Details:

Alternative Title:
J Infect Dis
Personal Author:
Assiri, Abdullah M. ; Midgley, Claire M. ; Abedi, Glen R. ; Saeed, Abdulaziz Bin ; Almasri, Malak M. ; ... More +
Assiri, Abdullah M. ; Midgley, Claire M. ; Abedi, Glen R. ; Saeed, Abdulaziz Bin ; Almasri, Malak M. ; Lu, Xiaoyan ; Al-Abdely, Hail M. ; Abdalla, Osman ; Mohammed, Mutaz ; Algarni, Homoud S. ; Alhakeem, Raafat F. ; Sakthivel, Senthilkumar K. ; Nooh, Randa ; Alshayab, Zainab ; Alessa, Mohammad ; Srinivasamoorthy, Ganesh ; AlQahtani, Saeed Yahya ; Kheyami, Ali ; HajOmar, Waleed Husein ; Banaser, Talib M. ; Esmaeel, Ahmad ; Hall, Aron J. ; Curns, Aaron T. ; Tamin, Azaibi ; Alsharef, Ali Abraheem ; Erdman, Dean ; Watson, John T. ; Gerber, Susan I. Less -
Description:
Background

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain.

Methods

We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January– 30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing.

Results

During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015.

Discussions

Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.


Subject:
[+]
Adult
Aged
Aged, 80 And Over
Article
Cluster Analysis
Coronavirus Infections
Female
Humans
Male
Middle Aged
Middle East Respiratory Syndrome Coronavirus
Molecular Epidemiology
Phylogeny
Sequence Analysis, DNA
Sequence Homology
Spike Glycoprotein, Coronavirus
Young Adult

Source:
J Infect Dis. 214(5):712-721
Pubmed ID:
27302191
Pubmed Central ID:
PMC5712457
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Saudi Arabia
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:164c86eba9ee5f8d25ba61da4eb945dc159d6b2995553b8ac57636503556489f
File Type:

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