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Showing 1621 - 1640 of 1966 results

Molecular characterization and experimental utility of monoclonal antibodies with specificity for aliphatic di- and polyisocyanates.

Liu J ;

Wisnewski AV

2020/06/19 | National Institute for Occupational Safety and Health (NIOSH)

Aliphatic di- and polyisocyanates are crucial chemical ingredients in many industrial processes and are a well-recognized cause of occupational asthma. Serologic detection of "chemical epitopes" in biological samples could serve as an exposure surveillance approach toward disease prevention, and thus we sought to generate aliphatic isocyanate-speci ...

12/01/2025

Title : Molecular characterization and experimental utility of monoclonal antibodies with specificity for aliphatic di- and polyisocyanates. Personal Author(s) : Liu J;Wisnewski AV; Published Date : 2020/06/19 Pages in Document : 66-73 URL : https://stacks.cdc.gov/view/cdc/249351 Liu J and Wisnewski AV (2020). Molecular characterization and experimental utility of monoclonal antibodies with specificity for aliphatic di- and polyisocyanates.. 39(3). Liu J and Wisnewski AV "Molecular characterization and experimental utility of monoclonal antibodies with specificity for aliphatic di- and polyisocyanates." 39, no. 3 (2020) Liu J and Wisnewski AV "Molecular characterization and experimental utility of monoclonal antibodies with specificity for aliphatic di- and polyisocyanates." vol. 39, no. 3, 2020 Export RIS Citation Information. TY - Journal Article AU - Liu J AU - Wisnewski AV AB - Aliphatic di- and polyisocyanates are crucial chemical ingredients in many industrial processes and are a well-recognized cause of occupational asthma. Serologic detection of "chemical epitopes" in biological samples could serve as an exposure surveillance approach toward disease prevention, and thus we sought to generate aliphatic isocyanate-specific monoclonal antibodies (mAbs). Three hybridomas were generated from Balb/c mice immunized with a commercial product containing a combination of uretdione, homopolymer, and monomeric forms of hexamethylene diisocyanate (HDI). Three stable hybridomas were subcloned by limiting dilution, two secreting IgG1? and one secreting IgM? mAb that bind aliphatic di- and polyisocyanates (conjugated to albumin), but not aromatic toluene or methylene diphenyl diisocyanate (TDI or MDI). Each mAb demonstrates slight differences in epitope specificity, for example, recognition of hydrogenated MDI (HMDI) or different carrier proteins (transferrin, actin) reacted with vapor phase HDI, and is encoded by unique recombination of different germline antibody genes, with distinct complementary determining regions. By western blot, all three mAbs detect a molecule with characteristics of an albumin adduct uniquely in urine from mice skin exposed to a mixture of aliphatic di- and polyisocyanate. Together, the data define molecular determinants of humoral immune recognition of aliphatic di- and polyisocyanates through new mAbs, which will serve as useful research reagents and may be applicable to future exposure surveillance efforts. [Description provided by NIOSH] AN - cdc:249351 IS - 3 KW - Animals KW - Antibodies KW - Asthma, Occupational KW - Isocyanates KW - Occupational Exposure KW - Occupational Health KW - Safety KW - Diisocyanates; Occupational asthma; Chemicals; Industrial exposures; Biological monitoring; Antibody response; Animal studies; Molecular epidemiology; Hexamethylene diisocyanate; KW - Author Keywords: diisocyanate; aliphatic; aromatic; hexamethylene; uretdione; homopolymer KW - Animals KW - Antibodies KW - Asthma, Occupational KW - Isocyanates KW - Occupational Exposure KW - Occupational Health KW - Safety LA - eng PY - 2020/06/19 TI - Molecular characterization and experimental utility of monoclonal antibodies with specificity for aliphatic di- and polyisocyanates. VL - 39 UR - https://stacks.cdc.gov/view/cdc/249351 ER -
Total Worker Health: implications for the occupational health nurse.

Burns C ;

Campbell K

2015/07/17 | National Institute for Occupational Safety and Health (NIOSH)

Total Worker HealthTM is defined as a "strategy integrating occupational safety and health protection with health promotion to prevent worker injury and illness and to advance worker health and well-being." This strategy aligns workplace safety with individual behaviors that support healthy lifestyles. The Patient Protection and Affordable Care Act ...

12/01/2025

Title : Total Worker Health: implications for the occupational health nurse. Personal Author(s) : Burns C;Campbell K; Published Date : 2015/07/17 Pages in Document : 316-319 URL : https://stacks.cdc.gov/view/cdc/249350 Burns C and Campbell K (2015). Total Worker Health: implications for the occupational health nurse.. 63(7). Burns C and Campbell K "Total Worker Health: implications for the occupational health nurse." 63, no. 7 (2015) Burns C and Campbell K "Total Worker Health: implications for the occupational health nurse." vol. 63, no. 7, 2015 Export RIS Citation Information. TY - Journal Article AU - Burns C AU - Campbell K AB - Total Worker HealthTM is defined as a "strategy integrating occupational safety and health protection with health promotion to prevent worker injury and illness and to advance worker health and well-being." This strategy aligns workplace safety with individual behaviors that support healthy lifestyles. The Patient Protection and Affordable Care Act of 2010 presumes that incentive-oriented worksite health promotion provides a critical pathway to reduce group health costs. Because of their scientific and clinical backgrounds, professional nurses are well qualified to educate and assist individuals with healthy lifestyle choices. Occupational health nurses and patient advocates can shape wellness initiatives that best serve both employees and their employers. [Description provided by NIOSH] AN - cdc:249350 IS - 7 KW - Accident Prevention KW - Accidents KW - Behavior KW - Hazardous Substances KW - Health Promotion KW - Occupational Health KW - Preventive Medicine KW - Safety KW - Safety Management KW - Staff Development KW - Total-Worker-Health; Worker-health; Health-programs; Protective measures; Preventive measures; Health care; Health-protection; Safety-practices; Safety-programs; Behavior; Work-operations; Work-practices; Occupational-health-programs; Occupational-safety-programs; Injury-prevention; Disease-prevention; Accident-prevention; Health-hazards; Work-operations; Work-organization; KW - Author Keywords: Total Worker Health; onsite wellness KW - Accident Prevention KW - Accidents KW - Behavior KW - Hazardous Substances KW - Health Promotion KW - Occupational Health KW - Preventive Medicine KW - Safety KW - Safety Management KW - Staff Development LA - eng PY - 2015/07/17 TI - Total Worker Health: implications for the occupational health nurse. VL - 63 UR - https://stacks.cdc.gov/view/cdc/249350 ER -
Effectiveness of a federal Healthy Start Program on HIV/AIDS risk reduction among women in Hillsborough County, Florida.

Adegoke KK ;

Aliyu MH

2015/04/01 | National Institute for Occupational Safety and Health (NIOSH)

Objectives: To examine the impact of the Central Hillsborough Healthy Start Project (CHHS) on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) diagnosis rates in women in Hillsborough County, Florida. Methods: Project records were linked to hospital discharge data and vital statistics (Florida, 1998-2007; N = 1,696,221). ...

