The Association of Urine Arsenic with Prevalent and Incident Chronic Kidney Disease: Evidence from the Strong Heart Study

Zheng, Laura Y.; Umans, Jason G.; Yeh, Fawn; Francesconi, Kevin A.; Goessler, Walter; Silbergeld, Ellen K; Bandeen-Roche, Karen; Guallar, Eliseo; Howard, Barbara V.; Weaver, Virginia M.; Navas-Acien, Ana

doi:10.1097/EDE.0000000000000313

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

The Association of Urine Arsenic with Prevalent and Incident Chronic Kidney Disease: Evidence from the Strong Heart Study

Published Date:

Jul 2015

Publisher's site:

http://dx.doi.org/10.1097/EDE.0000000000000313 New Site Icon

Source:

Epidemiology. 26(4):601-612.

Language:

English

[PDF-527.16 KB]

Details:

Personal Authors:

Zheng, Laura Y. ; Umans, Jason G. ; Yeh, Fawn ; Francesconi, Kevin A. ; Goessler, Walter ; ... More ▼

Keywords:

[+]

Pubmed ID:

25929811

Pubmed Central ID:

PMC4844343

Description:

Background

Few studies have evaluated associations between low to moderate arsenic levels and chronic kidney disease (CKD). The objective was to evaluate the associations of inorganic arsenic exposure with prevalent and incident CKD in American Indian adults.

Methods

We evaluated the associations of inorganic arsenic exposure with CKD in American Indians who participated in the Strong Heart Study (SHS) in 3,851 adults aged 45–74 years in a cross-sectional analysis, and 3,119 adults with follow-up data in a prospective analysis. Inorganic arsenic, monomethylarsonate, and dimethylarsinate were measured in urine at baseline. CKD was defined as eGFR≤60 mL/min/1.73m2, kidney transplant or dialysis.

Results

CKD prevalence was 10.3%. The median (IQR) concentration of inorganic plus methylated arsenic species (total arsenic) in urine was 9.7 (5.8, 15.7) μg/L. The adjusted OR (95% CI) of prevalent CKD for an interquartile range in total arsenic was 0.7 (0.6, 0.8), mostly due to an inverse association with inorganic arsenic (OR 0.4 (0.3, 0.4)). Monomethylarsonate and dimethylarsinate were positively associated with prevalent CKD after adjustment for inorganic arsenic (OR 3.8 and 1.8). The adjusted HR of incident CKD for an IQR in ΣAs was 1.2 (1.03, 1.41). The corresponding HR for inorganic arsenic, monomethylarsonate and dimethylarsinate were 1.0 (0.9, 1.2), 1.2 (1.00, 1.3) and 1.2 (1.0, 1.4).

Conclusions

The inverse association of urine inorganic arsenic with prevalent CKD suggests that kidney disease affects excretion of inorganic arsenic. Arsenic species were positively associated with incident CKD. Studies with repeated measures are needed to further characterize the relationship between arsenic and kidney disease development.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Place as Subject:

Arizona ; North Dakota ; Oklahoma ; South Dakota ;

Supporting Files:

	nihms764370f2.gif	image/gif
	nihms764370f2.jpg	image/jpeg
	nihms764370f3.gif	image/gif
	nihms764370f3.jpg	image/jpeg
	NIHMS764370-supplement-Supplement_1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS764370-supplement-Supplement_2.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS764370-supplement-Supplement_3.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS764370-supplement-Supplement_4.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS764370-supplement-Supplement_5.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms764370.nxml	application/octet-stream
	nihms764370f1.gif	image/gif
	nihms764370f1.jpg	image/jpeg

No Related Documents.

You May Also Like:

Arsenic and Chronic Kidney Disease: A Systematic Review

Personal Author:

Zheng, Laura; Kuo, Chin-Chi; Fadrowski, Jeffrey; Agnew, Jackie; Weaver, Virginia M.; Navas-Acien, Ana;

Published:

Sep 1 2014

Source:

Curr Environ Health Rep. 1(3):192-207.

Description:

In epidemiologic studies, high arsenic exposure has been associated with adverse kidney disease outcomes. We performed a systematic review of the epidemiologic evidence of the association between arsenic and various kidney disease outcomes. The searc...

File Type:

[PDF - 802.47 KB]
Occupational exposure to inorganic arsenic : new criteria, 1975

Personal Author:

Hardin, Bryan D.

Corporate Author:

National Institute for Occupational Safety and Health. Office of Research and Standards Development.. Tabershaw-Cooper Associates..

Published:

1975

Series:

Criteria for a recommended standard
DHEW publication ; no. (NIOSH) 75-149

Description:

"This criteria document recommends revised standards for occupational exposure to elemental arsenic (7440382) and all of its inorganic compounds, including arsine (7784421) and lead-arsenate (7645252) in the workplace air and by skin exposure. Standa...

Status:

current

File Type:

[PDF - 2.03 MB]
Occupational exposure to inorganic arsenic

Corporate Author:

National Institute for Occupational Safety and Health.

Published:

1973

Series:

Criteria for a recommended standard
DHEW publication ; no. (NIOSH) 74-110

Description:

Issued initially without DHEW ennumeration, but retroactively numbered: DHEW publication no. (NIOSH) 74-110. : "The criteria and the recommended standard based thereon are presented for meeting the need for preventing occupational diseases arising fr...

File Type:

[PDF - 3.56 MB]
A guide to the work-relatedness of disease

Personal Author:

Kusnetz, Stanley; Hutchison, Marilyn K., 1918-;

Corporate Author:

National Institute for Occupational Safety and Health

Published:

Rev. ed. January 1979

Series:

DHEW publication ; no. (NIOSH) 79-116

Description:

"Factors concerning the relationship between disease and occupation, including evidence of disease, epidemiology, evidence of exposure, aggravation of preexisting conditions, and validity of testimony, are discussed to aid physicians, state agencies,...

File Type:

[PDF - 4.18 MB]
Arsenic exposure and hepatitis E virus infection during pregnancy

Personal Author:

Heaney, Christopher D.; Kmush, Brittany; Navas-Acien, Ana; Francesconi, Kevin; Gössler, Walter; Schulze, Kerry; Fairweather, DeLisa; Mehra, Sucheta; Nelson, Kenrad E.; Klein, Sabra L.; Li, Wei; Ali, Hasmot; Shaikh, Saijuddin; Merrill, Rebecca D.; Wu, Lee; West, Keith P.; Christian, Parul; Labrique, Alain B.;

Published:

Jul 15 2015

Source:

Environ Res. 142:273-280.

Description:

Background : Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans. : Objectives : We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E v...

File Type:

[PDF - 519.67 KB]