Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs

Tan, Emily L.C.; Ooi, Eng Eong; Lin, Chin-Yo; Tan, Hwee Cheng; Ling, Ai Ee; Lim, Bing; Stanton, Lawrence W.

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Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs

Published Date:

Apr 2004

Source:

Emerg Infect Dis. 10(4):581-586.

[PDF-131.59 KB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

Tan, Emily L.C. ; Ooi, Eng Eong ; Lin, Chin-Yo ; Tan, Hwee Cheng ; Ling, Ai Ee ; ... More ▼

Description:

Severe acute respiratory syndrome (SARS) is an infectious disease caused by a newly identified human coronavirus (SARS-CoV). Currently, no effective drug exists to treat SARS-CoV infection. In this study, we investigated whether a panel of commercially available antiviral drugs exhibit in vitro anti-SARS-CoV activity. A drug-screening assay that scores for virus-induced cytopathic effects on cultured cells was used. Tested were 19 clinically approved compounds from several major antiviral pharmacologic classes: nucleoside analogs, interferons, protease inhibitors, reverse transcriptase inhibitors, and neuraminidase inhibitors. Complete inhibition of cytopathic effects of SARS-CoV in culture was observed for interferon subtypes, b-1b, a-n1, a-n3, and human leukocyte interferon a. These findings support clinical testing of approved interferons for the treatment of SARS.

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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