Outcomes of Breast Cancer Screening in the National Breast and Cervical Cancer Early Detection Program by Race/ethnicity. VL - 36 UR - https://stacks.cdc.gov/view/cdc/261432 ER -
Thematic Analysis of Medical Examiner Narratives to Understand the Socio-spatial Context, Recency of Drug Use, and Likely Mechanism of Stimulant Toxicity Deaths.

Finn, Black ;

McMahan, Vanessa M

July 2025 | Drug and Alcohol Dependence, 2025, v. 272

Drug toxicity as a cause of death is challenging to establish and may be based on limited evidence, especially in deaths attributed to stimulants. We developed a method for characterizing stimulant deaths, focusing on potential mechanisms and opportunities for intervention.We used medical examiner case narratives and medical records from a mixed me ...

10/09/2026

Supporting Files

Title : Thematic Analysis of Medical Examiner Narratives to Understand the Socio-spatial Context, Recency of Drug Use, and Likely Mechanism of Stimulant Toxicity Deaths. Personal Author(s) : Finn, Black;McMahan, Vanessa M;Chang, Yi-Shin G;Rodda, Luke N;Coffin, Phillip O; Published Date : July 2025 Pages in Document : 112700 (12 pdf pages) Source : Drug and Alcohol Dependence, 2025, v. 272 DOI : https://doi.org/10.1016/j.drugalcdep.2025.112700 Journal Title : Drug and Alcohol Dependence
Finn, B., McMahan, V. M., Chang, Y. S. G., Rodda, L. N., & Coffin, P. O. (2025). Thematic Analysis of Medical Examiner Narratives to Understand the Socio-spatial Context, Recency of Drug Use, and Likely Mechanism of Stimulant Toxicity Deaths. Drug and Alcohol Dependence, 272. https://doi.org/10.1016/j.drugalcdep.2025.112700

Finn, Black, Vanessa M McMahan, Yi-Shin G Chang, Luke N Rodda, and Phillip O Coffin. "Thematic Analysis of Medical Examiner Narratives to Understand the Socio-spatial Context, Recency of Drug Use, and Likely Mechanism of Stimulant Toxicity Deaths." Drug and Alcohol Dependence 272 (2025). https://doi.org/10.1016/j.drugalcdep.2025.112700.

Finn, Black, et al. "Thematic Analysis of Medical Examiner Narratives to Understand the Socio-spatial Context, Recency of Drug Use, and Likely Mechanism of Stimulant Toxicity Deaths." Drug and Alcohol Dependence, vol. 272, 2025. Stacks. https://doi.org/10.1016/j.drugalcdep.2025.112700.
Export RIS Citation Information. TY - Journal Article AU - Finn, Black AU - McMahan, Vanessa M AU - Chang, Yi-Shin G AU - Rodda, Luke N AU - Coffin, Phillip O AB - Drug toxicity as a cause of death is challenging to establish and may be based on limited evidence, especially in deaths attributed to stimulants. We developed a method for characterizing stimulant deaths, focusing on potential mechanisms and opportunities for intervention. AB - We used medical examiner case narratives and medical records from a mixed methods study of fatal acute stimulant toxicity in San Francisco. We coded case narratives for circumstances surrounding death events, including physical location, bystander presence, decedent disposition, and evidence of recent street drug use; medical records provided data on potential mechanism of death when not present in case narratives. AB - Of 101 deaths (70 stimulants-no-opioids, 31 stimulants-fentanyl), 85 were unwitnessed, including 69 unwitnessed deaths in spaces inaccessible to bystanders. Drug use was observed before collapse in 1 of 14 witnessed stimulant-no-opioid and 1 of 2 witnessed stimulant-fentanyl deaths. Among unwitnessed events, scene evidence of drug use was found in 36 of 56 stimulant-no-opioid and 25 of 29 stimulant-fentanyl deaths. Twelve of 14 witnessed stimulant-no-opioid deaths and none of two witnessed stimulant-fentanyl deaths included an apparent cardiovascular or cerebrovascular event. AB - Deaths occurred in physically and socially isolated contexts, limiting opportunities for bystander intervention. Compared to stimulant-fentanyl deaths, stimulant-no-opioid deaths may be more likely to be witnessed and involve a cardiovascular event, and less likely to involve recent drug use. Applying a thematic analysis of medical examiner records to a larger sample, including other opioid deaths, could guide prevention strategies. AB - Author manuscript AN - cdc:261431 C4 - PMC12135998 DO - https://doi.org/10.1016/j.drugalcdep.2025.112700 J2 - Drug and Alcohol Dependence KW - Narration KW - Female KW - Central Nervous System Stimulants KW - Male KW - Middle Aged KW - Humans KW - Substance-Related Disorders KW - Young Adult KW - Coroners and Medical Examiners KW - Cause of Death KW - Adult KW - Drug Overdose KW - overdose KW - stimulants KW - medical examiner KW - coroner KW - methamphetamine KW - cocaine KW - toxicity KW - Humans KW - Central Nervous System Stimulants KW - Male KW - Female KW - Adult KW - Coroners and Medical Examiners KW - Drug Overdose KW - Narration KW - Middle Aged KW - Substance-Related Disorders KW - Cause of Death KW - Young Adult LA - eng PY - 2025 T2 - Drug and Alcohol Dependence T2 - Drug and Alcohol Dependence, 2025, v. 272 TI - Thematic Analysis of Medical Examiner Narratives to Understand the Socio-spatial Context, Recency of Drug Use, and Likely Mechanism of Stimulant Toxicity Deaths. VL - 272 UR - https://stacks.cdc.gov/view/cdc/261431 ER -
Evaluation of the Current State of Thyroid Hormone Testing in Human Serum-Results of the Free Thyroxine and Thyrotropin Interlaboratory Comparison Study.

Ribera, Ashley ;

Sugahara, Otoe

May 2025 | Thyroid : Official Journal of the American Thyroid Association, 2025, v. 35, no. 5

Performance of thyroid function assays can vary significantly. To address this issue, the Centers for Disease Control and Prevention (CDC) Clinical Standardization Programs conducted an interlaboratory comparison of free thyroxine (fT4) immunoassays (IAs) and laboratory-developed tests (LDTs). This assessment aimed to determine the current performa ...