12/01/2025

Title : Effectiveness of a federal Healthy Start Program on HIV/AIDS risk reduction among women in Hillsborough County, Florida. Personal Author(s) : Adegoke KK;Aliyu MH;August E;Berry EL;de la Cruz C;Mbah A;Okwechime I;Salihu HM; Published Date : 2015/04/01 Pages in Document : 235-241 URL : https://stacks.cdc.gov/view/cdc/249349 Adegoke KK et al. (2015). Effectiveness of a federal Healthy Start Program on HIV/AIDS risk reduction among women in Hillsborough County, Florida.. 108(4). Adegoke KK et al. "Effectiveness of a federal Healthy Start Program on HIV/AIDS risk reduction among women in Hillsborough County, Florida." 108, no. 4 (2015) Adegoke KK et al. "Effectiveness of a federal Healthy Start Program on HIV/AIDS risk reduction among women in Hillsborough County, Florida." vol. 108, no. 4, 2015 Export RIS Citation Information. TY - Journal Article AU - Adegoke KK AU - Aliyu MH AU - August E AU - Berry EL AU - de la Cruz C AU - Mbah A AU - Okwechime I AU - Salihu HM AB - Objectives: To examine the impact of the Central Hillsborough Healthy Start Project (CHHS) on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) diagnosis rates in women in Hillsborough County, Florida. Methods: Project records were linked to hospital discharge data and vital statistics (Florida, 1998-2007; N = 1,696,221). The x(2) test was used to compare rates for HIV/AIDS and pregnancy-related complications for mothers within the CHHS service area with mothers in Hillsborough County and the rest of Florida. Results: During a 10-year period, HIV/AIDS diagnosis rates among women in the CHHS service area declined by 56.3% (P = 0.01). The observed decline was most evident among black women. HIV/AIDS diagnosis rates in the rest of Hillsborough County and Florida remained unchanged (P = 0.48). Conclusions: Lessons learned from the CHHS Project can be used to develop effective and comprehensive models for addressing the HIV epidemic. [Description provided by NIOSH] AN - cdc:249349 IS - 4 KW - Demography KW - Education KW - HIV KW - Occupational Health KW - Pregnancy KW - Preventive Medicine KW - Race Factors KW - Safety KW - Women KW - Humans; Women; HIV; Human Immunodeficiency Virus; AIDS; Acquired Immune Deficiency Syndrome; Pregnancy; Racial factors; Demographic characteristics; Education; Preventive measures; KW - Author Keywords: Florida; Healthy Start; HIV/AIDS prevention; trends; women KW - Demography KW - Education KW - HIV KW - Occupational Health KW - Pregnancy KW - Preventive Medicine KW - Race Factors KW - Safety KW - Women LA - eng PY - 2015/04/01 TI - Effectiveness of a federal Healthy Start Program on HIV/AIDS risk reduction among women in Hillsborough County, Florida. VL - 108 UR - https://stacks.cdc.gov/view/cdc/249349 ER -
Immigration-related stressors and health outcomes among low-wage immigrant hotel workers: a pilot study.

Li Y ;

Polick C

2022/09/01 | National Institute for Occupational Safety and Health (NIOSH)

Background: Immigrants comprise over 40% of the low-wage workforce. They are more likely to be employed in service industries, paid less, and experience more illness and injuries than their native counterparts. Design/objective: The aim of this cross-sectional pilot study was to explore the relationship between immigrant workers' stressors and heal ...

12/01/2025

Title : Immigration-related stressors and health outcomes among low-wage immigrant hotel workers: a pilot study. Personal Author(s) : Li Y;Polick C;Rosemberg M-AS; Published Date : 2022/09/01 URL : https://stacks.cdc.gov/view/cdc/249348 Li Y et al. (2022). Immigration-related stressors and health outcomes among low-wage immigrant hotel workers: a pilot study.. 39(5). Li Y and Polick C and Rosemberg M-AS "Immigration-related stressors and health outcomes among low-wage immigrant hotel workers: a pilot study." 39, no. 5 (2022) Li Y et al. "Immigration-related stressors and health outcomes among low-wage immigrant hotel workers: a pilot study." vol. 39, no. 5, 2022 Export RIS Citation Information. TY - Journal Article AU - Li Y AU - Polick C AU - Rosemberg M-AS AB - Background: Immigrants comprise over 40% of the low-wage workforce. They are more likely to be employed in service industries, paid less, and experience more illness and injuries than their native counterparts. Design/objective: The aim of this cross-sectional pilot study was to explore the relationship between immigrant workers' stressors and health. Sample: Twenty-five female Mexican immigrant hotel workers. Measurements: Surveys and blood samples were analyzed and compared to national data. Descriptive statistics and linear regression were used for analysis. Results: Longer length of stay, older age at migration, and higher Demands of Immigration (DI) were significantly associated with more chronic conditions. Higher DI were significantly associated with more depressive symptoms. This is comparable to national data (n = 468) which shows a significant relationship between length of stay, Allostatic Load (AL), and chronic conditions (Beta = 0.14, p = .043; Beta = 0.13, p = .025). Conclusions: Immigrant-specific factors affect individuals' health. More studies are needed to further explore the relationship between DI and health among foreign-born workers. [Description provided by NIOSH] AN - cdc:249348 IS - 5 KW - Emigration and Immigration KW - Healthcare Disparities KW - Household Work KW - Mental Health KW - Nervous System KW - Occupational Health KW - Safety KW - Stress, Psychological KW - Women KW - Immigrant workers; Women; Job stress; Mental health; Service industries; Housekeeping personnel; Cross sectional studies; Health disparities; KW - Author Keywords: allostatic load; health disparities; hotel workers; immigrants; Mexican immigrant; stress; worker health KW - Emigration and Immigration KW - Healthcare Disparities KW - Household Work KW - Mental Health KW - Nervous System KW - Occupational Health KW - Safety KW - Stress, Psychological KW - Women LA - eng PY - 2022/09/01 TI - Immigration-related stressors and health outcomes among low-wage immigrant hotel workers: a pilot study. VL - 39 UR - https://stacks.cdc.gov/view/cdc/249348 ER -
Impact on rats from acute intratracheal inhalation exposures to WTC dusts.

Chen L-C ;

Cohen MD

2020/04/15 | National Institute for Occupational Safety and Health (NIOSH)

Background: Studies have revealed the increased incidence of health disorders in First Responders (FR) who were at Ground Zero over the initial 72 hr after the World Trade Center (WTC) collapses. Previous studies in rats exposed to WTC dusts using exposure scenarios that mimicked FR mouthbreathing showed exposure led to altered expression of genes ...

12/01/2025

Title : Impact on rats from acute intratracheal inhalation exposures to WTC dusts. Personal Author(s) : Chen L-C;Cohen MD;Horton L;Lee H-W;Park S-H;Prophete C;Sisco M;Zelikoff J; Published Date : 2020/04/15 Pages in Document : 218-230 URL : https://stacks.cdc.gov/view/cdc/249347 Chen L-C et al. (2020). Impact on rats from acute intratracheal inhalation exposures to WTC dusts.. 32(5). Chen L-C et al. "Impact on rats from acute intratracheal inhalation exposures to WTC dusts." 32, no. 5 (2020) Chen L-C et al. "Impact on rats from acute intratracheal inhalation exposures to WTC dusts." vol. 32, no. 5, 2020 Export RIS Citation Information. TY - Journal Article AU - Chen L-C AU - Cohen MD AU - Horton L AU - Lee H-W AU - Park S-H AU - Prophete C AU - Sisco M AU - Zelikoff J AB - Background: Studies have revealed the increased incidence of health disorders in First Responders (FR) who were at Ground Zero over the initial 72 hr after the World Trade Center (WTC) collapses. Previous studies in rats exposed to WTC dusts using exposure scenarios that mimicked FR mouthbreathing showed exposure led to altered expression of genes whose products could be involved in lung ailments. Nevertheless, it was uncertain if repeated exposures (as occurred in earliest days post-disaster) might have given rise to long-term changes in the lungs/other organs, in white blood cell (WBC) profiles, and/or systemic expression of select (mostly immune-related) proteins. Methods: To examine this, rats were exposed on 2 consecutive days (2 hr/d, intratracheal inhalation) to WTC dusts and then examined over a 1-yr period thereafter. At select times post-exposure, organ (lung, heart, liver, kidney, spleen) weights, WBC profiles, and blood levels of a variety of proteins were evaluated. Results: The study showed that over the 1-yr period, there were nominal effects on organ weights (absolute, index) as a result of the dust exposures. There were significant changes (relative to in naïve rats) in WBC profiles, with exposed rats having increased monocyte-macrophage and decreased lymphocyte percentages. The study also found that dust exposure led to significant systemic increases in many proteins, including MCP-1, RANTES, MMP-9, RAGE, and Galectin-3. Conclusions: These results provide further support for our longstanding hypothesis that the WTC dusts could potentially have acted as direct inducers of many of the health effects that have been seen in the exposed FR. [Description provided by NIOSH] AN - cdc:249347 IS - 5 KW - Animals KW - Dust KW - Emergency Responders KW - Immune System KW - Occupational Health KW - Safety KW - September 11 Terrorist Attacks KW - World Trade Center; WTC; First responders; Disaster response; Gene expression; Immune reaction; Animal studies; Dust exposure; Dusts; Proteins; Health effects; KW - Author Keywords: WTC; World Trade Center; dust; heart; lung; spleen; liver; kidney; serum KW - Animals KW - Dust KW - Emergency Responders KW - Immune System KW - Occupational Health KW - Safety KW - September 11 Terrorist Attacks LA - eng PY - 2020/04/15 TI - Impact on rats from acute intratracheal inhalation exposures to WTC dusts. VL - 32 UR - https://stacks.cdc.gov/view/cdc/249347 ER -
Posttraumatic stress disorder in reserve veterans: important reintegration considerations for the occupational health nurse.

