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Showing 801 - 820 of 1969 results

Baloxavir Treatment to Reduce Influenza Virus Transmission.

Uyeki, Timothy M. ;

Dugan, Vivien G.

April 24, 2025 | The New England Journal of Medicine, 2025, v. 392, no. 16

Antiviral treatment of influenza is recommended as soon as possible for hospitalized patients and for outpatients who are at increased risk for influenza-related complications. The Food and Drug Administration-approved oral antiviral agent oseltamivir is the most widely used antiviral medication for the treatment of influenza and for postexposure p ...

10/09/2026

Supporting Files

Title : Baloxavir Treatment to Reduce Influenza Virus Transmission. Personal Author(s) : Uyeki, Timothy M.;Dugan, Vivien G.;Daskalakis, Demetre C.; Published Date : April 24, 2025 Pages in Document : 1652-1654 (4 pdf pages) Source : The New England Journal of Medicine, 2025, v. 392, no. 16 DOI : https://doi.org/10.1056/NEJMe2503242 Journal Title : The New England Journal of Medicine
Uyeki, T. M., Dugan, V. G., & Daskalakis, D. C. (2025). Baloxavir Treatment to Reduce Influenza Virus Transmission. The New England Journal of Medicine, 392(16). https://doi.org/10.1056/NEJMe2503242

Uyeki, Timothy M., Vivien G. Dugan, and Demetre C. Daskalakis. "Baloxavir Treatment to Reduce Influenza Virus Transmission." The New England Journal of Medicine 392, no. 16 (2025). https://doi.org/10.1056/NEJMe2503242.

Uyeki, Timothy M., et al. "Baloxavir Treatment to Reduce Influenza Virus Transmission." The New England Journal of Medicine, vol. 392, no. 16, 2025. Stacks. https://doi.org/10.1056/NEJMe2503242.
Export RIS Citation Information. TY - Journal Article AU - Uyeki, Timothy M. AU - Dugan, Vivien G. AU - Daskalakis, Demetre C. AB - Antiviral treatment of influenza is recommended as soon as possible for hospitalized patients and for outpatients who are at increased risk for influenza-related complications. The Food and Drug Administration-approved oral antiviral agent oseltamivir is the most widely used antiviral medication for the treatment of influenza and for postexposure prophylaxis to control institutional outbreaks of influenza. Baloxavir marboxil (baloxavir) is an oral antiviral medication that is FDA-approved for early treatment (within 48 hours after symptom onset) of uncomplicated influenza and for postexposure prophylaxis against influenza in persons 5 years of age and older. Randomized, controlled trials of early treatment with baloxavir, as compared with oseltamivir or placebo, showed that the efficacy of a single dose of baloxavir was similar to that of oseltamivir taken twice daily for 5 days for reducing the time to alleviation of influenza symptoms in adolescents and adults, including those at increased risk for influenza-related complications. In addition, upper respiratory tract virus levels were significantly lower with baloxavir than with oseltamivir or placebo as early as 24 hours after treatment, a finding consistent with its mechanism of action in inhibiting viral replication.3,4 Early treatment with oseltamivir or baloxavir has efficacy in reducing the risks of some influenza-related complications, as compared with placebo. AB - Author manuscript AN - cdc:261462 C4 - PMC12362349 DO - https://doi.org/10.1056/NEJMe2503242 IS - 16 J2 - The New England Journal of Medicine KW - Outpatients KW - Antiviral Agents KW - Respiratory System KW - Virus Replication KW - United States Food and Drug Administration KW - Oseltamivir KW - baloxavirbaloxavir: No Relevant Scope Data KW - Disease Outbreaks KW - Influenza, Human KW - baloxavirbaloxavir: No Relevant Scope Data KW - Influenza, Human KW - Oseltamivir KW - Outpatients KW - United States Food and Drug Administration KW - Respiratory System KW - Virus Replication KW - Antiviral Agents KW - Disease Outbreaks LA - eng PY - 2025 T2 - The New England Journal of Medicine T2 - The New England Journal of Medicine, 2025, v. 392, no. 16 TI - Baloxavir Treatment to Reduce Influenza Virus Transmission. VL - 392 UR - https://stacks.cdc.gov/view/cdc/261462 ER -
Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019.

Beltran, Theo G. ;

Pence, Brian W.

April 2025 | Pharmacoepidemiology and Drug Safety, 2025, v. 34, no. 4

Impact of policies limiting opioid prescribing for acute and post-surgical pain among racially minoritized populations is not well understood. We evaluated the impact of two North Carolina (NC) policies on outpatient opioid prescribing among injury and surgical patients by race, ethnicity, age, and sex.We conducted controlled and single series inte ...

10/09/2026

Supporting Files

Title : Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019. Personal Author(s) : Beltran, Theo G.;Pence, Brian W.;Fulcher, Naoko;Dasgupta, Nabarun;Maierhofer, Courtney N.;DiPrete, Bethany L.;Marshall, Stephen W.;Nocera, Maryalice;Proescholdbell, Scott K.;Wu, Li-Tzy;Edwards, David A.;Carey, Timothy S.;Chelminski, Paul R.;Hincapie-Castillo, Juan M.;Mathias, Joacy G.;Ranapurwala, Shabbar I.; Published Date : April 2025 Pages in Document : e70144 (19 pdf pages) Source : Pharmacoepidemiology and Drug Safety, 2025, v. 34, no. 4 DOI : https://doi.org/10.1002/pds.70144 Journal Title : Pharmacoepidemiology and Drug Safety
Beltran, T. G., Pence, B. W., Fulcher, N., Dasgupta, N., Maierhofer, C. N., DiPrete, B. L., Marshall, S. W., Nocera, M., Proescholdbell, S. K., Wu, L. T., Edwards, D. A., Carey, T. S., Chelminski, P. R., Hincapie-Castillo, J. M., Mathias, J. G., & Ranapurwala, S. I. (2025). Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019. Pharmacoepidemiology and Drug Safety, 34(4). https://doi.org/10.1002/pds.70144

Beltran, Theo G., Brian W. Pence, Naoko Fulcher, Nabarun Dasgupta, Courtney N. Maierhofer, Bethany L. DiPrete, and Stephen W. Marshall, et al.. "Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019." Pharmacoepidemiology and Drug Safety 34, no. 4 (2025). https://doi.org/10.1002/pds.70144.

Beltran, Theo G., et al. "Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019." Pharmacoepidemiology and Drug Safety, vol. 34, no. 4, 2025. Stacks. https://doi.org/10.1002/pds.70144.
Export RIS Citation Information. TY - Journal Article AU - Beltran, Theo G. AU - Pence, Brian W. AU - Fulcher, Naoko AU - Dasgupta, Nabarun AU - Maierhofer, Courtney N. AU - DiPrete, Bethany L. AU - Marshall, Stephen W. AU - Nocera, Maryalice AU - Proescholdbell, Scott K. AU - Wu, Li-Tzy AU - Edwards, David A. AU - Carey, Timothy S. AU - Chelminski, Paul R. AU - Hincapie-Castillo, Juan M. AU - Mathias, Joacy G. AU - Ranapurwala, Shabbar I. AB - Impact of policies limiting opioid prescribing for acute and post-surgical pain among racially minoritized populations is not well understood. We evaluated the impact of two North Carolina (NC) policies on outpatient opioid prescribing among injury and surgical patients by race, ethnicity, age, and sex. AB - We conducted controlled and single series interrupted time series using electronic health data from two integrated healthcare systems in NC, among > 11 years-old patients having acute injuries and surgery between April 2014 and December 2019. The policy interventions were safe opioid prescribing investigative initiative (SOPI, May 2016) and NC law limiting opioid days' supply (STOP Act, January 2018). Outcomes included, proportion of patients receiving index opioid prescription after surgery or injury event, receipt of subsequent opioid prescriptions, days' supply, and milligrams of morphine equivalents (MME). AB - Of the 621 997 surgical and 864 061 injury patients, 69.4% and 19.7%, respectively, received an index opioid analgesic prescription. There were sustained declines in index opioid prescription among post-surgical patients after SOPI [-2.7% per year (-4.6, -0.9)] and STOP act [-4.1% (-5.9, -2.2)], but no change among injury patients. Policy-related opioid prescribing declines were larger among black, native American, and Hispanic post-surgical patients than whites and Asians. Index and subsequent opioid days' supply showed sustained declines after SOPI and STOP Act among post-surgical patients. There was no policy impact on MME. AB - Policies were associated with reductions in opioid prescribing, particularly in post-surgical patients; however, racialized inequities likely reflect implicit and explicit racialized biases in pain management practices. AB - Author manuscript AN - cdc:261461 C4 - PMC12082966 DO - https://doi.org/10.1002/pds.70144 IS - 4 J2 - Pharmacoepidemiology and Drug Safety KW - Adolescent KW - Female KW - Wounds and Injuries KW - Aged KW - Young Adult KW - Child KW - Analgesics, Opioid KW - Postoperative Pain KW - Interrupted Time Series Analysis KW - Health Policy KW - Male KW - Drug Prescriptions KW - Middle Aged KW - Humans KW - Adult KW - Practice Patterns, Physicians' KW - opioids KW - opioid prescribing KW - policies KW - Humans KW - Analgesics, Opioid KW - Male KW - Interrupted Time Series Analysis KW - Female KW - Postoperative Pain KW - Practice Patterns, Physicians' KW - Middle Aged KW - Adult KW - Drug Prescriptions KW - Young Adult KW - Aged KW - Adolescent KW - Wounds and Injuries KW - Health Policy KW - Child LA - eng PY - 2025 T2 - Pharmacoepidemiology and Drug Safety T2 - Pharmacoepidemiology and Drug Safety, 2025, v. 34, no. 4 TI - Impact of State Policies on Opioid Prescribing Among Surgery and Injury Patients: Controlled Interrupted Time-Series Study, North Carolina, 2014-2019. VL - 34 UR - https://stacks.cdc.gov/view/cdc/261461 ER -
Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects.

Luben, Thomas J. ;

Roell, Kyle

April 2025 | Birth Defects Research, 2025, v. 117, no. 4

The prevalence of tetralogy of Fallot (TOF), a common congenital heart defect, has increased over the last two decades.Genome-wide CpG methylation patterns were assessed and analyzed in relation to gestational air pollution exposure among 24 infants with TOF and 24 sex-matched control infants without a birth defect from a North Carolina population- ...

10/09/2026

Supporting Files

Title : Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects. Personal Author(s) : Luben, Thomas J.;Roell, Kyle;Harrington, Cailee E.;Stingone, Jeanette A.;Ward-Caviness, Cavin K.;Desrosiers, Tania A.;Fry, Rebecca C.;Olshan, Andrew F.; Published Date : April 2025 Pages in Document : e2473 (24 pdf pages) Source : Birth Defects Research, 2025, v. 117, no. 4 DOI : https://doi.org/10.1002/bdr2.2473 Journal Title : Birth Defects Research
Luben, T. J., Roell, K., Harrington, C. E., Stingone, J. A., Ward-Caviness, C. K., Desrosiers, T. A., Fry, R. C., & Olshan, A. F. (2025). Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects. Birth Defects Research, 117(4). https://doi.org/10.1002/bdr2.2473

Luben, Thomas J., Kyle Roell, Cailee E. Harrington, Jeanette A. Stingone, Cavin K. Ward-Caviness, Tania A. Desrosiers, Rebecca C. Fry, and Andrew F. Olshan. "Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects." Birth Defects Research 117, no. 4 (2025). https://doi.org/10.1002/bdr2.2473.

