Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women

Peres, Lauren C.; Moorman, Patricia G.; Alberg, Anthony J.; Bandera, Elisa V.; Barnholtz-Sloan, Jill; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul D.; Abbott, Sarah E.; Camacho, Fabian; Wang, Frances; Schildkraut, Joellen M.

doi:10.1007/s10552-017-0853-7

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women

5 2017
By Peres, Lauren C. ; Moorman, Patricia G. ; Alberg, Anthony J. ; ...
http://dx.doi.org/10.1007/s10552-017-0853-7
Source: Cancer Causes Control. 28(5):405-414

[PDF-100.07 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Cancer Causes Control
Personal Author:

Peres, Lauren C. ; Moorman, Patricia G. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill ; ... More +

Peres, Lauren C. ; Moorman, Patricia G. ; Alberg, Anthony J. ; Bandera, Elisa V. ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul D. ; Abbott, Sarah E. ; Camacho, Fabian ; Wang, Frances ; Schildkraut, Joellen M. Less -
Description:

Purpose

Incessant ovulation has been consistently linked to epithelial ovarian cancer (EOC). Although reproductive characteristics differ substantially by race, the association between incessant ovulation and EOC has been evaluated only in populations of predominantly white women. In the present study, we examined the association between lifetime number of ovulatory cycles (LOCs) and EOC risk among African American (AA) women.

Methods

We used data from 534 cases and 722 controls enrolled in the African American Cancer Epidemiology Study (AACES). LOCs were determined using the standard method, with modifications to include episodes of irregular or missed periods. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between LOCs and EOC risk overall and by age, while adjusting for appropriate confounders.

Results

The mean number of LOCs was 378.2 ± 105.8 for cases and 346.4 ± 117.3 for controls. Women in the highest tertile of LOCs had a 59% higher odds of EOC compared to women in the lowest tertile (OR=1.59; 95% CI=1.15–2.20). When examining this relationship by age, the positive association with EOC was stronger among women <50 years of age (OR for highest vs. lowest tertile=2.61; 95% CI=1.15–5.94), followed by women aged 50–60 years (OR=2.27; 95% CI=1.30–3.94). Yet, no association was present among women aged >60 years (OR=0.79; 95% CI=0.45–1.40).

Conclusions

In a population of AA women, we observed a positive association between LOCs and EOC risk, providing further support for the hypothesis that incessant ovulation contributes to the etiology of EOC.
Subjects:

[+]

Adult Aged Age Factors Black Or African American Carcinoma, Ovarian Epithelial Case-Control Studies Female Humans Middle Aged Neoplasms, Glandular And Epithelial Ovarian Neoplasms Ovulation Risk Factors Smoking Women's Health
Keywords:

[+]

African American Women Lifetime Ovulatory Cycles Ovarian Cancer
Source:

Cancer Causes Control. 28(5):405-414
Pubmed ID:

28251458
Pubmed Central ID:

PMC5410663
Document Type:

Journal Article
Funding:

U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA138313/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; P30 CA022453/CA/NCI NIH HHSUnited States/ ; R01 CA142081/CA/NCI NIH HHSUnited States/ ; ... More +

U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA138313/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; P30 CA022453/CA/NCI NIH HHSUnited States/ ; R01 CA142081/CA/NCI NIH HHSUnited States/ ; HHSN261201000028C/CA/NCI NIH HHSUnited States/ Less -
Volume:

28
Issue:

5
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:0e47b05efd770ab0fbf20a8914c919ed1941af2ff81963c3eba87c54f07d067a
Download URL:

https://stacks.cdc.gov/view/cdc/45449/cdc_45449_DS1.pdf
File Type:

nihms856805.nxml

xml

More +