Impact of personal, subhourly exposure to ultrafine particles on respiratory health in adolescents with asthma.

Details

• Personal Author:
  Brokamp C ; Reponen T ; Ryan PH ; Turner AL ; Wolfe C
• Description:
  Rationale: Ultrafine particle (UFP; particles < 0.1 µm in diameter) concentrations exhibit high spatiotemporal variability, thus individual-level exposures and health risks are difficult to estimate. Objectives: To determine the effects of recent UFP exposures on respiratory health outcomes in children and determine if children with asthma are at increased risk. Methods: Personal sampling of UFPs was completed by adolescents in combination with repeated personal spirometry measurements and ecological momentary assessment of respiratory symptoms (wheeze, cough, shortness of breath). We assessed the association between UFP exposures every 30-mins up to 150 min prior to measuring FEV1 (forced expiratory volume in 1 s), PEF (peak expiratory flow), and respiratory symptoms using mixed-effects models, and interaction with asthma diagnosis. Measurements and Main Results: Participants (n = 105; 43% with asthma) completed an average of 11 spirometry measurements and 16 symptom responses throughout sampling. After adjustments (maternal education, physical activity, season, and distance to nearest roadway), a 10-fold increase in UFP exposure was significantly associated with a 0.04 L decrease (95% CI: -0.07, -0.001) in FEV1 90 minutes later. Asthma status modified this association in which asthmatics experienced significantly lower FEV1 values in response to UFP exposures 30 minutes prior compared to non-asthmatics. We found a significant increase in the odds of reporting a respiratory symptom 30 mins following increased UFP exposure (OR: 1.8, 95% CI [1.00, 3.00]). Conclusion: Greater UFP exposure conferred deleterious effects on lung function and respiratory symptoms within 90 minutes of exposure, and was more pronounced among asthmatics. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Environmental Exposure Lung Occupational Health Respiratory Function Tests Respiratory System Safety
• Keywords:
  Acute Exposure; Pediatric Asthma Author Keywords: Ambient Particulate Matter; Environmental Epidemiology; Exposure Monitoring; Ultrafine Particles; Respiratory Health; Children; Asthma; Sampling Methods; Spirometry; Lung Function; Exposure Assessment; Environmental Exposure;
• ISSN:
  2329-6933
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  9
• NIOSHTIC Number:
  nn:20065130
• Citation:
  Ann Am Thorac Soc 2022 Sep; 19(9):1516-1524
• Contact Point Address:
  Ashley Turner, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229
• Email:
  okonal@mail.uc.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of the American Thoracic Society
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6f2a6a850e0fa14b7c53130de720ca365e65c0d4ba8ac4277e9e61907b29654b18f12745e2736e4ffbf0b54c4060f548a2a51d2a9ba30aeb53ec3f58816c6545
• Download URL:
  https://stacks.cdc.gov/view/cdc/249343/cdc_249343_DS1.pdf
• File Type:
  [PDF - 2.79 MB ]