Bruns C ;

Henderson LA

2015/01/01 | National Institute for Occupational Safety and Health (NIOSH)

Posttraumatic stress disorder (PTSD) is a serious mental health concern for returning U.S. military personnel who have a higher prevalence rate of PTSD than the general population. Among the military population, reserve service members are at increased risk of developing PTSD compared with full-time active duty service members mainly due to difficu ...

12/01/2025

Title : Posttraumatic stress disorder in reserve veterans: important reintegration considerations for the occupational health nurse. Personal Author(s) : Bruns C;Henderson LA; Published Date : 2015/01/01 Pages in Document : 27-32 URL : https://stacks.cdc.gov/view/cdc/249346 Bruns C and Henderson LA (2015). Posttraumatic stress disorder in reserve veterans: important reintegration considerations for the occupational health nurse.. 63(1). Bruns C and Henderson LA "Posttraumatic stress disorder in reserve veterans: important reintegration considerations for the occupational health nurse." 63, no. 1 (2015) Bruns C and Henderson LA "Posttraumatic stress disorder in reserve veterans: important reintegration considerations for the occupational health nurse." vol. 63, no. 1, 2015 Export RIS Citation Information. TY - Journal Article AU - Bruns C AU - Henderson LA AB - Posttraumatic stress disorder (PTSD) is a serious mental health concern for returning U.S. military personnel who have a higher prevalence rate of PTSD than the general population. Among the military population, reserve service members are at increased risk of developing PTSD compared with full-time active duty service members mainly due to difficulty reintegrating into civilian life. Understanding the social risk factors along with the protective effects social support has on PTSD in veterans will provide occupational health professionals the opportunity to support reserve veterans with adjustment into post-deployment life. This literature review examines PTSD in reserve veterans, with a focus on occupational factors, social factors, guideline recommendations, available resources, as well as provides suggestions for occupational health nurses caring for reserve veterans returning to the workplace. [Description provided by NIOSH] AN - cdc:249346 IS - 1 KW - Health Personnel KW - Mental Health KW - Nervous System KW - Occupational Health KW - Risk Assessment KW - Risk Factors KW - Safety KW - PTSD; Post-traumatic stress disorder; Mental health; Military personnel; Nursing; Nurses; Psychology; Psychological stress; Psychological effects; Sociological factors; Risk factors; Guidelines; KW - Author Keywords: PTSD; posttraumatic stress disorder; veteran occupational reintegration KW - Health Personnel KW - Mental Health KW - Nervous System KW - Occupational Health KW - Risk Assessment KW - Risk Factors KW - Safety LA - eng PY - 2015/01/01 TI - Posttraumatic stress disorder in reserve veterans: important reintegration considerations for the occupational health nurse. VL - 63 UR - https://stacks.cdc.gov/view/cdc/249346 ER -
Meta-analysis of work-family conflict mean differences: does national context matter?

Allen TD ;

Dumani S

2015/10/01 | National Institute for Occupational Safety and Health (NIOSH)

Work-family conflict continues to be a topic of considerable interest to researchers and practitioners across the globe. In the current study, meta-analysis is used to compare cross-national mean differences in work-to-family conflict and family-to-work conflict across cultural, institutional, and economic aspects of context. No significant differe ...

12/01/2025

Title : Meta-analysis of work-family conflict mean differences: does national context matter? Personal Author(s) : Allen TD;Dumani S;French KA;Shockley KM; Published Date : 2015/10/01 Pages in Document : 90-100 URL : https://stacks.cdc.gov/view/cdc/249345 Allen TD et al. (2015). Meta-analysis of work-family conflict mean differences: does national context matter?. 90 Allen TD et al. "Meta-analysis of work-family conflict mean differences: does national context matter?" 90 (2015) Allen TD et al. "Meta-analysis of work-family conflict mean differences: does national context matter?" vol. 90, 2015 Export RIS Citation Information. TY - Journal Article AU - Allen TD AU - Dumani S AU - French KA AU - Shockley KM AB - Work-family conflict continues to be a topic of considerable interest to researchers and practitioners across the globe. In the current study, meta-analysis is used to compare cross-national mean differences in work-to-family conflict and family-to-work conflict across cultural, institutional, and economic aspects of context. No significant differences in work-to-family conflict were detected. Reports of family-to-work conflict were higher in more collectivistic versus more individualistic cultures, in countries with a higher versus a lower economic gender gap, and in countries other than the U.S. versus the U.S. [Description provided by NIOSH] AN - cdc:249345 KW - Family KW - Men KW - Occupational Health KW - Safety KW - Women KW - Workers; Work-life balance; Families; Socioeconomics; Sociological factors; Humans; Men; Women; KW - Author Keywords: Work-family conflict; Cross-national research; Institutional context; Cultural values KW - Family KW - Men KW - Occupational Health KW - Safety KW - Women LA - eng PY - 2015/10/01 TI - Meta-analysis of work-family conflict mean differences: does national context matter? VL - 90 UR - https://stacks.cdc.gov/view/cdc/249345 ER -
Improving balance control: current state and practices.

Bhattacharya, Amit ;

Dunning K

2016/10/20 | National Institute for Occupational Safety and Health (NIOSH)

Falls are multifactorial, due to both internal and external factors. Balance is an important intrinsic factor to prevent falls and injury. This chapter will review strategies that improve balance, specifically those that train the internal physiological systems, and provide recommendations for those who work at elevation or inclined surfaces. [Desc ...