10/09/2026

Supporting Files

Title : Evaluation of the Current State of Thyroid Hormone Testing in Human Serum-Results of the Free Thyroxine and Thyrotropin Interlaboratory Comparison Study. Personal Author(s) : Ribera, Ashley;Sugahara, Otoe;Buchannan, Tatiana;Vazquez, Norma;Lyle, Alicia N.;Zhang, Li;Danilenko, Uliana;Vesper, Hubert W.; Published Date : May 2025 Pages in Document : 471-484 (24 pdf pages) Source : Thyroid : Official Journal of the American Thyroid Association, 2025, v. 35, no. 5 DOI : https://doi.org/10.1089/thy.2024.0728 Journal Title : Thyroid : Official Journal of the American Thyroid Association
Ribera, A., Sugahara, O., Buchannan, T., Vazquez, N., Lyle, A. N., Zhang, L., Danilenko, U., & Vesper, H. W. (2025). Evaluation of the Current State of Thyroid Hormone Testing in Human Serum-Results of the Free Thyroxine and Thyrotropin Interlaboratory Comparison Study. Thyroid : Official Journal of the American Thyroid Association, 35(5). https://doi.org/10.1089/thy.2024.0728

Ribera, Ashley, Otoe Sugahara, Tatiana Buchannan, Norma Vazquez, Alicia N. Lyle, Li Zhang, Uliana Danilenko, and Hubert W. Vesper. "Evaluation of the Current State of Thyroid Hormone Testing in Human Serum-Results of the Free Thyroxine and Thyrotropin Interlaboratory Comparison Study." Thyroid : Official Journal of the American Thyroid Association 35, no. 5 (2025). https://doi.org/10.1089/thy.2024.0728.

Ribera, Ashley, et al. "Evaluation of the Current State of Thyroid Hormone Testing in Human Serum-Results of the Free Thyroxine and Thyrotropin Interlaboratory Comparison Study." Thyroid : Official Journal of the American Thyroid Association, vol. 35, no. 5, 2025. Stacks. https://doi.org/10.1089/thy.2024.0728.
Export RIS Citation Information. TY - Journal Article AU - Ribera, Ashley AU - Sugahara, Otoe AU - Buchannan, Tatiana AU - Vazquez, Norma AU - Lyle, Alicia N. AU - Zhang, Li AU - Danilenko, Uliana AU - Vesper, Hubert W. AB - Performance of thyroid function assays can vary significantly. To address this issue, the Centers for Disease Control and Prevention (CDC) Clinical Standardization Programs conducted an interlaboratory comparison of free thyroxine (fT4) immunoassays (IAs) and laboratory-developed tests (LDTs). This assessment aimed to determine the current performance characteristics of these assays as a first step toward measurement standardization. Thyrotropin (TSH) IAs were also evaluated. AB - Assays measured 41 blinded individual-donor sera, including a sample from a pregnant woman (for fT4 analysis only) and three serum pools, with 11.3-32.1 pmol/L (0.881-2.49 ng/dL) fT4 and 0.337-21.6 mIU/L TSH in duplicate over 2 days. Passing-Bablok regression analysis performed pre-recalibration compared assays performance to the CDC fT4 reference measurement procedure (RMP) or TSH all-lab mean (ALM). Additionally, the impact of linear regression-based recalibration of assays to the CDC fT4 RMP or TSH ALM was estimated. Inter-assay agreement of sample classification according to the assay-specific reference interval (RI) was assessed pre- and post-recalibration. AB - A total of 21 fT4 and 17 TSH assays participated. Pre-recalibration, median biases of TSH measurements to the ALM were -1.2% [confidence interval or CI -1.8% to -0.4%], and good classification agreement among TSH assays was observed. fT4 assays all showed a negative median bias to the RMP, with higher bias among IAs (median: -20.3%, CI [-21.5% to -19.4%]) than LDTs (median: -4.5%, [CI -6.1% to -3.2%]). Of the individual-donor sera, only 21 out of 40 samples were classified uniformly by all fT4 assays, indicating poor inter-assay agreement. Post-recalibration, agreement improved to 33 out of 40 individual-donor sera correctly classified by all tested IAs and LDTs. Similar improvement in post-recalibration median percent bias was observed for fT4 IAs (median: -0.2, [CI -1.2% to 0.6%]) and LDTs (median: -0.3%, [CI -2.5% to 1.4%]). AB - The comparison among fT4 assays emphasizes the need for measurement standardization to improve accuracy and comparability. This and previous studies demonstrate the possibility to develop common fT4 RIs via standardization, enabling the use of evidence-based clinical guidelines universally in patient care. Recalibration can effectively address high variability in fT4 assays, ensuring consistent diagnostic classification. AB - Author manuscript AN - cdc:261430 C4 - PMC13126375 DO - https://doi.org/10.1089/thy.2024.0728 IS - 5 J2 - Thyroid : Official Journal of the American Thyroid Association KW - Pregnancy KW - Reproducibility of Results KW - Female KW - Thyroxine KW - Immunoassay KW - Thyroid Function Tests KW - Thyrotropin KW - Humans KW - Free thyroxine KW - thyroxine standardization KW - thyroid stimulating hormone (TSH) KW - immuno assays KW - laboratory developed tests KW - interlaboratory comparison study KW - Humans KW - Thyroxine KW - Thyrotropin KW - Female KW - Thyroid Function Tests KW - Immunoassay KW - Pregnancy KW - Reproducibility of Results LA - eng PY - 2025 T2 - Thyroid : Official Journal of the American Thyroid Association T2 - Thyroid : Official Journal of the American Thyroid Association, 2025, v. 35, no. 5 TI - Evaluation of the Current State of Thyroid Hormone Testing in Human Serum-Results of the Free Thyroxine and Thyrotropin Interlaboratory Comparison Study. VL - 35 UR - https://stacks.cdc.gov/view/cdc/261430 ER -
A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections.

Wikswo, Mary E. ;

Kambhampati, Anita K.

July 2025 | Journal of Infection and Public Health, 2025, v. 18, no. 7

Human adenovirus (HAdV), especially HAdV species F (HAdV-F) is recognized as a cause of acute gastroenteritis (AGE) worldwide. To assess the global prevalence of HAdV in case-patients of all ages with AGE, we conducted a systematic literature search for studies published in English during 2015-2022. We generated pooled prevalence estimates using ge ...

10/09/2026

Supporting Files

Title : A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections. Personal Author(s) : Wikswo, Mary E.;Kambhampati, Anita K.;Mattison, Claire P.;Chhabra, Preeti;Olojo, Oluwatosin;Rana, Taha;Vinjé, Jan;Kirkwood, Carl D.;Parashar, Umesh D.;Mirza, Sara A.; Published Date : July 2025 Pages in Document : 102800 (17 pdf pages) Source : Journal of Infection and Public Health, 2025, v. 18, no. 7 DOI : https://doi.org/10.1016/j.jiph.2025.102800 Journal Title : Journal of Infection and Public Health
Wikswo, M. E., Kambhampati, A. K., Mattison, C. P., Chhabra, P., Olojo, O., Rana, T., Vinjé, J., Kirkwood, C. D., Parashar, U. D., & Mirza, S. A. (2025). A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections. Journal of Infection and Public Health, 18(7). https://doi.org/10.1016/j.jiph.2025.102800

Wikswo, Mary E., Anita K. Kambhampati, Claire P. Mattison, Preeti Chhabra, Oluwatosin Olojo, Taha Rana, Jan Vinjé, Carl D. Kirkwood, Umesh D. Parashar, and Sara A. Mirza. "A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections." Journal of Infection and Public Health 18, no. 7 (2025). https://doi.org/10.1016/j.jiph.2025.102800.

