Details:

Alternative Title:
Nat Rev Mol Cell Biol
Personal Author:
Joung, J. Keith ; Sander, Jeffry D.
Joung, J. Keith ; Sander, Jeffry D. Less -
Description:
Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases.
Subject:
[+]
Animals
Article
Deoxyribonucleases
DNA
DNA-Binding Proteins
Genome
Humans
Protein Engineering
Protein Structure, Tertiary
Transcriptional Activation

Source:
Nat Rev Mol Cell Biol. 14(1):49-55.
Pubmed ID:
23169466
Pubmed Central ID:
PMC3547402
Document Type:
Journal Article
Funding:
DP1 GM105378/DP/NCCDPHP CDC HHS/United States ; DP1 GM105378/GM/NIGMS NIH HHS/United States ; P50 HG005550/HG/NHGRI NIH HHS/United States ; P50 HG005550/HG/NHGRI NIH HHS/United States ; R01 GM088040/GM/NIGMS NIH HHS/United States ; ... More +
DP1 GM105378/DP/NCCDPHP CDC HHS/United States ; DP1 GM105378/GM/NIGMS NIH HHS/United States ; P50 HG005550/HG/NHGRI NIH HHS/United States ; P50 HG005550/HG/NHGRI NIH HHS/United States ; R01 GM088040/GM/NIGMS NIH HHS/United States ; R01 GM088040/GM/NIGMS NIH HHS/United States ; T32CA009216/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a5f6996eb0759ba28d50339aa0e12d0e494e44874de8415ef6ed8cbf3072d579
File Type:

Supporting Files

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  	NIHMS429552-supplement-S2.docx	docx
  	NIHMS429552-supplement-S3.docx	docx
  	NIHMS429552-supplement-S4.docx	docx
  	NIHMS429552-supplement-S4_figure_on_last_page.pdf	pdf
  	NIHMS429552-supplement-S5.doc	doc
  	nihms429552.nxml	txt
  	nihms429552f1.gif	gif

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