12/01/2025

Title : Improving balance control: current state and practices. Personal Author(s) : Bhattacharya, Amit;Dunning K;Mani A; Published Date : 2016/10/20 Pages in Document : 223-239 URL : https://stacks.cdc.gov/view/cdc/249344 Bhattacharya, Amit et al. (2016). Improving balance control: current state and practices.. Bhattacharya, Amit and Dunning K and Mani A "Improving balance control: current state and practices." (2016) Bhattacharya, Amit et al. "Improving balance control: current state and practices." , 2016 Export RIS Citation Information. TY - Book AU - Bhattacharya, Amit AU - Dunning K AU - Mani A AB - Falls are multifactorial, due to both internal and external factors. Balance is an important intrinsic factor to prevent falls and injury. This chapter will review strategies that improve balance, specifically those that train the internal physiological systems, and provide recommendations for those who work at elevation or inclined surfaces. [Description provided by NIOSH] AN - cdc:249344 KW - Accident Prevention KW - Accidental Falls KW - Accidents KW - Occupational Health KW - Safety KW - Falls; Fall protection; Injury prevention; Accident prevention; Physiological factors; Safety practices; Body mechanics KW - Accident Prevention KW - Accidental Falls KW - Accidents KW - Occupational Health KW - Safety LA - eng PB - CRC Press PY - 2016/10/20 TI - Improving balance control: current state and practices. UR - https://stacks.cdc.gov/view/cdc/249344 ER -
Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma.

Brokamp C ;

Reponen T

2022/09/01 | National Institute for Occupational Safety and Health (NIOSH)

Rationale: Ultrafine particle (UFP; particles < 0.1 µm in diameter) concentrations exhibit high spatiotemporal variability, thus individual-level exposures and health risks are difficult to estimate. Objectives: To determine the effects of recent UFP exposures on respiratory health outcomes in children and determine if children with asthma are at i ...

12/01/2025

Title : Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma. Personal Author(s) : Brokamp C;Reponen T;Ryan PH;Turner AL;Wolfe C; Published Date : 2022/09/01 URL : https://stacks.cdc.gov/view/cdc/249343 Brokamp C et al. (2022). Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma.. 19(9). Brokamp C et al. "Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma." 19, no. 9 (2022) Brokamp C et al. "Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma." vol. 19, no. 9, 2022 Export RIS Citation Information. TY - Journal Article AU - Brokamp C AU - Reponen T AU - Ryan PH AU - Turner AL AU - Wolfe C AB - Rationale: Ultrafine particle (UFP; particles < 0.1 µm in diameter) concentrations exhibit high spatiotemporal variability, thus individual-level exposures and health risks are difficult to estimate. Objectives: To determine the effects of recent UFP exposures on respiratory health outcomes in children and determine if children with asthma are at increased risk. Methods: Personal sampling of UFPs was completed by adolescents in combination with repeated personal spirometry measurements and ecological momentary assessment of respiratory symptoms (wheeze, cough, shortness of breath). We assessed the association between UFP exposures every 30-mins up to 150 min prior to measuring FEV1 (forced expiratory volume in 1 s), PEF (peak expiratory flow), and respiratory symptoms using mixed-effects models, and interaction with asthma diagnosis. Measurements and Main Results: Participants (n = 105; 43% with asthma) completed an average of 11 spirometry measurements and 16 symptom responses throughout sampling. After adjustments (maternal education, physical activity, season, and distance to nearest roadway), a 10-fold increase in UFP exposure was significantly associated with a 0.04 L decrease (95% CI: -0.07, -0.001) in FEV1 90 minutes later. Asthma status modified this association in which asthmatics experienced significantly lower FEV1 values in response to UFP exposures 30 minutes prior compared to non-asthmatics. We found a significant increase in the odds of reporting a respiratory symptom 30 mins following increased UFP exposure (OR: 1.8, 95% CI [1.00, 3.00]). Conclusion: Greater UFP exposure conferred deleterious effects on lung function and respiratory symptoms within 90 minutes of exposure, and was more pronounced among asthmatics. [Description provided by NIOSH] AN - cdc:249343 IS - 9 KW - Asthma KW - Asthma, Occupational KW - Environmental Exposure KW - Lung KW - Occupational Health KW - Respiratory Function Tests KW - Respiratory System KW - Safety KW - Ultrafine particles; Respiratory health; Children; Asthma; Sampling methods; Spirometry; Lung function; Exposure assessment; Environmental exposure; KW - Author Keywords: ambient particulate matter; environmental epidemiology; exposure monitoring; KW - acute exposure; pediatric asthma KW - Asthma KW - Asthma, Occupational KW - Environmental Exposure KW - Lung KW - Occupational Health KW - Respiratory Function Tests KW - Respiratory System KW - Safety LA - eng PY - 2022/09/01 TI - Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma. VL - 19 UR - https://stacks.cdc.gov/view/cdc/249343 ER -
To branch out or stay focused? Affective shifts differentially predict organizational citizenship behavior and task performance.

Simon LS ;

Wang L

2016/06/01 | National Institute for Occupational Safety and Health (NIOSH)

We draw from personality systems interaction (PSI) theory (Kuhl, 2000) and regulatory focus theory (Higgins, 1997) to examine how dynamic positive and negative affective processes interact to predict both task and contextual performance. Using a twice-daily diary design over the course of a 3-week period, results from multilevel regression analysis ...

12/01/2025

Title : To branch out or stay focused? Affective shifts differentially predict organizational citizenship behavior and task performance. Personal Author(s) : Simon LS;Wang L;Yang L-Q;Zheng X; Published Date : 2016/06/01 URL : https://stacks.cdc.gov/view/cdc/249342 Simon LS et al. (2016). To branch out or stay focused? Affective shifts differentially predict organizational citizenship behavior and task performance.. 101(6). Simon LS et al. "To branch out or stay focused? Affective shifts differentially predict organizational citizenship behavior and task performance." 101, no. 6 (2016) Simon LS et al. "To branch out or stay focused? Affective shifts differentially predict organizational citizenship behavior and task performance." vol. 101, no. 6, 2016 Export RIS Citation Information. TY - Journal Article AU - Simon LS AU - Wang L AU - Yang L-Q AU - Zheng X AB - We draw from personality systems interaction (PSI) theory (Kuhl, 2000) and regulatory focus theory (Higgins, 1997) to examine how dynamic positive and negative affective processes interact to predict both task and contextual performance. Using a twice-daily diary design over the course of a 3-week period, results from multilevel regression analysis revealed that distinct patterns of change in positive and negative affect optimally predicted contextual and task performance among a sample of 71 employees at a medium-sized technology company. Specifically, within persons, increases (upshifts) in positive affect over the course of a workday better predicted the subsequent day's organizational citizenship behavior (OCB) when such increases were coupled with decreases (downshifts) in negative affect. The optimal pattern of change in positive and negative affect differed, however, in predicting task performance. That is, upshifts in positive affect over the course of the workday better predicted the subsequent day's task performance when such upshifts were accompanied by upshifts in negative affect. The contribution of our findings to PSI theory and the broader affective and motivation regulation literatures, along with practical implications, are discussed. [Description provided by NIOSH] AN - cdc:249342 IS - 6 KW - Behavior KW - Men KW - Mental Health KW - Occupational Health KW - Safety KW - Women KW - Workplace KW - Workers; Work environment; Behavior; Task performance; Personality traits; Regression analysis; Employees; Humans; Men; Women; Psychology; Sociological factors; KW - Author Keywords: positive affect; negative affect; affective shift; organizational citizenship behavior; task performance KW - Behavior KW - Men KW - Mental Health KW - Occupational Health KW - Safety KW - Women KW - Workplace LA - eng PY - 2016/06/01 TI - To branch out or stay focused? Affective shifts differentially predict organizational citizenship behavior and task performance. VL - 101 UR - https://stacks.cdc.gov/view/cdc/249342 ER -
Synthesis tuning for manufacturing carbon hybrid materials.

Anantharaman D ;

Chauhan D

2021/12/01 | National Institute for Occupational Safety and Health (NIOSH)

The overall hypothesis for this paper is that accurately tuning the gas phase pyrolysis synthesis process and using appropriate raw materials will enable manufacturing different types of carbon hybrid materials (CHM). Optimizing multiple variables including particle melting and vaporization temperatures, fuel flow rate, gas flow rates, gas velocity ...