Wikswo, Mary E., et al. "A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections." Journal of Infection and Public Health, vol. 18, no. 7, 2025. Stacks. https://doi.org/10.1016/j.jiph.2025.102800.
Export RIS Citation Information. TY - Journal Article AU - Wikswo, Mary E. AU - Kambhampati, Anita K. AU - Mattison, Claire P. AU - Chhabra, Preeti AU - Olojo, Oluwatosin AU - Rana, Taha AU - Vinjé, Jan AU - Kirkwood, Carl D. AU - Parashar, Umesh D. AU - Mirza, Sara A. AB - Human adenovirus (HAdV), especially HAdV species F (HAdV-F) is recognized as a cause of acute gastroenteritis (AGE) worldwide. To assess the global prevalence of HAdV in case-patients of all ages with AGE, we conducted a systematic literature search for studies published in English during 2015-2022. We generated pooled prevalence estimates using generalized linear mixed models. Using data from 147 included articles, the overall pooled prevalence among AGE case-patients of any species of HAdV (pan-HAdV) was 5.8 % and 6.0 % for HAdV-F. The prevalence of HAdV was significantly higher among case-patients < 5 years of age compared with case-patients ≥ 5 years of age (pan-HAdV: 6.6 % vs. 2.0 %, p < 0.0001; HAdV-F: 8.7 % vs. 2.3 %, p = 0.04). Prevalence was significantly higher in high mortality developing countries and lowest in developed countries (pan-HAdV: 9.4 % vs. 4.0 %, p < 0.0001; HAdV-F: 11.6 % vs. 3.2 %, p = 0.0003). Understanding the burden of HAdV-associated AGE may be useful for targeted interventions, including future vaccine development. AB - Author manuscript AN - cdc:261429 C4 - PMC12160367 DO - https://doi.org/10.1016/j.jiph.2025.102800 IS - 7 J2 - Journal of Infection and Public Health KW - Child KW - Global Health KW - Gastroenteritis KW - Adenovirus Infections, Human KW - Prevalence KW - Adenoviruses, Human KW - Humans KW - Child, Preschool KW - Adenovirus KW - Gastroenteritis KW - Diarrhea KW - Meta-analysis KW - Literature review KW - Humans KW - Adenovirus Infections, Human KW - Prevalence KW - Global Health KW - Adenoviruses, Human KW - Gastroenteritis KW - Child, Preschool KW - Child LA - eng PY - 2025 T2 - Journal of Infection and Public Health T2 - Journal of Infection and Public Health, 2025, v. 18, no. 7 TI - A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections. VL - 18 UR - https://stacks.cdc.gov/view/cdc/261429 ER -
Barriers to Rapid Enrollment and ART Initiation Among U.S. HIV Care Facilities.

O'Shea, Jesse ;

Yuan, Xin

May 2025 | Journal of Acquired Immune Deficiency Syndromes (1999), May 2025

Rapid linkage to HIV care and antiretroviral therapy (ART) initiation is now the standard of care for treating people with HIV (PWH). Understanding and intervening on barriers to rapid enrollment and ART initiation are needed to meet the goals of the Ending the HIV Epidemic in the U.S. initiative.We analyzed 2021 data from the Medical Monitoring Pr ...

10/09/2026

Supporting Files

Title : Barriers to Rapid Enrollment and ART Initiation Among U.S. HIV Care Facilities. Personal Author(s) : O'Shea, Jesse;Yuan, Xin;Lu, Jen-Feng;Buchacz, Kate;Iqbal, Kashif;Johnston, Marie;Beer, Linda;Weiser, John; Published Date : May 2025 Pages in Document : 11 pdf pages Source : Journal of Acquired Immune Deficiency Syndromes (1999), May 2025 DOI : https://doi.org/10.1097/QAI.0000000000003690 Journal Title : Journal of Acquired Immune Deficiency Syndromes (1999)
O'Shea, J., Yuan, X., Lu, J. F., Buchacz, K., Iqbal, K., Johnston, M., Beer, L., & Weiser, J. (2025). Barriers to Rapid Enrollment and ART Initiation Among U.S. HIV Care Facilities. Journal of Acquired Immune Deficiency Syndromes (1999). https://doi.org/10.1097/QAI.0000000000003690

O'Shea, Jesse, Xin Yuan, Jen-Feng Lu, Kate Buchacz, Kashif Iqbal, Marie Johnston, Linda Beer, and John Weiser. "Barriers to Rapid Enrollment and ART Initiation Among U.S. HIV Care Facilities." Journal of Acquired Immune Deficiency Syndromes (1999) (2025). https://doi.org/10.1097/QAI.0000000000003690.

O'Shea, Jesse, et al. "Barriers to Rapid Enrollment and ART Initiation Among U.S. HIV Care Facilities." Journal of Acquired Immune Deficiency Syndromes (1999), 2025. Stacks. https://doi.org/10.1097/QAI.0000000000003690.
Export RIS Citation Information. TY - Journal Article AU - O'Shea, Jesse AU - Yuan, Xin AU - Lu, Jen-Feng AU - Buchacz, Kate AU - Iqbal, Kashif AU - Johnston, Marie AU - Beer, Linda AU - Weiser, John AB - Rapid linkage to HIV care and antiretroviral therapy (ART) initiation is now the standard of care for treating people with HIV (PWH). Understanding and intervening on barriers to rapid enrollment and ART initiation are needed to meet the goals of the Ending the HIV Epidemic in the U.S. initiative. AB - We analyzed 2021 data from the Medical Monitoring Project on characteristics of 455 facilities providing care to a national probability sample of U.S. PWH. AB - Overall, only 19.9% (95% CI 16.0%-23.9%) of HIV facilities could routinely offer a first appointment in <1 business day (rapid enrollment). The most commonly reported barriers to rapid enrollment were insufficient provider capacity (56%), patient preference (50%), and patients lacking required documents (19%). The most commonly reported documents required for enrollment were positive HIV antibody or detectable viral load (52%), government-issued identification (36%), proof of residence (24%), and proof of income (22%). RWHAP-funded facilities more frequently required these documents than non-RWHAP-funded facilities. Most facilities (73%) were routinely able to obtain a 30-day supply of ART during the first HIV care provider visit (rapid ART initiation). The most commonly reported barriers to rapid ART included unavailable test results (56%), delays in getting medication paid for (49%), unavailable starter packs (36%), inability to afford copayment (31%), and patient preference (29%). AB - Structural, provider-related, or patient-level barriers may delay rapid clinic enrollment or ART initiation. HIV care programs can benefit from removing barriers to care, easing requirements for clinical enrollment and ART prescriptions, and improving patient readiness. AB - Author manuscript AN - cdc:261428 C4 - PMC12378994 DO - https://doi.org/10.1097/QAI.0000000000003690 J2 - Journal of Acquired Immune Deficiency Syndromes (1999) KW - Antiretroviral Therapy, Highly Active KW - HIV KW - HIV Infections KW - rapid start KW - clinic enrollment KW - HIV KW - antiretroviral therapy KW - Antiretroviral Therapy, Highly Active KW - HIV Infections KW - HIV LA - eng PY - 2025 T2 - Journal of Acquired Immune Deficiency Syndromes (1999) T2 - Journal of Acquired Immune Deficiency Syndromes (1999), May 2025 TI - Barriers to Rapid Enrollment and ART Initiation Among U.S. HIV Care Facilities. UR - https://stacks.cdc.gov/view/cdc/261428 ER -
Comparative Analysis of Machine Learning Models For Predicting Hospital- and Community-associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors.