Luben, Thomas J., et al. "Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects." Birth Defects Research, vol. 117, no. 4, 2025. Stacks. https://doi.org/10.1002/bdr2.2473.
Export RIS Citation Information. TY - Journal Article AU - Luben, Thomas J. AU - Roell, Kyle AU - Harrington, Cailee E. AU - Stingone, Jeanette A. AU - Ward-Caviness, Cavin K. AU - Desrosiers, Tania A. AU - Fry, Rebecca C. AU - Olshan, Andrew F. AB - The prevalence of tetralogy of Fallot (TOF), a common congenital heart defect, has increased over the last two decades. AB - Genome-wide CpG methylation patterns were assessed and analyzed in relation to gestational air pollution exposure among 24 infants with TOF and 24 sex-matched control infants without a birth defect from a North Carolina population-based, case-control study of major structural birth defects (2006-2011). Air pollution exposure during obstetric weeks 3-8 was assigned based on self-reported residence. DNA was extracted from residual newborn blood spots, and DNA methylation levels were measured using the Illumina EPIC Array. AB - Cases had higher exposure to both PM AB - and O AB - compared to controls. No specific CpG loci were statistically significantly associated with TOF status or air pollution exposure; however, we observed associations between TOF case status and DNA methylation at specific genomic regions with genes enriched for functions in metabolism. Additionally, there were significant regions that displayed differential DNA methylation in relation to air pollution exposure within genes involved in apoptosis, necrosis, inflammation, and immune response pathways. AB - Generally, air pollution exposure and TOF were associated with differential DNA methylation in distinct genes. These results highlight suggestive links between the environment, epigenome, and TOF to be further investigated in larger studies. AB - Author manuscript AN - cdc:261460 C4 - PMC12799053 DO - https://doi.org/10.1002/bdr2.2473 IS - 4 J2 - Birth Defects Research KW - Pregnancy KW - Tetralogy of Fallot KW - DNA Methylation KW - Female KW - Ozone KW - Infant, Newborn KW - Particulate Matter KW - CpG Islands KW - Air Pollution KW - Case-Control Studies KW - Heart Defects, Congenital KW - Male KW - Humans KW - Environmental Exposure KW - Air Pollutants KW - Birth Defects KW - Dried Blood Spots KW - Epigenetics KW - DNA Methylation KW - Air Pollution KW - Humans KW - DNA Methylation KW - Infant, Newborn KW - CpG Islands KW - Female KW - Air Pollution KW - Male KW - Case-Control Studies KW - Heart Defects, Congenital KW - Tetralogy of Fallot KW - Pregnancy KW - Particulate Matter KW - Environmental Exposure KW - Ozone KW - Air Pollutants LA - eng PY - 2025 T2 - Birth Defects Research T2 - Birth Defects Research, 2025, v. 117, no. 4 TI - Using Residual Newborn Blood Spots to Investigate CpG Methylation in Relation to Air Pollution and Congenital Heart Defects. VL - 117 UR - https://stacks.cdc.gov/view/cdc/261460 ER -
Pre-exposure Prophylaxis Providers in Birmingham, Alabama, and New York City, New York, Identify Critical Barriers to Newer Pre-exposure Prophylaxis Strategies: a Mixed Methods Study.

Kay, Emma Sophia ;

Shourya, Shivesh

April 4, 2026 | The Journal of the Association of Nurses in AIDS Care : JANAC, 2026, v. 36, no. 3

Young Black and Latino men who have sex with men are disproportionately affected by the U.S. HIV Epidemic, yet pre-exposure prophylaxis (PrEP) uptake remains low. To understand barriers and facilitators to PrEP uptake and persistence, we used a concurrent mixed methods design (quantitative: online surveys, n = 19; qualitative: individual interviews ...

10/09/2026

Supporting Files

Title : Pre-exposure Prophylaxis Providers in Birmingham, Alabama, and New York City, New York, Identify Critical Barriers to Newer Pre-exposure Prophylaxis Strategies: a Mixed Methods Study. Personal Author(s) : Kay, Emma Sophia;Shourya, Shivesh;Brin, Maeve;Batey, D. Scott;Radix, Asa;Belkind, Uri;Tanner, Mary;Galindo, Carla;Ferrara, Stephen;Ott, Corilyn;Schnall, Rebecca; Published Date : April 4, 2026 Pages in Document : 284-296 (21 pdf pages) Source : The Journal of the Association of Nurses in AIDS Care : JANAC, 2026, v. 36, no. 3 DOI : https://doi.org/10.1097/JNC.0000000000000532 Journal Title : The Journal of the Association of Nurses in AIDS Care : JANAC
Kay, E. S., Shourya, S., Brin, M., Batey, D. S., Radix, A., Belkind, U., Tanner, M., Galindo, C., Ferrara, S., Ott, C., & Schnall, R. (2026). Pre-exposure Prophylaxis Providers in Birmingham, Alabama, and New York City, New York, Identify Critical Barriers to Newer Pre-exposure Prophylaxis Strategies: a Mixed Methods Study. The Journal of the Association of Nurses in AIDS Care : JANAC, 36(3). https://doi.org/10.1097/JNC.0000000000000532

Kay, Emma Sophia, Shivesh Shourya, Maeve Brin, D. Scott Batey, Asa Radix, Uri Belkind, and Mary Tanner, et al.. "Pre-exposure Prophylaxis Providers in Birmingham, Alabama, and New York City, New York, Identify Critical Barriers to Newer Pre-exposure Prophylaxis Strategies: a Mixed Methods Study." The Journal of the Association of Nurses in AIDS Care : JANAC 36, no. 3 (2026). https://doi.org/10.1097/JNC.0000000000000532.

Kay, Emma Sophia, et al. "Pre-exposure Prophylaxis Providers in Birmingham, Alabama, and New York City, New York, Identify Critical Barriers to Newer Pre-exposure Prophylaxis Strategies: a Mixed Methods Study." The Journal of the Association of Nurses in AIDS Care : JANAC, vol. 36, no. 3, 2026. Stacks. https://doi.org/10.1097/JNC.0000000000000532.
Export RIS Citation Information. TY - Journal Article AU - Kay, Emma Sophia AU - Shourya, Shivesh AU - Brin, Maeve AU - Batey, D. Scott AU - Radix, Asa AU - Belkind, Uri AU - Tanner, Mary AU - Galindo, Carla AU - Ferrara, Stephen AU - Ott, Corilyn AU - Schnall, Rebecca AB - Young Black and Latino men who have sex with men are disproportionately affected by the U.S. HIV Epidemic, yet pre-exposure prophylaxis (PrEP) uptake remains low. To understand barriers and facilitators to PrEP uptake and persistence, we used a concurrent mixed methods design (quantitative: online surveys, n = 19; qualitative: individual interviews, n = 15) from providers (e.g., nurse practitioners, clinicians, and social workers) at 4 clinics providing PrEP services in Birmingham, Alabama and New York City. Although all providers were comfortable prescribing daily oral PrEP, they had concerns about on-demand PrEP (e.g., complex dosing schedule) and injectable PrEP (e.g., insurance barriers). Provider training is needed to address barriers to providing PrEP modalities beyond daily oral PrEP and increase uptake among young Black and Latino men who have sex with men. Additionally, in order to increase uptake of injectable PrEP, rising PrEP costs due to changes in the 340B Drug Pricing Program will need to be addressed. AB - Author manuscript AN - cdc:261459 C4 - PMC12037144 DO - https://doi.org/10.1097/JNC.0000000000000532 IS - 3 J2 - The Journal of the Association of Nurses in AIDS Care : JANAC KW - Attitude of Health Personnel KW - Female KW - Hispanic or Latino KW - Anti-HIV Agents KW - Qualitative Research KW - Health Personnel KW - Interviews as Topic KW - Young Adult KW - Homosexuality, Male KW - Pre-Exposure Prophylaxis KW - Surveys and Questionnaires KW - Male KW - Humans KW - Middle Aged KW - Black or African American KW - Adult KW - HIV Infections KW - barriers to PrEP KW - HIV pre-exposure prophylaxis (PrEP) KW - men who have sex with men KW - mixed methods KW - PrEP new formulations KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Young Adult KW - Anti-HIV Agents KW - Attitude of Health Personnel KW - Black or African American KW - Health Personnel KW - Hispanic or Latino KW - HIV Infections KW - Homosexuality, Male KW - Interviews as Topic KW - Pre-Exposure Prophylaxis KW - Qualitative Research KW - Surveys and Questionnaires LA - eng PY - 2026 T2 - The Journal of the Association of Nurses in AIDS Care : JANAC T2 - The Journal of the Association of Nurses in AIDS Care : JANAC, 2026, v. 36, no. 3 TI - Pre-exposure Prophylaxis Providers in Birmingham, Alabama, and New York City, New York, Identify Critical Barriers to Newer Pre-exposure Prophylaxis Strategies: a Mixed Methods Study. VL - 36 UR - https://stacks.cdc.gov/view/cdc/261459 ER -
Multiwalled Carbon Nanotubes Activate the NLRP3 Inflammasome-dependent Pyroptosis in Macrophages.

Lim, Chol Seung ;

Gu, Ja Kook

May 2025 | Molecular Pharmacology, 2025, v. 107, no. 5

Macrophages are major innate immune cells for the clearance of inhaled nanoparticles but may undergo cell death upon phagocytosis of certain nanoparticles due to their resistance to lysosomal degradation and high toxicity to the cell. Here we investigated the pyroptotic effect of exposure to fibrogenic multiwalled carbon nanotubes (MWCNTs) on macro ...

10/09/2026

Supporting Files

Title : Multiwalled Carbon Nanotubes Activate the NLRP3 Inflammasome-dependent Pyroptosis in Macrophages. Personal Author(s) : Lim, Chol Seung;Gu, Ja Kook;Ma, Qiang; Published Date : May 2025 Pages in Document : 100031 (23 pdf pages) Source : Molecular Pharmacology, 2025, v. 107, no. 5 DOI : https://doi.org/10.1016/j.molpha.2025.100031 Journal Title : Molecular Pharmacology
Lim, C. S., Gu, J. K., & Ma, Q. (2025). Multiwalled Carbon Nanotubes Activate the NLRP3 Inflammasome-dependent Pyroptosis in Macrophages. Molecular Pharmacology, 107(5). https://doi.org/10.1016/j.molpha.2025.100031

Lim, Chol Seung, Ja Kook Gu, and Qiang Ma. "Multiwalled Carbon Nanotubes Activate the NLRP3 Inflammasome-dependent Pyroptosis in Macrophages." Molecular Pharmacology 107, no. 5 (2025). https://doi.org/10.1016/j.molpha.2025.100031.

Lim, Chol Seung, et al. "Multiwalled Carbon Nanotubes Activate the NLRP3 Inflammasome-dependent Pyroptosis in Macrophages." Molecular Pharmacology, vol. 107, no. 5, 2025. Stacks. https://doi.org/10.1016/j.molpha.2025.100031.
Export RIS Citation Information. TY - Journal Article AU - Lim, Chol Seung AU - Gu, Ja Kook AU - Ma, Qiang AB - Macrophages are major innate immune cells for the clearance of inhaled nanoparticles but may undergo cell death upon phagocytosis of certain nanoparticles due to their resistance to lysosomal degradation and high toxicity to the cell. Here we investigated the pyroptotic effect of exposure to fibrogenic multiwalled carbon nanotubes (MWCNTs) on macrophages, an inflammatory form of cell death. We first evaluated MWCNT-induced cell death in M1 and M2 macrophages that mediate the temporal inflammatory response to MWCNTs in mammalian lungs. Macrophages were differentiated from human monocytic THP-1 cells, followed by polarization to M1 or M2 cells. MWCNTs caused concentration- and time-dependent cytotoxicity in M1 and, to a lesser extent, M2 cells. Carbon black, an amorphous carbonous material control for CNTs, did not cause apparent toxicity in the cells. MWCNTs increased the production and secretion of IL-1β, accompanied by activation of caspase-1, in M1, but not M2, cells. Moreover, MWCNTs induced the formation of apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain specks and the release of cathepsin B in M1 cells, revealing activation of the nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome via lysosomal damage. MWCNTs induced the cleavage of gasdermin D (GSDMD) to form the 31 kDa N-terminal fragment (GSDMD-N), the pore-forming peptide causing pyroptotic cell death. Increased IL-1β release was completely suppressed by AC-YVAD-CMK (a caspase-1 inhibitor), MCC-950 (an NLRP3 inflammasome inhibitor), or CA-074 Me (a cathepsin B inhibitor), alongside the blockage of MWCNT-induced cleavage of GSDMD. The study demonstrates that MWCNTs trigger pyroptosis in M1 macrophages and boost sterile inflammation by activating the NLRP3 inflammasome pathway. SIGNIFICANCE STATEMENT: The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing 3 inflammasome mediates the inflammatory response to fibrogenic nanoparticles in the lung via multiple means. The current study uncovers the induction of pyroptotic death of macrophages as a major means of nanotoxicity and sterile inflammation via the nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing 3 pathway by nanoparticles. AB - Author manuscript AN - cdc:261458 C4 - PMC12305632 DO - https://doi.org/10.1016/j.molpha.2025.100031 IS - 5 J2 - Molecular Pharmacology KW - Inflammasomes KW - Caspase 1 KW - Nanotubes, Carbon KW - Macrophages KW - Humans KW - THP-1 Cells KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - Interleukin-1beta KW - Pyroptosis KW - IL-1 KW - β KW - Inflammation KW - M1 macrophage KW - MWCNT KW - NLRP3 KW - Pyroptosis KW - Nanotubes, Carbon KW - Humans KW - Pyroptosis KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - Inflammasomes KW - Macrophages KW - THP-1 Cells KW - Interleukin-1beta KW - Caspase 1 LA - eng PY - 2025 T2 - Molecular Pharmacology T2 - Molecular Pharmacology, 2025, v. 107, no. 5 TI - Multiwalled Carbon Nanotubes Activate the NLRP3 Inflammasome-dependent Pyroptosis in Macrophages. VL - 107 UR - https://stacks.cdc.gov/view/cdc/261458 ER -
TB BASICS: a Framework to Improve Infection Prevention and Control Practices.

