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CDC Public Access

CDC Stacks Public Health Publications

Items in this collection are manuscripts and articles written by CDC or CDC-funded authors, and published in scholarly journals outside CDC. These items are available in compliance with the 2024 update of CDC-GA-2013-01 CDC Public Access to CDC-Funded Publications, available at: https://stacks.cdc.gov/view/cdc/159734.

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Showing 22801 - 22820 of 27884 results
  • CRISPR RNAguided activation of endogenous human genes
    CRISPR RNA-guided activation of endogenous human genes
    Maeder, Morgan L ;
    Linder, Samantha J
    Jul 25 2013 | Nat Methods. 10(10):977-979.
    Short guide RNAs (gRNAs) can direct catalytically inactive CRISPR-associated 9 nuclease (dCas9) to repress endogenous genes in bacteria and human cells. Here we show that single or multiple gRNAs can direct dCas9 fused to a VP64 transcriptional activation domain to increase expression of endogenous human genes. This proof-of-principle work shows th ...
    Supporting Files
  • Phenotypic Assays For Amyloid In Mouse Embryonic Stem Cellderived Neurons
    Phenotypic Assays For β-Amyloid In Mouse Embryonic Stem Cell-derived Neurons
    McIntire, Laura Beth J. ;
    Landman, Natalie
    Jul 25 2013 | Chem Biol. 2013; 20(7):956-967.
    Given the complex nature of Alzheimer's disease (AD), a cell-based model that recapitulates the physiological properties of the target neuronal population would be extremely valuable for discovering improved drug candidates and chemical probes to uncover disease mechanisms. We established phenotypic neuronal assays for the biogenesis and synaptic a ...
    Supporting Files
  • Childhood vision impairment hearing loss and cooccurring autism spectrum disorder
    Childhood vision impairment, hearing loss and co-occurring autism spectrum disorder
    Kancherla, Vijaya ;
    Van Naarden Braun, Kim
    Jul 25 2013 | Disabil Health J. 6(4):333-342.
    BackgroundLimited population-based data on prevalence of childhood vision impairment (VI) and hearing loss (HL), and their co-occurrence with autism spectrum disorder (ASD) exists.ObjectiveTo examine prevalence and characteristics of VI, HL and co-occurring ASD among 8-year-olds in metropolitan Atlanta 2000–2008.MethodsWe used data from the populat ...
    Supporting Files
  • Raccoon Rabies Virus Variant Transmission Through Solid Organ Transplantation
    Raccoon Rabies Virus Variant Transmission Through Solid Organ Transplantation
    Vora, Neil M. ;
    Basavaraju, Sridhar V.
    7 24 2013 | JAMA. 310(4):398-407
    IMPORTANCEThe rabies virus causes a fatal encephalitis and can be transmitted through tissue or organ transplantation. In February 2013, a kidney recipient with no reported exposures to potentially rabid animals died from rabies 18 months after transplantation.OBJECTIVESTo investigate whether organ transplantation was the source of rabies virus exp ...
    Supporting Files
  • Publication practices and attitudes towards evidencebased medicine in central Asia
    Publication practices and attitudes towards evidence-based medicine in central Asia
    Yamshchikov, Galina V ;
    Schmid, George P
    Jul 24 2013 | Lancet Glob Health. 1(2):e73-e74.
    No Description
    Supporting Files
  • injury
    injury
    Kuklina, Elena V. ;
    Hagen, Ellen Merete
    Jul 24 2013 | Neurology. 2013; 81(8):700-701.
    No Description
    Supporting Files
  • Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma
    Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma
    Shoffstall, Andrew J. ;
    Everhart, Lydia M.
    Jul 24 2013 | Biomacromolecules. 14(8):2790-2797.
    Targeted nanoparticles are being pursued for a range of medical applications. Here we utilized targeted nanoparticles (synthetic platelets) to halt bleeding in acute trauma. One of the major questions that arises in the field is the role of surface ligand density in targeted nanoparticles' performance. We developed intravenous hemostatic nanopartic ...