Arjmand, Arash ;

Bani-Yaghoub, Majid

August 2025 | The Journal of Hospital Infection, 2025, v. 162

Differentiating between community-associated (CA-) and healthcare-associated (HA-) urinary tract infection (UTI) is crucial for understanding their epidemiology, identifying risk factors, and developing appropriate treatment strategies.To build, validate, and compare machine learning models: Decision Tree, Neural Network, Logistic Regression, Rando ...

10/09/2026

Supporting Files

Title : Comparative Analysis of Machine Learning Models For Predicting Hospital- and Community-associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors. Personal Author(s) : Arjmand, Arash;Bani-Yaghoub, Majid;Sutkin, Gary;Corkran, Kiel;Paschal, Susanna; Published Date : August 2025 Pages in Document : 263-271 (19 pdf pages) Source : The Journal of Hospital Infection, 2025, v. 162 DOI : https://doi.org/10.1016/j.jhin.2025.04.024 Journal Title : The Journal of Hospital Infection
Arjmand, A., Bani-Yaghoub, M., Sutkin, G., Corkran, K., & Paschal, S. (2025). Comparative Analysis of Machine Learning Models For Predicting Hospital- and Community-associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors. The Journal of Hospital Infection, 162. https://doi.org/10.1016/j.jhin.2025.04.024

Arjmand, Arash, Majid Bani-Yaghoub, Gary Sutkin, Kiel Corkran, and Susanna Paschal. "Comparative Analysis of Machine Learning Models For Predicting Hospital- and Community-associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors." The Journal of Hospital Infection 162 (2025). https://doi.org/10.1016/j.jhin.2025.04.024.

Arjmand, Arash, et al. "Comparative Analysis of Machine Learning Models For Predicting Hospital- and Community-associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors." The Journal of Hospital Infection, vol. 162, 2025. Stacks. https://doi.org/10.1016/j.jhin.2025.04.024.
Export RIS Citation Information. TY - Journal Article AU - Arjmand, Arash AU - Bani-Yaghoub, Majid AU - Sutkin, Gary AU - Corkran, Kiel AU - Paschal, Susanna AB - Differentiating between community-associated (CA-) and healthcare-associated (HA-) urinary tract infection (UTI) is crucial for understanding their epidemiology, identifying risk factors, and developing appropriate treatment strategies. AB - To build, validate, and compare machine learning models: Decision Tree, Neural Network, Logistic Regression, Random Forest, and Extreme Gradient Boosting to differentiate between the incidences of HA-UTI and CA-UTI; additionally, to identify key predictors of UTI using demographic, hospital, and socioeconomic variables. AB - Patient demographics, hospital, and socioeconomic data from 2019 to 2023 were analysed. AB - The Decision Tree model demonstrated the highest sensitivity, particularly in handling the highly imbalanced data of HAI, with a sensitivity of 87%. Logistic Regression achieved the best overall accuracy, at 95.9% for distinguishing HA-UTI from UTI-free and 93.2% for HA-UTI vs CA-UTI. Random Forest performed best in cross-validation, reaching 99.1% for HA-UTI vs UTI free and 96.2% for HA-UTI vs CA-UTI. Neural Network showed the highest specificity, at 93.4%, for HA-UTI vs CA-UTI. The area-under-the-curve values further supported these findings, ranging from 71.9% for Neural Network to 94% for Random Forest, reflecting the robustness of these models across different annual datasets. Among patient demographics, hospital, and socioeconomic variables, all models consistently identified the Nurse Units (e.g. Inpatient Units and Mental Health Units) as the most significant predictors of UTI. In addition to Nurse Units, Logistic Regression and Decision Tree identified location (e.g. various clinics and medical centres) as a key predictor. AB - The machine learning models demonstrated comparable overall accuracy, but differed in sensitivity and specificity across the two classification tasks-HA-UTI vs CA-UTI and HA-UTI vs UTI-free. Nurse Units consistently emerge as the most significant predictors across all years. The importance of all predictors varies from year to year. AB - Author manuscript AN - cdc:261427 C4 - PMC12875383 DO - https://doi.org/10.1016/j.jhin.2025.04.024 J2 - The Journal of Hospital Infection KW - Adolescent KW - Female KW - Sensitivity and Specificity KW - Aged KW - Urinary Tract Infections KW - Young Adult KW - Socioeconomic Factors KW - Machine Learning KW - Cross Infection KW - Aged, 80 and over KW - Risk Factors KW - Hospitals KW - Incidence KW - Male KW - Humans KW - Middle Aged KW - Decision Trees KW - Adult KW - Community-Acquired Infections KW - Urinary tract infection KW - community-associated infection KW - healthcare-associated infection KW - machine learning KW - socioeconomic factors KW - Humans KW - Machine Learning KW - Urinary Tract Infections KW - Community-Acquired Infections KW - Male KW - Female KW - Middle Aged KW - Cross Infection KW - Aged KW - Hospitals KW - Adult KW - Socioeconomic Factors KW - Risk Factors KW - Young Adult KW - Incidence KW - Aged, 80 and over KW - Sensitivity and Specificity KW - Decision Trees KW - Adolescent LA - eng PY - 2025 T2 - The Journal of Hospital Infection T2 - The Journal of Hospital Infection, 2025, v. 162 TI - Comparative Analysis of Machine Learning Models For Predicting Hospital- and Community-associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors. VL - 162 UR - https://stacks.cdc.gov/view/cdc/261427 ER -
Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation For Neutrophil-Mediated Drug Delivery to In Vitro Thrombi.

Maiocchi, Sophie ;

Burnham, Erica E.

June 2025 | Advanced Healthcare Materials, 2025, v. 14, no. 15

Activated neutrophils release Neutrophil Extracellular Traps (NETs), comprising decondensed chromatin, peroxidases, and serine proteases, which aid in host defense but are also implicated in thrombosis and resistance to thrombolysis. Recombinant DNase 1, which degrades NETs, may aid in thrombus dissolution synergistically with fibrinolytics. Howeve ...

