Welcome to CDC stacks | Using epidemiology to regulate food additives: saccharin case-control studies. - 66117 | Public Health Reports
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Using epidemiology to regulate food additives: saccharin case-control studies.
  • Published Date:
    1984 Jul-Aug
  • Source:
    Public Health Rep. 99(4):365-369
  • Language:
    English
Filetype[PDF-1.20 MB]


Details:
  • Pubmed ID:
    6431484
  • Pubmed Central ID:
    PMCnull
  • Description:
    The increasing use of nonnutritive sweeteners and the widely publicized 1969 ban on cyclamate led to additional investigations in rodents of the carcinogenic potential of saccharin. Preliminary results of a long-term feeding study indicated formation of bladder tumors in rodents, and collective experimental evidence has demonstrated that high doses of the synthetic sweetener saccharin can cause bladder cancer in rodents. Based on the results of that and other rodent studies indicating an increased risk of bladder cancer associated with saccharin, the Commissioner of the Food and Drug Administration announced the agency's intention to propose a ban on saccharin. This intention was made known in April 1977 under the Delaney Clause of the Food, Drug, and Cosmetic Act. The clause essentially states that no additive shall be deemed safe if it is found to induce cancer in man or animals, or if it is found, after tests appropriate for the evaluation of the safety of food additives, to induce cancer in man or animals. Also in 1977, a group of epidemiologists began to assess the available epidemiologic information to determine the potential human risk. This report describes the assessment of several human epidemiologic studies available then and the results of more recent epidemiologic studies.

  • Document Type:
  • Main Document Checksum:
  • Supporting Files:
    No Additional Files
You May Also Like: