Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan-Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D’Ambrosio, Lia; Sotgiu, Giovanni; Migliori, Giovanni Battista

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Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

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Oct 17 2017
By Maryandyshev, Andrey ; Pontali, Emanuele ; Tiberi, Simon ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Maryandyshev, Andrey ; Pontali, Emanuele ; Tiberi, Simon ; Akkerman, Onno ; Ganatra, Shashank ; Sadutshang, Tsetan Dorji ; Alffenaar, Jan-Willem ; Amale, Rohit ; Mullerpattan, Jai ; Topgyal, Sonam ; Udwadia, Zarir Farokh ; Centis, Rosella ; D’Ambrosio, Lia ; Sotgiu, Giovanni ; Migliori, Giovanni Battista
Description:

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
Subjects:

Adolescent Adult Antitubercular Agents Diarylquinolines Dispatch Drug Therapy, Combination Extensively Drug-Resistant Tuberculosis/drug Therapy Female Humans Male Nitroimidazoles Oxazoles Tuberculosis, Pulmonary Young Adult
Source:

Emerg Infect Dis. 23(10):1718-1721.
Pubmed ID:

28758888
Pubmed Central ID:

PMC5621558
Document Type:

Journal Article
Place as Subject:

Europe ; Netherlands ; India ; Russia ; United Kingdom ; Switzerland
Location:

Europe ; Asia
Volume:

23
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:0cbaa4068cb2ec61d1337b9cccbd985214cd04284291b9795ebef8396dc73071
Download URL:

https://stacks.cdc.gov/view/cdc/48994/cdc_48994_DS1.pdf
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[PDF - 997.61 KB ]

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File Language:

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