10/09/2026

Supporting Files

Title : Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation For Neutrophil-Mediated Drug Delivery to In Vitro Thrombi. Personal Author(s) : Maiocchi, Sophie;Burnham, Erica E.;Cartaya, Ana;Lisi, Veronica;Buechler, Nancy;Pollard, Rachel;Babaki, Danial;Bergmeier, Wolfgang;Pinkerton, Nathalie M.;Bahnson, Edward; Published Date : June 2025 Pages in Document : e2404584 (47 pdf pages) Source : Advanced Healthcare Materials, 2025, v. 14, no. 15 DOI : https://doi.org/10.1002/adhm.202404584 Journal Title : Advanced Healthcare Materials
Maiocchi, S., Burnham, E. E., Cartaya, A., Lisi, V., Buechler, N., Pollard, R., Babaki, D., Bergmeier, W., Pinkerton, N. M., & Bahnson, E. (2025). Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation For Neutrophil-Mediated Drug Delivery to In Vitro Thrombi. Advanced Healthcare Materials, 14(15). https://doi.org/10.1002/adhm.202404584

Maiocchi, Sophie, Erica E. Burnham, Ana Cartaya, Veronica Lisi, Nancy Buechler, Rachel Pollard, Danial Babaki, Wolfgang Bergmeier, Nathalie M. Pinkerton, and Edward Bahnson. "Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation For Neutrophil-Mediated Drug Delivery to In Vitro Thrombi." Advanced Healthcare Materials 14, no. 15 (2025). https://doi.org/10.1002/adhm.202404584.

Maiocchi, Sophie, et al. "Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation For Neutrophil-Mediated Drug Delivery to In Vitro Thrombi." Advanced Healthcare Materials, vol. 14, no. 15, 2025. Stacks. https://doi.org/10.1002/adhm.202404584.
Export RIS Citation Information. TY - Journal Article AU - Maiocchi, Sophie AU - Burnham, Erica E. AU - Cartaya, Ana AU - Lisi, Veronica AU - Buechler, Nancy AU - Pollard, Rachel AU - Babaki, Danial AU - Bergmeier, Wolfgang AU - Pinkerton, Nathalie M. AU - Bahnson, Edward AB - Activated neutrophils release Neutrophil Extracellular Traps (NETs), comprising decondensed chromatin, peroxidases, and serine proteases, which aid in host defense but are also implicated in thrombosis and resistance to thrombolysis. Recombinant DNase 1, which degrades NETs, may aid in thrombus dissolution synergistically with fibrinolytics. However, its short half-life and susceptibility to plasma proteases limit its therapeutic applicability. To address these limitations, DNase1 is encapsulated into polymeric nanoparticles (DNPs) using inverse Flash Nanoprecipitation (iFNP), a scalable nanoparticle synthesis technique. Previously only used with model proteins, the study demonstrates for the first time the feasibility of extending iFNP to the encapsulation of therapeutic proteins. Conditions that promote DNase1 solubility, preserve activity, and demonstrate release resulting in ex vivo NET degradation are detailed. Furthermore, the use of neutrophils, the source of NETs, as carriers for DNPs to enhance targeted delivery is investigated. These findings confirm that DNP-loaded neutrophils maintain key functionalities, including viability and oxidative burst, and associate with in vitro blood clots to deliver nanoparticles, and DNase1 protein. This study not only extends the feasibility of applying iFNP to encapsulate therapeutic proteins into polymeric nanoparticles, a promising alternative to lipid nanoparticles, but also contributes to the emerging literature on neutrophils as delivery vectors for nanocarriers. AB - Author manuscript AN - cdc:261426 C4 - PMC12148695 DO - https://doi.org/10.1002/adhm.202404584 IS - 15 J2 - Advanced Healthcare Materials KW - Deoxyribonuclease I KW - Polymers KW - Nanoparticles KW - Extracellular Traps KW - Drug Delivery Systems KW - Humans KW - Neutrophils KW - Thrombosis KW - Inverse Flash Nanoprecipitation KW - DNase 1 KW - Protein delivery KW - Neutrophil nanomaterial interaction KW - Neutrophil Extracellular Traps KW - Cell Mediated Drug Delivery KW - Deoxyribonuclease I KW - Neutrophils KW - Nanoparticles KW - Humans KW - Thrombosis KW - Extracellular Traps KW - Polymers KW - Drug Delivery Systems LA - eng PY - 2025 T2 - Advanced Healthcare Materials T2 - Advanced Healthcare Materials, 2025, v. 14, no. 15 TI - Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation For Neutrophil-Mediated Drug Delivery to In Vitro Thrombi. VL - 14 UR - https://stacks.cdc.gov/view/cdc/261426 ER -
Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice.

Crawford, Meli'sa S. ;

Ulu, Arzu

September 2025 | Journal of Applied Toxicology : JAT, 2025, v. 45, no. 9

Exposure to agricultural dust containing antimicrobial-resistant pathogens poses significant health risks for workers in animal agriculture production. Beyond causing severe airway inflammation, pollutants are linked to intestinal diseases. Swine farm dust is rich in ultrafine particles, gram-positive and gram-negative bacteria, and bacterial compo ...

10/09/2026

Supporting Files

Title : Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice. Personal Author(s) : Crawford, Meli'sa S.;Ulu, Arzu;Ramirez, Briana M.;Santos, Alina N.;Chatterjee, Pritha;Canale, Vinicius;Manz, Salomon;Lei, Hillmin;Soriano, Sarah Mae;Nordgren, Tara M.;McCole, Declan F.; Published Date : September 2025 Pages in Document : 1798-1810 (26 pdf pages) Source : Journal of Applied Toxicology : JAT, 2025, v. 45, no. 9 DOI : https://doi.org/10.1002/jat.4808 Journal Title : Journal of Applied Toxicology : JAT
Crawford, M. S., Ulu, A., Ramirez, B. M., Santos, A. N., Chatterjee, P., Canale, V., Manz, S., Lei, H., Soriano, S. M., Nordgren, T. M., & McCole, D. F. (2025). Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice. Journal of Applied Toxicology : JAT, 45(9). https://doi.org/10.1002/jat.4808

Crawford, Meli'sa S., Arzu Ulu, Briana M. Ramirez, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, and Salomon Manz, et al.. "Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice." Journal of Applied Toxicology : JAT 45, no. 9 (2025). https://doi.org/10.1002/jat.4808.

