Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016

Baranovich, Tatiana; Vongphrachanh, Phengta; Ketmayoon, Pakapak; Sisouk, Thongchanh; Chomlasack, Khampheng; Khanthamaly, Viengphone; Nguyen, Ha Thuy; Mishin, Vasiliy P.; Marjuki, Henju; Barnes, John R.; Garten, Rebecca J.; Stevens, James; Wentworth, David E.; Gubareva, Larisa V.

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Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016

Apr 2017
By Baranovich, Tatiana ; Vongphrachanh, Phengta ; Ketmayoon, Pakapak ; ...
Source: Emerg Infect Dis. 23(4):686-690.

[PDF-2.20 MB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Baranovich, Tatiana ; Vongphrachanh, Phengta ; Ketmayoon, Pakapak ; Sisouk, Thongchanh ; Chomlasack, Khampheng ; ... More +

Baranovich, Tatiana ; Vongphrachanh, Phengta ; Ketmayoon, Pakapak ; Sisouk, Thongchanh ; Chomlasack, Khampheng ; Khanthamaly, Viengphone ; Nguyen, Ha Thuy ; Mishin, Vasiliy P. ; Marjuki, Henju ; Barnes, John R. ; Garten, Rebecca J. ; Stevens, James ; Wentworth, David E. ; Gubareva, Larisa V. Less -
Description:

In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
Subjects:

[+]

Antimicrobial Resistance Antiviral Drug–Resistant Antiviral Drug–Resistant Influenza B Viruses Carrying H134N Substitution In Neuraminidase, Laos, February 2016 Dispatch H134N Substitution Influenza Influenza B Viruses Laos Mutation Neuraminidase Viruses
Source:

Emerg Infect Dis. 23(4):686-690.
Pubmed ID:

28322707
Pubmed Central ID:

PMC5367415
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:cd03c77cc4b1a517e41243ace7e897f0d3a599415b361afc6d360cf84d92ceae
Download URL:

https://stacks.cdc.gov/view/cdc/45045/cdc_45045_DS1.pdf
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