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Emerging Infectious Diseases
Emerging Infectious Diseases (EID) is a peer-reviewed, monthly journal published by the Centers for Disease Control and Prevention (CDC). It offers the latest scientific information on emerging infectious diseases and trends. Emerging Infectious Diseases is freely available to the public as Diamond Open Access. For more on EID, visit https://wwwnc.cdc.gov/eid.
We report a case of human herpesvirus 6 (HHV-6) encephalomyelitis in an immunocompetent patient, which was confirmed by viral amplification from cerebrospinal fluid. Cidofovir was used, followed by ganciclovir, because of an adverse effect to probenecid. The patient recovered. HHV-6 should be recognized as one of the causes of encephalomyelitis.
Supporting FilesPublic Domain
Denes, E., Magy, L., Pradeau, K., Alain, S., Weinbreck, P., & Ranger-Rogez, S. (2004). Successful Treatment of Human Herpesvirus 6 Encephalomyelitis in Immunocompetent Patient. https://stacks.cdc.gov/view/cdc/14445
Denes, Eric, Laurent Magy, Karine Pradeau, Sophie Alain, Pierre Weinbreck, and Sylvie Ranger-Rogez. Successful Treatment of Human Herpesvirus 6 Encephalomyelitis in Immunocompetent Patient. 2004. https://stacks.cdc.gov/view/cdc/14445.
Denes, Eric, et al. Successful Treatment of Human Herpesvirus 6 Encephalomyelitis in Immunocompetent Patient. 2004, Stacks. https://stacks.cdc.gov/view/cdc/14445.
To determine whether maternal placental malaria is associated with an increased risk for perinatal mother-to-child HIV transmission (MTCT), we studied HIV-positive women in western Kenya. We enrolled 512 mother-infant pairs; 128 (25.0%) women had placental malaria, and 102 (19.9%) infants acquired HIV perinatally. Log10 HIV viral load and episiotom
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Supporting FilesPublic Domain
Ayisi, J. G., van Eijk, A. M., Newman, R. D., ter Kuile, F. O., Shi, Y. P., Yang, C., Kolczak, M. S., Otieno, J. A., Misore, A. O., Kager, P. A., Lal, R. B., Steketee, R. W., & Nahlen, B. L. (2004). Maternal Malaria and Perinatal HIV Transmission, Western Kenya1,2. https://stacks.cdc.gov/view/cdc/7717
Ayisi, John G., Anna M. van Eijk, Robert D. Newman, Feiko O. ter Kuile, Ya Ping Shi, Chunfu Yang, and Margarette S. Kolczak, et al.. Maternal Malaria and Perinatal HIV Transmission, Western Kenya1,2. 2004. https://stacks.cdc.gov/view/cdc/7717.
Subtypes, defined by variation in the outer membrane protein PorA, are an integral part of the characterization scheme for Neisseria meningitidis. Identification of these variants remains important as the PorA protein is a major immunogenic component of several meningococcal vaccines under development, and characteristics of PorA are used to provid
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Supporting FilesPublic Domain
Russell, J. E., Jolley, K. A., Feavers, I. M., Maiden, M. C. J., & Suker, J. (2004). PorA Variable Regions of Neisseria meningitidis. https://stacks.cdc.gov/view/cdc/14313
Russell, Joanne E., Keith A. Jolley, Ian M. Feavers, Martin C. J. Maiden, and Janet Suker. PorA Variable Regions of Neisseria meningitidis. 2004. https://stacks.cdc.gov/view/cdc/14313.
We document effects of West Nile virus (WNV) on American Crows. More than two thirds of our crows died of WNV infection, peaking when the proportion of infected mosquitoes at roosts was greatest. WNV antibody prevalence in crows was low. Local ecologic effects can be dramatic as WNV inhabits new areas.
