N-acetyltransferase 2 genotypes are associated with diisocyanate-induced asthma
Published Date:Dec 2015
Source:J Occup Environ Med. 57(12):1331-1336.
Keywords:4,4′- Diphenylmethane Diisocyanate
Genetic Predisposition To Disease
Polymorphism, Single Nucleotide
Single Nucleotide Polymorphism
Pubmed Central ID:PMC5215051
Funding:R01 OH008795/OH/NIOSH CDC HHS/United States
ZIA ES103106-05/Intramural NIH HHS/United States
R01 OH 008795/OH/NIOSH CDC HHS/United States
Intramural NIH HHS/United States
To investigate whether genetic variants of N-acetyl transferase genes (NAT1 and NAT2) are associated with diisocyanate asthma (DA).
The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed on genomic DNA, using a 5′ nuclease PCR assay.
The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in univariate analysis. In the first logistic regression model comparing DA+ and AW groups, the genotype combination, NAT2 rs2410556 and NAT2 rs4271002, showed association with DA risk (p=0.005). In the second model comparing DA+ and DA− groups, NAT2 rs4271002 and NAT2 rs13277605 variants were significantly associated with an increased risk of DA (p=0.002 and p=0.027, respectively). In the third model comparing DA− and AW groups, the NAT1 rs4921580 SNP and the combined genotype NAT2 rs2410556/rs4271002 showed association with the DA− phenotype (p=0.017, p<0.001, respectively).
These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility.
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