Details:

Alternative Title:
J Infect Dis
Personal Author:
Assiri, Abdullah M. ; Midgley, Claire M. ; Abedi, Glen R. ; Saeed, Abdulaziz Bin ; Almasri, Malak M. ; ... More +
Assiri, Abdullah M. ; Midgley, Claire M. ; Abedi, Glen R. ; Saeed, Abdulaziz Bin ; Almasri, Malak M. ; Lu, Xiaoyan ; Al-Abdely, Hail M. ; Abdalla, Osman ; Mohammed, Mutaz ; Algarni, Homoud S. ; Alhakeem, Raafat F. ; Sakthivel, Senthilkumar K. ; Nooh, Randa ; Alshayab, Zainab ; Alessa, Mohammad ; Srinivasamoorthy, Ganesh ; AlQahtani, Saeed Yahya ; Kheyami, Ali ; HajOmar, Waleed Husein ; Banaser, Talib M. ; Esmaeel, Ahmad ; Hall, Aron J. ; Curns, Aaron T. ; Tamin, Azaibi ; Alsharef, Ali Abraheem ; Erdman, Dean ; Watson, John T. ; Gerber, Susan I. Less -
Description:
Background

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain.

Methods

We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January– 30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing.

Results

During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015.

Discussions

Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.


Subjects:
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Adult Aged Aged, 80 And Over Article Cluster Analysis Coronavirus Coronavirus Infections Female Humans Male MERS MERS Epidemiology MERS Phylogeny MERS Transmission Middle Aged Middle East Respiratory Syndrome Middle East Respiratory Syndrome Coronavirus Molecular Epidemiology Phylogeny Recombinant Saudi Arabia Sequence Analysis, DNA Sequence Homology Spike Glycoprotein, Coronavirus Young Adult
Source:
J Infect Dis. 214(5):712-721
Pubmed ID:
27302191
Pubmed Central ID:
PMC5712457
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:164c86eba9ee5f8d25ba61da4eb945dc159d6b2995553b8ac57636503556489f
Download URL:
https://stacks.cdc.gov/view/cdc/50467/cdc_50467_DS1.pdf
File Type:

Supporting Files

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  	NIHMS921223-supplement-Supp_Fig_1.pptx	pptx
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