A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections.

Details

• Alternative Title:
  Journal of Infection and Public Health, 2025, v. 18, no. 7: A Systematic Review and Meta-analysis of the Global Prevalence of Human Enteric Adenovirus Infections.
• Journal Article:
  Journal of Infection and Public Health
• Personal Author:
  Wikswo, Mary E. ; Kambhampati, Anita K. ; Mattison, Claire P. ; Chhabra, Preeti ; Olojo, Oluwatosin ; Rana, Taha ; Vinjé, Jan ; Kirkwood, Carl D. ; Parashar, Umesh D. ; Mirza, Sara A.
• Description:
  Human adenovirus (HAdV), especially HAdV species F (HAdV-F) is recognized as a cause of acute gastroenteritis (AGE) worldwide. To assess the global prevalence of HAdV in case-patients of all ages with AGE, we conducted a systematic literature search for studies published in English during 2015-2022. We generated pooled prevalence estimates using generalized linear mixed models. Using data from 147 included articles, the overall pooled prevalence among AGE case-patients of any species of HAdV (pan-HAdV) was 5.8 % and 6.0 % for HAdV-F. The prevalence of HAdV was significantly higher among case-patients < 5 years of age compared with case-patients ≥ 5 years of age (pan-HAdV: 6.6 % vs. 2.0 %, p < 0.0001; HAdV-F: 8.7 % vs. 2.3 %, p = 0.04). Prevalence was significantly higher in high mortality developing countries and lowest in developed countries (pan-HAdV: 9.4 % vs. 4.0 %, p < 0.0001; HAdV-F: 11.6 % vs. 3.2 %, p = 0.0003). Understanding the burden of HAdV-associated AGE may be useful for targeted interventions, including future vaccine development.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Adenovirus Infections, Human
  • Prevalence
  • Global Health
  • Adenoviruses, Human
  • Gastroenteritis
  • Child, Preschool
  • Child
• Keywords:
  • Adenovirus
  • Gastroenteritis
  • Diarrhea
  • Meta-analysis
  • Literature review
• Source:
  Journal of Infection and Public Health, 2025, v. 18, no. 7
• DOI:
  https://doi.org/10.1016/j.jiph.2025.102800
• ISSN:
  1876-0341 ; 1876-035X
• Pubmed ID:
  40334566
• Pubmed Central ID:
  PMC12160367
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  102800 (17 pdf pages)
• Volume:
  18
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/261429/cdc_261429_DS1.pdf
• File Type:
  [PDF - 642.06 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a1f11609c81366d3bf737ba29f87456600a9074b806d4b8ab3e2315740bd64c516192888a90ec68d64b96537b80443913d3484a79e2cfaf3b8ac5e2d00f4813c