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Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

CITE Title : Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases Personal Author(s) : Tsai, Shengdar Q.;Joung, J. Keith; Published Date : May 2016;5-2016; Source : Nat Rev Genet. 17(5):300-312 URL : https://stacks.cdc.gov/view/cdc/88020 Tsai, Shengdar Q. and Joung, J. Keith (2016). Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases. 17(5). Tsai, Shengdar Q. and Joung, J. Keith "Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases" 17, no. 5 (2016) Tsai, Shengdar Q. and Joung, J. Keith "Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases" vol. 17, no. 5, 2016 Export RIS Citation Information.

:

Tsai, Shengdar Q. ;

Joung, J. Keith

May 2016 | Nat Rev Genet. 17(5):300-312

:

CRISPR-Cas9 RNA-guided nucleases are a transformative technology for biology, genetics and medicine owing to the simplicity with which they can be pro...
GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

CITE Title : GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases Personal Author(s) : Tsai, Shengdar Q.;Zheng, Zongli;Nguyen, Nhu T.;Liebers, Matthew;Topkar, Ved V.;Thapar, Vishal;Wyvekens, Nicolas;Khayter, Cyd;Iafrate, A. John;Le, Long P.;Aryee, Martin J.;Joung, J. Keith; Published Date : Dec 16 2014 Source : Nat Biotechnol. 33(2):187-197 URL : https://stacks.cdc.gov/view/cdc/30281 Tsai, Shengdar Q. et al. (2014). GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. 33(2). Tsai, Shengdar Q. et al. "GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases" 33, no. 2 (2014) Tsai, Shengdar Q. et al. "GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases" vol. 33, no. 2, 2014 Export RIS Citation Information.

:

Tsai, Shengdar Q. ;

Zheng, Zongli

Dec 16 2014 | Nat Biotechnol. 33(2):187-197

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CRISPR RNA-guided nucleases (RGNs) are widely used genome-editing reagents, but methods to delineate their genome-wide, off-target cleavage activities...
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

CITE Title : In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites Personal Author(s) : Sander, Jeffry D.;Ramirez, Cherie L.;Linder, Samantha J.;Pattanayak, Vikram;Shoresh, Noam;Ku, Manching;Foden, Jennifer A.;Reyon, Deepak;Bernstein, Bradley E.;Liu, David R.;Joung, J. Keith; Published Date : Aug 14 2013 Source : Nucleic Acids Res. 2013; 41(19):e181. URL : https://stacks.cdc.gov/view/cdc/22560 Sander, Jeffry D. et al. (2013). In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. 41(19). Sander, Jeffry D. et al. "In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites" 41, no. 19 (2013) Sander, Jeffry D. et al. "In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites" vol. 41, no. 19, 2013 Export RIS Citation Information.

:

Sander, Jeffry D. ;

Ramirez, Cherie L.

Aug 14 2013 | Nucleic Acids Res. 2013; 41(19):e181.

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Gene-editing nucleases enable targeted modification of DNA sequences in living cells, thereby facilitating efficient knockout and precise editing of e...
CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants

CITE Title : CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants Personal Author(s) : Spisak, Sandor;Lawrenson, Kate;Fu, Yanfang;Csabai, Istvan;Cottman, Rebecca T.;Haiman, Christopher;Han, Ying;Seo, Ji-Heui;Lenci, Romina;Li, Qiyuan;Tisza, Viktoria;Szallasi, Zoltan;Herbert, Zachery T.;Chabot, Matthew;Pomerantz, Mark;Solymosi, Norbert;Gayther, Simon;Joung, J. Keith;Freedman, Matthew L.; Published Date : Sep 23 2015 Source : Nat Med. 21(11):1357-1363. URL : https://stacks.cdc.gov/view/cdc/37901 Spisak, Sandor et al. (2015). CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants. 21(11). Spisak, Sandor et al. "CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants" 21, no. 11 (2015) Spisak, Sandor et al. "CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants" vol. 21, no. 11, 2015 Export RIS Citation Information.

:

Spisak, Sandor ;

Lawrenson, Kate

Sep 23 2015 | Nat Med. 21(11):1357-1363.