12/01/2025

Title : Synthesis tuning for manufacturing carbon hybrid materials. Personal Author(s) : Anantharaman D;Chauhan D;Chen D;Chitranshi M;Hudepohl R;Kim SY;Kubley A;Ng V;Pujari A;Schulz M;Shanov V; Published Date : 2021/12/01 URL : https://stacks.cdc.gov/view/cdc/249341 Anantharaman D et al. (2021). Synthesis tuning for manufacturing carbon hybrid materials.. 12(11). Anantharaman D et al. "Synthesis tuning for manufacturing carbon hybrid materials." 12, no. 11 (2021) Anantharaman D et al. "Synthesis tuning for manufacturing carbon hybrid materials." vol. 12, no. 11, 2021 Export RIS Citation Information. TY - Journal Article AU - Anantharaman D AU - Chauhan D AU - Chen D AU - Chitranshi M AU - Hudepohl R AU - Kim SY AU - Kubley A AU - Ng V AU - Pujari A AU - Schulz M AU - Shanov V AB - The overall hypothesis for this paper is that accurately tuning the gas phase pyrolysis synthesis process and using appropriate raw materials will enable manufacturing different types of carbon hybrid materials (CHM). Optimizing multiple variables including particle melting and vaporization temperatures, fuel flow rate, gas flow rates, gas velocity, and sock wind-up speed is needed to achieve reliability of the synthesis process. Results from our specific reactor are presented to show how the process variables interact and how they affect CNT sock yield and stability. Metal nanoparticle (NP) injection enables the formation of hybrid materials. Several types of CHM materials created by incorporating different types of NPs into the carbon nanotube (CNT) synthesis process and CNT sock are discussed. Many possible combinations of metal NPs can be used in the process to customize the properties of CHM. However, it is a complex problem to determine what metal compounds can chemically join with CNT. Some of the first results testing the new CHM process are presented in this paper. [Description provided by NIOSH] AN - cdc:249341 IS - 11 KW - Manufacturing and Industrial Facilities KW - Occupational Health KW - Pyrolysis KW - Safety KW - Textile Industry KW - Carbon nanotubes; CNT; Pyrolysis; Textiles; Fabrics; Manufacturing; Nanoparticles; Materials testing; KW - Author Keywords: Carbon nanotube manufacturing; hybrid materials; nanoparticles; fabric KW - Manufacturing and Industrial Facilities KW - Occupational Health KW - Pyrolysis KW - Safety KW - Textile Industry LA - eng PY - 2021/12/01 TI - Synthesis tuning for manufacturing carbon hybrid materials. VL - 12 UR - https://stacks.cdc.gov/view/cdc/249341 ER -
Reactor design for manufacturing carbon hybrid materials.

Anantharaman D ;

Chauhan D

2022/03/01 | National Institute for Occupational Safety and Health (NIOSH)

This paper addresses the design of a reactor system for manufacturing carbon nanotube (CNT) fabric and carbon hybrid materials (CHM). A web or sock of CNT is formed in a reactor tube in the gas phase pyrolysis method. The sock exits the reactor tube and is wound layer by layer onto a drum to directly form a nonwoven fabric. Metal nanoparticles and ...

12/01/2025

Title : Reactor design for manufacturing carbon hybrid materials. Personal Author(s) : Anantharaman D;Chauhan D;Chen D;Chitranshi M;Hudepohl R;Kim SY;Kubley A;Ng V;Pujari A;Schulz M;Shanov V; Published Date : 2022/03/01 URL : https://stacks.cdc.gov/view/cdc/249340 Anantharaman D et al. (2022). Reactor design for manufacturing carbon hybrid materials.. 13(1). Anantharaman D et al. "Reactor design for manufacturing carbon hybrid materials." 13, no. 1 (2022) Anantharaman D et al. "Reactor design for manufacturing carbon hybrid materials." vol. 13, no. 1, 2022 Export RIS Citation Information. TY - Journal Article AU - Anantharaman D AU - Chauhan D AU - Chen D AU - Chitranshi M AU - Hudepohl R AU - Kim SY AU - Kubley A AU - Ng V AU - Pujari A AU - Schulz M AU - Shanov V AB - This paper addresses the design of a reactor system for manufacturing carbon nanotube (CNT) fabric and carbon hybrid materials (CHM). A web or sock of CNT is formed in a reactor tube in the gas phase pyrolysis method. The sock exits the reactor tube and is wound layer by layer onto a drum to directly form a nonwoven fabric. Metal nanoparticles and continuous microfibers can be integrated into the synthesis process to form CHM. Continuous direct manufacturing of fabric is an advantage of the method. However, the reliability of this manufacturing process in our particular reactor system is affected by several problems. These include occasional breaking of the sock, the need for daily cleaning of the ceramic reactor tube due to carbon deposits on the inside, sagging/bending of the reactor tube, and safety in handling the hydrogen gas produced from the reaction. Possible solutions to the problems are proposed. The importance of this research is that no other bulk material has the combination of properties of CNT hybrid fabric. If the properties can be further improved and customized, and if manufacturing of the material can be scaled-up at reasonable cost, many new commercial applications for nanotube custom materials could open up. [Description provided by NIOSH] AN - cdc:249340 IS - 1 KW - Manufacturing and Industrial Facilities KW - Occupational Health KW - Safety KW - Textile Industry KW - Carbon nanotubes; CNT; Textiles; Fabrics; Manufacturing; Nanoparticles; Materials testing; Equipment design; KW - Author Keywords: Carbon nanotube manufacturing; hybrid material; nanoparticles KW - Manufacturing and Industrial Facilities KW - Occupational Health KW - Safety KW - Textile Industry LA - eng PY - 2022/03/01 TI - Reactor design for manufacturing carbon hybrid materials. VL - 13 UR - https://stacks.cdc.gov/view/cdc/249340 ER -
Methods for evaluating the combined effects of chemical and nonchemical exposures for cumulative environmental health risk assessment.

Carr Shmool JL ;

Clougherty JE

2018/12/01 | National Institute for Occupational Safety and Health (NIOSH)

Cumulative risk assessment (CRA) has been proposed as a means of evaluating possible additive and synergistic effects of multiple chemical, physical and social stressors on human health, with the goal of informing policy and decision-making, and protecting public health. Routine application of CRA to environmental regulatory and policy decision mak ...