Supporting Files
Yaremych, S. A., Warner, R. E., Mankin, P. C., Brawn, J. D., Raim, A., & Novak, R. (2004). West Nile Virus and High Death Rate in American Crows. http://dx.doi.org/10.3201/eid1004.030499
Yaremych, Sarah A., Richard E. Warner, Phil C. Mankin, Jeff D. Brawn, Arlo Raim, and Robert Novak. West Nile Virus and High Death Rate in American Crows. 2004. http://dx.doi.org/10.3201/eid1004.030499.
Approximately 21,700 seals died during a morbillivirus epidemic in northwestern Europe in 2002. Phocine distemper virus 1 was isolated from seals in German waters. The sequence of the P gene showed 97% identity with the Dutch virus isolated in 1988. There was 100% identity with the Dutch isolate from 2002 and a single nucleotide mismatch with the D
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Supporting FilesPublic Domain
Müller, G., Wohlsein, P., Beineke, A., Haas, L., Greiser-Wilke, I., Siebert, U., Fonfara, S., Harder, T., Stede, M., Gruber, A., & Baumgärtner, W. (2004). Phocine Distemper in German Seals, 2002. https://stacks.cdc.gov/view/cdc/14446
Müller, Gundi, Peter Wohlsein, Andreas Beineke, Ludwig Haas, Irene Greiser-Wilke, Ursula Siebert, and Sonja Fonfara, et al.. Phocine Distemper in German Seals, 2002. 2004. https://stacks.cdc.gov/view/cdc/14446.
Severe acute respiratory syndrome (SARS) is an infectious disease caused by a newly identified human coronavirus (SARS-CoV). Currently, no effective drug exists to treat SARS-CoV infection. In this study, we investigated whether a panel of commercially available antiviral drugs exhibit in vitro anti-SARS-CoV activity. A drug-screening assay that sc
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Supporting FilesPublic Domain
Tan, E. L., Ooi, E. E., Lin, C. Y., Tan, H. C., Ling, A. E., Lim, B., & Stanton, L. W. (2004). Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs. https://stacks.cdc.gov/view/cdc/14395
Tan, Emily L.C., Eng Eong Ooi, Chin-Yo Lin, Hwee Cheng Tan, Ai Ee Ling, Bing Lim, and Lawrence W. Stanton. Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs. 2004. https://stacks.cdc.gov/view/cdc/14395.
Tan, Emily L.C., et al. Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs. 2004, Stacks. https://stacks.cdc.gov/view/cdc/14395.
Global evaluation of influenza vaccination in children indicates that current recommendations are not followed. Most children at high risk for influenza-related complications do not receive the vaccine, and increased efforts are needed to protect them. Furthermore, vaccinating healthy infants 6-23 months of age and their close contacts should be st
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Murphy, F. A., Calisher, C. H., Tesh, R. B., & Walker, D. H. (2004). In Memoriam Robert Ellis Shope 1929–2004. https://stacks.cdc.gov/view/cdc/14613
Murphy, Frederick A., Charles H. Calisher, Robert B. Tesh, and David H. Walker. In Memoriam Robert Ellis Shope 1929–2004. 2004. https://stacks.cdc.gov/view/cdc/14613.
We describe a pilot study that attempted to infect human volunteers with Cyclospora cayetanensis. Seven healthy volunteers ingested an inoculum of Cyclospora oocysts (approximately 200-49,000 oocysts). The volunteers did not experience symptoms of gastroenteritis, and no oocysts were detected in any stool samples during the 16 weeks volunteers were
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Supporting FilesPublic Domain
Alfano-Sobsey, E. M., Eberhard, M. L., Seed, J. R., Weber, D. J., Won, K. Y., Nace, E. K., & Moe, C. L. (2004). Human Challenge Pilot Study with Cyclospora cayetanensis. https://stacks.cdc.gov/view/cdc/7718
Alfano-Sobsey, Edith M., Mark L. Eberhard, John R. Seed, David J. Weber, Kimberly Y. Won, Eva K. Nace, and Christine L. Moe. Human Challenge Pilot Study with Cyclospora cayetanensis. 2004. https://stacks.cdc.gov/view/cdc/7718.