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The vast majority of disease-associated single-nucleotide polymorphisms (SNPs) mapped by genome-wide association studies (GWASs) are located in the no...
Context Influences on TALE-DNA Binding Revealed by Quantitative Profiling

CITE Title : Context Influences on TALE-DNA Binding Revealed by Quantitative Profiling Personal Author(s) : Rogers, Julia M.;Barrera, Luis A.;Reyon, Deepak;Sander, Jeffry D.;Kellis, Manolis;Joung, J. Keith;Bulyk, Martha L.; Published Date : June 11 2015 Source : Nat Commun. 6:7440 URL : https://stacks.cdc.gov/view/cdc/32847 Rogers, Julia M. et al. (2015). Context Influences on TALE-DNA Binding Revealed by Quantitative Profiling. 6 Rogers, Julia M. et al. "Context Influences on TALE-DNA Binding Revealed by Quantitative Profiling" 6 (2015) Rogers, Julia M. et al. "Context Influences on TALE-DNA Binding Revealed by Quantitative Profiling" vol. 6, 2015 Export RIS Citation Information.

:

Rogers, Julia M. ;

Barrera, Luis A.

June 11 2015 | Nat Commun. 6:7440

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Transcription activator-like effector (TALE) proteins recognize DNA using a seemingly simple DNA-binding code, which makes them attractive for use in ...
Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions

CITE Title : Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions Personal Author(s) : Mendenhall, Eric M.;Williamson, Kaylyn E.;Reyon, Deepak;Zou, James Y.;Ram, Oren;Joung, J. Keith;Bernstein, Bradley E.; Published Date : Sep 08 2013 Source : Nat Biotechnol. 31(12):1133-1136. URL : https://stacks.cdc.gov/view/cdc/23418 Mendenhall, Eric M. et al. (2013). Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions. 31(12). Mendenhall, Eric M. et al. "Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions" 31, no. 12 (2013) Mendenhall, Eric M. et al. "Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions" vol. 31, no. 12, 2013 Export RIS Citation Information.

:

Mendenhall, Eric M. ;

Williamson, Kaylyn E.

Sep 08 2013 | Nat Biotechnol. 31(12):1133-1136.

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Mammalian gene regulation is dependent on tissue-specific enhancers that can act across large distances to influence transcriptional activity. Mapping...
Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo

CITE Title : Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo Personal Author(s) : Zuris, John A.;Thompson, David B.;Shu, Yilai;Guilinger, John P.;Bessen, Jeffrey L.;Hu, Johnny H.;Maeder, Morgan L.;Joung, J. Keith;Chen, Zheng-Yi;Liu, David R.; Published Date : Oct 30 2014 Source : Nat Biotechnol. 33(1):73-80. URL : https://stacks.cdc.gov/view/cdc/30227 Zuris, John A. et al. (2014). Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo. 33(1). Zuris, John A. et al. "Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo" 33, no. 1 (2014) Zuris, John A. et al. "Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo" vol. 33, no. 1, 2014 Export RIS Citation Information.

:

Zuris, John A. ;

Thompson, David B.

Oct 30 2014 | Nat Biotechnol. 33(1):73-80.

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Efficient intracellular delivery of proteins is needed to fully realize the potential of protein therapeutics. Current methods of protein delivery com...
Engineered CRISPR-Cas9 nucleases with altered PAM specificities

CITE Title : Engineered CRISPR-Cas9 nucleases with altered PAM specificities Personal Author(s) : Kleinstiver, Benjamin P.;Prew, Michelle S.;Tsai, Shengdar Q.;Topkar, Ved;Nguyen, Nhu T.;Zheng, Zongli;Gonzales, Andrew P.W.;Li, Zhuyun;Peterson, Randall T.;Yeh, Jing-Ruey Joanna;Aryee, Martin J.;Joung, J. Keith; Published Date : Jun 22 2015 Source : Nature. 523(7561):481-485. URL : https://stacks.cdc.gov/view/cdc/32948 Kleinstiver, Benjamin P. et al. (2015). Engineered CRISPR-Cas9 nucleases with altered PAM specificities. 523(7561). Kleinstiver, Benjamin P. et al. "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" 523, no. 7561 (2015) Kleinstiver, Benjamin P. et al. "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" vol. 523, no. 7561, 2015 Export RIS Citation Information.

:

Kleinstiver, Benjamin P. ;

Prew, Michelle S.

Jun 22 2015 | Nature. 523(7561):481-485.

