Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

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• Alternative Title:
  Int J Cancer
• Personal Author:
  Præstegaard, Camilla ; Jensen, Allan ; Jensen, Signe M. ; Nielsen, Thor S. S. ; Webb, Penelope M. ; Nagle, Christina M. ; DeFazio, Anna ; Høgdall, Estrid ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Wicklund, Kristine G. ; Goodman, Marc T. ; Modugno, Francesmary ; Moysich, Kirsten ; Ness, Roberta B. ; Edwards, Robert ; Matsuo, Keitaro ; Hosono, Satoyo ; Goode, Ellen L. ; Winham, Stacey J ; Fridley, Brooke L. ; Cramer, Daniel W. ; Terry, Kathryn L. ; Schildkraut, Joellen M. ; Berchuck, Andrew ; Bandera, Elisa V. ; Paddock, Lisa E. ; Massuger, Leon F. ; Wentzensen, Nicolas ; Pharoah, Paul ; Song, Honglin ; Whittemore, Alice ; McGuire, Valerie ; Sieh, Weiva ; Rothstein, Joseph ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Menon, Usha ; Gayther, Simon A. ; Ramus, Susan J. ; Gentry-Maharaj, Alexandra ; Wu, Anna H. ; Pearce, Celeste L. ; Pike, Malcolm ; Lee, Alice W. ; Sutphen, Rebecca ; Chang-Claude, Jenny ; Risch, Harvey A. ; Kjaer, Susanne K.
• Corporate Authors:
  on behalf of the Australian Ovarian Cancer Study Group
• Description:
  Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08-1.28) and former smokers (pHR = 1.10, 95% CI: 1.02-1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01-3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00-1.23; former smoking: pHR = 1.12, 95% CI: 1.04-1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.
• Subjects:
  Adult Aged Aged, 80 And Over Carcinoma, Ovarian Epithelial Case-Control Studies Female Humans Middle Aged Neoplasms, Glandular And Epithelial Nicotiana Ovarian Neoplasms Proportional Hazards Models Risk Factors Smoking Young Adult

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• Keywords:
  Cigarette Smoking Ovarian Cancer Pooled Analysis Survival
• Source:
  Int J Cancer. 140(11):2422-2435
• Pubmed ID:
  28063166
• Pubmed Central ID:
  PMC5489656
• Document Type:
  Journal Article
• Funding:
  10124/CRUK_/Cancer Research UKUnited Kingdom/ ; P30 ES007048/ES/NIEHS NIH HHSUnited States/ ; R01 CA074850/CA/NCI NIH HHSUnited States/ ; K07 CA092044/CA/NCI NIH HHSUnited States/ ; P50 CA105009/CA/NCI NIH HHSUnited States/ ; P30 CA076292/CA/NCI NIH HHSUnited States/ ; P30 CA014089/CA/NCI NIH HHSUnited States/ ; R01 CA188900/CA/NCI NIH HHSUnited States/ ; R01 CA076016/CA/NCI NIH HHSUnited States/ ; K07 CA143047/CA/NCI NIH HHSUnited States/ ; C490/A10119/CRUK_/Cancer Research UKUnited Kingdom/ ; P01 CA017054/CA/NCI NIH HHSUnited States/ ; P30 CA016359/CA/NCI NIH HHSUnited States/ ; K07 CA095666/CA/NCI NIH HHSUnited States/ ; U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; U01 CA069417/CA/NCI NIH HHSUnited States/ ; N01 CN025403/CN/NCI NIH HHSUnited States/ ; N01 PC067010/PC/NCI NIH HHSUnited States/ ; P50 CA159981/CA/NCI NIH HHSUnited States/ ; P30 CA016056/CA/NCI NIH HHSUnited States/ ; R01 CA087538/CA/NCI NIH HHSUnited States/ ; R01 CA106414/CA/NCI NIH HHSUnited States/ ; M01 RR000056/RR/NCRR NIH HHSUnited States/ ; P30 CA072720/CA/NCI NIH HHSUnited States/ ; R03 CA113148/CA/NCI NIH HHSUnited States/ ; R01 CA058598/CA/NCI NIH HHSUnited States/ ; K22 CA138563/CA/NCI NIH HHSUnited States/ ; R01 CA058860/CA/NCI NIH HHSUnited States/ ; DH_/Department of HealthUnited Kingdom/ ; R01 CA080742/CA/NCI NIH HHSUnited States/ ; K07 CA080668/CA/NCI NIH HHSUnited States/ ; C490/A10124/CRUK_/Cancer Research UKUnited Kingdom/ ; R03 CA115195/CA/NCI NIH HHSUnited States/ ; R01 AG061132/AG/NIA NIH HHSUnited States/ ; R01 CA054419/CA/NCI NIH HHSUnited States/ ; R01 CA122443/CA/NCI NIH HHSUnited States/ ; P30 CA015083/CA/NCI NIH HHSUnited States/ ; 16561/CRUK_/Cancer Research UKUnited Kingdom/ ; R01 CA112523/CA/NCI NIH HHSUnited States/ ; P50 CA136393/CA/NCI NIH HHSUnited States/
• Volume:
  140
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:412e2795a8a4b8f3a6523fc39ece35e10a59d0a4d2858d244ccac0657b984a95
• Download URL:
  https://stacks.cdc.gov/view/cdc/46654/cdc_46654_DS1.pdf
• File Type:
  [PDF - 292.39 KB ]