Crawford, Meli'sa S., et al. "Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice." Journal of Applied Toxicology : JAT, vol. 45, no. 9, 2025. Stacks. https://doi.org/10.1002/jat.4808.
Export RIS Citation Information. TY - Journal Article AU - Crawford, Meli'sa S. AU - Ulu, Arzu AU - Ramirez, Briana M. AU - Santos, Alina N. AU - Chatterjee, Pritha AU - Canale, Vinicius AU - Manz, Salomon AU - Lei, Hillmin AU - Soriano, Sarah Mae AU - Nordgren, Tara M. AU - McCole, Declan F. AB - Exposure to agricultural dust containing antimicrobial-resistant pathogens poses significant health risks for workers in animal agriculture production. Beyond causing severe airway inflammation, pollutants are linked to intestinal diseases. Swine farm dust is rich in ultrafine particles, gram-positive and gram-negative bacteria, and bacterial components such as lipopolysaccharides (LPS; endotoxins). In our previous study, we demonstrated that intranasal exposure of male and female C57BL/6J mice to 12.5% hog dust extract (HDE, containing 22.1-91.1 EU/mL) for 3 weeks resulted in elevated total cell and neutrophil counts in bronchoalveolar lavage fluid and increased intestinal permeability compared to saline controls. Now, we report that 16S and metagenomic analyses of Week 3 stool samples from HDE-treated mice indicate a reduced abundance of the beneficial species Akkermansia muciniphila and Clostridium sp. ASF356 and Lachnospiraceae bacterium. Bacterial alpha diversity showed increased species evenness in fecal samples from HDE-treated mice (Pielou's evenness, p = 0.047, n = 5-6/group). Metabolomic analysis also indicated significant reductions in key metabolites involved in energy metabolism, including riboflavin (p = 0.027, n = 11) and nicotinic acid (p = 0.049, n = 11), as well as essential amino acids, such as inosine (p = 0.043, n = 11) and leucine (p = 0.018, n = 11). While HDE exposure does not robustly alter overall microbial abundance or community structure, it leads to specific reductions in beneficial bacterial species and critical metabolites necessary for maintaining intestinal homeostasis by supporting energy metabolism, gut barrier function, microbiota balance, and immune regulation. The results of this study underscore the potential risks for gut health posed by inhalation of agricultural dust. AB - Author manuscript AN - cdc:261425 C4 - PMC12790881 DO - https://doi.org/10.1002/jat.4808 IS - 9 J2 - Journal of Applied Toxicology : JAT KW - Gastrointestinal Microbiome KW - Female KW - Swine KW - Feces KW - Agriculture KW - Animals KW - Dust KW - Mice, Inbred C57BL KW - Male KW - Inhalation Exposure KW - Mice KW - agricultural pollution KW - Akkermansia muciniphila KW - gut microbiome KW - gut-lung axis KW - intestinal barrier function KW - Animals KW - Dust KW - Gastrointestinal Microbiome KW - Female KW - Mice, Inbred C57BL KW - Male KW - Mice KW - Inhalation Exposure KW - Feces KW - Swine KW - Agriculture LA - eng PY - 2025 T2 - Journal of Applied Toxicology : JAT T2 - Journal of Applied Toxicology : JAT, 2025, v. 45, no. 9 TI - Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice. VL - 45 UR - https://stacks.cdc.gov/view/cdc/261425 ER -
Effect of Temperature and Time on RNA Detection by RT-qPCR in Rodent Tissue and Blood Samples Stored in MagMAX™ Lysis/Binding Solution Concentrate: Considerations For RNA Detection in Specimens Stored Under Suboptimal Conditions.

Davies, Katherine A. ;

Welch, Stephen R.

September 2025 | Journal of Virological Methods, 2025, v. 337

For detection of viral RNA in blood or tissue, samples are often collected into lysis buffers prior to downstream molecular analysis. Immediate sample processing and cold storage are not always possible during large-scale or field studies, or in facilities lacking a stable electrical supply. Additionally, samples may need to be transported signific ...

10/09/2026

Supporting Files

Title : Effect of Temperature and Time on RNA Detection by RT-qPCR in Rodent Tissue and Blood Samples Stored in MagMAX™ Lysis/Binding Solution Concentrate: Considerations For RNA Detection in Specimens Stored Under Suboptimal Conditions. Personal Author(s) : Davies, Katherine A.;Welch, Stephen R.;Sorvillo, Teresa E.;Coleman-McCray, JoAnn D.;Spiropoulou, Christina F.;Spengler, Jessica R.; Published Date : September 2025 Pages in Document : 115175 (10 pdf pages) Source : Journal of Virological Methods, 2025, v. 337 DOI : https://doi.org/10.1016/j.jviromet.2025.115175 Journal Title : Journal of Virological Methods
Davies, K. A., Welch, S. R., Sorvillo, T. E., Coleman-McCray, J. D., Spiropoulou, C. F., & Spengler, J. R. (2025). Effect of Temperature and Time on RNA Detection by RT-qPCR in Rodent Tissue and Blood Samples Stored in MagMAX™ Lysis/Binding Solution Concentrate: Considerations For RNA Detection in Specimens Stored Under Suboptimal Conditions. Journal of Virological Methods, 337. https://doi.org/10.1016/j.jviromet.2025.115175

Davies, Katherine A., Stephen R. Welch, Teresa E. Sorvillo, JoAnn D. Coleman-McCray, Christina F. Spiropoulou, and Jessica R. Spengler. "Effect of Temperature and Time on RNA Detection by RT-qPCR in Rodent Tissue and Blood Samples Stored in MagMAX™ Lysis/Binding Solution Concentrate: Considerations For RNA Detection in Specimens Stored Under Suboptimal Conditions." Journal of Virological Methods 337 (2025). https://doi.org/10.1016/j.jviromet.2025.115175.

Davies, Katherine A., et al. "Effect of Temperature and Time on RNA Detection by RT-qPCR in Rodent Tissue and Blood Samples Stored in MagMAX™ Lysis/Binding Solution Concentrate: Considerations For RNA Detection in Specimens Stored Under Suboptimal Conditions." Journal of Virological Methods, vol. 337, 2025. Stacks. https://doi.org/10.1016/j.jviromet.2025.115175.
Export RIS Citation Information. TY - Journal Article AU - Davies, Katherine A. AU - Welch, Stephen R. AU - Sorvillo, Teresa E. AU - Coleman-McCray, JoAnn D. AU - Spiropoulou, Christina F. AU - Spengler, Jessica R. AB - For detection of viral RNA in blood or tissue, samples are often collected into lysis buffers prior to downstream molecular analysis. Immediate sample processing and cold storage are not always possible during large-scale or field studies, or in facilities lacking a stable electrical supply. Additionally, samples may need to be transported significant distances before processing. Here, using peptidylprolyl isomerase A (Ppia), a stably expressed gene in rodent tissues, we investigate the long-term stability and detection of RNA in guinea pig tissues stored for up to 52 weeks and in hamster blood stored for up to 12 weeks in MagMAX Lysis/Binding Solution Concentrate at -80°C, 4°C, 21°C, and 32°C. AB - Author manuscript AN - cdc:261424 C4 - PMC12232495 DO - https://doi.org/10.1016/j.jviromet.2025.115175 J2 - Journal of Virological Methods KW - Specimen Handling KW - RNA, Viral KW - Temperature KW - Real-Time Polymerase Chain Reaction KW - Cricetinae KW - Animals KW - Guinea Pigs KW - Time Factors KW - RNA stability KW - lysis buffer KW - storage KW - temperature KW - Animals KW - Specimen Handling KW - Temperature KW - RNA, Viral KW - Guinea Pigs KW - Time Factors KW - Cricetinae KW - Real-Time Polymerase Chain Reaction LA - eng PY - 2025 T2 - Journal of Virological Methods T2 - Journal of Virological Methods, 2025, v. 337 TI - Effect of Temperature and Time on RNA Detection by RT-qPCR in Rodent Tissue and Blood Samples Stored in MagMAX™ Lysis/Binding Solution Concentrate: Considerations For RNA Detection in Specimens Stored Under Suboptimal Conditions. VL - 337 UR - https://stacks.cdc.gov/view/cdc/261424 ER -
Recommended Immunizations to Reduce Respiratory Morbidity and Mortality Among US Adults With Asthma, by Age.

