Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Patel, Mira C. ; Nguyen, Ha T. ; Pascua, Philippe Noriel Q. ; Gao, Rongyuan ; Steel, John ; Kondor, Rebecca J. ; Gubareva, Larisa V.
• Description:
  Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
• Subjects:
  • Dispatch
  • Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024
  • Oseltamivir
  • Influenza A Virus, H1N1 Subtype
  • Humans
  • Antiviral Agents
  • Influenza, Human
  • Neuraminidase
  • Drug Resistance, Viral
  • Phylogeny
  More +
• Keywords:
  • Influenza
  • antiviral
  • neuraminidase inhibitors
  • oseltamivir
  • reduced inhibition
  • substitution
  • baloxavir
  • phenotypic testing
  • viruses
  • influenza A(H1N1)pdm09
  More +
• Source:
  Emerg Infect Dis. 2024; 30(7):1410-1415
• Pubmed ID:
  38916572
• Pubmed Central ID:
  PMC11210663
• Document Type:
  Journal Article
• Volume:
  30
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/158120/cdc_158120_DS1.pdf
• File Type:
  [PDF - 1.29 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:a66916ef6104047ce0d5cdd615b20c5a88851e2f12af3bd085dcf5cbd365e24ce600244d11d8823ea9ad3ce18e3f02ac559e754861e5335e6515f2f72c15c6ed