12/01/2025

Title : Methods for evaluating the combined effects of chemical and nonchemical exposures for cumulative environmental health risk assessment. Personal Author(s) : Carr Shmool JL;Clougherty JE;Cory-Slechta DA;Laumbach R;Levy JI;Linder S;Payne-Sturges DC;Scammell MK;Symanski, Elaine; Published Date : 2018/12/01 URL : https://stacks.cdc.gov/view/cdc/249339 Carr Shmool JL et al. (2018). Methods for evaluating the combined effects of chemical and nonchemical exposures for cumulative environmental health risk assessment.. 15(12). Carr Shmool JL et al. "Methods for evaluating the combined effects of chemical and nonchemical exposures for cumulative environmental health risk assessment." 15, no. 12 (2018) Carr Shmool JL et al. "Methods for evaluating the combined effects of chemical and nonchemical exposures for cumulative environmental health risk assessment." vol. 15, no. 12, 2018 Export RIS Citation Information. TY - Journal Article AU - Carr Shmool JL AU - Clougherty JE AU - Cory-Slechta DA AU - Laumbach R AU - Levy JI AU - Linder S AU - Payne-Sturges DC AU - Scammell MK AU - Symanski, Elaine AB - Cumulative risk assessment (CRA) has been proposed as a means of evaluating possible additive and synergistic effects of multiple chemical, physical and social stressors on human health, with the goal of informing policy and decision-making, and protecting public health. Routine application of CRA to environmental regulatory and policy decision making, however, has been limited due to a perceived lack of appropriate quantitative approaches for assessing combined effects of chemical and nonchemical exposures. Seven research projects, which represented a variety of disciplines, including population health science, laboratory science, social sciences, geography, statistics and mathematics, were funded by the US Environmental Protection Agency (EPA) to help address this knowledge gap. We synthesize key insights from these unique studies to determine the implications for CRA practice and priorities for further research. Our analyses of these seven projects demonstrate that the necessary analytical methods to support CRA are available but are ultimately context-dependent. These projects collectively provided advancements for CRA in the areas of community engagement, characterization of exposures to nonchemical stressors, and assessment of health effects associated with joint exposures to chemical and psychosocial stressors. [Description provided by NIOSH] AN - cdc:249339 IS - 12 KW - Community Health Services KW - Occupational Health KW - Safety KW - Risk assessment; Quantitative analysis; Stress; Chemicals; Sociological factors; Psychosocial factors; Mixed exposures; Community health; Policy; Environmental health; KW - Author Keywords: cumulative risk; methods; community health; environmental justice; psychosocial stressors KW - Community Health Services KW - Occupational Health KW - Safety LA - eng PY - 2018/12/01 TI - Methods for evaluating the combined effects of chemical and nonchemical exposures for cumulative environmental health risk assessment. VL - 15 UR - https://stacks.cdc.gov/view/cdc/249339 ER -
Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia.

Chan W ;

Chen T-Y

2019/07/01 | National Institute for Occupational Safety and Health (NIOSH)

Epidemiology studies relying on one address to assign exposures over time share common methodological limitations in failing to account for mobility that may introduce potential exposure misclassification. Using Texas birth certificate and cancer registry data, we identified predictors of residential mobility among mothers of children diagnosed wit ...

12/01/2025

Title : Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia. Personal Author(s) : Chan W;Chen T-Y;Symanski, Elaine;Tee Lewis PG; Published Date : 2019/07/01 URL : https://stacks.cdc.gov/view/cdc/249338 Chan W et al. (2019). Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia.. 29(4). Chan W et al. "Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia." 29, no. 4 (2019) Chan W et al. "Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia." vol. 29, no. 4, 2019 Export RIS Citation Information. TY - Journal Article AU - Chan W AU - Chen T-Y AU - Symanski, Elaine AU - Tee Lewis PG AB - Epidemiology studies relying on one address to assign exposures over time share common methodological limitations in failing to account for mobility that may introduce potential exposure misclassification. Using Texas birth certificate and cancer registry data, we identified predictors of residential mobility among mothers of children diagnosed with early childhood leukemia in Texas from 1995 to 2011. We used U.S. Environmental Protection Agency (EPA) National Air Toxics Assessment data to estimate residential levels of benzene and 1,3-butadiene based on addresses at birth and diagnosis and applied mixed-effects ordinal logistic regression models to evaluate differences in exposure classification between the two time periods. In total, 55% of children moved from time of birth to diagnosis, although they generally did not move far (median distance moved was 8 km). Predictors of mobility, at delivery, included younger age, being unmarried and living in neighborhoods with high benzene levels, and, at diagnosis, increasing child's age and living in neighborhoods with low poverty rates. We observed that the odds of being assigned to a higher exposure quartile at diagnosis relative to the time of birth decreased by 31% for 1,3-butadiene (OR = 0.69, 95% CI 0.59-0.82) and by 12% for benzene (OR = 0.88, 95% CI 0.75, 1.05). [Description provided by NIOSH] AN - cdc:249338 IS - 4 KW - Air Pollutants, Occupational KW - Air Pollution KW - Benzene KW - Butadienes KW - Environmental Exposure KW - Epidemiology KW - Occupational Health KW - Safety KW - Women KW - Children; Women; Air pollution; Air pollutants; Benzene; 1,3-Butadiene; Environmental exposure; Air quality monitoring; Population based studies; Epidemiology; KW - Author Keywords: Air Pollution; Benzene; Butadiene; Leukemia; Exposure; Misclassification KW - Air Pollutants, Occupational KW - Air Pollution KW - Benzene KW - Butadienes KW - Environmental Exposure KW - Epidemiology KW - Occupational Health KW - Safety KW - Women LA - eng PY - 2019/07/01 TI - Predictors of residential mobility and its impact on air pollution exposure among children diagnosed with early childhood leukemia. VL - 29 UR - https://stacks.cdc.gov/view/cdc/249338 ER -
Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: a real-world study.

Alimokhtari S ;

Black KG

2022/04/01 | National Institute for Occupational Safety and Health (NIOSH)

Individuals with COVID-19 who do not require hospitalization are instructed to self-isolate in their residences. Due to high secondary infection rates in household members, there is a need to understand airborne transmission of SARS-CoV-2 within residences. We report the first naturalistic intervention study suggesting a reduction of such transmiss ...

12/01/2025

Title : Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: a real-world study. Personal Author(s) : Alimokhtari S;Black KG;Calderón L;De Resende A;Kipen HM;Laumbach RJ;Legard A;Lu FT;Mainelis G;Myers NT;Ohman-Strickland P; Published Date : 2022/04/01 URL : https://stacks.cdc.gov/view/cdc/249337 Alimokhtari S et al. (2022). Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: a real-world study.. 32(4). Alimokhtari S et al. "Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: a real-world study." 32, no. 4 (2022) Alimokhtari S et al. "Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: a real-world study." vol. 32, no. 4, 2022 Export RIS Citation Information. TY - Journal Article AU - Alimokhtari S AU - Black KG AU - Calderón L AU - De Resende A AU - Kipen HM AU - Laumbach RJ AU - Legard A AU - Lu FT AU - Mainelis G AU - Myers NT AU - Ohman-Strickland P AB - Individuals with COVID-19 who do not require hospitalization are instructed to self-isolate in their residences. Due to high secondary infection rates in household members, there is a need to understand airborne transmission of SARS-CoV-2 within residences. We report the first naturalistic intervention study suggesting a reduction of such transmission risk using portable air cleaners (PACs) with HEPA filters. Seventeen individuals with newly diagnosed COVID-19 infection completed this single-blind, crossover, randomized study. Total and size-fractionated aerosol samples were collected simultaneously in the self-isolation room with the PAC (primary) and another room (secondary) for two consecutive 24-h periods, one period with HEPA filtration and the other with the filter removed (sham). Seven out of sixteen (44%) air samples in primary rooms were positive for SARS-CoV-2 RNA during the sham period. With the PAC operated at its lowest setting (clean air delivery rate [CADR] = 263 cfm) to minimize noise, positive aerosol samples decreased to four out of sixteen residences (25%; p = 0.229). A slight decrease in positive aerosol samples was also observed in the secondary room. As the world confronts both new variants and limited vaccination rates, our study supports this practical intervention to reduce the presence of viral aerosols in a real-world setting. [Description provided by NIOSH] AN - cdc:249337 IS - 4 KW - Aerosols KW - Communicable Diseases KW - Environmental Monitoring KW - Noise KW - Occupational Health KW - Safety KW - Viral Diseases KW - Aerosols; COVID-19; Sampling; HEPA filters; High-efficiency particulate air filters; Air samples; Noise; Statistical analysis; Vaccines; Intervention; Viral diseases; KW - Author Keywords: Air change rate; Airborne transmission; COVID-19 pandemic; COVID-19 symptoms; PTFE filter virus sampling; SARS-CoV-2 aerosols KW - Aerosols KW - Communicable Diseases KW - Environmental Monitoring KW - Noise KW - Occupational Health KW - Safety KW - Viral Diseases LA - eng PY - 2022/04/01 TI - Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: a real-world study. VL - 32 UR - https://stacks.cdc.gov/view/cdc/249337 ER -
Respiratory deposition of ultrafine welding fume particles.