Dowling, Tia C. ;

Shah, Melisa M.

May 2025 | Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 2025, v. 134, no. 5

Respiratory infections, including some that are preventable by vaccination, can trigger asthma attacks. The figure is a summary of some vaccines recommended for US adults with asthma. These recommendations largely parallel recommendations for adults without asthma. For example:• A 2024-2025 COVID-19 vaccination is recommended for all adults to prot ...

10/09/2026

Supporting Files

Title : Recommended Immunizations to Reduce Respiratory Morbidity and Mortality Among US Adults With Asthma, by Age. Personal Author(s) : Dowling, Tia C.;Shah, Melisa M.;Moulia, Danielle L.;Hsu, Joy; Published Date : May 2025 Pages in Document : 535-538 (6 pdf pages) Source : Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 2025, v. 134, no. 5 DOI : https://doi.org/10.1016/j.anai.2025.01.019 Journal Title : Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Dowling, T. C., Shah, M. M., Moulia, D. L., & Hsu, J. (2025). Recommended Immunizations to Reduce Respiratory Morbidity and Mortality Among US Adults With Asthma, by Age. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 134(5). https://doi.org/10.1016/j.anai.2025.01.019

Dowling, Tia C., Melisa M. Shah, Danielle L. Moulia, and Joy Hsu. "Recommended Immunizations to Reduce Respiratory Morbidity and Mortality Among US Adults With Asthma, by Age." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology 134, no. 5 (2025). https://doi.org/10.1016/j.anai.2025.01.019.

Dowling, Tia C., et al. "Recommended Immunizations to Reduce Respiratory Morbidity and Mortality Among US Adults With Asthma, by Age." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 134, no. 5, 2025. Stacks. https://doi.org/10.1016/j.anai.2025.01.019.
Export RIS Citation Information. TY - Journal Article AU - Dowling, Tia C. AU - Shah, Melisa M. AU - Moulia, Danielle L. AU - Hsu, Joy AB - Respiratory infections, including some that are preventable by vaccination, can trigger asthma attacks. The figure is a summary of some vaccines recommended for US adults with asthma. These recommendations largely parallel recommendations for adults without asthma. For example: AB - • A 2024-2025 COVID-19 vaccination is recommended for all adults to protect against severe COVID-19-associated illness and death.1,2 A second dose of 2024-2025 COVID-19 vaccine is recommended for people 65 years and older and people with moderate or severe immunocompromise.3 Footnote 2 (Figure) has more information on COVID-19 vaccination. AB - • To protect against pertussis, all adults should receive one dose of Tdap vaccine if they did not receive Tdap on or after the age of 10 years. A Td or Tdap booster every 10 years is recommended for all adults to prevent tetanus and diphtheria.1 AB - • Routine annual influenza vaccination is recommended for all persons aged ≥6 months who have no contraindications. All persons should receive an age-appropriate influenza vaccine (i.e., one approved for their age). The exception is that solid organ transplant recipients aged 18-64 years receiving immunosuppressive medication regimens may receive trivalent high-dose inactivated influenza vaccine (HD-IIV3) or trivalent adjuvanted inactivated influenza vaccine (aIIV3) as acceptable options, without a preference over other age-appropriate inactivated or recombinant influenza vaccines.1,4 Trivalent high-dose inactivated influenza vaccine (HD-IIV3), trivalent recombinant influenza vaccine (RIV3), and trivalent adjuvanted inactivated influenza vaccine (aIIV3) are preferentially recommended for persons aged ≥65 years. AB - Author manuscript AN - cdc:261423 C4 - PMC12356084 DO - https://doi.org/10.1016/j.anai.2025.01.019 IS - 5 J2 - Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology KW - Diphtheria KW - Organ Transplantation KW - Vaccination KW - COVID-19 Vaccines KW - Asthma KW - Whooping Cough KW - Humans KW - COVID-19 KW - Tetanus KW - Adult KW - Influenza Vaccines KW - Influenza, Human KW - Humans KW - Adult KW - COVID-19 KW - COVID-19 Vaccines KW - Diphtheria KW - Influenza Vaccines KW - Influenza, Human KW - Tetanus KW - Whooping Cough KW - Organ Transplantation KW - Vaccination KW - Asthma LA - eng PY - 2025 T2 - Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology T2 - Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 2025, v. 134, no. 5 TI - Recommended Immunizations to Reduce Respiratory Morbidity and Mortality Among US Adults With Asthma, by Age. VL - 134 UR - https://stacks.cdc.gov/view/cdc/261423 ER -
Introducing the Impact Wellbeing ™ Guide: Taking Action to Improve Health Care Worker Well-being.

Novicki, Emily ;

Howard, John

June 2025 | Workplace Health & Safety, 2025, v. 73, no. 6

Our work environments have a significant impact on our well-being. Stress, strain, or interpersonal challenges for workers can cause both physical and psychological impacts, including burnout (5). It is well known that burnout has been an ongoing crisis in health care, reaching peak levels during the COVID-19 pandemic. A study of health workers by ...

10/09/2026

Supporting Files

Title : Introducing the Impact Wellbeing ™ Guide: Taking Action to Improve Health Care Worker Well-being. Personal Author(s) : Novicki, Emily;Howard, John;Simmons, Stefanie; Published Date : June 2025 Pages in Document : 320 (3 pdf pages) Source : Workplace Health & Safety, 2025, v. 73, no. 6 DOI : https://doi.org/10.1177/21650799241290541 Journal Title : Workplace Health & Safety
Novicki, E., Howard, J., & Simmons, S. (2025). Introducing the Impact Wellbeing ™ Guide: Taking Action to Improve Health Care Worker Well-being. Workplace Health & Safety, 73(6). https://doi.org/10.1177/21650799241290541

Novicki, Emily, John Howard, and Stefanie Simmons. "Introducing the Impact Wellbeing ™ Guide: Taking Action to Improve Health Care Worker Well-being." Workplace Health & Safety 73, no. 6 (2025). https://doi.org/10.1177/21650799241290541.

