Biodiesel versus diesel exposure: Enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

Details

• Alternative Title:
  Toxicol Appl Pharmacol
• Personal Author:
  Yanamala, Naveena ; Hatfield, Meghan K. ; Farcas, Mariana T. ; Schwegler-Berry, Diane ; Hummer, Jon A. ; Shurin, Michael R. ; Birch, M. Eileen ; Gutkin, Dmitriy W. ; Kisin, Elena ; Kagan, Valerian E. ; Bugarski, Aleksandar D. ; Shvedova, Anna A.
• Description:
  The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable approach to reduce occupational and environmental exposures to particulate matter (PM). Due to its lower particulate mass emissions compared to D, use of BD is thought to alleviate adverse health effects. Considering BD fuel is mainly composed of unsaturated fatty acids, we hypothesize that BD exhaust particles could induce pronounced adverse outcomes, due to their ability to readily oxidize. The main objective of this study was to compare the effects of particles generated by engine fueled with neat BD and neat petroleum-based D. Biomarkers of tissue damage and inflammation were significantly elevated in lungs of mice exposed to BD particulates. Additionally, BD particulates caused a significant accumulation of oxidatively modified proteins and an increase in 4-hydroxynonenal. The up-regulation of inflammatory cytokines/chemokines/growth factors was higher in lungs upon BD particulate exposure. Histological evaluation of lung sections indicated presence of lymphocytic infiltrate and impaired clearance with prolonged retention of BD particulate in pigment laden macrophages. Taken together, these results clearly indicate that BD exhaust particles could exert more toxic effects compared to D.
• Subjects:
  Animals Article Aspiration Exposure Biodiesel Particle Retention Biofuels Bronchoalveolar Lavage Fluid Cytokine Panel Cytokines Female Gasoline Inflammation Lipid Droplets Lung Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Oxidative Stress Particulate Matter Pneumonia Pulmonary Toxicity Vehicle Emissions

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• Source:
  Toxicol Appl Pharmacol. 272(2):373-383
• Pubmed ID:
  23886933
• Pubmed Central ID:
  PMC4664159
• Document Type:
  Journal Article
• Funding:
  R01 HL070755/HL/NHLBI NIH HHS/United States ; R01 ES-019304/ES/NIEHS NIH HHS/United States ; R01 OH008282/OH/NIOSH CDC HHS/United States ; U19 AI068021/AI/NIAID NIH HHS/United States ; OH008282/OH/NIOSH CDC HHS/United States ; CC999999/Intramural CDC HHS/United States ; HL-070755/HL/NHLBI NIH HHS/United States ; U19 AI-068021/AI/NIAID NIH HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States
• Volume:
  272
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:073a7e4fba4ee273053fb016b5c523b9e9ac549612f80cc1ec61f678b39037d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/36243/cdc_36243_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]