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Although CRISPR-Cas9 nucleases are widely used for genome editing, the range of sequences that Cas9 can recognize is constrained by the need for a spe...
Continuous directed evolution of DNA-binding proteins to improve TALEN specificity

CITE Title : Continuous directed evolution of DNA-binding proteins to improve TALEN specificity Personal Author(s) : Hubbard, Basil P.;Badran, Ahmed H.;Zuris, John A.;Guilinger, John P.;Davis, Kevin M.;Chen, Liwei;Tsai, Shengdar Q.;Sander, Jeffry D.;Joung, J. Keith;Liu, David R.; Published Date : Aug 10 2015 Source : Nat Methods. 12(10):939-942. URL : https://stacks.cdc.gov/view/cdc/36969 Hubbard, Basil P. et al. (2015). Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. 12(10). Hubbard, Basil P. et al. "Continuous directed evolution of DNA-binding proteins to improve TALEN specificity" 12, no. 10 (2015) Hubbard, Basil P. et al. "Continuous directed evolution of DNA-binding proteins to improve TALEN specificity" vol. 12, no. 10, 2015 Export RIS Citation Information.

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Hubbard, Basil P. ;

Badran, Ahmed H.

Aug 10 2015 | Nat Methods. 12(10):939-942.

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Nucleases containing programmable DNA-binding domains can alter the genomes of model organisms and have the potential to become human therapeutics. He...
Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases

CITE Title : Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases Personal Author(s) : Qi, Yiping;Li, Xiaohong;Zhang, Yong;Starker, Colby G.;Baltes, Nicholas J.;Zhang, Feng;Sander, Jeffry D.;Reyon, Deepak;Joung, J. Keith;Voytas, Daniel F.; Published Date : Oct 03 2013 Source : G3 (Bethesda). 2013; 3(10):1707-1715. URL : https://stacks.cdc.gov/view/cdc/22559 Qi, Yiping et al. (2013). Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases. 3(10). Qi, Yiping et al. "Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases" 3, no. 10 (2013) Qi, Yiping et al. "Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases" vol. 3, no. 10, 2013 Export RIS Citation Information.

:

Qi, Yiping ;

Li, Xiaohong

Oct 03 2013 | G3 (Bethesda). 2013; 3(10):1707-1715.

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Tandemly arrayed genes (TAGs) or gene clusters are prevalent in higher eukaryotic genomes. For example, approximately 17% of genes are organized in ta...
High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

CITE Title : High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells Personal Author(s) : Fu, Yanfang;Foden, Jennifer A.;Khayter, Cyd;Maeder, Morgan L.;Reyon, Deepak;Joung, J. Keith;Sander, Jeffry D.; Published Date : Jun 23 2013 Source : Nat Biotechnol. 31(9):822-826. URL : https://stacks.cdc.gov/view/cdc/22517 Fu, Yanfang et al. (2013). High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. 31(9). Fu, Yanfang et al. "High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells" 31, no. 9 (2013) Fu, Yanfang et al. "High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells" vol. 31, no. 9, 2013 Export RIS Citation Information.

:

Fu, Yanfang ;

Foden, Jennifer A.

Jun 23 2013 | Nat Biotechnol. 31(9):822-826.

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Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) have rapidly emerged as a facile and efficient platfor...
CRISPR-Cas systems for genome editing, regulation and targeting

CITE Title : CRISPR-Cas systems for genome editing, regulation and targeting Personal Author(s) : Sander, Jeffry D.;Joung, J. Keith; Published Date : 4 2014;4-2014; Source : Nat Biotechnol. 32(4):347-355 URL : https://stacks.cdc.gov/view/cdc/29957 Sander, Jeffry D. and Joung, J. Keith (2014). CRISPR-Cas systems for genome editing, regulation and targeting. 32(4). Sander, Jeffry D. and Joung, J. Keith "CRISPR-Cas systems for genome editing, regulation and targeting" 32, no. 4 (2014) Sander, Jeffry D. and Joung, J. Keith "CRISPR-Cas systems for genome editing, regulation and targeting" vol. 32, no. 4, 2014 Export RIS Citation Information.