    Supporting Files
  • Linking TimeVarying Symptomatology and Intensity of Infectiousness to Patterns of Norovirus Transmission
    Linking Time-Varying Symptomatology and Intensity of Infectiousness to Patterns of Norovirus Transmission
    Zelner, Jonathan L. ;
    Lopman, Benjamin A.
    Jul 24 2013
    BackgroundNorovirus (NoV) transmission may be impacted by changes in symptom intensity. Sudden onset of vomiting, which may cause an initial period of hyper-infectiousness, often marks the beginning of symptoms. This is often followed by: a 1–3 day period of milder symptoms, environmental contamination following vomiting, and post-symptomatic shedd ...
    Supporting Files Public Domain
  • Safety in Numbers Are Major Cities the Safest Places in the United States
    Safety in Numbers: Are Major Cities the Safest Places in the United States?
    Myers, Sage R. ;
    Branas, Charles C.
    Jul 23 2013 | Ann Emerg Med. 2013; 62(4):408-418.e3.
    Study objectivesMany US cities have experienced population reductions, often blamed on crime and interpersonal injury. Yet the overall injury risk in urban areas compared with suburban and rural areas has not been fully described. We begin to investigate this evidence gap by looking specifically at injury-related mortality risk, determining the ris ...
    Supporting Files
  • Local illness concepts and their relevance for the prevention and control of malaria during pregnancy in Ghana Kenya and Malawi findings from a comparative qualitative study
    Local illness concepts and their relevance for the prevention and control of malaria during pregnancy in Ghana, Kenya and Malawi: findings from a comparative qualitative study
    Menaca, Arantza ;
    Pell, Christopher
    Jul 22 2013 | Malar J. 2013; 12:257.
    BackgroundIn sub-Saharan Africa, the burden of morbidity and mortality linked to malaria during pregnancy (MiP) is significant and compounded by its unclear symptoms and links with other health problems during pregnancy. Mindful of the biomedical and social complexity of MiP, this article explores and compares local understandings of MiP and their ...
    Supporting Files Public Domain
  • Biodiesel versus diesel exposure Enhanced pulmonary inflammation oxidative stress and differential morphological changes in the mouse lung
    Biodiesel versus diesel exposure: Enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung
    Yanamala, Naveena ;
    Hatfield, Meghan K.
    Jul 22 2013 | Toxicol Appl Pharmacol. 272(2):373-383
    The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable approach to reduce occupational and environmental exposures to particulate matter (PM). Due to its lower particulate mass emissions compared to D, use of BD is thought to alleviate adverse health effects. Considering BD fuel is mainly composed of unsatura ...
    Supporting Files
  • Childhood Intussusception A Literature Review
    Childhood Intussusception: A Literature Review
    Jiang, James ;
    Jiang, Baoming
    Jul 22 2013 | PLoS One. 2013; 8(7).
    BackgroundPostlicensure data has identified a causal link between rotavirus vaccines and intussusception in some settings. As rotavirus vaccines are introduced globally, monitoring intussusception will be crucial for ensuring safety of the vaccine programs.MethodsTo obtain updated information on background rates and clinical management of intussusc ...
    Supporting Files Public Domain
  • First Detection of Heartland Virus Bunyaviridae Phlebovirus from Field Collected Arthropods
    First Detection of Heartland Virus (Bunyaviridae: Phlebovirus) from Field Collected Arthropods
    Savage, Harry M. ;
    Godsey, Marvin S.
    Jul 22 2013 | Am J Trop Med Hyg. 2013; 89(3):445-452.
    Heartland virus (HRTV), the first pathogenic Phlebovirus (Family: Bunyaviridae) discovered in the United States, was recently described from two Missouri farmers. In 2012, we collected 56,428 ticks representing three species at 12 sites including both patients' farms. Amblyomma americanum and Dermacentor variabilis accounted for nearly all ticks co ...
    Supporting Files Public Domain
  • DNA targeting specificity of RNAguided Cas9 nucleases
    DNA targeting specificity of RNA-guided Cas9 nucleases
    Hsu, Patrick D. ;
    Scott, David A.
    Jul 21 2013 | Nat Biotechnol. 2013; 31(9):827-832.