O'Connor, Stephanie ;

Ali, Hammad

April 2025 | The European Respiratory Journal, 2025, v. 65, no. 4

TB BASICS is a framework for improving infection prevention and control policies and practices at the health facility level. Implementation of this framework now spans over a decade, with countries around the world sharing valuable lessons. https://bit.ly/41VGEB8

10/09/2026

Supporting Files

Title : TB BASICS: a Framework to Improve Infection Prevention and Control Practices. Personal Author(s) : O'Connor, Stephanie;Ali, Hammad; Published Date : April 2025 Pages in Document : 2500382(4 pdf pages) Source : The European Respiratory Journal, 2025, v. 65, no. 4 DOI : https://doi.org/10.1183/13993003.00382-2025 Journal Title : The European Respiratory Journal
O'Connor, S., & Ali, H. (2025). TB BASICS: a Framework to Improve Infection Prevention and Control Practices. The European Respiratory Journal, 65(4). https://doi.org/10.1183/13993003.00382-2025

O'Connor, Stephanie and Hammad Ali. "TB BASICS: a Framework to Improve Infection Prevention and Control Practices." The European Respiratory Journal 65, no. 4 (2025). https://doi.org/10.1183/13993003.00382-2025.

O'Connor, Stephanie, and Hammad Ali "TB BASICS: a Framework to Improve Infection Prevention and Control Practices." The European Respiratory Journal, vol. 65, no. 4, 2025. Stacks. https://doi.org/10.1183/13993003.00382-2025.
Export RIS Citation Information. TY - Journal Article AU - O'Connor, Stephanie AU - Ali, Hammad AB - TB BASICS is a framework for improving infection prevention and control policies and practices at the health facility level. Implementation of this framework now spans over a decade, with countries around the world sharing valuable lessons. https://bit.ly/41VGEB8 AB - Author manuscript AN - cdc:261457 C4 - PMC12519562 DO - https://doi.org/10.1183/13993003.00382-2025 IS - 4 J2 - The European Respiratory Journal KW - Tuberculosis KW - Tuberculosis LA - eng PY - 2025 T2 - The European Respiratory Journal T2 - The European Respiratory Journal, 2025, v. 65, no. 4 TI - TB BASICS: a Framework to Improve Infection Prevention and Control Practices. VL - 65 UR - https://stacks.cdc.gov/view/cdc/261457 ER -
An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications.

Kutler, Rachel B. ;

Setzen, Sean A.

October 2025 | The Laryngoscope, 2025, v. 135, no. 10

Since the release of ChatGPT-4 in March 2023, large language models (LLMs) application in biomedical manuscript production has been widespread. GPT-modified text detectors, such as GPTzero, lack sensitivity and reliability and do not quantify the amount of AI-generated text. However, recent work has identified certain adjectives more frequently use ...

10/09/2026

Supporting Files

Title : An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications. Personal Author(s) : Kutler, Rachel B.;Setzen, Sean A.;Tsai, Samantha;Rameau, Anaïs; Published Date : October 2025 Pages in Document : 3579-3587 (15 pdf pages) Source : The Laryngoscope, 2025, v. 135, no. 10 DOI : https://doi.org/10.1002/lary.32202 Journal Title : The Laryngoscope
Kutler, R. B., Setzen, S. A., Tsai, S., & Rameau, A. (2025). An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications. The Laryngoscope, 135(10). https://doi.org/10.1002/lary.32202

Kutler, Rachel B., Sean A. Setzen, Samantha Tsai, and Anaïs Rameau. "An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications." The Laryngoscope 135, no. 10 (2025). https://doi.org/10.1002/lary.32202.

Kutler, Rachel B., et al. "An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications." The Laryngoscope, vol. 135, no. 10, 2025. Stacks. https://doi.org/10.1002/lary.32202.
Export RIS Citation Information. TY - Journal Article AU - Kutler, Rachel B. AU - Setzen, Sean A. AU - Tsai, Samantha AU - Rameau, Anaïs AB - Since the release of ChatGPT-4 in March 2023, large language models (LLMs) application in biomedical manuscript production has been widespread. GPT-modified text detectors, such as GPTzero, lack sensitivity and reliability and do not quantify the amount of AI-generated text. However, recent work has identified certain adjectives more frequently used by LLMs that can help identify and quantify LLM-modified text. The aim of this study is to utilize these adjectives to identify LLM-generated text in otolaryngology publications. AB - Meta-research. AB - Twenty-five otolaryngology journals were studied between November 2022 and July 2024, encompassing 8751 published works. Articles from countries where ChatGPT-4 is not available were removed, yielding 7702 articles for study inclusion. These publications were analyzed using a Python script to determine the frequency of the top 100 adjectives disproportionately generated by ChatGPT-4. AB - A significant increase in the frequency of adjectives associated with GPT use was observed from November 2023 to July 2024 across all journals (p < 0.001), with a significant difference before and after the release of ChatGPT in March 2023. Journals with higher impact factors had significantly lower usage of GPT-associated adjectives than those with lower impact factors (p < 0.001). There was no significant difference in GPT-associated adjective use by first authors with a doctoral degree versus those without. Publications by authors from English-speaking countries demonstrated a significantly more frequent use of LLM-associated adjectives (p < 0.001). AB - This study suggests that ChatGPT use in otolaryngology manuscript production has significantly increased since the release of ChatGPT-4. Future research should be aimed at further characterizing the landscape of AI-generated text in otolaryngology and developing tools that encourage authors' transparency regarding the use of LLMs. AB - NA. AB - Author manuscript AN - cdc:261456 C4 - PMC12353330 DO - https://doi.org/10.1002/lary.32202 IS - 10 J2 - The Laryngoscope KW - Periodicals as Topic KW - Language KW - Otolaryngology KW - Humans KW - Natural Language Processing KW - artificial intelligence KW - large language models KW - otolaryngology KW - Otolaryngology KW - Humans KW - Periodicals as Topic KW - Language KW - Natural Language Processing LA - eng PY - 2025 T2 - The Laryngoscope T2 - The Laryngoscope, 2025, v. 135, no. 10 TI - An Evaluation of Current Trends in AI-Generated Text in Otolaryngology Publications. VL - 135 UR - https://stacks.cdc.gov/view/cdc/261456 ER -
Pediatric Self-Harm Injuries and Child Protection Histories.

Rebbe, Rebecca ;

Huang, Jeannie S.

August 2025 | The Journal of Pediatrics, 2025, v. 283

We assessed the child protective services (CPS) histories of children with medical encounters for self-harm (SH) using linked medical and CPS data. Most children with SH had prior CPS reports (61.0%), but few had foster care placements (5.9%). CPS histories may be important to understand, treat, and prevent pediatric SH.

10/09/2026

Supporting Files

Title : Pediatric Self-Harm Injuries and Child Protection Histories. Personal Author(s) : Rebbe, Rebecca;Huang, Jeannie S.;Kuelbs, Cynthia L.;Laub, Natalie;Lanier, Paul;Putnam-Hornstein, Emily; Published Date : August 2025 Pages in Document : 114619 (9 pdf pages) Source : The Journal of Pediatrics, 2025, v. 283 DOI : https://doi.org/10.1016/j.jpeds.2025.114619 Journal Title : The Journal of Pediatrics
Rebbe, R., Huang, J. S., Kuelbs, C. L., Laub, N., Lanier, P., & Putnam-Hornstein, E. (2025). Pediatric Self-Harm Injuries and Child Protection Histories. The Journal of Pediatrics, 283. https://doi.org/10.1016/j.jpeds.2025.114619

Rebbe, Rebecca, Jeannie S. Huang, Cynthia L. Kuelbs, Natalie Laub, Paul Lanier, and Emily Putnam-Hornstein. "Pediatric Self-Harm Injuries and Child Protection Histories." The Journal of Pediatrics 283 (2025). https://doi.org/10.1016/j.jpeds.2025.114619.

Rebbe, Rebecca, et al. "Pediatric Self-Harm Injuries and Child Protection Histories." The Journal of Pediatrics, vol. 283, 2025. Stacks. https://doi.org/10.1016/j.jpeds.2025.114619.
Export RIS Citation Information. TY - Journal Article AU - Rebbe, Rebecca AU - Huang, Jeannie S. AU - Kuelbs, Cynthia L. AU - Laub, Natalie AU - Lanier, Paul AU - Putnam-Hornstein, Emily AB - We assessed the child protective services (CPS) histories of children with medical encounters for self-harm (SH) using linked medical and CPS data. Most children with SH had prior CPS reports (61.0%), but few had foster care placements (5.9%). CPS histories may be important to understand, treat, and prevent pediatric SH. AB - Author manuscript AN - cdc:261455 C4 - PMC12276971 DO - https://doi.org/10.1016/j.jpeds.2025.114619 J2 - The Journal of Pediatrics KW - Self-Injurious Behavior KW - Child KW - Adolescent KW - Female KW - Child Protective Services KW - Foster Home Care KW - Male KW - Humans KW - Child, Preschool KW - self-harm KW - child protection KW - child maltreatment KW - COVID-19 KW - pandemic KW - injury KW - Humans KW - Self-Injurious Behavior KW - Child KW - Male KW - Female KW - Child Protective Services KW - Adolescent KW - Child, Preschool KW - Foster Home Care LA - eng PY - 2025 T2 - The Journal of Pediatrics T2 - The Journal of Pediatrics, 2025, v. 283 TI - Pediatric Self-Harm Injuries and Child Protection Histories. VL - 283 UR - https://stacks.cdc.gov/view/cdc/261455 ER -
Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home?

Tong, Guangyu ;

Sivaraman, Josie Caves

February 2026 | Journal of the American Academy of Child and Adolescent Psychiatry, 2026, v. 65, no. 2

To test whether changes in children's and adolescents' mental health symptoms predict changes in their access to unlocked guns at home.This study used data from a longitudinal cohort study of 1,420 youth and their parents in the southeastern United States. Parents were assessed annually up to 8 times about their child's mental health (ie, conduct, ...

10/09/2026

Supporting Files

Title : Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home? Personal Author(s) : Tong, Guangyu;Sivaraman, Josie Caves;Easter, Michele M.;Duke, Naomi N.;Ranney, Megan L.;Swanson, Jeffrey W.;Copeland, William E.; Published Date : February 2026 Pages in Document : 291-300 (18 pdf pages) Source : Journal of the American Academy of Child and Adolescent Psychiatry, 2026, v. 65, no. 2 DOI : https://doi.org/10.1016/j.jaac.2025.04.011 Journal Title : Journal of the American Academy of Child and Adolescent Psychiatry
Tong, G., Sivaraman, J. C., Easter, M. M., Duke, N. N., Ranney, M. L., Swanson, J. W., & Copeland, W. E. (2026). Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home?. Journal of the American Academy of Child and Adolescent Psychiatry, 65(2). https://doi.org/10.1016/j.jaac.2025.04.011

Tong, Guangyu, Josie Caves Sivaraman, Michele M. Easter, Naomi N. Duke, Megan L. Ranney, Jeffrey W. Swanson, and William E. Copeland. "Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home?." Journal of the American Academy of Child and Adolescent Psychiatry 65, no. 2 (2026). https://doi.org/10.1016/j.jaac.2025.04.011.

