Epidemiology and Clinical Outcomes of Hospitalizations for Acute Respiratory or Febrile Illness and Laboratory-Confirmed Influenza Among Pregnant Women During Six Influenza Seasons, 2010–2016

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Dawood, Fatimah S. ; Garg, Shikha ; Fink, Rebecca V. ; Russell, Margaret L. ; Regan, Annette K. ; Katz, Mark A. ; Booth, Stephanie ; Chung, Hannah ; Klein, Nicola P. ; Kwong, Jeffrey C. ; Levy, Avram ; Naleway, Allison ; Riesel, Dan ; Thompson, Mark G. ; Wyant, Brandy E. ; Fell, Deshayne B.
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• Description:
  Background. ; Pregnant women are at increased risk of seasonal influenza hospitalizations, but data about the epidemiology of severe influenza among pregnant women remain largely limited to pandemics. ; Methods. ; To describe the epidemiology of hospitalizations for acute respiratory infection or febrile illness (ARFI) and influenza-associated ARFI among pregnant women, administrative and electronic health record data were analyzed from retrospective cohorts of pregnant women hospitalized with ARFI who had testing for influenza viruses by reverse-transcription polymerase chain reaction (RT-PCR) in Australia, Canada, Israel, and the United States during 2010–2016. ; Results. ; Of 18 048 ARFI-coded hospitalizations, 1064 (6%) included RT-PCR testing for influenza viruses, 614 (58%) of which were influenza positive. Of 614 influenza-positive ARFI hospitalizations, 35% were in women with low socioeconomic status, 20% with underlying conditions, and 67% in their third trimesters. The median length of influenza-positive hospitalizations was 2 days (interquartile range, 1–4), 18% (95% confidence interval CI, 15%–21%) resulted in delivery, 10% (95% CI, 8%–12%) included a pneumonia diagnosis, 5% (95% CI, 3%–6%) required intensive care, 2% (95% CI, 1%–3%) included a sepsis diagnosis, and <1% (95% CI, 0%–1%) resulted in respiratory failure. ; Conclusions. ; Our findings characterize seasonal influenza hospitalizations among pregnant women and can inform assessments of the public health and economic impact of seasonal influenza on pregnant women.
• Keywords:
  • hospitalization
  • influenza
  • pregnant
  • Adolescent
  • Adult
  • Cohort Studies
  • Female
  • Fever
  • Global Health
  • Hospitalization
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• Source:
  J Infect Dis. 221(10):1703-1712
• Pubmed ID:
  31875916
• Pubmed Central ID:
  PMC10563870
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  221
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/134134/cdc_134134_DS1.pdf
• File Type:
  [PDF - 543.07 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5d23c4a07247b899295481f572acc0f3a53e8bbf7e67dae29f24d7c2acd8572c