Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Read, Tim R.H. ; Jensen, Jørgen S. ; Fairley, Christopher K. ; Grant, Mieken ; Danielewski, Jennifer A. ; ... More +
Read, Tim R.H. ; Jensen, Jørgen S. ; Fairley, Christopher K. ; Grant, Mieken ; Danielewski, Jennifer A. ; Su, Jenny ; Murray, Gerald L. ; Chow, Eric P.F. ; Worthington, Karen ; Garland, Suzanne M. ; Tabrizi, Sepehr N. ; Bradshaw, Catriona S. Less -
Description:
High levels of macrolide resistance and increasing fluoroquinolone resistance are found in Mycoplasma genitalium in many countries. We evaluated pristinamycin for macrolide-resistant M. genitalium in a sexual health center in Australia. Microbiologic cure was determined by M. genitalium-specific 16S PCR 14-90 days after treatment began. Of 114 persons treated with pristinamycin, infection was cured in 85 (75%). This percentage did not change when pristinamycin was given at daily doses of 2 g or 4 g or at 3 g combined with 200 mg doxycycline. In infections with higher pretreatment bacterial load, treatment was twice as likely to fail for each 1 log10 increase in bacterial load. Gastrointestinal side effects occurred in 7% of patients. Pristinamycin at maximum oral dose, or combined with doxycycline, cured 75% of macrolide-resistant M. genitalium infections. Pristinamycin is well-tolerated and remains an option where fluoroquinolones have failed or cannot be used.
Subject:
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Adult
Anti-Bacterial Agents/pharmacology
Drug Resistance, Multiple, Bacterial
Female
Humans
Macrolides/pharmacology
Male
Mycoplasma Genitalium/drug Effects
Mycoplasma Genitalium/genetics
Mycoplasma Infections/drug Therapy
Mycoplasma Infections/microbiology
Pristinamycin/therapeutic Use
Research

Source:
Emerg Infect Dis. 24(2):328-335.
Pubmed ID:
29350154
Pubmed Central ID:
PMC5782881
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:60d8f81558507018a7246380b8974d06a932876238eba0ccea2272ec2a62d9f1
File Type:

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