Novicki, Emily, et al. "Introducing the Impact Wellbeing ™ Guide: Taking Action to Improve Health Care Worker Well-being." Workplace Health & Safety, vol. 73, no. 6, 2025. Stacks. https://doi.org/10.1177/21650799241290541.
Export RIS Citation Information. TY - Journal Article AU - Novicki, Emily AU - Howard, John AU - Simmons, Stefanie AB - Our work environments have a significant impact on our well-being. Stress, strain, or interpersonal challenges for workers can cause both physical and psychological impacts, including burnout (5). It is well known that burnout has been an ongoing crisis in health care, reaching peak levels during the COVID-19 pandemic. A study of health workers by the National Institute for Occupational Safety and Health (NIOSH) compared self-reported mental health symptoms in 2018 with 2022, before and after the onset of the pandemic (4). The study included patient-facing health care workers as well as support staff and public health workers. Nearly half of health workers (46%) reported often feeling burned out in 2022, up from 32% in 2018. However, health workers who reported positive working conditions, such as trust in management, were less likely to experience poor mental health symptoms and burnout. AB - Author manuscript AN - cdc:261422 C4 - PMC12065978 DO - https://doi.org/10.1177/21650799241290541 IS - 6 J2 - Workplace Health & Safety KW - Burnout, Psychological KW - Health Personnel KW - Mental Health KW - Resilience, Psychological KW - health care workers KW - burnout KW - mental health KW - Mental Health KW - Resilience, Psychological KW - Health Personnel KW - Burnout, Psychological LA - eng PY - 2025 T2 - Workplace Health & Safety T2 - Workplace Health & Safety, 2025, v. 73, no. 6 TI - Introducing the Impact Wellbeing ™ Guide: Taking Action to Improve Health Care Worker Well-being. VL - 73 UR - https://stacks.cdc.gov/view/cdc/261422 ER -
Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients.

Jackson, Sarah S ;

Pfeiffer, Ruth M

August 2025 | International Journal of Cancer, 2025, v. 157, no. 3

Males have increased mortality after a cancer diagnosis than females, possibly due to poorer immunosurveillance. We tested whether the female survival advantage is lost with immunosuppression by evaluating 17,048 cancer patients (68% male) with a prior solid organ transplant using data from the US Transplant Cancer Match Study and 1,221,914 cancer ...

10/09/2026

Supporting Files

Title : Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients. Personal Author(s) : Jackson, Sarah S;Pfeiffer, Ruth M;Gardner, Erin;Hsieh, Mei-Chin;Insaf, Tabassum;Lynch, Charles F;Morawski, Bozena;Wang, Shuhui;Yu, Kelly J;Engels, Eric A; Published Date : August 2025 Pages in Document : 427-435 (16 pdf pages) Source : International Journal of Cancer, 2025, v. 157, no. 3 DOI : https://doi.org/10.1002/ijc.35415 Journal Title : International Journal of Cancer
Jackson, S. S., Pfeiffer, R. M., Gardner, E., Hsieh, M. C., Insaf, T., Lynch, C. F., Morawski, B., Wang, S., Yu, K. J., & Engels, E. A. (2025). Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients. International Journal of Cancer, 157(3). https://doi.org/10.1002/ijc.35415

Jackson, Sarah S, Ruth M Pfeiffer, Erin Gardner, Mei-Chin Hsieh, Tabassum Insaf, Charles F Lynch, Bozena Morawski, Shuhui Wang, Kelly J Yu, and Eric A Engels. "Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients." International Journal of Cancer 157, no. 3 (2025). https://doi.org/10.1002/ijc.35415.

Jackson, Sarah S, et al. "Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients." International Journal of Cancer, vol. 157, no. 3, 2025. Stacks. https://doi.org/10.1002/ijc.35415.
Export RIS Citation Information. TY - Journal Article AU - Jackson, Sarah S AU - Pfeiffer, Ruth M AU - Gardner, Erin AU - Hsieh, Mei-Chin AU - Insaf, Tabassum AU - Lynch, Charles F AU - Morawski, Bozena AU - Wang, Shuhui AU - Yu, Kelly J AU - Engels, Eric A AB - Males have increased mortality after a cancer diagnosis than females, possibly due to poorer immunosurveillance. We tested whether the female survival advantage is lost with immunosuppression by evaluating 17,048 cancer patients (68% male) with a prior solid organ transplant using data from the US Transplant Cancer Match Study and 1,221,914 cancer patients (58% male) from the general population using data from the Surveillance, Epidemiology, and End Results Program. We evaluated 13 solid cancers that occur in both sexes. We compared mortality due to cancer in males and females using a male:female hazard ratio (M:F HR) derived from Cox proportional hazards models adjusted for age, race/ethnicity, diagnosis year, stage, and cancer treatment. Among cancer patients in the general population, males had higher cancer-specific mortality than females for cancers of the lip, stomach, colorectum, anus, liver, lung, skin, brain, and thyroid, with M:F HRs ranging from 1.06 to 1.59. Only colorectal cancer showed an attenuation in the female mortality advantage in transplant recipients (M:F HR AB - : 0.89; 95% CI: 0.77, 1.03; vs. M:F HR AB - : 1.07; 95% CI: 1.06, 1.08; P-interaction = 0.007). Among kidney cancer patients, the female mortality advantage was stronger in the transplant population (M:F HR AB - : 1.33; 95% CI: 1.11, 1.60; M:F HR AB - : 1.02; 95% CI: 0.99, 1.04; P-interaction = 0.003). Overall, we did not find consistent evidence that the female advantage in cancer mortality is weakened among immunosuppressed transplant recipients, suggesting that non-immune factors contribute to the female advantage among cancer patients in the general population. AB - Author manuscript AN - cdc:261421 C4 - PMC12143962 DO - https://doi.org/10.1002/ijc.35415 IS - 3 J2 - International Journal of Cancer KW - Transplant Recipients KW - Organ Transplantation KW - Female KW - Sex Factors KW - Neoplasms KW - SEER Program KW - Male KW - Aged KW - Humans KW - Middle Aged KW - Adult KW - Sex differences KW - cancer KW - mortality KW - immunosurveillance KW - organ transplantation KW - Humans KW - Female KW - Male KW - Neoplasms KW - Organ Transplantation KW - Middle Aged KW - Transplant Recipients KW - SEER Program KW - Aged KW - Adult KW - Sex Factors LA - eng PY - 2025 T2 - International Journal of Cancer T2 - International Journal of Cancer, 2025, v. 157, no. 3 TI - Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients. VL - 157 UR - https://stacks.cdc.gov/view/cdc/261421 ER -

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