Ixodes scapularis (deer ticks) from Maine were tested for multiple infections by polymerase chain reaction and immunofluorescence. In 1995, 29.5%, 9.5%, and 1.9% of deer ticks were infected with Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti, respectively. In 1996 and 1997, the number of A. phagocytophilum-infected ticks marke
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Supporting Files
Holman, M. S., Caporale, D. A., Goldberg, J., Lacombe, E., Lubelczyk, C., Rand, P. W., & Smith, R. P. (2004). Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, Southern Coastal Maine. http://dx.doi.org/10.3201/eid1004.030566
Holman, Mary S., Diane A. Caporale, John Goldberg, Eleanor Lacombe, Charles Lubelczyk, Peter W. Rand, and Robert P. Smith. Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, Southern Coastal Maine. 2004. http://dx.doi.org/10.3201/eid1004.030566.
Holman, Mary S., et al. Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, Southern Coastal Maine. 2004, Stacks. http://dx.doi.org/10.3201/eid1004.030566.
Approximately 6,000 cases of cutaneous leishmaniasis are reported annually in Colombia, a greater than twofold increase since the 1980s. Such reports certainly underestimate true incidence, and their geographic distribution is likely biased by local health service effectiveness. We investigated how well freely available environmental data explain t
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Supporting FilesPublic Domain
King, R. J., Campbell-Lendrum, D. H., & Davies, C. R. (2004). Predicting Geographic Variation in Cutaneous Leishmaniasis, Colombia. https://stacks.cdc.gov/view/cdc/7713
King, Raymond J., Diarmid H. Campbell-Lendrum, and Clive R. Davies. Predicting Geographic Variation in Cutaneous Leishmaniasis, Colombia. 2004. https://stacks.cdc.gov/view/cdc/7713.
King, Raymond J., et al. Predicting Geographic Variation in Cutaneous Leishmaniasis, Colombia. 2004, Stacks. https://stacks.cdc.gov/view/cdc/7713.
Procop, G. W., Yen-Lieberman, B., Prayson, R. A., & Gordon, S. M. (2004). Mollaret-like Cells in Patients with West Nile Virus Infection. https://stacks.cdc.gov/view/cdc/14500
Procop, Gary W., Belinda Yen-Lieberman, Richard A. Prayson, and Steve M. Gordon. Mollaret-like Cells in Patients with West Nile Virus Infection. 2004. https://stacks.cdc.gov/view/cdc/14500.
In 2001, Myanmar (Burma) had its largest outbreak of dengue-15,361 reported cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), including 192 deaths. That year, 95% of dengue viruses isolated from patients were serotype 1 viruses belonging to two lineages that had diverged from an earlier, now extinct, lineage sometime before 1998. T
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Supporting FilesPublic Domain
Thu, H. M., Lowry, K., Myint, T. T., Shwe, T. N., Han, A. M., Khin, K. K., Thant, K. Z., Thein, S., & Aaskov, J. (2004). Myanmar Dengue Outbreak Associated with Displacement of Serotypes 2, 3, and 4 by Dengue 1. https://stacks.cdc.gov/view/cdc/14300
Thu, Hlaing Myat, Kym Lowry, Thein Thein Myint, Than Nu Shwe, Aye Maung Han, Kyu Kyu Khin, Kyaw Zin Thant, Soe Thein, and John Aaskov. Myanmar Dengue Outbreak Associated with Displacement of Serotypes 2, 3, and 4 by Dengue 1. 2004. https://stacks.cdc.gov/view/cdc/14300.
Thu, Hlaing Myat, et al. Myanmar Dengue Outbreak Associated with Displacement of Serotypes 2, 3, and 4 by Dengue 1. 2004, Stacks. https://stacks.cdc.gov/view/cdc/14300.
