Noninvasive, multiOmic, and Multicompartmental Biomarkers of Reflux Disease: A Systematic Review

Details

• Personal Author:
  Crowley G ; Farooqi MS ; Francois F ; Grunig G ; Javed U ; Khan AR ; Kwon S ; Li Y ; Liu M ; Nolan A ; Podury S
• Description:
  Background and Aims: Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder that may complicate conditions such as obstructive airway disease. Our group has identified predictive biomarkers of GERD in particulate exposed first responders with obstructive airway disease. In addition, GERD diagnosis and treatment is costly and invasive. In light of these clinical concerns, we aimed to systematically review studies identifying noninvasive, multiOmic, and multicompartmental biomarkers of GERD. Methods: A systematic review of PubMed and Embase was performed using keywords focusing on reflux disease and biomarkers and registered with PROSPERO. We included original human studies in English, articles focusing on noninvasive biomarkers of GERD published after December 31, 2009. GERD subtypes (non-erosive reflux disease and erosive esophagitis) and related conditions (Barrett's Esophagus [BE] and Esophageal Adenocarcinoma). Predictive measures were synthesized and risk of bias assessed (Newcastle-Ottawa Scale). Results: Initial search identified n = 238 studies and n = 13 articles remained after applying inclusion/exclusion criteria. Salivary pepsin was the most studied biomarker with significant sensitivity and specificity for GERD. Serum assessment showed elevated levels of Tumor Necrosis Factor- alpha in both GERD and Barrett's. Exhaled breath volatile sulfur compounds and acetic acid were associated with GERD. Oral Microbiome: Models with Lautropia, Streptococcus, and Bacteroidetes showed the greatest discrimination between BE and controls vs Lautropia; ROCAUC 0.94 (95% confidence interval; 0.85-1.00). Conclusion: Prior studies identified significant multiOmic, multicompartmental noninvasive biomarker risks for GERD and BE. However, studies have a high risk of bias and the reliability and accuracy of the biomarkers identified are greatly limited, which further highlights the need to discover and validate clinically relevant noninvasive biomarkers of GERD. [Description provided by NIOSH]
• Subjects:
  Biomarkers Occupational Health Safety
• Keywords:
  Author Keywords: Systematic Review Barrett's Esophagus Gastroesophageal Reflux Disease Gastrointestinal System GERD Reflux Disease Systematic Reviews
• ISSN:
  2772-5723
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20068883
• Citation:
  Gastro Hep Adv 2023 Apr; 2(4):608-620
• Contact Point Address:
  Anna Nolan, MD, MS, New York University Grossman School of Medicine Department of Medicine/Division of Pulmonary, Critical Care and Sleep New Bellevue, 16 S Room 16, 462 1st Avenue, New York, New York 10016
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Gastro Hep Advances
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:895b177b43722a967ad463b63458f4587faf20b5b3edfff0b66e79c455ea289f886fc822545255ecd30500d1c881164aa7a4c237668687832aa6af6cfff62209
• Download URL:
  https://stacks.cdc.gov/view/cdc/207448/cdc_207448_DS1.pdf
• File Type:
  [PDF - 890.42 KB ]