Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients.

Details

• Alternative Title:
  International Journal of Cancer, 2025, v. 157, no. 3: Sex Differences in Cancer Mortality Among Solid Organ Transplant Recipients.
• Journal Article:
  International Journal of Cancer
• Personal Author:
  Jackson, Sarah S ; Pfeiffer, Ruth M ; Gardner, Erin ; Hsieh, Mei-Chin ; Insaf, Tabassum ; Lynch, Charles F ; Morawski, Bozena ; Wang, Shuhui ; Yu, Kelly J ; Engels, Eric A
• Description:
  Males have increased mortality after a cancer diagnosis than females, possibly due to poorer immunosurveillance. We tested whether the female survival advantage is lost with immunosuppression by evaluating 17,048 cancer patients (68% male) with a prior solid organ transplant using data from the US Transplant Cancer Match Study and 1,221,914 cancer patients (58% male) from the general population using data from the Surveillance, Epidemiology, and End Results Program. We evaluated 13 solid cancers that occur in both sexes. We compared mortality due to cancer in males and females using a male:female hazard ratio (M:F HR) derived from Cox proportional hazards models adjusted for age, race/ethnicity, diagnosis year, stage, and cancer treatment. Among cancer patients in the general population, males had higher cancer-specific mortality than females for cancers of the lip, stomach, colorectum, anus, liver, lung, skin, brain, and thyroid, with M:F HRs ranging from 1.06 to 1.59. Only colorectal cancer showed an attenuation in the female mortality advantage in transplant recipients (M:F HR
  
  : 0.89; 95% CI: 0.77, 1.03; vs. M:F HR
  
  : 1.07; 95% CI: 1.06, 1.08; P-interaction = 0.007). Among kidney cancer patients, the female mortality advantage was stronger in the transplant population (M:F HR
  
  : 1.33; 95% CI: 1.11, 1.60; M:F HR
  
  : 1.02; 95% CI: 0.99, 1.04; P-interaction = 0.003). Overall, we did not find consistent evidence that the female advantage in cancer mortality is weakened among immunosuppressed transplant recipients, suggesting that non-immune factors contribute to the female advantage among cancer patients in the general population.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Male
  • Neoplasms
  • Organ Transplantation
  • Middle Aged
  • Transplant Recipients
  • SEER Program
  • Aged
  • Adult
  More +
• Keywords:
  • Sex differences
  • cancer
  • mortality
  • immunosurveillance
  • organ transplantation
• Source:
  International Journal of Cancer, 2025, v. 157, no. 3
• DOI:
  https://doi.org/10.1002/ijc.35415
• ISSN:
  0020-7136 ; 1097-0215
• Pubmed ID:
  40347031
• Pubmed Central ID:
  PMC12143962
• Document Type:
  Text
• Funding:
  27307C0011/ES/NIEHS NIH HHSUnited States/ ; HHSN261201000036C/CA/NCI NIH HHSUnited States/ ; HHSN261201800013C/CA/NCI NIH HHSUnited States/ ; N01 PC035137/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; Z99 CA999999/ImNIH/Intramural NIH HHSUnited States/ ; 75N92021D00009/HL/NHLBI NIH HHSUnited States/ ; HHSN261201800012I/CA/NCI NIH HHSUnited States/ ; HHSN261201800002B/CA/NCI NIH HHSUnited States/ ; 75N98021D00006/OD/NIH HHSUnited States/ ; HHSN261201000037C/CA/NCI NIH HHSUnited States/ ; 27305C0011/ES/NIEHS NIH HHSUnited States/ ; 75N96021D00006/ES/NIEHS NIH HHSUnited States/ ; HHSN261201800004C/CA/NCI NIH HHSUnited States/ ; N01 PC035143/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; 75N97021D00006/LM/NLM NIH HHSUnited States/ ; HHSN261201800014C/CA/NCI NIH HHSUnited States/ ; HHSN261201800016C/CA/NCI NIH HHSUnited States/ ; N01 PC035139/CA/NCI NIH HHSUnited States/ ; 75N99021D00009/OF/ORFDO NIH HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; NU58DP007160/DP/NCCDPHP CDC HHSUnited States/ ; 27398C0011/ES/NIEHS NIH HHSUnited States/ ; HHSN261201800016I/CA/NCI NIH HHSUnited States/ ; U58 DP003933/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000848/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800012C/CA/NCI NIH HHSUnited States/ ; 75N90021D00009/CL/CLC NIH HHSUnited States/ ; HHSN261201000035C/PC/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003921/DP/NCCDPHP CDC HHSUnited States/ ; 75N92021D00006/HL/NHLBI NIH HHSUnited States/ ; HHSN261201800014I/CA/NCI NIH HHSUnited States/ ; 75N96021D00009/ES/NIEHS NIH HHSUnited States/ ; HHSN261201800002C/CA/NCI NIH HHSUnited States/ ; HHSN261201800013I/CA/NCI NIH HHSUnited States/ ; HHSN261201800006I/CA/NCI NIH HHSUnited States/ ; U58 DP000824/DP/NCCDPHP CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  427-435 (16 pdf pages)
• Volume:
  157
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/261421/cdc_261421_DS1.pdf
• File Type:
  [PDF - 159.67 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:20fdcb2dcf5acefdbfe5686d01c21173c624b88b17fbeacef4447f4111afde3b8094be74b54d553d92e2886056f3b38c63b57d0eb1babf2872120ac711560837