Risk Assessment for o-Toluidine and Bladder Cancer Incidence
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Risk Assessment for o-Toluidine and Bladder Cancer Incidence

Filetype[PDF-1.20 MB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Am J Ind Med
    • Publisher's site:
      http://dx.doi.org/10.1002/ajim.23265
    • Personal Author:
    • Description:
      Background.

      Elevated bladder cancer incidence has been reported in a cohort of 1,875 workers manufacturing chemicals used in the rubber industry and employed any time during 1946–2006. ortho-Toluidine (OT), an aromatic amine, was the prime suspect agent. Using the available environmental data and process characterization, previous investigators assigned ranks to volatile chemical air concentrations across time in departments and jobs, reflecting probabilities of exposure and use of personal protective equipment for airborne and dermal exposures. Aniline, another aromatic amine, was present at comparable concentrations and is known to be an animal carcinogen but produced lower levels in post-shift urine and of hemoglobin adducts than OT in a group of workers.

      Methods.

      A quantitative risk assessment was performed based on this same population. In this work, cumulative OT exposures were estimated a) based on previously assigned ranks of exposure intensity and reported actual exposures in jobs with the highest assigned rank, and b) directly from the historical environmental sampling for OT. Models of bladder cancer incidence were evaluated taking into account possible healthy worker survivor effects.

      Results.

      Under various assumptions regarding workforce turnover, the excess lifetime risk of bladder cancer from OT exposure at 1 ppb was estimated to be in the range 1–7 per thousand.

      Conclusions.

      The current ACGIH TLV and OSHA standards for OT are 2 ppm and 5 ppm, respectively, one thousand-fold higher than the exposure estimated here for 1–7 per thousand excess lifetime risk.

    • Subject:
    • Source:
      Am J Ind Med. 64(9):758-770
    • Pubmed ID:
      34114240
    • Pubmed Central ID:
      PMC8363590
    • Document Type:
      Journal Article
    • Funding:
      CC999999/ImCDC/Intramural CDC HHSUnited States/
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov