Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Murray, Gerald L.; Bradshaw, Catriona S.; Bissessor, Melanie; Danielewski, Jennifer; Garland, Suzanne M.; Jensen, Jørgen S.; Fairley, Christopher K.; Tabrizi, Sepehr N.

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Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

May 2017
By Murray, Gerald L. ; Bradshaw, Catriona S. ; Bissessor, Melanie ; ...
Source: Emerg Infect Dis. 23(5):809-812.

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Murray, Gerald L. ; Bradshaw, Catriona S. ; Bissessor, Melanie ; Danielewski, Jennifer ; Garland, Suzanne M. ; ... More +

Murray, Gerald L. ; Bradshaw, Catriona S. ; Bissessor, Melanie ; Danielewski, Jennifer ; Garland, Suzanne M. ; Jensen, Jørgen S. ; Fairley, Christopher K. ; Tabrizi, Sepehr N. Less -
Description:

Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.
Subjects:

[+]

Anti-Bacterial Agents Drug Resistance, Bacterial Female Fluoroquinolones Genes, Bacterial Humans Macrolides Male Mycoplasma Genitalium Mycoplasma Infections Polymorphism, Single Nucleotide
Source:

Emerg Infect Dis. 23(5):809-812.
Pubmed ID:

28418319
Pubmed Central ID:

PMC5403035
Document Type:

Journal Article
Place as Subject:

Australia
Volume:

23
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:1ac2f94fe51e9f7784e9d085170ed1dac52c3722c557602a0044831b5a48df41
Download URL:

https://stacks.cdc.gov/view/cdc/45630/cdc_45630_DS1.pdf
File Type:

	16-1745-Techapp-s1.pdf	pdf
	16-1745.nxml	bin

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