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N-acetyltransferase 2 genotypes are associated with diisocyanate-induced asthma
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Dec 2015
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Source: J Occup Environ Med. 57(12):1331-1336.
Details:
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Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objective
To investigate whether genetic variants of N-acetyl transferase genes (NAT1 and NAT2) are associated with diisocyanate asthma (DA).
Methods
The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed on genomic DNA, using a 5′ nuclease PCR assay.
Results
The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in univariate analysis. In the first logistic regression model comparing DA+ and AW groups, the genotype combination, NAT2 rs2410556 and NAT2 rs4271002, showed association with DA risk (p=0.005). In the second model comparing DA+ and DA− groups, NAT2 rs4271002 and NAT2 rs13277605 variants were significantly associated with an increased risk of DA (p=0.002 and p=0.027, respectively). In the third model comparing DA− and AW groups, the NAT1 rs4921580 SNP and the combined genotype NAT2 rs2410556/rs4271002 showed association with the DA− phenotype (p=0.017, p<0.001, respectively).
Conclusion
These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility.
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Source:
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Pubmed ID:26641831
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Pubmed Central ID:PMC5215051
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Volume:57
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Issue:12
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