    The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs (sgRNAs) to enable genome editing. Here, we characterize SpCas9 targeting specificity in human cells to inform the selection of target sites and avoid off-target effects. Our study evaluates >700 guide RNA variants and SpCas9- ...
    Supporting Files
  • Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain
    Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain
    Winter, Jaclyn M. ;
    Chiou, Grace
    7 19 2013 | Org Lett. 15(14):3774-3777
    A strategy for introducing structural diversity into polyketides by exploiting the promiscuity of an in-line methyltransferase domain in a multidomain polyketide synthase is reported. In vitro investigations using the highly-reducing fungal polyketide synthase CazF revealed that its methyltransferase domain accepts the nonnatural cofactor propargyl ...
    Supporting Files
  • Low Power Upconverted NearIR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release
    Low Power Upconverted Near-IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release
    Viger, Mathieu L. ;
    Grossman, Madeleine
    7 19 2013 | Adv Mater. 25(27):3733-3738
    By encapsulating NaYF4 :Tm.Yb upconverting nanocrystals in UV-degradable polymer capsules, it is possible to access efficient polymer photodegradation and remotely controlled release using near-IR laser light at an unprecedentedly low power.
    Supporting Files
  • Association of Early Age at Establishment of Chronic Hepatitis B Infection with Persistent Viral Replication Liver Cirrhosis and Hepatocellular Carcinoma A Systematic Review
    Association of Early Age at Establishment of Chronic Hepatitis B Infection with Persistent Viral Replication, Liver Cirrhosis and Hepatocellular Carcinoma: A Systematic Review
    Shimakawa, Yusuke ;
    Yan, Hong-Jing
    Jul 19 2013 | PLoS One. 2013; 8(7).
    Age at infection with hepatitis B virus (HBV) is a known risk factor for chronic HBV infection. However, in addition, there is some evidence that early age at infection further increases the risk of primary liver cancer beyond its association with increased risk of chronic infection. This systematic review of observational studies assesses the asso ...
    Supporting Files Public Domain
  • A randomized trial of artemetherlumefantrine and dihydroartemisininpiperaquine in the treatment of uncomplicated malaria among children in western Kenya
    A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya
    Agarwal, Aarti ;
    McMorrow, Meredith
    Jul 19 2013 | Malar J. 2013; 12:254.
    BackgroundArtemether-lumefantrine (AL) was adopted as first-line treatment for uncomplicated malaria in Kenya in 2006. Monitoring drug efficacy at regular intervals is essential to prevent unnecessary morbidity and mortality. The efficacy of AL and dihydroartemisinin-piperaquine (DP) were evaluated for the treatment of uncomplicated malaria in chil ...
    Supporting Files Public Domain
  • Occupational Carbon Monoxide Fatalities in the US From Unintentional NonFire Related Exposures 19922008
    Occupational Carbon Monoxide Fatalities in the US From Unintentional Non-Fire Related Exposures, 1992–2008
    Henn, Scott A. ;
    Bell, Jennifer L.
    Jul 19 2013 | Am J Ind Med. 56(11):1280-1289.
    ObjectiveTo analyze characteristics of, and trends in, work-related carbon monoxide (CO) fatalities in the US.MethodsRecords of unintentional, non-fire related fatalities from CO exposure were extracted from the Bureau of Labor Statistics’ Census of Fatal Occupational Injuries and the Occupational Safety and Health Administration’s Integrated Manag ...
    Supporting Files
  • Antimalarial prescription practices among outpatients with laboratoryconfirmed malaria in the setting of a health facilitybased sentinel site surveillance system in Uganda
    Anti-malarial prescription practices among outpatients with laboratory-confirmed malaria in the setting of a health facility-based sentinel site surveillance system in Uganda
    Sears, David ;
    Kigozi, Ruth
    Jul 19 2013 | Malar J. 2013; 12:252.
    BackgroundMost African countries have adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. The World Health Organization now recommends limiting anti-malarial treatment to those with a positive malaria test result. Limited data exist on how these policies have affected ACT prescription practices ...
    Supporting Files
22801 - 22820 / 27884