Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024

Patel, Mira C.; Nguyen, Ha T.; Pascua, Philippe Noriel Q.; Gao, Rongyuan; Steel, John; Kondor, Rebecca J.; Gubareva, Larisa V.

doi:10.3201/eid3007.240480

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024

7 2024
By Patel, Mira C. ; Nguyen, Ha T. ; Pascua, Philippe Noriel Q. ; ...
http://dx.doi.org/10.3201/eid3007.240480
Source: Emerg Infect Dis. 2024; 30(7):1410-1415

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Patel, Mira C. ; Nguyen, Ha T. ; Pascua, Philippe Noriel Q. ; Gao, Rongyuan ; Steel, John ; ... More +

Patel, Mira C. ; Nguyen, Ha T. ; Pascua, Philippe Noriel Q. ; Gao, Rongyuan ; Steel, John ; Kondor, Rebecca J. ; Gubareva, Larisa V. Less -
Description:

Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
Subjects:

[+]

Antiviral Agents Dispatch Drug Resistance, Viral Humans Influenza, Human Influenza A Virus, H1N1 Subtype Multicountry Spread Of Influenza A(H1N1)pdm09 Viruses With Reduced Oseltamivir Inhibition, May 2023–February 2024 Mutation Neuraminidase Oseltamivir Phylogeny
Keywords:

[+]

Antimicrobial Resistance Antiviral Bacteria Baloxavir Germ Theory H1N1 Infectious Diseases Influenza Influenza A(H1N1)pdm09 Neuraminidase Inhibitors Oseltamivir PH1N1 Phenotypic Testing Public Health Public Health History Reduced Inhibition Science Pioneers Substitution United States Viruses
Source:

Emerg Infect Dis. 2024; 30(7):1410-1415
Pubmed ID:

38916572
Pubmed Central ID:

PMC11210663
Document Type:

Journal Article
Volume:

30
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha-512:a66916ef6104047ce0d5cdd615b20c5a88851e2f12af3bd085dcf5cbd365e24ce600244d11d8823ea9ad3ce18e3f02ac559e754861e5335e6515f2f72c15c6ed
Download URL:

https://stacks.cdc.gov/view/cdc/158120/cdc_158120_DS1.pdf
File Type:

[PDF-1.29 MB]

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