Metabolomics analysis of post-traumatic stress disorder symptoms in World Trade Center responders.

Details

• Personal Author:
  Bromet E ; Clouston S ; Kotov R ; Kuan P-F ; Luft BJ ; Yang X
• Description:
  Metabolomics has yielded promising insights into the pathophysiology of post-traumatic stress disorder (PTSD). The current study expands understanding of the systems-level effects of metabolites by using global metabolomics and complex lipid profiling in plasma samples from 124 World Trade Center responders (56 PTSD, 68 control) on 1628 metabolites. Differential metabolomics analysis identified hexosylceramide HCER(26:1) associated with PTSD at FDR < 0.1. The multi-metabolite composite score achieved an AUC of 0.839 for PTSD versus unaffected control classification. Independent component analysis identified three metabolomic modules significantly associated with PTSD. These modules were significantly enriched in bile acid metabolism, fatty acid metabolism and pregnenolone steroids, which are involved in innate immunity, inflammatory process and neuronal excitability, respectively. Integrative analysis of metabolomics and our prior proteomics datasets on subsample of 96 responders identified seven proteomic modules significantly correlated with metabolic modules. Overall, our findings shed light on the molecular alterations and identify metabolomic-proteomic signatures associated with PTSD by using machine learning and network approaches to enhance understanding of the pathways implicated in PTSD. If present results are confirmed in follow-up studies, they may inform development of novel treatments. [Description provided by NIOSH]
• Subjects:
  Emergency Responders Energy Metabolism Lipids Occupational Health Pathology Safety September 11 Terrorist Attacks Steroids
• Keywords:
  PTSD; Post-traumatic stress disorder; Pathology; Physiology; Metabolites; Lipids; Blood plasma; Sampling; WTC; World Trade Center; First responders; Emergency responders; Metabolism; Steroids
• ISSN:
  2158-3188
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• NIOSHTIC Number:
  nn:20065104
• Citation:
  Transl Psychiatry 2022 Apr; 12:174
• Contact Point Address:
  Pei-Fen Kuan, Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA
• Email:
  PeiFen.Kuan@stonybrook.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Translational Psychiatry
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:95e58992fc81e369f6d99a59008fa0072514519b384c4df5d873c0ab430c0600a105adef1b5198eeb06ac43a491300ae50ee7bcf602371754965d300ae1affe7
• Download URL:
  https://stacks.cdc.gov/view/cdc/249335/cdc_249335_DS1.pdf
• File Type:
  [PDF - 601.27 KB ]