Antigenic and Genetic Variability of Human Metapneumoviruses

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  van den Hoogen, Bernadette G. ; Herfst, Sander ; Sprong, Leo ; Cane, Patricia A. ; Forleo-Neto, Eduardo ; de Swart, Rik L. ; Osterhaus, Albert D.M.E. ; Fouchier, Ron A.M.
• Description:
  Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxo- viridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups on the basis of genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set of available sequences. We address the antigenic relationship between genetic lineages in virus neutralization assays. In addition, we analyzed the genetic diversity of HMPV by phylogenetic analysis of sequences obtained for part of the fusion protein (n = 84) and the complete attachment protein open reading frames (n = 35). On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined. Each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences.
• Subjects:
  Amino Acid Sequence Genetic Variation HN Protein Humans Metapneumovirus Molecular Sequence Data Open Reading Frames Phylogeny Viral Envelope Proteins Viral Fusion Proteins Viral Vaccines

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• Source:
  Emerg Infect Dis. 10(4):658-666.
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c31a8298e4de30dc5b1322b307c6d483b277d1dcc14262973ff35339a2a97b8c
• Download URL:
  https://stacks.cdc.gov/view/cdc/14365/cdc_14365_DS1.pdf
• File Type:
  [PDF - 532.76 KB ]