Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Baranovich, Tatiana ; Vongphrachanh, Phengta ; Ketmayoon, Pakapak ; Sisouk, Thongchanh ; Chomlasack, Khampheng ; Khanthamaly, Viengphone ; Nguyen, Ha Thuy ; Mishin, Vasiliy P. ; Marjuki, Henju ; Barnes, John R. ; Garten, Rebecca J. ; Stevens, James ; Wentworth, David E. ; Gubareva, Larisa V.
• Description:
  In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
• Subjects:
  Antimicrobial Resistance Antiviral Drug–Resistant Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution In Neuraminidase, Laos, February 2016 Dispatch H134N Substitution Influenza Influenza B Viruses Laos Mutation Neuraminidase Viruses

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• Source:
  Emerg Infect Dis. 23(4):686-690.
• Pubmed ID:
  28322707
• Pubmed Central ID:
  PMC5367415
• Document Type:
  Journal Article
• Volume:
  23
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cd03c77cc4b1a517e41243ace7e897f0d3a599415b361afc6d360cf84d92ceae
• Download URL:
  https://stacks.cdc.gov/view/cdc/45045/cdc_45045_DS1.pdf
• File Type:
  [PDF - 2.20 MB ]