Recent studies have associated human metapneu-movirus (HMPV) infection in children with respiratory disease of similar severity as respiratory syncytial virus (RSV) infection. We studied 668 banked swab specimens (one per admission) collected from a population-based, prospective study of acute respiratory illness among inpatient children from two U
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Supporting Files
Mullins, J. A., Erdman, D. D., Weinberg, G. A., Edwards, K., Hall, C. B., Walker, F. J., Iwane, M., & Anderson, L. J. (2004). Human Metapneumovirus Infection among Children Hospitalized with Acute Respiratory Illness. http://dx.doi.org/10.3201/eid1004.030555
Mullins, James A., Dean D. Erdman, Geoffrey A. Weinberg, Kathryn Edwards, Caroline B. Hall, Frances J. Walker, Marika Iwane, and Larry J. Anderson. Human Metapneumovirus Infection among Children Hospitalized with Acute Respiratory Illness. 2004. http://dx.doi.org/10.3201/eid1004.030555.
Mullins, James A., et al. Human Metapneumovirus Infection among Children Hospitalized with Acute Respiratory Illness. 2004, Stacks. http://dx.doi.org/10.3201/eid1004.030555.
Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxo- viridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups on the basis of genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been descri
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Supporting FilesPublic Domain
van den Hoogen, B. G., Herfst, S., Sprong, L., Cane, P. A., Forleo-Neto, E., de Swart, R. L., Osterhaus, A. D., & Fouchier, R. A. (2004). Antigenic and Genetic Variability of Human Metapneumoviruses. https://stacks.cdc.gov/view/cdc/14365
van den Hoogen, Bernadette G., Sander Herfst, Leo Sprong, Patricia A. Cane, Eduardo Forleo-Neto, Rik L. de Swart, Albert D.M.E. Osterhaus, and Ron A.M. Fouchier. Antigenic and Genetic Variability of Human Metapneumoviruses. 2004. https://stacks.cdc.gov/view/cdc/14365.
van den Hoogen, Bernadette G., et al. Antigenic and Genetic Variability of Human Metapneumoviruses. 2004, Stacks. https://stacks.cdc.gov/view/cdc/14365.
Most reported U.S. zoonotic cases of babesiosis have occurred in the Northeast and been caused by Babesia microti. In Washington State, three cases of babesiosis have been reported previously, which were caused by WA1 (for "Washington 1")-type parasites. We investigated a case of babesiosis in Washington in an 82-year-old man whose spleen had been
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Supporting FilesPublic Domain
Herwaldt, B. L., de Bruyn, G., Pieniazek, N. J., Homer, M., Lofy, K. H., Slemenda, S. B., Fritsche, T. R., Persing, D. H., & Limaye, A. P. (2004). Babesia divergens–like Infection, Washington State. https://stacks.cdc.gov/view/cdc/7719
Herwaldt, Barbara L., Guy de Bruyn, Norman J. Pieniazek, Mary Homer, Kathryn H. Lofy, Susan B. Slemenda, Thomas R. Fritsche, David H. Persing, and Ajit P. Limaye. Babesia divergens–like Infection, Washington State. 2004. https://stacks.cdc.gov/view/cdc/7719.
The economics of preventing hospital-acquired infections is most often described in general terms. The underlying concepts and mechanisms are rarely made explicit but should be understood for research and policy-making. We define the key economic concepts and specify an illustrative model that uses hypothetical data to identify how two related ques
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Migliori, G. B., Centis, R., Fattorini, L., Besozzi, G., Saltini, C., Scarparo, C., Cirillo, D., Gori, A., Cassone, A., & Piersimoni, C. (2004). Mycobacterium tuberculosis Complex Drug Resistance in Italy. https://stacks.cdc.gov/view/cdc/14471
Migliori, Giovanni B., Rosella Centis, Lanfranco Fattorini, Giorgio Besozzi, Cesare Saltini, Claudio Scarparo, Daniela Cirillo, A. Gori, Antonio Cassone, and Claudio Piersimoni. Mycobacterium tuberculosis Complex Drug Resistance in Italy. 2004. https://stacks.cdc.gov/view/cdc/14471.
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