Bezerra M ;

Chen Y

2019/10/01 | National Institute for Occupational Safety and Health (NIOSH)

The inhalation and the deposition of welding-generated ultrafine particles in welders' respiratory tracts have been linked to severe pulmonary impairments. In the present study, a mobile aerosol lung deposition apparatus (MALDA) was developed and applied to study the respiratory deposition of ultrafine welding fume particles. The MALDA was construc ...

12/01/2025

Title : Respiratory deposition of ultrafine welding fume particles. Personal Author(s) : Bezerra M;Chen Y;Su W-C;Wang J; Published Date : 2019/10/01 URL : https://stacks.cdc.gov/view/cdc/249336 Bezerra M et al. (2019). Respiratory deposition of ultrafine welding fume particles.. 16(10). Bezerra M et al. "Respiratory deposition of ultrafine welding fume particles." 16, no. 10 (2019) Bezerra M et al. "Respiratory deposition of ultrafine welding fume particles." vol. 16, no. 10, 2019 Export RIS Citation Information. TY - Journal Article AU - Bezerra M AU - Chen Y AU - Su W-C AU - Wang J AB - The inhalation and the deposition of welding-generated ultrafine particles in welders' respiratory tracts have been linked to severe pulmonary impairments. In the present study, a mobile aerosol lung deposition apparatus (MALDA) was developed and applied to study the respiratory deposition of ultrafine welding fume particles. The MALDA was constructed with a set of physiologically representative human tracheobronchial airway replicas made with high-resolution 3D printers. Ultrafine welding fume particles were generated in a welding fume chamber and delivered to the MALDA. A series of respiratory deposition experiments were carried out using the MALDA to investigate the deposition of ultrafine welding fume particles in different airway generations of the tracheobronchial airways. The results showed that the fractional deposition of ultrafine welding fume particle in the human tracheobronchial airways down to the 9th airway generation could be readily and systematically measured by the MALDA. The estimated cumulative respiratory deposition ranged from approximately 9-31% for ultrafine welding fume particles between 10 and 100 nm in diameter. The results acquired demonstrated that the MALDA developed has the potential to become a useful apparatus in the future to estimate the respiratory deposition of ultrafine particles in real workplaces. [Description provided by NIOSH] AN - cdc:249336 IS - 10 KW - Aerosols KW - Metals KW - Occupational Health KW - Particulate Matter KW - Respiratory System KW - Safety KW - Welding KW - Ultrafine particles; Welding fumes; Welders; Welding; Metals; Particle size; Particle diameter; Inhalation; Aerosols; Respiratory health; KW - Author Keywords: Human airway replica; respiratory deposition; ultrafine particle; welding fume KW - Aerosols KW - Metals KW - Occupational Health KW - Particulate Matter KW - Respiratory System KW - Safety KW - Welding LA - eng PY - 2019/10/01 TI - Respiratory deposition of ultrafine welding fume particles. VL - 16 UR - https://stacks.cdc.gov/view/cdc/249336 ER -
Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders.

Bromet E ;

Clouston S

2022/04/28 | National Institute for Occupational Safety and Health (NIOSH)

Metabolomics has yielded promising insights into the pathophysiology of post-traumatic stress disorder (PTSD). The current study expands understanding of the systems-level effects of metabolites by using global metabolomics and complex lipid profiling in plasma samples from 124 World Trade Center responders (56 PTSD, 68 control) on 1628 metabolites ...

12/01/2025

Title : Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders. Personal Author(s) : Bromet E;Clouston S;Kotov R;Kuan P-F;Luft BJ;Yang X; Published Date : 2022/04/28 URL : https://stacks.cdc.gov/view/cdc/249335 Bromet E et al. (2022). Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders.. 12 Bromet E et al. "Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders." 12 (2022) Bromet E et al. "Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders." vol. 12, 2022 Export RIS Citation Information. TY - Journal Article AU - Bromet E AU - Clouston S AU - Kotov R AU - Kuan P-F AU - Luft BJ AU - Yang X AB - Metabolomics has yielded promising insights into the pathophysiology of post-traumatic stress disorder (PTSD). The current study expands understanding of the systems-level effects of metabolites by using global metabolomics and complex lipid profiling in plasma samples from 124 World Trade Center responders (56 PTSD, 68 control) on 1628 metabolites. Differential metabolomics analysis identified hexosylceramide HCER(26:1) associated with PTSD at FDR < 0.1. The multi-metabolite composite score achieved an AUC of 0.839 for PTSD versus unaffected control classification. Independent component analysis identified three metabolomic modules significantly associated with PTSD. These modules were significantly enriched in bile acid metabolism, fatty acid metabolism and pregnenolone steroids, which are involved in innate immunity, inflammatory process and neuronal excitability, respectively. Integrative analysis of metabolomics and our prior proteomics datasets on subsample of 96 responders identified seven proteomic modules significantly correlated with metabolic modules. Overall, our findings shed light on the molecular alterations and identify metabolomic-proteomic signatures associated with PTSD by using machine learning and network approaches to enhance understanding of the pathways implicated in PTSD. If present results are confirmed in follow-up studies, they may inform development of novel treatments. [Description provided by NIOSH] AN - cdc:249335 KW - Emergency Responders KW - Energy Metabolism KW - Lipids KW - Occupational Health KW - Pathology KW - Safety KW - September 11 Terrorist Attacks KW - Steroids KW - PTSD; Post-traumatic stress disorder; Pathology; Physiology; Metabolites; Lipids; Blood plasma; Sampling; WTC; World Trade Center; First responders; Emergency responders; Metabolism; Steroids KW - Emergency Responders KW - Energy Metabolism KW - Lipids KW - Occupational Health KW - Pathology KW - Safety KW - September 11 Terrorist Attacks KW - Steroids LA - eng PY - 2022/04/28 TI - Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders. VL - 12 UR - https://stacks.cdc.gov/view/cdc/249335 ER -
Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways.

Chen Y ;

Su W-C

2020/11/01 | National Institute for Occupational Safety and Health (NIOSH)

3D printers have been widely used as a tool for prototype manufacturing in industries, schools, and homes. During operation, 3D printers emit ultrafine particles that could be inhaled by the user and induce adverse health effects. Thus, exposure to ultrafine 3D-printing generated particles has drawn the attention of occupational and environmental h ...

12/01/2025

Title : Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways. Personal Author(s) : Chen Y;Su W-C;Xi J; Published Date : 2020/11/01 URL : https://stacks.cdc.gov/view/cdc/249334 Chen Y et al. (2020). Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways.. 149 Chen Y and Su W-C and Xi J "Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways." 149 (2020) Chen Y et al. "Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways." vol. 149, 2020 Export RIS Citation Information. TY - Journal Article AU - Chen Y AU - Su W-C AU - Xi J AB - 3D printers have been widely used as a tool for prototype manufacturing in industries, schools, and homes. During operation, 3D printers emit ultrafine particles that could be inhaled by the user and induce adverse health effects. Thus, exposure to ultrafine 3D-printing generated particles has drawn the attention of occupational and environmental health researchers. In this study, a recently developed Mobile Aerosol Lung Deposition Apparatus (MALDA) was applied to investigate the respiratory deposition of ultrafine 3D printing particles. The MALDA consists of a set of representative human airway replicas from mouth, throat, trachea, down to the bronchiolar airways of the 11th bifurcation generation. A series of respiratory deposition experiments were carried out in the laboratory using the MALDA and a desktop 3D printer to estimate the deposition of ultrafine 3D printing particles in individual generations of the lung. Results showed that the cumulative deposition from the 1st to 11th bifurcation generations was found to be 1%-13% depending on the particle size, which was slightly less than the respiratory deposition predicted from the conventional deposition curve. [Description provided by NIOSH] AN - cdc:249334 KW - Aerosols KW - Occupational Health KW - Particulate Matter KW - Printing KW - Printing, Three-Dimensional KW - Respiratory System KW - Safety KW - Three dimensional printing; 3D printing; Printers; Printer-emitted particles; Ultrafine particles; Particle size; Chemical deposition; Inhalation; Aerosols; KW - Author Keywords: Ultrafine particles; 3D printer; Respiratory deposition; Bifurcation generation KW - Aerosols KW - Occupational Health KW - Particulate Matter KW - Printing KW - Printing, Three-Dimensional KW - Respiratory System KW - Safety LA - eng PY - 2020/11/01 TI - Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways. VL - 149 UR - https://stacks.cdc.gov/view/cdc/249334 ER -
Manufacturing and characterization of customizable flexible carbon nanotube fabrics for smart wearable applications.

