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Deaths in children and adolescents associated with COVID-19 and MIS-C in the United States
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11 2021
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Source: Pediatrics. 148(5)
[PDF-661.47 KB]
Details:
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Alternative Title:Pediatrics
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Personal Author:
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Description:Objective
To describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a SARS-CoV-2-associated death.
Methods
We conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12–July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records and entered them into an electronic database.
Results
We included 112 SARS-CoV-2 associated deaths from 25 participating jurisdictions. The median age was 17 years (interquartile range 8.5–19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least one underlying condition; obesity (47/112, 42%), asthma (33/112, 29%), and developmental disorders (25/112, 22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (45/60, 75%), acute respiratory failure (51/62, 82%), and acute renal failure (21/62, 34%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, gender, and race/ethnicity to decedents without MIS-C, and 11/16 (69%) had at least one underlying condition.
Conclusion
SARS-CoV-2-associated deaths among persons <21 years of age during February–July 2020 occurred predominantly among Black (non-Hispanic) and Hispanic persons, males, and older adolescents of all races/ethnicities. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with COVID-19 disease were more likely than those with MIS-C to have underlying medical conditions.
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Pubmed ID:34385349
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Pubmed Central ID:PMC9837742
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Funding:
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Volume:148
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Issue:5
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