Tong, Guangyu, et al. "Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home?." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 65, no. 2, 2026. Stacks. https://doi.org/10.1016/j.jaac.2025.04.011.
Export RIS Citation Information. TY - Journal Article AU - Tong, Guangyu AU - Sivaraman, Josie Caves AU - Easter, Michele M. AU - Duke, Naomi N. AU - Ranney, Megan L. AU - Swanson, Jeffrey W. AU - Copeland, William E. AB - To test whether changes in children's and adolescents' mental health symptoms predict changes in their access to unlocked guns at home. AB - This study used data from a longitudinal cohort study of 1,420 youth and their parents in the southeastern United States. Parents were assessed annually up to 8 times about their child's mental health (ie, conduct, oppositional defiant, depression, and anxiety symptoms) between ages 9 and 16 years (6,674 observations total). Parents were also asked whether there were guns in their home and whether they were locked. Generalized linear mixed-effect models were used to test associations between changes in symptoms and in-home gun access adjusted for sociodemographic variables. Children with or without access to unlocked guns at baseline were differentiated in analyses. AB - In all, 66% of parents reported that their child had access to an unlocked gun at some point between the ages of 9 and 16 years. In homes in which children did not have gun access at baseline, changes in youth mental health symptoms did not increase or decrease the likelihood of the child having access to unlocked guns subsequently. In homes in which children did have guns access at baseline, however, increases in some mental health symptoms (either oppositional defiant (odds ratio = 0.43, 95% CI = 0.35-0.53, p < .001) or depression (OR = 0.74, 95% CI = 0.59-0.92, p < .008)) symptoms were associated with reduced gun access at the next timepoint. These associations were strongest for adolescents. AB - In an area where gun culture is strong, parents reported making safety-conscious adjustments to their children's gun access when their children displayed emotional or behavioral symptoms. AB - Using data from the Great Smoky Mountain Study, this study found that 66% of parents reported that their child had access to an unlocked gun at some point between the ages of 9 and 16 years. However, parents in gun-owning households reduced firearm access when children exhibited increased symptoms of oppositional defiant disorder or depression, especially in adolescence. AB - Author manuscript AN - cdc:261454 C4 - PMC12353267 DO - https://doi.org/10.1016/j.jaac.2025.04.011 IS - 2 J2 - Journal of the American Academy of Child and Adolescent Psychiatry KW - Longitudinal Studies KW - Child KW - Adolescent KW - Female KW - Firearms KW - Male KW - Humans KW - Attention Deficit and Disruptive Behavior Disorders KW - Anxiety KW - Depression KW - mental health KW - in-home gun access KW - conduct disorder KW - oppositional defiant disorder KW - depression KW - Humans KW - Adolescent KW - Child KW - Male KW - Female KW - Firearms KW - Longitudinal Studies KW - Depression KW - Anxiety KW - Attention Deficit and Disruptive Behavior Disorders LA - eng PY - 2026 T2 - Journal of the American Academy of Child and Adolescent Psychiatry T2 - Journal of the American Academy of Child and Adolescent Psychiatry, 2026, v. 65, no. 2 TI - Do Children's Mental Health Symptoms Impact Their Access to Unlocked Guns at Home? VL - 65 UR - https://stacks.cdc.gov/view/cdc/261454 ER -
Early Immune System Changes in Amyotrophic Lateral Sclerosis Correlate With Later Disease Progression.

Murdock, Benjamin J. ;

Zhao, Bangyao

August 2025 | Med (New York, N.Y.), 2025, v. 6, no. 8

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with no cure and limited treatment options. The immune system is implicated in disease pathology, unlocking a potential therapeutic avenue. However, it is unclear whether immune changes are a cause or consequence of disease progression.Peripheral immune cells were longitudinally me ...

10/09/2026

Supporting Files

Title : Early Immune System Changes in Amyotrophic Lateral Sclerosis Correlate With Later Disease Progression. Personal Author(s) : Murdock, Benjamin J.;Zhao, Bangyao;Webber-Davis, Ian F.;Teener, Samuel J.;Pawlowski, Kristen D.;Famie, Joshua P.;Piecuch, Caroline E.;Jang, Dae Gyu;Feldman, Eva L.;Zhao, Lili;Goutman, Stephen A.; Published Date : August 2025 Pages in Document : 100673 (28 pdf pages) Source : Med (New York, N.Y.), 2025, v. 6, no. 8 DOI : https://doi.org/10.1016/j.medj.2025.100673 Journal Title : Med (New York, N.Y.)
Murdock, B. J., Zhao, B., Webber-Davis, I. F., Teener, S. J., Pawlowski, K. D., Famie, J. P., Piecuch, C. E., Jang, D. G., Feldman, E. L., Zhao, L., & Goutman, S. A. (2025). Early Immune System Changes in Amyotrophic Lateral Sclerosis Correlate With Later Disease Progression. Med (New York, N.Y.), 6(8). https://doi.org/10.1016/j.medj.2025.100673

Murdock, Benjamin J., Bangyao Zhao, Ian F. Webber-Davis, Samuel J. Teener, Kristen D. Pawlowski, Joshua P. Famie, and Caroline E. Piecuch, et al.. "Early Immune System Changes in Amyotrophic Lateral Sclerosis Correlate With Later Disease Progression." Med (New York, N.Y.) 6, no. 8 (2025). https://doi.org/10.1016/j.medj.2025.100673.

Murdock, Benjamin J., et al. "Early Immune System Changes in Amyotrophic Lateral Sclerosis Correlate With Later Disease Progression." Med (New York, N.Y.), vol. 6, no. 8, 2025. Stacks. https://doi.org/10.1016/j.medj.2025.100673.
Export RIS Citation Information. TY - Journal Article AU - Murdock, Benjamin J. AU - Zhao, Bangyao AU - Webber-Davis, Ian F. AU - Teener, Samuel J. AU - Pawlowski, Kristen D. AU - Famie, Joshua P. AU - Piecuch, Caroline E. AU - Jang, Dae Gyu AU - Feldman, Eva L. AU - Zhao, Lili AU - Goutman, Stephen A. AB - Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with no cure and limited treatment options. The immune system is implicated in disease pathology, unlocking a potential therapeutic avenue. However, it is unclear whether immune changes are a cause or consequence of disease progression. AB - Peripheral immune cells were longitudinally measured at monthly intervals in 55 ALS and 50 control participants. 22 peripheral immune markers in the blood were assessed using flow cytometry, and clinical progression was assessed using the revised ALS functional rating scale (ALSFRS-R). Individual immune markers, their trajectories, and overall variability were compared in ALS versus control participants; ALS participants were also stratified by clinical progression rates and assessed similarly across progression groups. Finally, a novel, lagged linear regression model correlated the rate of immune changes to subsequent downstream ALSFRS-R changes. AB - Numerous immune markers were dysregulated in ALS versus control participants, with altered levels, trajectories, or variability in immune populations and surface markers. ALS participants had increased immune variability relative to control participants; within ALS participants, faster progressors overall had decreased marker variability. Finally, natural killer (NK) cell numbers, NK cell subpopulations, and NK cell surface markers were significantly associated with downstream ALS progression. AB - The immune system is dysregulated in ALS and more consistently dysregulated in faster ALS progression, and immune dysregulation occurs upstream of clinical changes. These findings suggest that the immune system is a causal factor of ALS progression in human patients. AB - CReATe Consortium, NIH, Target ALS, DoD, ALSA. AB - Author manuscript AN - cdc:261453 C4 - PMC12335928 DO - https://doi.org/10.1016/j.medj.2025.100673 IS - 8 J2 - Med (New York, N.Y.) KW - Biomarkers KW - Longitudinal Studies KW - Female KW - Immunity, Cellular KW - Case-Control Studies KW - Male KW - Aged KW - Middle Aged KW - Humans KW - Amyotrophic Lateral Sclerosis KW - Disease Progression KW - Flow Cytometry KW - Immune system KW - amyotrophic lateral sclerosis KW - ALS KW - NK cells KW - neuroinflammation KW - Amyotrophic Lateral Sclerosis KW - Disease Progression KW - Case-Control Studies KW - Biomarkers KW - Flow Cytometry KW - Longitudinal Studies KW - Immunity, Cellular KW - Humans KW - Male KW - Female KW - Middle Aged KW - Aged LA - eng PY - 2025 T2 - Med (New York, N.Y.) T2 - Med (New York, N.Y.), 2025, v. 6, no. 8 TI - Early Immune System Changes in Amyotrophic Lateral Sclerosis Correlate With Later Disease Progression. VL - 6 UR - https://stacks.cdc.gov/view/cdc/261453 ER -
Safety and Efficacy of Single-dose Primaquine to Interrupt Plasmodium Falciparum Malaria Transmission in Children Compared With Adults: a Systematic Review and Individual Patient Data Meta-analysis.

Yilma, Daniel ;

Stepniewska, Kasia

September 2025 | The Lancet. Infectious Diseases, 2025, v. 25, no. 9

Adding a single dose of primaquine to artemisinin-based combination therapy (ACT) for the treatment of falciparum malaria can reduce the transmission of Plasmodium falciparum and could limit the spread of artemisinin partial resistance, including in Africa, where the disease burden is greatest. We aimed to compare the safety and efficacy of single- ...

10/09/2026

Supporting Files

Title : Safety and Efficacy of Single-dose Primaquine to Interrupt Plasmodium Falciparum Malaria Transmission in Children Compared With Adults: a Systematic Review and Individual Patient Data Meta-analysis. Personal Author(s) : Yilma, Daniel;Stepniewska, Kasia;Bousema, Teun;Drakeley, Chris;Eachempati, Prashanti;Guerin, Philippe J;Mårtensson, Andreas;Mwaiswelo, Richard;Taylor, Walter R;Barnes, Karen I; Published Date : September 2025 Pages in Document : 965-976 (24 pdf pages) Source : The Lancet. Infectious Diseases, 2025, v. 25, no. 9 DOI : https://doi.org/10.1016/S1473-3099(25)00078-7 Journal Title : The Lancet. Infectious Diseases
Yilma, D., Stepniewska, K., Bousema, T., Drakeley, C., Eachempati, P., Guerin, P. J., Mårtensson, A., Mwaiswelo, R., Taylor, W. R., & Barnes, K. I. (2025). Safety and Efficacy of Single-dose Primaquine to Interrupt Plasmodium Falciparum Malaria Transmission in Children Compared With Adults: a Systematic Review and Individual Patient Data Meta-analysis. The Lancet. Infectious Diseases, 25(9). https://doi.org/10.1016/S1473-3099(25)00078-7

Yilma, Daniel, Kasia Stepniewska, Teun Bousema, Chris Drakeley, Prashanti Eachempati, Philippe J Guerin, Andreas Mårtensson, Richard Mwaiswelo, Walter R Taylor, and Karen I Barnes. "Safety and Efficacy of Single-dose Primaquine to Interrupt Plasmodium Falciparum Malaria Transmission in Children Compared With Adults: a Systematic Review and Individual Patient Data Meta-analysis." The Lancet. Infectious Diseases 25, no. 9 (2025). https://doi.org/10.1016/S1473-3099(25)00078-7.

