The health and economic burden of respiratory syncytial virus associated hospitalizations in adults

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Prasad, Namrata ; Newbern, E. Claire ; Trenholme, Adrian A. ; Thompson, Mark G. ; McArthur, Colin ; Wong, Conroy A. ; Jelley, Lauren ; Aminisani, Nayyereh ; Huang, Q. Sue ; Grant, Cameron C.
• Description:
  Background
  
  Respiratory syncytial virus (RSV) is increasingly recognized as an important cause of illness in adults; however, data on RSV disease and economic burden in this age group remain limited. We aimed to provide comprehensive estimates of RSV disease burden among adults aged ≥18 years.
  
  Methods
  
  During 2012–2015, population-based, active surveillance of acute respiratory infection (ARI) hospitalizations enabled estimation of the seasonal incidence of RSV hospitalizations and direct health costs in adults aged ≥18 years in Auckland, New Zealand.
  
  Results
  
  Of 4,600 ARI hospitalizations tested for RSV, 348 (7.6%) were RSV positive. The median (interquartile range) length of hospital stay for RSV positive patients was 4 (2–6) days. The seasonal incidence rate (IR) of RSV hospitalizations, corrected for non-testing, was 23.6 (95% confidence intervals [CI] 21.0–26.1) per 100,000 adults aged ≥18 years. Hospitalization risk increased with age with the highest incidence among adults aged ≥80 years (IR 190.8 per 100,000, 95% CI 137.6–244.0). Being of Māori or Pacific ethnicity or living in a neighborhood with low socioeconomic status (SES) were independently associated with increased RSV hospitalization rates. We estimate RSV-associated hospitalizations among adults aged ≥18 years to cost on average NZD $4,758 per event.
  
  Conclusions
  
  RSV infection is associated with considerable disease and economic cost in adults. RSV disproportionally affects adult sub-groups defined by age, ethnicity, and neighborhood SES. An effective RSV vaccine or RSV treatment may offer benefits for older adults.
  
  
• Subjects:
  Adult Cost Of Illness Female Hospitalization Humans Male Respiratory Syncytial Virus Infections Retrospective Studies Seasons
• Source:
  PLoS One. 2020; 15(6)
• Pubmed ID:
  32525898
• Pubmed Central ID:
  PMC7289360
• Document Type:
  Journal Article
• Volume:
  15
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7dc0ea6ef9bfc4713af081fa026cd0affff33e616a5db90d377229f96c70832f
• Download URL:
  https://stacks.cdc.gov/view/cdc/89520/cdc_89520_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]