Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Read, Tim R.H. ; Jensen, Jørgen S. ; Fairley, Christopher K. ; Grant, Mieken ; Danielewski, Jennifer A. ; Su, Jenny ; Murray, Gerald L. ; Chow, Eric P.F. ; Worthington, Karen ; Garland, Suzanne M. ; Tabrizi, Sepehr N. ; Bradshaw, Catriona S.
• Description:
  High levels of macrolide resistance and increasing fluoroquinolone resistance are found in Mycoplasma genitalium in many countries. We evaluated pristinamycin for macrolide-resistant M. genitalium in a sexual health center in Australia. Microbiologic cure was determined by M. genitalium-specific 16S PCR 14-90 days after treatment began. Of 114 persons treated with pristinamycin, infection was cured in 85 (75%). This percentage did not change when pristinamycin was given at daily doses of 2 g or 4 g or at 3 g combined with 200 mg doxycycline. In infections with higher pretreatment bacterial load, treatment was twice as likely to fail for each 1 log10 increase in bacterial load. Gastrointestinal side effects occurred in 7% of patients. Pristinamycin at maximum oral dose, or combined with doxycycline, cured 75% of macrolide-resistant M. genitalium infections. Pristinamycin is well-tolerated and remains an option where fluoroquinolones have failed or cannot be used.
• Subjects:
  Adult Anti-Bacterial Agents / Pharmacology Drug Resistance, Multiple, Bacterial Female Humans Macrolides / Pharmacology Male Mycoplasma Genitalium / Drug Effects Mycoplasma Genitalium / Genetics Mycoplasma Infections / Drug Therapy Mycoplasma Infections / Microbiology Pristinamycin / Therapeutic Use

  More +
• Source:
  Emerg Infect Dis. 24(2):328-335.
• Pubmed ID:
  29350154
• Pubmed Central ID:
  PMC5782881
• Document Type:
  Text
• Genre:
  Journal Article
• Volume:
  24
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:14b9a2b7f0393d547bca3fa4bfb7e65eb532a4a002d0400cd46f3efdfcc211a297d971b1bbcfae7a4daa3a047fa665ad2021be1efdde13b121c2b9db6f7697fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/51376/cdc_51376_DS1.pdf
• File Type:
  [PDF - 623.04 KB ]