Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Assiri, Abdullah M.; Midgley, Claire M.; Abedi, Glen R.; Saeed, Abdulaziz Bin; Almasri, Malak M.; Lu, Xiaoyan; Al-Abdely, Hail M.; Abdalla, Osman; Mohammed, Mutaz; Algarni, Homoud S.; Alhakeem, Raafat F.; Sakthivel, Senthilkumar K.; Nooh, Randa; Alshayab, Zainab; Alessa, Mohammad; Srinivasamoorthy, Ganesh; AlQahtani, Saeed Yahya; Kheyami, Ali; HajOmar, Waleed Husein; Banaser, Talib M.; Esmaeel, Ahmad; Hall, Aron J.; Curns, Aaron T.; Tamin, Azaibi; Alsharef, Ali Abraheem; Erdman, Dean; Watson, John T.; Gerber, Susan I.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Published Date:

Jun 14 2016

Source:

J Infect Dis. 214(5):712-721.

[PDF-603.66 KB]

Details:

Alternative Title:

J Infect Dis

Personal Author:

Assiri, Abdullah M. ; Midgley, Claire M. ; Abedi, Glen R. ; Saeed, Abdulaziz Bin ; Almasri, Malak M. ; ... More ▼

Description:

Background

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain.

Methods

We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January– 30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing.

Results

During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015.

Discussions

Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.

Subject:

[+]

Pubmed ID:

27302191

Pubmed Central ID:

PMC5712457

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	nihms921223.nxml	text/xml
	nihms921223f1.gif	image/gif
	nihms921223f1.jpg	image/jpeg
	nihms921223f2.gif	image/gif
	nihms921223f2.jpg	image/jpeg
	nihms921223f3.gif	image/gif
	nihms921223f3.jpg	image/jpeg
	nihms921223f4.gif	image/gif
	nihms921223f4.jpg	image/jpeg
	NIHMS921223-supplement-Supp_Fig_1.pptx	application/vnd.openxmlformats-officedocument.presentationml.presentation
	NIHMS921223-supplement-Supp_Fig_1_legend.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS921223-supplement-Supp_Table_1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS921223-supplement-Supp_Table_2.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS921223-supplement-Supp_Table_3.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS921223-supplement-Supp_Table_4.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
	NIHMS921223-supplement-Supp_Table_5.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS921223-supplement-Supp_Table_6.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document

No Related Documents.

You May Also Like:

Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2017–2018

Personal Author:

Hakawi, Ahmed; Rose, Erica Billig; Biggs, Holly M.; Lu, Xiaoyan; Mohammed, Mutaz; Abdalla, Osman; Abedi, Glen R.; Alsharef, Ali A.; Alamri, Aref Ali; Bereagesh, Samar Ahmad; Al Dosari, Kamel M.; Ashehri, Saad Abdullah; Fakhouri, Waad Ghassan; Alzaid, Saleh Zaid; Lindstrom, Stephen; Gerber, Susan I.; Asiri, Abdullah; Jokhdar, Hani; Watson, John T.;

Published Date:

November 17 2019

Source:

Emerg Infect Dis. 25(11):2149-2151

Description:

We characterized exposures and demographics of Middle East respiratory syndrome coronavirus cases reported to the Saudi Arabia Ministry of Health during July 1-October 31, 2017, and June 1-September 16, 2018. Molecular characterization of available s...

File Type:

[PDF - 820.90 KB]
January–February 2016

Personal Author:

Alhakeem, Raafat F.; Midgley, Claire M.; Assiri, Abdullah M.; Alessa, Mohammed; Al Hawaj, Hassan; Saeed, Abdulaziz Bin; Almasri, Malak M.; Lu, Xiaoyan; Abedi, Glen R.; Abdalla, Osman; Mohammed, Mutaz; Algarni, Homoud S.; Al-Abdely, Hail M.; Alsharef, Ali Abraheem; Nooh, Randa; Erdman, Dean D.; Gerber, Susan I.; Watson, John T.;

Published Date:

Nov 15 2016

Source:

Emerg Infect Dis. 22(11):2020-2022.

File Type:

[PDF - 316.83 KB]
Multihospital Outbreak of a Middle East Respiratory Syndrome Coronavirus Deletion Variant, Jordan: A Molecular, Serologic, and Epidemiologic Investigation

Personal Author:

Payne, Daniel C.; Biggs, Holly M.; Al-Abdallat, Mohammad Mousa; Alqasrawi, Sultan; Lu, Xiaoyan; Abedi, Glen R.; Haddadin, Aktham; Iblan, Ibrahim; Alsanouri, Tarek; Al Nsour, Mohannad; Sheikh Ali, Sami; Rha, Brian; Trivedi, Suvang U.; Rasheed, Mohammed Ata Ur; Tamin, Azaibi; Lamers, Mart M.; Haagmans, Bart L.; Erdman, Dean D.; Thornburg, Natalie J.; Gerber, Susan I.;

Published Date:

Apr 28 2018

Source:

Open Forum Infect Dis. 2018; 5(5).

Description:

BackgroundAn outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Jordan in 2015 involved a variant virus that acquired distinctive deletions in the accessory open reading frames. We conducted a molecular and seroepidemiologic inves...

File Type:

[PDF - 265.64 KB]
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015

Personal Author:

Excler, Jean-Louis; Delvecchio, Christopher J.; Wiley, Ryan E.; Williams, Marni; Yoon, In-Kyu; Modjarrad, Kayvon; Boujelal, Mohamed; Moorthy, Vasee S.; Hersi, Ahmad Salah; Kim, Jerome H.;

Corporate Authors:

on behalf of the MERS-CoV Vaccine Working Group

Published Date:

August 2016

Source:

Emerg Infect Dis. 22(8)

Description:

Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and r...

File Type:

[PDF - 823.75 KB]
Antibodies against MERS Coronavirus in Dromedary Camels, United Arab Emirates, 2003 and 2013

Personal Author:

Meyer, Benjamin; Müller, Marcel A.; Corman, Victor M.; Reusken, Chantal B.E.M.; Ritz, Daniel; Godeke, Gert-Jan; Lattwein, Erik; Kallies, Stephan; Siemens, Artem; van Beek, Janko; Drexler, Jan F.; Muth, Doreen; Bosch, Berend-Jan; Wernery, Ulrich; Koopmans, Marion P.G.; Wernery, Renate; Drosten, Christian;

Published Date:

Apr 2014

Source:

Emerg Infect Dis. 20(4):552-559.

Description:

Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We u...

File Type:

[PDF - 492.92 KB]