:

Sander, Jeffry D. ;

Joung, J. Keith

4 2014 | Nat Biotechnol. 32(4):347-355

:

Targeted genome editing using engineered nucleases has rapidly gone from being a niche technology to a mainstream method used by many biological resea...
Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo

CITE Title : Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo Personal Author(s) : Zuris, John A.;Thompson, David B.;Shu, Yilai;Guilinger, John P.;Bessen, Jeffrey L.;Hu, Johnny H.;Maeder, Morgan L.;Joung, J. Keith;Chen, Zheng-Yi;Liu, David R.; Published Date : 1 2015;1-2015; Source : Nat Biotechnol. 33(1):73-80 URL : https://stacks.cdc.gov/view/cdc/149749 Zuris, John A. et al. (2015). Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo. 33(1). Zuris, John A. et al. "Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo" 33, no. 1 (2015) Zuris, John A. et al. "Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo" vol. 33, no. 1, 2015 Export RIS Citation Information.

:

Zuris, John A. ;

Thompson, David B.

1 2015 | Nat Biotechnol. 33(1):73-80

:

Efficient intracellular delivery of proteins is needed to fully realize the potential of protein therapeutics. Current methods of protein delivery com...
GENOME EDITING IN HUMAN CELLS USING CRISPR/CAS NUCLEASES

CITE Title : GENOME EDITING IN HUMAN CELLS USING CRISPR/CAS NUCLEASES Personal Author(s) : Wyvekens, Nicolas;Tsai, Shengdar;Joung, J. Keith; Published Date : Oct 01 2015 Source : Curr Protoc Mol Biol. 112:31.3.1-31.318. URL : https://stacks.cdc.gov/view/cdc/39220 Wyvekens, Nicolas et al. (2015). GENOME EDITING IN HUMAN CELLS USING CRISPR/CAS NUCLEASES. 112 Wyvekens, Nicolas and Tsai, Shengdar and Joung, J. Keith "GENOME EDITING IN HUMAN CELLS USING CRISPR/CAS NUCLEASES" 112 (2015) Wyvekens, Nicolas et al. "GENOME EDITING IN HUMAN CELLS USING CRISPR/CAS NUCLEASES" vol. 112, 2015 Export RIS Citation Information.

:

Wyvekens, Nicolas ;

Tsai, Shengdar

Oct 01 2015 | Curr Protoc Mol Biol. 112:31.3.1-31.318.

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The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system has been broadly adopted for highly efficient gen...
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

CITE Title : Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing Personal Author(s) : Tsai, Shengdar Q.;Wyvekens, Nicolas;Khayter, Cyd;Foden, Jennifer A.;Thapar, Vishal;Reyon, Deepak;Goodwin, Mathew J.;Aryee, Martin J.;Joung, J. Keith; Published Date : Apr 25 2014 Source : Nat Biotechnol. 32(6):569-576. URL : https://stacks.cdc.gov/view/cdc/27889 Tsai, Shengdar Q. et al. (2014). Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. 32(6). Tsai, Shengdar Q. et al. "Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing" 32, no. 6 (2014) Tsai, Shengdar Q. et al. "Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing" vol. 32, no. 6, 2014 Export RIS Citation Information.

:

Tsai, Shengdar Q. ;

Wyvekens, Nicolas

Apr 25 2014 | Nat Biotechnol. 32(6):569-576.

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Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here w...
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

CITE Title : Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells Personal Author(s) : Liao, Jing;Karnik, Rahul;Gu, Hongcang;Ziller, Michael J.;Clement, Kendell;Tsankov, Alexander M.;Akopian, Veronika;Gifford, Casey A.;Donaghey, Julie;Galonska, Christina;Pop, Ramona;Reyon, Deepak;Tsai, Shengdar Q.;Mallard, William;Joung, J. Keith;Rinn, John L.;Gnirke, Andreas;Meissner, Alexander; Published Date : 5 2015;5-2015; Source : Nat Genet. 47(5):469-478 URL : https://stacks.cdc.gov/view/cdc/31723 Liao, Jing et al. (2015). Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. 47(5). Liao, Jing et al. "Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells" 47, no. 5 (2015) Liao, Jing et al. "Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells" vol. 47, no. 5, 2015 Export RIS Citation Information.