Yilma, Daniel, et al. "Safety and Efficacy of Single-dose Primaquine to Interrupt Plasmodium Falciparum Malaria Transmission in Children Compared With Adults: a Systematic Review and Individual Patient Data Meta-analysis." The Lancet. Infectious Diseases, vol. 25, no. 9, 2025. Stacks. https://doi.org/10.1016/S1473-3099(25)00078-7.
Export RIS Citation Information. TY - Journal Article AU - Yilma, Daniel AU - Stepniewska, Kasia AU - Bousema, Teun AU - Drakeley, Chris AU - Eachempati, Prashanti AU - Guerin, Philippe J AU - Mårtensson, Andreas AU - Mwaiswelo, Richard AU - Taylor, Walter R AU - Barnes, Karen I AB - Adding a single dose of primaquine to artemisinin-based combination therapy (ACT) for the treatment of falciparum malaria can reduce the transmission of Plasmodium falciparum and could limit the spread of artemisinin partial resistance, including in Africa, where the disease burden is greatest. We aimed to compare the safety and efficacy of single-dose primaquine plus ACT between young children (aged <5 years) and older children (aged 5 years to <15 years) and adults (aged ≥15 years), and between low and moderate-to-high transmission areas. AB - For this systematic review and individual patient data meta-analysis, we searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, WHO Global Index Medicus, OpenGrey.eu, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform, from database inception to April 3, 2024, with no language restrictions. We included prospective studies on efficacy against falciparum malaria that enrolled at least one child younger than 15 years and involved a study group given a single dose of primaquine (≤0·75 mg/kg) plus ACT. Studies involving mass drug administration, healthy volunteers, or patients with severe malaria or mixed (with non-falciparum) infections were excluded. For inclusion in the efficacy analysis, data on transmission potential (as determined by gametocytaemia, infectivity, or both) at enrolment and follow-up (day 3, day 7, or day 14) were required; the safety analysis required data on haemoglobin concentrations or haematocrit values at enrolment and at one or more follow-up visits by day 7, any data on adverse events, or both. After independent screening of the search results by two reviewers, the investigators of eligible studies were invited to contribute individual patient data. We quantified day 7 gametocyte carriage, probability of infecting a mosquito, decreases (>25%) in haemoglobin concentration associated with anaemia, and adverse events until day 28 using regression analyses, with random study-site intercepts to account for clustered data. These analyses were registered with PROSPERO, CRD42021279363 (safety) and CRD42021279369 (efficacy). AB - Of 5697 records identified by the search, 30 studies were eligible for analysis. Of these, individual patient data were shared for 23 studies, including 6056 patients from 16 countries: 1171 (19·3%) young children (aged <5 years), 2827 (46·7%) older children (aged 5 years to <15 years), and 2058 (34·0%) adults (aged ≥15 years). Adding a single low dose of primaquine (0·2-0·25 mg/kg) to ACTs reduced day 7 gametocyte positivity (adjusted odds ratio [aOR] 0·34, 95% CI 0·22-0·52; p<0·001) and infectivity to mosquitoes over time (aOR per day 0·02, 0·01-0·07, p<0·001). No difference was found in the effect of single low-dose primaquine both on gametocyte positivity in young children compared with older children (1·08, 0·52-2·23; p=0·84) and adults (0·50, 0·20-1·25; p=0·14) and between low-transmission and moderate-to-high transmission settings (1·07, 0·46-2·52; p=0·86), and on infectivity to mosquitoes in young children compared with older children (1·36, 0·07-27·71; p=0·84) and adults (0·31, 0·01-8·84; p=0·50) and between low-transmission and moderate-to-high transmission settings (0·18, 0·01-2·95; p=0·23). Gametocyte clearance was also similar for different ACTs (dihydroartemisinin-piperaquine vs artemether-lumefantrine) when combined with a primaquine target dose of 0·25 mg/kg (1·56, 0·65-3·79; p=0·32 at day 7). However, patients given a primaquine dose of less than 0·2 mg/kg with dihydroartemisinin-piperaquine were more likely to have gametocytaemia than those treated with artemether-lumefantrine (5·68, 1·38-23·48; p=0·016 at day 7). There was no increase in anaemia-associated declines in haemoglobin concentration (>25%) at a primaquine dose of 0·25 mg/kg, regardless of age group, transmission setting, and glucose-6-phosphate dehydrogenase status. The risks of adverse events of grade 2 or higher and of serious adverse events were similar between primaquine and no-primaquine groups, including in young children. AB - Regardless of malaria transmission intensity and age group, a single dose of 0·25 mg/kg primaquine is safe and efficacious for reducing P falciparum transmission. These findings underscore the need for primaquine formulations suitable for young children, and also provide supportive evidence to expand the use of single low-dose primaquine in regions with a moderate-to-high transmission rate that are threatened by artemisinin partial resistance. AB - The EU and the Bill & Melinda Gates Foundation. AB - Author manuscript AN - cdc:261452 C4 - PMC12353880 DO - https://doi.org/10.1016/S1473-3099(25)00078-7 IS - 9 J2 - The Lancet. Infectious Diseases KW - Drug Therapy, Combination KW - Adolescent KW - Malaria, Falciparum KW - Treatment Outcome KW - Plasmodium falciparum KW - Africa KW - Artemisinins KW - Child KW - Antimalarials KW - Infant KW - Male KW - Primaquine KW - Humans KW - Child, Preschool KW - Adult KW - Humans KW - Malaria, Falciparum KW - Primaquine KW - Antimalarials KW - Child KW - Child, Preschool KW - Adult KW - Adolescent KW - Plasmodium falciparum KW - Artemisinins KW - Drug Therapy, Combination KW - Treatment Outcome KW - Infant KW - Male KW - Africa LA - eng PY - 2025 T2 - The Lancet. Infectious Diseases T2 - The Lancet. Infectious Diseases, 2025, v. 25, no. 9 TI - Safety and Efficacy of Single-dose Primaquine to Interrupt Plasmodium Falciparum Malaria Transmission in Children Compared With Adults: a Systematic Review and Individual Patient Data Meta-analysis. VL - 25 UR - https://stacks.cdc.gov/view/cdc/261452 ER -
Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005-2014.

Gu, Ja K. ;

Charles, Luenda E.

June 2025 | American Journal of Industrial Medicine, 2025, v. 68, no. 6

Per- and polyfluoroalkyl substances (PFAS) are associated with multiple health effects including pregnancy-induced hypertension and pre-eclampsia, increased serum hepatic enzymes, increased in serum lipids, decreased antibody response to vaccines, and decreased birth weight. Millions of US workers are exposed to PFAS at their workplaces. Our object ...

10/09/2026

Supporting Files

Title : Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005-2014. Personal Author(s) : Gu, Ja K.;Charles, Luenda E.;Lim, Chol Seung;Mnatsakanova, Anna;Anderson, Stacey;Dzubak, Lisa;McCanlies, Erin; Published Date : June 2025 Pages in Document : 531-542 (17 pdf pages) Source : American Journal of Industrial Medicine, 2025, v. 68, no. 6 DOI : https://doi.org/10.1002/ajim.23726 Journal Title : American Journal of Industrial Medicine
Gu, J. K., Charles, L. E., Lim, C. S., Mnatsakanova, A., Anderson, S., Dzubak, L., & McCanlies, E. (2025). Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005-2014. American Journal of Industrial Medicine, 68(6). https://doi.org/10.1002/ajim.23726

Gu, Ja K., Luenda E. Charles, Chol Seung Lim, Anna Mnatsakanova, Stacey Anderson, Lisa Dzubak, and Erin McCanlies. "Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005-2014." American Journal of Industrial Medicine 68, no. 6 (2025). https://doi.org/10.1002/ajim.23726.

Gu, Ja K., et al. "Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005-2014." American Journal of Industrial Medicine, vol. 68, no. 6, 2025. Stacks. https://doi.org/10.1002/ajim.23726.
Export RIS Citation Information. TY - Journal Article AU - Gu, Ja K. AU - Charles, Luenda E. AU - Lim, Chol Seung AU - Mnatsakanova, Anna AU - Anderson, Stacey AU - Dzubak, Lisa AU - McCanlies, Erin AB - Per- and polyfluoroalkyl substances (PFAS) are associated with multiple health effects including pregnancy-induced hypertension and pre-eclampsia, increased serum hepatic enzymes, increased in serum lipids, decreased antibody response to vaccines, and decreased birth weight. Millions of US workers are exposed to PFAS at their workplaces. Our objective was to estimate the serum levels of the five PFAS that are most frequently detected in the US general population(perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDA), and perfluorononanoic acid (PFNA)) among US adult workers. AB - Participants were 4476 workers aged ≥ 20 years with PFAS analyte results available who participated in the National Health and Nutrition Examination Survey (NHANES), 2005-2014. Geometric mean serum levels of PFAS (ng/mL) were obtained across industry and occupation groups using the PFAS subsample weight in SAS-callable SUDAAN V11. AB - Among 21 industry groups, the highest geometric mean PFAS levels (ng/mL) were observed in Construction (PFOS = 12.61 ng/mL, PFOA = 3.76, PFHxS = 2.10, PFNA = 1.23, and PFDA = 0.33), followed by Utilities (PFOS = 12.46), and Real Estate/Rental/Leasing (PFOS = 12.15). The lowest geometric mean PFAS levels were seen in Private Households (PFOS = 6.34, PFOA = 2.12, PFHxS=0.75, PFNA = 0.86, and PFDA = 0.25). Among 22 occupation groups, the highest geometric mean PFAS levels were observed in Life/Physical/Social Science occupations (PFOS = 13.19, PFOA = 3.54, PFHxS= 1.69, PFNA = 1.23, and PFDA = 0.33), followed by Installation/Maintenance/Repair occupations (PFOS = 12.75), and Construction/Extraction occupations (PFOS = 12.15). The lowest geometric mean PFAS levels were found in Personal Care/Service occupations (PFOS = 7.25, PFOA = 2.43, PFHxS = 1.07, PFNA = 0.94, and PFDA = 0.25). AB - Some industry and occupation groups had higher geometric mean levels of PFAS in serum compared to others. Further investigation of these industries and occupations may result in a better understanding of the sources and degree of occupational exposure to PFAS. AB - Author manuscript AN - cdc:261451 C4 - PMC12333454 DO - https://doi.org/10.1002/ajim.23726 IS - 6 J2 - American Journal of Industrial Medicine KW - Occupational Exposure KW - Female KW - Nutrition Surveys KW - Sulfonic Acids KW - Young Adult KW - Fluorocarbons KW - Alkanesulfonic Acids KW - Decanoic Acids KW - Male KW - Industry KW - Occupations KW - Middle Aged KW - Humans KW - Caprylates KW - Adult KW - Fatty Acids KW - Industry KW - NHANES KW - occupation KW - PFAS KW - US workers KW - Humans KW - Fluorocarbons KW - Adult KW - Occupational Exposure KW - Female KW - Nutrition Surveys KW - Male KW - Caprylates KW - Alkanesulfonic Acids KW - Middle Aged KW - Industry KW - Occupations KW - Decanoic Acids KW - Young Adult KW - Sulfonic Acids KW - Fatty Acids LA - eng PY - 2025 T2 - American Journal of Industrial Medicine T2 - American Journal of Industrial Medicine, 2025, v. 68, no. 6 TI - Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005-2014. VL - 68 UR - https://stacks.cdc.gov/view/cdc/261451 ER -
Nipple-Sparing Mastectomy and Infection Risk After Immediate Breast Reconstruction.

Olsen, Margaret A ;

Nickel, Katelin B

August 2025 | Journal of the American College of Surgeons, 2025, v. 241, no. 2

Wound complications are known to occur after nipple-sparing mastectomy (NSM), especially in procedures involving a periareolar incision. We sought to determine the independent risk of infection and overall wound complications associated with NSM vs skin-sparing mastectomy (SSM) in a contemporary cohort of women undergoing immediate implant reconstr ...

10/09/2026

Supporting Files

Title : Nipple-Sparing Mastectomy and Infection Risk After Immediate Breast Reconstruction. Personal Author(s) : Olsen, Margaret A;Nickel, Katelin B;Margenthaler, Julie A;Myckatyn, Terence M;Warren, David K; Published Date : August 2025 Pages in Document : 254-260 (12 pdf pages) Source : Journal of the American College of Surgeons, 2025, v. 241, no. 2 DOI : https://doi.org/10.1097/XCS.0000000000001424 Journal Title : Journal of the American College of Surgeons
Olsen, M. A., Nickel, K. B., Margenthaler, J. A., Myckatyn, T. M., & Warren, D. K. (2025). Nipple-Sparing Mastectomy and Infection Risk After Immediate Breast Reconstruction. Journal of the American College of Surgeons, 241(2). https://doi.org/10.1097/XCS.0000000000001424

Olsen, Margaret A, Katelin B Nickel, Julie A Margenthaler, Terence M Myckatyn, and David K Warren. "Nipple-Sparing Mastectomy and Infection Risk After Immediate Breast Reconstruction." Journal of the American College of Surgeons 241, no. 2 (2025). https://doi.org/10.1097/XCS.0000000000001424.

