Dietary Inflammatory Index and Risk of Epithelial Ovarian Cancer in African American Women

Details

• Alternative Title:
  Int J Cancer
• Personal Author:
  Peres, Lauren C. ; Bandera, Elisa V. ; Qin, Bo ; Guertin, Kristin A. ; Shivappa, Nitin ; Hebert, James R. ; Abbott, Sarah E. ; Alberg, Anthony J. ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Moorman, Patricia G. ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul D. ; Camacho, Fabian ; Wang, Frances ; Schildkraut, Joellen M.
• Description:
  Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory index (DII), a novel literature-derived tool to assess the inflammatory potential of one's diet, and EOC risk in African American (AA) women in the African American Cancer Epidemiology Study, the largest population-based case-control study of EOC in AA women to date. The energy-adjusted DII (E-DII) was computed per 1,000 kilocalories from dietary intake data collected through a food frequency questionnaire, which measured usual dietary intake in the year prior to diagnosis for cases or interview for controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression for the association between the E-DII and EOC risk. 493 cases and 662 controls were included in the analyses. We observed a 10% increase in EOC risk per a one-unit change in the E-DII (OR = 1.10, 95% CI = 1.03-1.17). Similarly, women consuming the most pro-inflammatory diet had a statistically significant increased EOC risk in comparison to the most anti-inflammatory diet (OR|  = 1.72; 95% CI = 1.18-2.51). We also observed effect modification by age (p < 0.05), where a strong, significant association between the E-DII and EOC risk was observed among women older than 60 years, but no association was observed in women aged 60 years or younger. Our findings suggest that a more pro-inflammatory diet was associated with an increased EOC risk, especially among women older than 60 years.
• Subjects:
  Adult Black Or African American Carcinoma, Ovarian Epithelial Case-Control Studies Diet Female Humans Inflammation Logistic Models Middle Aged Neoplasms, Glandular And Epithelial Odds Ratio Ovarian Neoplasms Risk Factors Young Adult

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• Keywords:
  African American Diet Dietary Inflammatory Index Inflammation Ovarian Cancer
• Source:
  Int J Cancer. 140(3):535-543
• Pubmed ID:
  27727481
• Pubmed Central ID:
  PMC5159198
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA138313/CA/NCI NIH HHSUnited States/ ; P30 CA022453/CA/NCI NIH HHSUnited States/ ; R01 CA142081/CA/NCI NIH HHSUnited States/ ; R44 DK103377/DK/NIDDK NIH HHSUnited States/
• Volume:
  140
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b50e4b016bbfeb1497651328af73751ceccd6501e4bb5ae9a354aa01892587d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/43224/cdc_43224_DS1.pdf
• File Type:
  [PDF - 352.40 KB ]