Chitranshi M ;

Hou X

2021/12/01 | National Institute for Occupational Safety and Health (NIOSH)

The integration of carbon nanotube fabric into textiles is paving its way into smart materials and wearable applications. Potential novel applications of carbon nanotube hybrid (CNTH) materials and fabric composites span across a range of market levels from high-level PPE appropriate for military and industrial applications down to consumer product ...

12/01/2025

Title : Manufacturing and characterization of customizable flexible carbon nanotube fabrics for smart wearable applications. Personal Author(s) : Chitranshi M;Hou X;Kubley A;Schulz M; Published Date : 2021/12/01 URL : https://stacks.cdc.gov/view/cdc/249333 Chitranshi M et al. (2021). Manufacturing and characterization of customizable flexible carbon nanotube fabrics for smart wearable applications.. 1(3). Chitranshi M et al. "Manufacturing and characterization of customizable flexible carbon nanotube fabrics for smart wearable applications." 1, no. 3 (2021) Chitranshi M et al. "Manufacturing and characterization of customizable flexible carbon nanotube fabrics for smart wearable applications." vol. 1, no. 3, 2021 Export RIS Citation Information. TY - Journal Article AU - Chitranshi M AU - Hou X AU - Kubley A AU - Schulz M AB - The integration of carbon nanotube fabric into textiles is paving its way into smart materials and wearable applications. Potential novel applications of carbon nanotube hybrid (CNTH) materials and fabric composites span across a range of market levels from high-level PPE appropriate for military and industrial applications down to consumer products that can be used in everyday scenarios. The high-level performance properties of CNTH materials and their ability to be customized provide new possibilities for constructing fabrics with properties that are made to order. Furthermore, CNTH in combination with advanced textile compositing and construction methods allows the CNTH material to further leverage material customization aspects to meet specific requirements. The unique synthesis process for nanotube fabric allows for modification of the physical properties of the CNTH itself. The CNTH fabric combined with the customizability of standard textile composite materials and with the use of apparel design features allows for the design of materials with new combinations of physical properties. These unique properties offer high potential for developing families of smart wearable garments that can be scaled for industrial production. This article discusses the synthesis of carbon nanotube hybrid fabric, the process of hybrid fabric and textile integration, properties of the hybrid textile, and potential applications. The paper also provides an outlook towards large scale production of the hybrid textile material. [Description provided by NIOSH] AN - cdc:249333 IS - 3 KW - Occupational Health KW - Safety KW - Textile Industry KW - Carbon nanotubes; CNT; Wearable technologies; Textiles; Fabrics; Nanomaterials; KW - Author Keywords: carbon nanotube hybrid material; smart textile; flexible fabric KW - Occupational Health KW - Safety KW - Textile Industry LA - eng PY - 2021/12/01 TI - Manufacturing and characterization of customizable flexible carbon nanotube fabrics for smart wearable applications. VL - 1 UR - https://stacks.cdc.gov/view/cdc/249333 ER -
Evaluation of a new instrument for aerosol quantitative fit testing.

Grinshpun SA ;

Leppänen M

2017/07/01 | National Institute for Occupational Safety and Health (NIOSH)

Millions of workers exposed to various hazards perform fit testing to assure anticipated protection of their respirators. This testing has been conducted for about two decades mainly with a TSI PortaCount(R), an instrument that measures the aerosol concentrations inside and outside the respirator using a condensation nuclei counting principle. Rece ...

12/01/2025

Title : Evaluation of a new instrument for aerosol quantitative fit testing. Personal Author(s) : Grinshpun SA;Leppänen M;Wu B;Yermakov M; Published Date : 2017/07/01 Pages in Document : 111-127 URL : https://stacks.cdc.gov/view/cdc/249332 Grinshpun SA et al. (2017). Evaluation of a new instrument for aerosol quantitative fit testing.. 34(2). Grinshpun SA et al. "Evaluation of a new instrument for aerosol quantitative fit testing." 34, no. 2 (2017) Grinshpun SA et al. "Evaluation of a new instrument for aerosol quantitative fit testing." vol. 34, no. 2, 2017 Export RIS Citation Information. TY - Journal Article AU - Grinshpun SA AU - Leppänen M AU - Wu B AU - Yermakov M AB - Millions of workers exposed to various hazards perform fit testing to assure anticipated protection of their respirators. This testing has been conducted for about two decades mainly with a TSI PortaCount(R), an instrument that measures the aerosol concentrations inside and outside the respirator using a condensation nuclei counting principle. Recently, a new fit testing instrument, Fit Tester (MT-05U) was developed for quantitative fit testing based on the optical particle counting (OPC). The objective of this study was to explore if this type of particle counter can be used for quantitative respirator fit testing. The study was performed in accordance with the American National Standards Institute (ANSI) and the American Industrial Hygiene Association Z88.10-2010 criteria for evaluating new fit test methods with the TSI PortaCount(R) as the reference apparatus. The overall fit factors were measured with the two instruments operating in parallel with respirators donned by 26 subjects performing the standard OSHA exercises during fit testing. The experiments were conducted with three types of high-efficiency particulate filtering respirators: P100 filtering facepiece, and two elastomeric respirators, half facepiece and full facepiece. The results showed that the MT-05U can correctly identify an inadequate fit of the tested respirators as compared with the reference instrument (with a sensitivity between 0.98 and 1.00, exceeding the ANSI requirement of ≥ 0.95). The other advisory ANSI requirements/recommendations for statistics (i.e., predictive value of a pass, specificity, predictive value of a fail, and kappa statistics) were also met. Due to the difference in operational particle size ranges of the two instruments, fit factors within pair comparison measured by MT-05U were generally lower than fit factors measured by PortaCount(R). In conclusion, the new OPC-based MT-05U showed an acceptable performance in quantifying a respirator fit and, thus, can serve as an alternative method for respirators equipped with high-efficiency filters. [Description provided by NIOSH] AN - cdc:249332 IS - 2 KW - Aerosols KW - Occupational Health KW - Personal Protective Equipment KW - Respiratory Protective Devices KW - Safety KW - Respirators; Respiratory protection; Personal protective equipment; PPE; Aerosols; Fit testing; Particle counters; KW - Author Keywords: quantitative respirator fit testing; optical particle counter; OPC; condensation nuclei/particle counter; CNC/CPC; filtering facepiece respirator; elastomeric half facepiece respirator; elastomeric full facepiece respirator KW - Aerosols KW - Occupational Health KW - Personal Protective Equipment KW - Respiratory Protective Devices KW - Safety LA - eng PY - 2017/07/01 TI - Evaluation of a new instrument for aerosol quantitative fit testing. VL - 34 UR - https://stacks.cdc.gov/view/cdc/249332 ER -

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