Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Millard, James ; Rimmer, Stephanie ; Nimmo, Camus ; O’Donnell, Max
• Description:
  New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance. We report a case of bedaquiline and delamanid resistance in a 55-year-old woman in South Africa with extensively drug-resistant tuberculosis and known HIV.
• Subjects:
  Antitubercular Agents Diarylquinolines Female Humans Middle Aged Nitroimidazoles Oxazoles Tuberculosis, Multidrug-Resistant
• Source:
  Emerg Infect Dis. 2023; 29(5):1081-1084
• Pubmed ID:
  37081529
• Pubmed Central ID:
  PMC10124645
• Document Type:
  Journal Article
• Funding:
  R01 AI124413/AI/NIAID NIH HHSUnited States/ ; R01 AI167795/AI/NIAID NIH HHSUnited States/ ; UL1 TR001873/TR/NCATS NIH HHSUnited States/ ; 203583/Z/16/Z/WT_/Wellcome TrustUnited Kingdom/ ; 203919/Z/16/Z/WT_/Wellcome TrustUnited Kingdom/ ; CC2169/CRUK_/Cancer Research UKUnited Kingdom/ ; CC2169/MRC_/Medical Research CouncilUnited Kingdom/ ; CC2169/WT_/Wellcome TrustUnited Kingdom/
• Genre:
  Research Letter
• Place as Subject:
  South Africa
• Volume:
  29
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cf94caabc383e6f03dc2099f8457a33006ea491c3e07e75b7833b4087a1a85fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/129110/cdc_129110_DS1.pdf
• File Type:
  [PDF - 544.89 KB ]