Olsen, Margaret A, et al. "Nipple-Sparing Mastectomy and Infection Risk After Immediate Breast Reconstruction." Journal of the American College of Surgeons, vol. 241, no. 2, 2025. Stacks. https://doi.org/10.1097/XCS.0000000000001424.
Export RIS Citation Information. TY - Journal Article AU - Olsen, Margaret A AU - Nickel, Katelin B AU - Margenthaler, Julie A AU - Myckatyn, Terence M AU - Warren, David K AB - Wound complications are known to occur after nipple-sparing mastectomy (NSM), especially in procedures involving a periareolar incision. We sought to determine the independent risk of infection and overall wound complications associated with NSM vs skin-sparing mastectomy (SSM) in a contemporary cohort of women undergoing immediate implant reconstruction. AB - We identified 352 women 21 years of age or older undergoing mastectomy and immediate implant reconstruction from September 2021 to December 2022 using electronic health records from 2 hospitals. The relative risk (RR) of surgical site infection (SSI) and of serious wound complication (infection or noninfectious wound complication [NIWC; dehiscence or tissue necrosis] requiring surgical treatment in the operating room) within 180 days after surgery associated with NSM vs SSM was determined using a modified Poisson regression model, controlling for established risk factors for SSI. AB - NSM was performed in 128 women (36.4%), most commonly via an inframammary fold incision (73.4%). SSI occurred in 49 (13.9%) women within 180 days after surgery, whereas 70 (19.9%) women developed an SSI or NIWC. Although the incidence of SSI and the composite SSI/NIWC outcomes was similar after NSM vs SSM (14.8% vs 13.4% and 21.1% vs 19.2%, respectively); in multivariable analysis, NSM was associated with increased risk of both SSI (RR 2.13, 95% CI 1.26 to 3.59) and SSI/NIWC (RR 2.19, 95% CI 1.40 to 3.43). AB - NSM was associated with increased risk of both SSI and NIWCs requiring surgical treatment after controlling for other established risk factors, despite uncommon use in this cohort of a periaerolar incision. This information should be communicated to women at the time of presurgical counseling to facilitate shared decision-making. AB - Author manuscript AN - cdc:261450 C4 - PMC12393666 DO - https://doi.org/10.1097/XCS.0000000000001424 IS - 2 J2 - Journal of the American College of Surgeons KW - Female KW - Mammaplasty KW - Nipples KW - Aged KW - Young Adult KW - Breast Neoplasms KW - Surgical Wound Infection KW - Retrospective Studies KW - Risk Factors KW - Mastectomy, Subcutaneous KW - Humans KW - Middle Aged KW - Adult KW - Adult KW - Aged KW - Female KW - Humans KW - Middle Aged KW - Breast Neoplasms KW - Mammaplasty KW - Mastectomy, Subcutaneous KW - Nipples KW - Retrospective Studies KW - Risk Factors KW - Surgical Wound Infection KW - Young Adult LA - eng PY - 2025 T2 - Journal of the American College of Surgeons T2 - Journal of the American College of Surgeons, 2025, v. 241, no. 2 TI - Nipple-Sparing Mastectomy and Infection Risk After Immediate Breast Reconstruction. VL - 241 UR - https://stacks.cdc.gov/view/cdc/261450 ER -
Exome Sequencing to Identify Novel Susceptibility Genes For Nonsyndromic Split-Hand/Ft Malformation: a Report From the National Birth Defects Prevention Study.

Carter, Tonia C. ;

Kay, Denise M.

May 2025 | Birth Defects Research, 2025, v. 117, no. 5

Split-hand/foot malformation (SHFM) is a rare, genetically heterogeneous, congenital limb defect. Some but not all associated genes are known; therefore, the aim was to identify genes underlying SHFM.Buccal cell-derived DNA from 26 children with SHFM and their parents who participated in the National Birth Defects Prevention Study was exome sequenc ...

10/09/2026

Supporting Files

Title : Exome Sequencing to Identify Novel Susceptibility Genes For Nonsyndromic Split-Hand/Ft Malformation: a Report From the National Birth Defects Prevention Study. Personal Author(s) : Carter, Tonia C.;Kay, Denise M.;Pangilinan, Faith;Almli, Lynn M.;Jenkins, Mary M.;Blue, Elizabeth E.;Sok, Pagna;White, Janson J.;Cunniff, Christopher M.;Agopian, A. J.;Bamshad, Michael J.;Botto, Lorenzo D.;Brody, Lawrence C.;Gucsavas-Calikoglu, Muge;Chong, Jessica X.;Gomez-Acevedo, Horacio;Lupo, Philip J.;Moore, Cynthia A.;Nembhard, Wendy N.;Olney, Richard S.;Olshan, Andrew F.;Orloff, Mohammed S.;Reefhuis, Jennita;Romitti, Paul A.;Shaw, Gary M.;Werler, Martha M.;Yazdy, Mahsa M.;Browne, Marilyn L.;Howley, Meredith M.; Corporate Authors(s) : University of Washington Center for Mendelian Genomics, NISC Comparative Sequencing Program, the National Birth Defects Prevention Study Published Date : May 2025 Pages in Document : e2472 (25 pdf pages) Source : Birth Defects Research, 2025, v. 117, no. 5 DOI : https://doi.org/10.1002/bdr2.2472 Journal Title : Birth Defects Research
Carter, T. C., Kay, D. M., Pangilinan, F., Almli, L. M., Jenkins, M. M., Blue, E. E., Sok, P., White, J. J., Cunniff, C. M., Agopian, A. J., Bamshad, M. J., Botto, L. D., Brody, L. C., Gucsavas-Calikoglu, M., Chong, J. X., Gomez-Acevedo, H., Lupo, P. J., Moore, C. A., Nembhard, W. N., ... Howley, M. M. (2025). Exome Sequencing to Identify Novel Susceptibility Genes For Nonsyndromic Split-Hand/Ft Malformation: a Report From the National Birth Defects Prevention Study. Birth Defects Research, 117(5). https://doi.org/10.1002/bdr2.2472

Carter, Tonia C., Denise M. Kay, Faith Pangilinan, Lynn M. Almli, Mary M. Jenkins, Elizabeth E. Blue, and Pagna Sok, et al.. "Exome Sequencing to Identify Novel Susceptibility Genes For Nonsyndromic Split-Hand/Ft Malformation: a Report From the National Birth Defects Prevention Study." Birth Defects Research 117, no. 5 (2025). https://doi.org/10.1002/bdr2.2472.

Carter, Tonia C., et al. "Exome Sequencing to Identify Novel Susceptibility Genes For Nonsyndromic Split-Hand/Ft Malformation: a Report From the National Birth Defects Prevention Study." Birth Defects Research, vol. 117, no. 5, 2025. Stacks. https://doi.org/10.1002/bdr2.2472.
Export RIS Citation Information. TY - Journal Article AU - Carter, Tonia C. AU - Kay, Denise M. AU - Pangilinan, Faith AU - Almli, Lynn M. AU - Jenkins, Mary M. AU - Blue, Elizabeth E. AU - Sok, Pagna AU - White, Janson J. AU - Cunniff, Christopher M. AU - Agopian, A. J. AU - Bamshad, Michael J. AU - Botto, Lorenzo D. AU - Brody, Lawrence C. AU - Gucsavas-Calikoglu, Muge AU - Chong, Jessica X. AU - Gomez-Acevedo, Horacio AU - Lupo, Philip J. AU - Moore, Cynthia A. AU - Nembhard, Wendy N. AU - Olney, Richard S. AU - Olshan, Andrew F. AU - Orloff, Mohammed S. AU - Reefhuis, Jennita AU - Romitti, Paul A. AU - Shaw, Gary M. AU - Werler, Martha M. AU - Yazdy, Mahsa M. AU - Browne, Marilyn L. AU - Howley, Meredith M. A2 - University of Washington Center for Mendelian Genomics, NISC Comparative Sequencing Program, the National Birth Defects Prevention Study AB - Split-hand/foot malformation (SHFM) is a rare, genetically heterogeneous, congenital limb defect. Some but not all associated genes are known; therefore, the aim was to identify genes underlying SHFM. AB - Buccal cell-derived DNA from 26 children with SHFM and their parents who participated in the National Birth Defects Prevention Study was exome sequenced. Family-based trio analyzes prioritized rare coding variants by inheritance patterns, predicted pathogenicity, and location within putative limb development genes. Copy-number variants in SHFM candidate genomic regions were also examined. Case-control analyzes compared coding variants between case children and 1191 controls (parents of children with non-limb birth defects). Variant validation was by Sanger sequencing or droplet digital polymerase chain reaction. AB - In family-based analyzes, the prioritized and validated variants (each in a single family) included likely damaging variants that were heterozygous and de novo in speckle type BTB/POZ protein (SPOP) and ubiquitin-like modifier activating enzyme 2 (UBA2), X-linked recessive in fibroblast growth factor 13 (FGF13) and RNA binding motif protein 10 (RBM10), and compound heterozygous in interleukin enhancer binding factor 3 (ILF3). Validation assays did not confirm predicted de novo copy-number gains at chromosomes 10q24 and 19p13.11. Case-control analyzes did not identify statistically significant associations. AB - Exome analysis nominated new susceptibility genes (FGF13, ILF3, RBM10, SPOP) and detected a variant in a known candidate gene (UBA2). Follow-up investigation is needed to ascertain damaging variants in these genes in additional cases with SHFM and evaluate the impact of the variants on gene expression, protein function, and limb development. AB - Author manuscript AN - cdc:261449 C4 - PMC12818101 DO - https://doi.org/10.1002/bdr2.2472 IS - 5 J2 - Birth Defects Research KW - Exome Sequencing KW - Female KW - Case-Control Studies KW - Genetic Predisposition to Disease KW - DNA Copy Number Variations KW - Male KW - Humans KW - Exome KW - Limb Deformities, Congenital KW - birth defects KW - congenital limb malformation KW - ectrodactyly KW - exome sequencing KW - NBDPS KW - split foot KW - split hand KW - Humans KW - Exome Sequencing KW - Female KW - Male KW - Genetic Predisposition to Disease KW - Case-Control Studies KW - Limb Deformities, Congenital KW - DNA Copy Number Variations KW - Exome LA - eng PY - 2025 T2 - Birth Defects Research T2 - Birth Defects Research, 2025, v. 117, no. 5 TI - Exome Sequencing to Identify Novel Susceptibility Genes For Nonsyndromic Split-Hand/Ft Malformation: a Report From the National Birth Defects Prevention Study. VL - 117 UR - https://stacks.cdc.gov/view/cdc/261449 ER -
The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption.

Gapstur, Susan M. ;

Mariosa, Daniela

May 1, 2025 | The New England Journal of Medicine, 2025, v. 392, no. 17

The International Agency for Research on Cancer IARC has classified alcoholic beverages as carcinogenic to humans Group 1 based on sufficient evidence of causality for seven types of cancer oral cavity pharynx larynx esophagus liver colorectum female breast 1 Globally an estimated 741 300 4 1 new cancer cases in 2020 were attributable to alcohol co ...

10/09/2026

Supporting Files

Title : The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption. Personal Author(s) : Gapstur, Susan M.;Mariosa, Daniela;Neamtiu, Luciana;Nethan, Suzanne T.;Rehm, Jürgen;Huckle, Taisia;Jernigan, David H.;O'Connor, Elizabeth A.;Štelemėkas, Mindaugas;Allebeck, Peter;Assanangkornchai, Sawitri;Carah, Nicholas;Chaiyasong, Surasak;Cukier, Samantha;Dao, The Son;John, Rijo M.;Matzopoulos, Richard;Meier, Petra S.;O'Brien, Paula;Paraje, Guillermo;Room, Robin;Wilkinson, Claire;Maldonado, Norman D.;Stockwell, Tim;Neufeld, Maria;Rekve, Dag;Lauby-Secretan, Béatrice; Published Date : May 1, 2025 Pages in Document : 1752-1759 (13 pdf pages) Source : The New England Journal of Medicine, 2025, v. 392, no. 17 DOI : https://doi.org/10.1056/NEJMsr2413289 Journal Title : The New England Journal of Medicine
Gapstur, S. M., Mariosa, D., Neamtiu, L., Nethan, S. T., Rehm, J., Huckle, T., Jernigan, D. H., O'Connor, E. A., Štelemėkas, M., Allebeck, P., Assanangkornchai, S., Carah, N., Chaiyasong, S., Cukier, S., Dao, T. S., John, R. M., Matzopoulos, R., Meier, P. S., O'Brien, P., ... Lauby-Secretan, B. (2025). The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption. The New England Journal of Medicine, 392(17). https://doi.org/10.1056/NEJMsr2413289

Gapstur, Susan M., Daniela Mariosa, Luciana Neamtiu, Suzanne T. Nethan, Jürgen Rehm, Taisia Huckle, and David H. Jernigan, et al.. "The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption." The New England Journal of Medicine 392, no. 17 (2025). https://doi.org/10.1056/NEJMsr2413289.

