Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Murray, Gerald L. ; Bradshaw, Catriona S. ; Bissessor, Melanie ; Danielewski, Jennifer ; Garland, Suzanne M. ; Jensen, Jørgen S. ; Fairley, Christopher K. ; Tabrizi, Sepehr N.
• Description:
  Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.
• Subjects:
  Anti-Bacterial Agents Drug Resistance, Bacterial Female Fluoroquinolones Genes, Bacterial Humans Macrolides Male Mycoplasma Genitalium Mycoplasma Infections Polymorphism, Single Nucleotide

  More +
• Source:
  Emerg Infect Dis. 23(5):809-812.
• Document Type:
  Journal Article
• Place as Subject:
  Australia
• Volume:
  23
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:2efcd843c000166ba5ff2472733f23873a2c9b19ad975ff636f9d9d4bc79860fedb222b671e35d8ef42b5f14f0a72bf46585fd784ba8ba76effd5ee732ca74a5
• Download URL:
  https://stacks.cdc.gov/view/cdc/45630/cdc_45630_DS1.pdf
• File Type:
  [PDF - 9.10 MB ]