Details:

Alternative Title:
Cancer Epidemiol Biomarkers Prev
Publisher's site:
http://dx.doi.org/10.1158/1055-9965.EPI-21-0129
Personal Author:
Chu, Janet N. ; Canchola, Alison J. ; Keegan, Theresa H. M. ; Nickell, Alyssa ; Oakley-Girvan, Ingrid ; ... More +
Chu, Janet N. ; Canchola, Alison J. ; Keegan, Theresa H. M. ; Nickell, Alyssa ; Oakley-Girvan, Ingrid ; Hamilton, Ann S. ; Yu, Rosa L. ; Lin Gomez, Scarlett ; Shariff-Marco, Salma ; Less -
Description:
Background: With almost 17 million U.S. cancer survivors, understanding multilevel factors impacting health-related quality of life (HRQOL) is critical to improving survivorship outcomes. Few studies have evaluated neighborhood impact on HRQOL among cancer survivors. Methods: We combined sociodemographic, clinical, and behavioral data from three registry-based studies in California. Using a 3-level mixed linear regression model (participants nested within block groups and study/regions) we examined associations of both independent neighborhood attributes and neighborhood archetypes, which capture interactions inherent among neighborhood attributes, with two HRQOL outcomes, physical (PCS) and mental (MCS) composite scores. Results: For the 2,477 survivors, 46% were 70+ years, 52% were non-Hispanic White, and 53% had localized disease. In models minimally adjusted for age, stage, and cancer recurrence, HRQOL was associated with neighborhood socioeconomic status (nSES), racial/ethnic composition, population density, street connectivity, restaurant environment index, traffic density, urbanicity, crowding, rental properties, and non-single family units. In fully adjusted models, higher nSES remained associated with better PCS, and restaurant environment index, specifically more unhealthy restaurants, associated with worse MCS. In multivariable-adjusted models of neighborhood archetype, compared to Upper middle-class suburb, Hispanic small town, and Inner city had lower PCS, and High status had higher MCS. Conclusions: Among survivors, higher nSES was associated with better HRQOL; more unhealthy restaurants were associated with worse HQROL. As some neighborhood archetypes were associated with HRQOL, they provide an approach to capture how neighborhood attributes interact to impact HRQOL. Impact: Elucidating the pathways through which neighborhood attributes influence HRQOL is important in improving survivorship outcomes.
Subject:
[+]
Archetypes
Article
Cancer Survivors
Health Related-quality Of Life
Neighborhoods
Social And Built Environments

Source:
Cancer Epidemiol Biomarkers Prev. 31(1):161-174 ;
Pubmed ID:
34728471
Pubmed Central ID:
PMC8755614
Document Type:
Journal Article ;
Funding:
HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; ... More +
HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ ; HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; R03 CA202192/CA/NCI NIH HHSUnited States/ ; N01PC35136/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5bd3845c1d39a5fd041ab982dc669318e1e70ac6870317bf05bdfd347a5f8855
File Type:

• Supporting Files:
  No Additional Files

More +