Gapstur, Susan M., et al. "The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption." The New England Journal of Medicine, vol. 392, no. 17, 2025. Stacks. https://doi.org/10.1056/NEJMsr2413289.
Export RIS Citation Information. TY - Journal Article AU - Gapstur, Susan M. AU - Mariosa, Daniela AU - Neamtiu, Luciana AU - Nethan, Suzanne T. AU - Rehm, Jürgen AU - Huckle, Taisia AU - Jernigan, David H. AU - O'Connor, Elizabeth A. AU - Štelemėkas, Mindaugas AU - Allebeck, Peter AU - Assanangkornchai, Sawitri AU - Carah, Nicholas AU - Chaiyasong, Surasak AU - Cukier, Samantha AU - Dao, The Son AU - John, Rijo M. AU - Matzopoulos, Richard AU - Meier, Petra S. AU - O'Brien, Paula AU - Paraje, Guillermo AU - Room, Robin AU - Wilkinson, Claire AU - Maldonado, Norman D. AU - Stockwell, Tim AU - Neufeld, Maria AU - Rekve, Dag AU - Lauby-Secretan, Béatrice AB - The International Agency for Research on Cancer IARC has classified alcoholic beverages as carcinogenic to humans Group 1 based on sufficient evidence of causality for seven types of cancer oral cavity pharynx larynx esophagus liver colorectum female breast 1 Globally an estimated 741 300 4 1 new cancer cases in 2020 were attributable to alcohol consumption 2 In addition to cancer alcohol consumption is a risk factor for numerous other health conditions. AB - Author manuscript AN - cdc:261448 C4 - PMC12331238 DO - https://doi.org/10.1056/NEJMsr2413289 IS - 17 J2 - The New England Journal of Medicine KW - Mouth KW - Female KW - Alcohol Drinking KW - Risk Factors KW - Esophagus KW - Neoplasms KW - Larynx KW - Alcoholic Beverages KW - Liver KW - Humans KW - Pharynx KW - International Agencies KW - Female KW - Humans KW - Pharynx KW - Neoplasms KW - International Agencies KW - Alcohol Drinking KW - Alcoholic Beverages KW - Mouth KW - Risk Factors KW - Esophagus KW - Larynx KW - Liver LA - eng PY - 2025 T2 - The New England Journal of Medicine T2 - The New England Journal of Medicine, 2025, v. 392, no. 17 TI - The IARC Perspective on the Effects of Policies on Reducing Alcohol Consumption. VL - 392 UR - https://stacks.cdc.gov/view/cdc/261448 ER -
A Longitudinal Assessment of Hearing Loss in the World Trade Center General Responder Cohort.

Sloan, Nancy L. ;

Dasaro, Christopher R.

September 2025 | Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 9

In analyses without adjustment for World Trade Center (WTC) noise exposure, people with WTC and neighborhood exposures from the September 11, 2001, attacks have experienced slightly elevated risks of hearing loss. We investigated incident hearing loss in the WTC General Responder Cohort by their levels of WTC exposure, their WTC noise exposure and ...

10/09/2026

Supporting Files

Title : A Longitudinal Assessment of Hearing Loss in the World Trade Center General Responder Cohort. Personal Author(s) : Sloan, Nancy L.;Dasaro, Christopher R.;Shapiro, Moshe Z.;Sacks, Henry S.;Udasin, Iris G.;Moline, Jacqueline M.;Luft, Benjamin J.;Harrison, Denise J.;Crane, Michael A.;Todd, Andrew C.;Teitelbaum, Susan L.; Published Date : September 2025 Pages in Document : 747-756 (30 pdf pages) Source : Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 9 DOI : https://doi.org/10.1097/JOM.0000000000003428 Journal Title : Journal of Occupational and Environmental Medicine
Sloan, N. L., Dasaro, C. R., Shapiro, M. Z., Sacks, H. S., Udasin, I. G., Moline, J. M., Luft, B. J., Harrison, D. J., Crane, M. A., Todd, A. C., & Teitelbaum, S. L. (2025). A Longitudinal Assessment of Hearing Loss in the World Trade Center General Responder Cohort. Journal of Occupational and Environmental Medicine, 67(9). https://doi.org/10.1097/JOM.0000000000003428

Sloan, Nancy L., Christopher R. Dasaro, Moshe Z. Shapiro, Henry S. Sacks, Iris G. Udasin, Jacqueline M. Moline, and Benjamin J. Luft, et al.. "A Longitudinal Assessment of Hearing Loss in the World Trade Center General Responder Cohort." Journal of Occupational and Environmental Medicine 67, no. 9 (2025). https://doi.org/10.1097/JOM.0000000000003428.

Sloan, Nancy L., et al. "A Longitudinal Assessment of Hearing Loss in the World Trade Center General Responder Cohort." Journal of Occupational and Environmental Medicine, vol. 67, no. 9, 2025. Stacks. https://doi.org/10.1097/JOM.0000000000003428.
Export RIS Citation Information. TY - Journal Article AU - Sloan, Nancy L. AU - Dasaro, Christopher R. AU - Shapiro, Moshe Z. AU - Sacks, Henry S. AU - Udasin, Iris G. AU - Moline, Jacqueline M. AU - Luft, Benjamin J. AU - Harrison, Denise J. AU - Crane, Michael A. AU - Todd, Andrew C. AU - Teitelbaum, Susan L. AB - In analyses without adjustment for World Trade Center (WTC) noise exposure, people with WTC and neighborhood exposures from the September 11, 2001, attacks have experienced slightly elevated risks of hearing loss. We investigated incident hearing loss in the WTC General Responder Cohort by their levels of WTC exposure, their WTC noise exposure and previous occupation. AB - Adjusted multivariable log binomial regression models assessed persistent (≥10 months) hearing loss associated with WTC exposures using 22 years of the monitoring visit data ( n = 45,537). AB - Compared with the lowest exposure level without WTC noise exposure, WTC noise exposure increased hearing loss risk (adjusted relative risk range: 1.19 [95% confidence interval 1.08, 1.30] to 1.58 [1.43, 1.76]). AB - The results clarify the importance of WTC noise when evaluating the associations of WTC exposures on hearing loss. AB - Author manuscript AN - cdc:261447 C4 - PMC12757932 DO - https://doi.org/10.1097/JOM.0000000000003428 IS - 9 J2 - Journal of Occupational and Environmental Medicine KW - Occupational Exposure KW - Longitudinal Studies KW - Female KW - Emergency Responders KW - Hearing Loss, Noise-Induced KW - Aged KW - Occupational Diseases KW - Hearing Loss KW - Male KW - Middle Aged KW - Humans KW - September 11 Terrorist Attacks KW - Adult KW - hearing loss KW - tinnitus KW - ear pain KW - World Trade Center KW - general responder cohort KW - Humans KW - September 11 Terrorist Attacks KW - Male KW - Female KW - Adult KW - Middle Aged KW - Longitudinal Studies KW - Hearing Loss, Noise-Induced KW - Occupational Exposure KW - Emergency Responders KW - Hearing Loss KW - Occupational Diseases KW - Aged LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Medicine T2 - Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 9 TI - A Longitudinal Assessment of Hearing Loss in the World Trade Center General Responder Cohort. VL - 67 UR - https://stacks.cdc.gov/view/cdc/261447 ER -
Erosion of Traditional Employment: Impact on Health and Economic Well-being.

Yelin, Edward ;

LaFrance, Alicia

September 2025 | Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 9

The aim of the study was to describe growth of alternative and contingent employment and the impacts of these changes in State of California.We administered surveys to random samples of population of the State in 1999-2000 and 2022-2023 to compare the frequency of kinds of work, working conditions, economic well-being, and health status in the two ...

10/09/2026

Supporting Files

Title : Erosion of Traditional Employment: Impact on Health and Economic Well-being. Personal Author(s) : Yelin, Edward;LaFrance, Alicia;Iley, Trisha; Published Date : September 2025 Pages in Document : 691-698 (22 pdf pages) Source : Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 9 DOI : https://doi.org/10.1097/JOM.0000000000003423 Journal Title : Journal of Occupational and Environmental Medicine
Yelin, E., LaFrance, A., & Iley, T. (2025). Erosion of Traditional Employment: Impact on Health and Economic Well-being. Journal of Occupational and Environmental Medicine, 67(9). https://doi.org/10.1097/JOM.0000000000003423

Yelin, Edward, Alicia LaFrance, and Trisha Iley. "Erosion of Traditional Employment: Impact on Health and Economic Well-being." Journal of Occupational and Environmental Medicine 67, no. 9 (2025). https://doi.org/10.1097/JOM.0000000000003423.

Yelin, Edward, et al. "Erosion of Traditional Employment: Impact on Health and Economic Well-being." Journal of Occupational and Environmental Medicine, vol. 67, no. 9, 2025. Stacks. https://doi.org/10.1097/JOM.0000000000003423.
Export RIS Citation Information. TY - Journal Article AU - Yelin, Edward AU - LaFrance, Alicia AU - Iley, Trisha AB - The aim of the study was to describe growth of alternative and contingent employment and the impacts of these changes in State of California. AB - We administered surveys to random samples of population of the State in 1999-2000 and 2022-2023 to compare the frequency of kinds of work, working conditions, economic well-being, and health status in the two dyads of years. AB - Between 1999-2000 and 2022-2023, decreasing fractions of the population of the State work full-time/full-year; report regular shifts, jobs with long tenures, and upward mobility in their careers, while increasing fractions report fair or poor health and financial strain. AB - Employment changes are associated with a worsening in the health status and economic well-being of the population of the State. Longitudinal follow-up of the same individuals would be necessary to establish a causal connection among these phenomena. AB - Author manuscript AN - cdc:261446 C4 - PMC12354229 DO - https://doi.org/10.1097/JOM.0000000000003423 IS - 9 J2 - Journal of Occupational and Environmental Medicine KW - Surveys and Questionnaires KW - Female KW - Health Status KW - Male KW - Middle Aged KW - Humans KW - Employment KW - Adult KW - Labor market dynamics KW - California KW - impact on health and economic well-being of working age population KW - Humans KW - Employment KW - Male KW - Health Status KW - Female KW - Adult KW - Middle Aged KW - Surveys and Questionnaires LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Medicine T2 - Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 9 TI - Erosion of Traditional Employment: Impact on Health and Economic Well-being. VL - 67 UR - https://stacks.cdc.gov/view/cdc/261446 ER -
Dissemination of Heat Safety Practices Among Florida Farmworker Crews.

Martin, Miranda Carver ;

Forst, Linda

August 2025 | Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 8

The aim of the study was to evaluate the effectiveness of heat-related illness (HRI) safety training tailored for farmworker harvesting crews.We surveyed 52 farmworkers in three crews on heat safety knowledge, self-reported behaviors, and heat illness symptoms. Each provided a pre and post shift urine sample for analysis of specific gravity. One cr ...

10/09/2026

Supporting Files

Title : Dissemination of Heat Safety Practices Among Florida Farmworker Crews. Personal Author(s) : Martin, Miranda Carver;Forst, Linda;Siciliano, Michael;Xiuhtecutli, Nezahualcoyotl;Monaghan, Paul; Published Date : August 2025 Pages in Document : e518-e524 (20 pdf pages) Source : Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 8 DOI : https://doi.org/10.1097/JOM.0000000000003421 Journal Title : Journal of Occupational and Environmental Medicine
Martin, M. C., Forst, L., Siciliano, M., Xiuhtecutli, N., & Monaghan, P. (2025). Dissemination of Heat Safety Practices Among Florida Farmworker Crews. Journal of Occupational and Environmental Medicine, 67(8). https://doi.org/10.1097/JOM.0000000000003421

Martin, Miranda Carver, Linda Forst, Michael Siciliano, Nezahualcoyotl Xiuhtecutli, and Paul Monaghan. "Dissemination of Heat Safety Practices Among Florida Farmworker Crews." Journal of Occupational and Environmental Medicine 67, no. 8 (2025). https://doi.org/10.1097/JOM.0000000000003421.

