Noninvasive, MultiOmic, and Multicompartmental Biomarkers of Reflux Disease: A Systematic Review

Details

• Alternative Title:
  Gastro Hep Adv
• Personal Author:
  Farooqi, Muhammad S. ; Podury, Sanjiti ; Crowley, George ; Javed, Urooj ; Li, Yiwei ; Liu, Mengling ; Kwon, Sophia ; Grunig, Gabriele ; Khan, Abraham R. ; Francois, Fritz ; Nolan, Anna
• Description:
  BACKGROUND AND AIMS:
  
  Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder that may complicate conditions such as obstructive airway disease. Our group has identified predictive biomarkers of GERD in particulate exposed first responders with obstructive airway disease. In addition, GERD diagnosis and treatment is costly and invasive. In light of these clinical concerns, we aimed to systematically review studies identifying noninvasive, multiOmic, and multicompartmental biomarkers of GERD.
  
  METHODS:
  
  A systematic review of PubMed and Embase was performed using keywords focusing on reflux disease and biomarkers and registered with PROSPERO. We included original human studies in English, articles focusing on noninvasive biomarkers of GERD published after December 31, 2009. GERD subtypes (non-erosive reflux disease and erosive esophagitis) and related conditions (Barrett’s Esophagus [BE] and Esophageal Adenocarcinoma). Predictive measures were synthesized and risk of bias assessed (Newcastle-Ottawa Scale).
  
  RESULTS:
  
  Initial search identified n = 238 studies andn 13 articles remained after applying inclusion/exclusion criteria. Salivary pepsin was the most studied biomarker with significant sensitivity and specificity for GERD. Serum assessment showed elevated levels of Tumor Necrosis Factor-alpha in both GERD and Barrett’s. Exhaled breath volatile sulfur compounds and acetic acid were associated with GERD. Oral Microbiome: Models with Lautropia, Streptococcus, and Bacteroidetes showed the greatest discrimination between BE and controls vs Lautropia; ROCAUC 0.94 (95% confidence interval; 0.85–1.00).
  
  CONCLUSION:
  
  Prior studies identified significant multiOmic, multicompartmental noninvasive biomarker risks for GERD and BE. However, studies have a high risk of bias and the reliability and accuracy of the biomarkers identified are greatly limited, which further highlights the need to discover and validate clinically relevant noninvasive biomarkers of GERD.
  
  
• Keywords:
  Barrett’s Esophagus Biomarkers GERD Reflux Disease Systematic Review
• Source:
  Gastro Hep Adv. 2(4):608-620
• Pubmed ID:
  38009162
• Pubmed Central ID:
  PMC10673619
• Document Type:
  Journal Article
• Funding:
  U01 OH012069/OH/NIOSH CDC HHSUnited States/ ; U01 OH011300/OH/NIOSH CDC HHSUnited States/ ; U01 OH011855/OH/NIOSH CDC HHSUnited States/ ; KL2 TR001446/TR/NCATS NIH HHSUnited States/ ; R01 ES032808/ES/NIEHS NIH HHSUnited States/ ; R01 HL119326/HL/NHLBI NIH HHSUnited States/
• Volume:
  2
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:b91123e78198b2676b7001fd3bbf1eb0ed79a90c50e8f21457143d6a936d5c65320c84adad49cf6f384fe3203b134a6fac559cd242d1d04eecdbd17c102eadfa
• Download URL:
  https://stacks.cdc.gov/view/cdc/135946/cdc_135946_DS1.pdf
• File Type:
  [PDF - 826.08 KB ]