Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Patel, Mira C. ; Nguyen, Ha T. ; Pascua, Philippe Noriel Q. ; Gao, Rongyuan ; Steel, John ; Kondor, Rebecca J. ; Gubareva, Larisa V.
• Description:
  Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
• Subjects:
  Antiviral Agents Dispatch Drug Resistance, Viral Humans Influenza, Human Influenza A Virus, H1N1 Subtype Multicountry Spread Of Influenza A(H1N1)pdm09 Viruses With Reduced Oseltamivir Inhibition, May 2023–February 2024 Mutation Neuraminidase Oseltamivir Phylogeny

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• Keywords:
  Antimicrobial Resistance Antiviral Bacteria Baloxavir Germ Theory H1N1 Infectious Diseases Influenza Influenza A(H1N1)pdm09 Neuraminidase Inhibitors Oseltamivir PH1N1 Phenotypic Testing Public Health Public Health History Reduced Inhibition Science Pioneers Substitution United States Viruses

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• Source:
  Emerg Infect Dis. 2024; 30(7):1410-1415
• Pubmed ID:
  38916572
• Pubmed Central ID:
  PMC11210663
• Document Type:
  Journal Article
• Volume:
  30
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:a66916ef6104047ce0d5cdd615b20c5a88851e2f12af3bd085dcf5cbd365e24ce600244d11d8823ea9ad3ce18e3f02ac559e754861e5335e6515f2f72c15c6ed
• Download URL:
  https://stacks.cdc.gov/view/cdc/158120/cdc_158120_DS1.pdf
• File Type:
  [PDF - 1.29 MB ]