:

Liao, Jing ;

Karnik, Rahul

5 2015 | Nat Genet. 47(5):469-478

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DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Here we inactivated all thr...
Efficient In Vivo Genome Editing Using RNA-Guided Nucleases

CITE Title : Efficient In Vivo Genome Editing Using RNA-Guided Nucleases Personal Author(s) : Hwang, Woong Y.;Fu, Yanfang;Reyon, Deepak;Maeder, Morgan L.;Tsai, Shengdar Q.;Sander, Jeffry D.;Peterson, Randall T.;Yeh, J.-R. Joanna;Joung, J. Keith; Published Date : 3 2013;3-2013; Source : Nat Biotechnol. 31(3):227-229 URL : https://stacks.cdc.gov/view/cdc/22570 Hwang, Woong Y. et al. (2013). Efficient In Vivo Genome Editing Using RNA-Guided Nucleases. 31(3). Hwang, Woong Y. et al. "Efficient In Vivo Genome Editing Using RNA-Guided Nucleases" 31, no. 3 (2013) Hwang, Woong Y. et al. "Efficient In Vivo Genome Editing Using RNA-Guided Nucleases" vol. 31, no. 3, 2013 Export RIS Citation Information.

:

Hwang, Woong Y. ;

Fu, Yanfang

3 2013 | Nat Biotechnol. 31(3):227-229

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In bacteria, foreign nucleic acids are silenced by clustered, regularly interspaced, short palindromic repeats (CRISPR)--CRISPR-associated (Cas) syste...
Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity

CITE Title : Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity Personal Author(s) : Guilinger, John P.;Pattanayak, Vikram;Reyon, Deepak;Tsai, Shengdar Q.;Sander, Jeffry D.;Joung, J. Keith;Liu, David R.; Published Date : 4 2014;4-2014; Source : Nat Methods. 11(4):429-435 URL : https://stacks.cdc.gov/view/cdc/25598 Guilinger, John P. et al. (2014). Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity. 11(4). Guilinger, John P. et al. "Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity" 11, no. 4 (2014) Guilinger, John P. et al. "Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity" vol. 11, no. 4, 2014 Export RIS Citation Information.

:

Guilinger, John P. ;

Pattanayak, Vikram

4 2014 | Nat Methods. 11(4):429-435

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Although transcription activator-like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have activity against related...
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation

CITE Title : Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation Personal Author(s) : Kwon, Kyong-Rim Kieffer;Tang, Zhonghui;Mathe, Ewy;Qian, Jason;Sung, Myong-Hee;Li, Guoliang;Resch, Wolfgang;Baek, Songjoon;Pruett, Nathanael;Grøntved, Lars;Vian, Laura;Nelson, Steevenson;Zare, Hossein;Hakim, Ofir;Reyon, Deepak;Yamane, Arito;Nakahashi, Hirotaka;Kovalchuk, Alexander L.;Zou, Jizhong;Joung, J. Keith;Sartorelli, Vittorio;Wei, Chia-Lin;Ruan, Xiaoan;Hager, Gordon L.;Ruan, Yijun;Casellas, Rafael; Published Date : 12 19 2013 Source : Cell. 155(7):1507-1520 URL : https://stacks.cdc.gov/view/cdc/29838 Kwon, Kyong-Rim Kieffer et al. (2013). Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. 155(7). Kwon, Kyong-Rim Kieffer et al. "Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation" 155, no. 7 (2013) Kwon, Kyong-Rim Kieffer et al. "Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation" vol. 155, no. 7, 2013 Export RIS Citation Information.

:

Kwon, Kyong-Rim Kieffer ;

Tang, Zhonghui

12 19 2013 | Cell. 155(7):1507-1520

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A key finding of the ENCODE project is that the enhancer landscape of mammalian cells undergoes marked alterations during ontogeny. However, the natur...
High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets

CITE Title : High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets Personal Author(s) : Kleinstiver, Benjamin P.;Pattanayak, Vikram;Prew, Michelle S.;Tsai, Shengdar Q.;Nguyen, Nhu;Zheng, Zongli;Joung, J. Keith; Published Date : Jan 06 2016 Source : Nature. 529(7587):490-495. URL : https://stacks.cdc.gov/view/cdc/39163 Kleinstiver, Benjamin P. et al. (2016). High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets. 529(7587). Kleinstiver, Benjamin P. et al. "High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets" 529, no. 7587 (2016) Kleinstiver, Benjamin P. et al. "High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets" vol. 529, no. 7587, 2016 Export RIS Citation Information.

:

Kleinstiver, Benjamin P. ;

Pattanayak, Vikram

Jan 06 2016 | Nature. 529(7587):490-495.

:

CRISPR-Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide of...

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