Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
van den Hoogen, Bernadette G. ; Herfst, Sander ; Sprong, Leo ; Cane, Patricia A. ; Forleo-Neto, Eduardo ; ... More +
van den Hoogen, Bernadette G. ; Herfst, Sander ; Sprong, Leo ; Cane, Patricia A. ; Forleo-Neto, Eduardo ; de Swart, Rik L. ; Osterhaus, Albert D.M.E. ; Fouchier, Ron A.M. Less -
Description:
Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxo- viridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups on the basis of genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set of available sequences. We address the antigenic relationship between genetic lineages in virus neutralization assays. In addition, we analyzed the genetic diversity of HMPV by phylogenetic analysis of sequences obtained for part of the fusion protein (n = 84) and the complete attachment protein open reading frames (n = 35). On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined. Each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences.
Subject:
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Amino Acid Sequence
Antigenic Variability
Attachment Protein
Fusion Protein
Genetic Variability
Genetic Variation
HN Protein
Human Metapneumovirus
Humans
Metapneumovirus
Molecular Sequence Data
Open Reading Frames
Paramyxoviridae
Phylogeny
Pneumovirinae
Research
Serotypes
Viral Envelope Proteins
Viral Fusion Proteins
Viral Vaccines

Source:
Emerg Infect Dis. 10(4):658-666.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:c31a8298e4de30dc5b1322b307c6d483b277d1dcc14262973ff35339a2a97b8c
File Type:

Supporting Files

• 	license.txt	txt
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