Details:

Alternative Title:
Am J Trop Med Hyg
Publisher's site:
http://dx.doi.org/10.4269/ajtmh.13-0209
Personal Author:
Savage, Harry M. ; Godsey, Marvin S. ; Lambert, Amy ; Panella, Nicholas A. ; Burkhalter, Kristen L. ; ... More +
Savage, Harry M. ; Godsey, Marvin S. ; Lambert, Amy ; Panella, Nicholas A. ; Burkhalter, Kristen L. ; Harmon, Jessica R. ; Lash, R. Ryan ; Ashley, David C. ; Nicholson, William L. ; Less -
Description:
Heartland virus (HRTV), the first pathogenic Phlebovirus (Family: Bunyaviridae) discovered in the United States, was recently described from two Missouri farmers. In 2012, we collected 56,428 ticks representing three species at 12 sites including both patients' farms. Amblyomma americanum and Dermacentor variabilis accounted for nearly all ticks collected. Ten pools composed of deplete nymphs of A. americanum collected at a patient farm and a nearby conservation area were reverse transcription-polymerase chain reaction positive, and eight pools yielded viable viruses. Sequence data from the nonstructural protein of the Small segment indicates that tick strains and human strains are very similar, ≥ 97.6% sequence identity. This is the first study to isolate HRTV from field-collected arthropods and to implicate ticks as potential vectors. Amblyomma americanum likely becomes infected by feeding on viremic hosts during the larval stage, and transmission to humans occurs during the spring and early summer when nymphs are abundant and actively host seeking.
Subject:
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Animals
Arachnid Vectors
Articles
Dermacentor
Humans
Ixodidae
Missouri
Nymph
Phlebovirus
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Sequence Analysis, DNA

Source:
Am J Trop Med Hyg. 2013 ; 89(3):445-452.;
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:056e8ad0d2e38170d011194b8ffc5ffb81c2518df1bc47f09007c7feaa8087be
File Type:

Supporting Files

• 	license.txt	txt
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  	tropmed-89-445-g001.jpg	jpeg
  	tropmed-89-445-g002.gif	gif
  	tropmed-89-445-g002.jpg	jpeg
  	tropmed-89-445.nxml	txt

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