Martin, Miranda Carver, et al. "Dissemination of Heat Safety Practices Among Florida Farmworker Crews." Journal of Occupational and Environmental Medicine, vol. 67, no. 8, 2025. Stacks. https://doi.org/10.1097/JOM.0000000000003421.
Export RIS Citation Information. TY - Journal Article AU - Martin, Miranda Carver AU - Forst, Linda AU - Siciliano, Michael AU - Xiuhtecutli, Nezahualcoyotl AU - Monaghan, Paul AB - The aim of the study was to evaluate the effectiveness of heat-related illness (HRI) safety training tailored for farmworker harvesting crews. AB - We surveyed 52 farmworkers in three crews on heat safety knowledge, self-reported behaviors, and heat illness symptoms. Each provided a pre and post shift urine sample for analysis of specific gravity. One crew received an HRI training program and a "buddy system" to remind co-workers to rest and hydrate. AB - The intervention crewmembers exchanged more heat safety reminders during the day and reported more rest and hydration. Social network analysis shows how coworkers disseminated heat safety messages. There was no difference in urine specific gravity among intervention or control crews. AB - Social networks within harvesting crews can be leveraged to disseminate heat safety messages. Dehydration measures indicate training is not sufficient to protect workers from symptoms of HRI. AB - Author manuscript AN - cdc:261445 C4 - PMC12857881 DO - https://doi.org/10.1097/JOM.0000000000003421 IS - 8 J2 - Journal of Occupational and Environmental Medicine KW - Occupational Exposure KW - Female KW - Health Knowledge, Attitudes, Practice KW - Farmers KW - Heat Stress Disorders KW - Occupational Health KW - Dehydration KW - Hot Temperature KW - Agriculture KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Agricultural Workers' Diseases KW - Farmworker safety KW - heat illness prevention KW - social network analysis KW - Humans KW - Heat Stress Disorders KW - Male KW - Adult KW - Female KW - Farmers KW - Hot Temperature KW - Middle Aged KW - Occupational Health KW - Health Knowledge, Attitudes, Practice KW - Occupational Exposure KW - Dehydration KW - Agricultural Workers' Diseases KW - Agriculture LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Medicine T2 - Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 8 TI - Dissemination of Heat Safety Practices Among Florida Farmworker Crews. VL - 67 UR - https://stacks.cdc.gov/view/cdc/261445 ER -
Michigan Screening and Intervention For Glaucoma and Eye Health Through Telemedicine Program: Impact on Vision, Follow-up, and Costs.

Newman-Casey, Paula Anne ;

Niziol, Leslie M.

September 2025 | Ophthalmology, 2025, v. 132, no. 9

To evaluate the impact of the Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) program on visual acuity (VA), vision-related quality of life (VRQOL), satisfaction, follow-up visit attendance, and costs among medically underserved participants receiving primary care at community health centers.Prospecti ...

10/09/2026

Supporting Files

Title : Michigan Screening and Intervention For Glaucoma and Eye Health Through Telemedicine Program: Impact on Vision, Follow-up, and Costs. Personal Author(s) : Newman-Casey, Paula Anne;Niziol, Leslie M.;Elam, Angela R.;Bicket, Amanda K.;Ramachandran, Rithambara;Johnson, Leroy;Kershaw, Martha;Winters, Suzanne;Woodward, Maria A.; Published Date : September 2025 Pages in Document : 1033-1044 (21 pdf pages) Source : Ophthalmology, 2025, v. 132, no. 9 DOI : https://doi.org/10.1016/j.ophtha.2025.04.027 Journal Title : Ophthalmology
Newman-Casey, P. A., Niziol, L. M., Elam, A. R., Bicket, A. K., Ramachandran, R., Johnson, L., Kershaw, M., Winters, S., & Woodward, M. A. (2025). Michigan Screening and Intervention For Glaucoma and Eye Health Through Telemedicine Program: Impact on Vision, Follow-up, and Costs. Ophthalmology, 132(9). https://doi.org/10.1016/j.ophtha.2025.04.027

Newman-Casey, Paula Anne, Leslie M. Niziol, Angela R. Elam, Amanda K. Bicket, Rithambara Ramachandran, Leroy Johnson, Martha Kershaw, Suzanne Winters, and Maria A. Woodward. "Michigan Screening and Intervention For Glaucoma and Eye Health Through Telemedicine Program: Impact on Vision, Follow-up, and Costs." Ophthalmology 132, no. 9 (2025). https://doi.org/10.1016/j.ophtha.2025.04.027.

Newman-Casey, Paula Anne, et al. "Michigan Screening and Intervention For Glaucoma and Eye Health Through Telemedicine Program: Impact on Vision, Follow-up, and Costs." Ophthalmology, vol. 132, no. 9, 2025. Stacks. https://doi.org/10.1016/j.ophtha.2025.04.027.
Export RIS Citation Information. TY - Journal Article AU - Newman-Casey, Paula Anne AU - Niziol, Leslie M. AU - Elam, Angela R. AU - Bicket, Amanda K. AU - Ramachandran, Rithambara AU - Johnson, Leroy AU - Kershaw, Martha AU - Winters, Suzanne AU - Woodward, Maria A. AB - To evaluate the impact of the Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) program on visual acuity (VA), vision-related quality of life (VRQOL), satisfaction, follow-up visit attendance, and costs among medically underserved participants receiving primary care at community health centers. AB - Prospective cohort study with an embedded randomized controlled trial. AB - Adults ≥ age 18. AB - The MI-SIGHT participants underwent an eye disease screening examination with a trained ophthalmic technician, received assistance ordering low-cost glasses, and completed surveys. Participants could return for repeat screening after 1 year. The prevalence of disease identified was compared with national rates using z tests. Visual acuity and VRQOL were compared between initial and repeat visits with paired t tests and Wilcoxon signed-rank tests. Satisfaction was summarized with descriptive statistics. Attendance at recommended follow-up was assessed overall and compared by arm (chi squared tests) for those screening positive for glaucoma who were randomized to care navigation plus personalized education and health coaching (treatment) or care navigation plus written education (control). AB - Eye disease prevalence, change in VA and VRQOL, program satisfaction, follow-up attendance, and costs. AB - Three thousand seven hundred fourteen participants were analyzed; 11.5% were visually impaired, 9.3% had uncorrected or undercorrected refractive error causing visual impairment, 22.4% had glaucoma or suspected glaucoma, 4.7% had diabetic retinopathy (all rates higher than national averages at P < 0.0001), 99% were satisfied or very satisfied, and 68% attended recommended follow-up. Nine hundred forty-three participants completed repeat screening where worse-eye presenting VA improved (from 0.25 ± 0.59 logarithm of the minimum angle of resolution [logMAR] to 0.21 ± 0.52 logMAR; P = 0.0012), as did VRQOL (9-item National Eye Institute Visual Function Questionnaire composite score of 81.1 ± 14.1 to 86.4 ± 12.0; P < 0.0001). Of the 490 participants who screened positive for glaucoma or suspected glaucoma who were randomized (n = 247 treatment group, n = 243 control group), follow-up attendance did not differ (61% vs. 59%; P = 0.74). The program cost $110.99 per participant served, and $206.72 per case of eye disease detected. AB - Expanding glaucoma and eye disease screening and treatment of refractive error to community health centers with care navigation support could improve vision and eye health outcomes. AB - Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. AB - Author manuscript AN - cdc:261444 C4 - PMC12353381 DO - https://doi.org/10.1016/j.ophtha.2025.04.027 IS - 9 J2 - Ophthalmology KW - Patient Satisfaction KW - Female KW - Vision Screening KW - Visual Acuity KW - Glaucoma KW - Aged KW - Prospective Studies KW - Surveys and Questionnaires KW - Follow-Up Studies KW - Prevalence KW - Quality of Life KW - Male KW - Middle Aged KW - Humans KW - Telemedicine KW - Adult KW - Health Care Costs KW - glaucoma screening KW - eye disease screening KW - vision related quality of life KW - costs KW - attendance at follow up KW - Humans KW - Male KW - Female KW - Telemedicine KW - Prospective Studies KW - Quality of Life KW - Visual Acuity KW - Middle Aged KW - Glaucoma KW - Follow-Up Studies KW - Aged KW - Health Care Costs KW - Patient Satisfaction KW - Adult KW - Vision Screening KW - Surveys and Questionnaires KW - Prevalence LA - eng PY - 2025 T2 - Ophthalmology T2 - Ophthalmology, 2025, v. 132, no. 9 TI - Michigan Screening and Intervention For Glaucoma and Eye Health Through Telemedicine Program: Impact on Vision, Follow-up, and Costs. VL - 132 UR - https://stacks.cdc.gov/view/cdc/261444 ER -
Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Qualitative Study.

Patterson, Sarah L. ;

Ruvalcaba, Denise

August 2025 | The Journal of Rheumatology, 2025, v. 52, no. 8

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic immune-mediated inflammatory diseases often complicated by persistent pain and fatigue, despite cutting-edge pharmacological treatments. Lifestyle medicine (LM) and complementary and integrative health (CIH) offer adjuvant therapies with the potential to alleviate these sy ...

10/09/2026

Supporting Files

Title : Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Qualitative Study. Personal Author(s) : Patterson, Sarah L.;Ruvalcaba, Denise;Issa, Arbella;Rai, Krish;Katz, Patricia;Koenig, Christopher J.; Published Date : August 2025 Pages in Document : 758-769 (20 pdf pages) Source : The Journal of Rheumatology, 2025, v. 52, no. 8 DOI : https://doi.org/10.3899/jrheum.2024-1218 Journal Title : The Journal of Rheumatology
Patterson, S. L., Ruvalcaba, D., Issa, A., Rai, K., Katz, P., & Koenig, C. J. (2025). Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Qualitative Study. The Journal of Rheumatology, 52(8). https://doi.org/10.3899/jrheum.2024-1218

Patterson, Sarah L., Denise Ruvalcaba, Arbella Issa, Krish Rai, Patricia Katz, and Christopher J. Koenig. "Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Qualitative Study." The Journal of Rheumatology 52, no. 8 (2025). https://doi.org/10.3899/jrheum.2024-1218.

Patterson, Sarah L., et al. "Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Qualitative Study." The Journal of Rheumatology, vol. 52, no. 8, 2025. Stacks. https://doi.org/10.3899/jrheum.2024-1218.
Export RIS Citation Information. TY - Journal Article AU - Patterson, Sarah L. AU - Ruvalcaba, Denise AU - Issa, Arbella AU - Rai, Krish AU - Katz, Patricia AU - Koenig, Christopher J. AB - Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic immune-mediated inflammatory diseases often complicated by persistent pain and fatigue, despite cutting-edge pharmacological treatments. Lifestyle medicine (LM) and complementary and integrative health (CIH) offer adjuvant therapies with the potential to alleviate these symptoms, but little is known about patients' experiences with these modalities. AB - This qualitative study explored the use of LM and CIH among English- and Spanish-speaking patients with RA and SLE. We conducted 5 focus groups using an original semistructured interview guide to examine participants' experiences with, and barriers to using, LM and CIH. Group discussions were recorded, transcribed verbatim, translated, and analyzed in a multistep iterative process to identify frequencies and thematic trends. AB - Thirty-nine participants with RA or SLE discussed using LM and CIH modalities to manage their disease in 130 mentions. Diet was the most frequently discussed LM modality, with participants noting specific foods that exacerbated or alleviated symptoms. Traditional Chinese medicine and natural products were the most-discussed CIH approaches, and participants expressed a strong interest in exploring additional CIH modalities to mitigate symptoms. The primary barriers to using LM and CIH were uncertainty regarding safe and effective practices and high out-of-pocket expenses. AB - Patients with RA and SLE are highly interested in using LM and CIH to manage their conditions, but many are unsure which adjunctive treatment approaches are safe and effective. More research on LM and CIH modalities is needed to facilitate clear, evidence-based answers to these common patient questions. AB - Author manuscript AN - cdc:261443 C4 - PMC12317831 DO - https://doi.org/10.3899/jrheum.2024-1218 IS - 8 J2 - The Journal of Rheumatology KW - Focus Groups KW - Integrative Medicine KW - Female KW - Qualitative Research KW - Aged KW - Life Style KW - Complementary Therapies KW - Lupus Erythematosus, Systemic KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Arthritis, Rheumatoid KW - Qualitative Research KW - Rheumatoid Arthritis KW - Systemic Lupus Erythematosus KW - Lifestyle Medicine KW - Complementary KW - Integrative Health KW - Humans KW - Lupus Erythematosus, Systemic KW - Arthritis, Rheumatoid KW - Female KW - Male KW - Complementary Therapies KW - Qualitative Research KW - Middle Aged KW - Adult KW - Focus Groups KW - Integrative Medicine KW - Aged KW - Life Style LA - eng PY - 2025 T2 - The Journal of Rheumatology T2 - The Journal of Rheumatology, 2025, v. 52, no. 8 TI - Experiences With Complementary and Integrative Health Among People With Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Qualitative Study. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261443 ER -

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