Details:

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Llata, Eloisa ; Tromble, Erin ; Schumacher, Christina ; Huspeni, Dawn ; Asbel, Lenore ; ... More +

  Llata, Eloisa ; Tromble, Erin ; Schumacher, Christina ; Huspeni, Dawn ; Asbel, Lenore ; Pathela, Preeti ; Kohn, Robert ; Kerani, Roxanne P. ; Barbee, Lindley ; Bachman, Laura Less -
• Description:
  Background
  
  Mycoplasma genitalium is a major contributor to persistent/recurrent urethritis cases. However, there are limited published studies on recent trends of persistent/recurrent urethritis.
  
  Methods
  
  A retrospective analysis was conducted of men presenting with symptomatic urethritis in 16 STD clinics from 2015–2019. Poisson regression was used to assess trends in the annual proportions of urethritis episodes with follow-up (FU) characterized with persistent/recurrent urethritis symptoms. Results were also stratified by results of chlamydia (CT) and gonorrhea (NG) testing and treatment prescribed.
  
  Results
  
  There were 99,897 urethritis episodes, from 67,546 unique men. The proportion of episodes with persistent/recurrent symptomatic FU visits increased 50.8% over a 4-year period (annual percentage change (APC) 11.3%, 95% CI, 6.5–16.3). Similar trends were observed in non-chlamydial non-gonococcal urethritis episodes(APC, 12.7%; 95% CI, 6.8–18.9) but increases among those positive for NG (APC, 12.1%; 95% CI, −2.3 −28.5) or for CT (APC, 7.3%; 95% CI, −6.7–23.5) were not statistically significant. Among episodes who received azithromycin as first-line treatment, increases in the proportion of persistent/recurrent FU visits were observed (APC, 12.6%; 95% CI, 8.6–16.7). For episodes where first-line treatment was doxycycline, no significant increases were detected (APC, 4.3%; 95% CI, −0.3–9.2).
  
  Conclusion
  
  We found an increase in the proportion of urethritis episodes with persistent or recurrent symptoms over time. Given these observed trends in episodes negative for NG or CT, an etiology not detectable by routine diagnostics was a likely factor in increased persistence, suggesting patients with urethritis may benefit from diagnostic testing for M. genitalium during an initial symptomatic presentation.
  
  
• Subjects:
  [+]

  Adolescent Adult Anti-Bacterial Agents Azithromycin Chlamydia Infections Doxycycline Gonorrhea Humans Male Middle Aged Mycoplasma Genitalium Mycoplasma Infections Recurrence Retrospective Studies Sexually Transmitted Diseases Urethritis Young Adult
• Keywords:
  [+]

  STD Clinics Urethritis
• Source:
  Sex Transm Dis. 51(7):493-498
• Pubmed ID:
  38602771
• Pubmed Central ID:
  PMC11182710
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha256:8176f984a45b5540c7375b89a35f14631b788c985a96c4f621acdfecb017be41
• File Type:

• Supporting Files:
  No Additional Files