Details:

Alternative Title:
Epidemiology
Publisher's site:
http://dx.doi.org/10.1097/EDE.0000000000000313
Personal Author:
Zheng, Laura Y. ; Umans, Jason G. ; Yeh, Fawn ; Francesconi, Kevin A. ; Goessler, Walter ; ... More +
Zheng, Laura Y. ; Umans, Jason G. ; Yeh, Fawn ; Francesconi, Kevin A. ; Goessler, Walter ; Silbergeld, Ellen K ; Bandeen-Roche, Karen ; Guallar, Eliseo ; Howard, Barbara V. ; Weaver, Virginia M. ; Navas-Acien, Ana Less -
Description:
Background

Few studies have evaluated associations between low to moderate arsenic levels and chronic kidney disease (CKD). The objective was to evaluate the associations of inorganic arsenic exposure with prevalent and incident CKD in American Indian adults.

Methods

We evaluated the associations of inorganic arsenic exposure with CKD in American Indians who participated in the Strong Heart Study (SHS) in 3,851 adults aged 45–74 years in a cross-sectional analysis, and 3,119 adults with follow-up data in a prospective analysis. Inorganic arsenic, monomethylarsonate, and dimethylarsinate were measured in urine at baseline. CKD was defined as eGFR≤60 mL/min/1.73m2, kidney transplant or dialysis.

Results

CKD prevalence was 10.3%. The median (IQR) concentration of inorganic plus methylated arsenic species (total arsenic) in urine was 9.7 (5.8, 15.7) μg/L. The adjusted OR (95% CI) of prevalent CKD for an interquartile range in total arsenic was 0.7 (0.6, 0.8), mostly due to an inverse association with inorganic arsenic (OR 0.4 (0.3, 0.4)). Monomethylarsonate and dimethylarsinate were positively associated with prevalent CKD after adjustment for inorganic arsenic (OR 3.8 and 1.8). The adjusted HR of incident CKD for an IQR in ΣAs was 1.2 (1.03, 1.41). The corresponding HR for inorganic arsenic, monomethylarsonate and dimethylarsinate were 1.0 (0.9, 1.2), 1.2 (1.00, 1.3) and 1.2 (1.0, 1.4).

Conclusions

The inverse association of urine inorganic arsenic with prevalent CKD suggests that kidney disease affects excretion of inorganic arsenic. Arsenic species were positively associated with incident CKD. Studies with repeated measures are needed to further characterize the relationship between arsenic and kidney disease development.


Subject:
[+]
Aged
Arsenic
Arsenicals
Article
Cacodylic Acid
Cohort Studies
Cross-Sectional Studies
Environmental Exposure
Female
Glomerular Filtration Rate
Humans
Incidence
Indians, North American
Male
Middle Aged
Prevalence
Proportional Hazards Models
Prospective Studies
Renal Insufficiency, Chronic

Source:
Epidemiology. 26(4):601-612.
Pubmed ID:
25929811
Pubmed Central ID:
PMC4844343
Document Type:
Journal Article
Funding:
5T32HL007024/HL/NHLBI NIH HHS/United States ; HL090863/HL/NHLBI NIH HHS/United States ; HL41642/HL/NHLBI NIH HHS/United States ; HL41652/HL/NHLBI NIH HHS/United States ; HL41654/HL/NHLBI NIH HHS/United States ; ... More +
5T32HL007024/HL/NHLBI NIH HHS/United States ; HL090863/HL/NHLBI NIH HHS/United States ; HL41642/HL/NHLBI NIH HHS/United States ; HL41652/HL/NHLBI NIH HHS/United States ; HL41654/HL/NHLBI NIH HHS/United States ; HL65521/HL/NHLBI NIH HHS/United States ; P30ES03819/ES/NIEHS NIH HHS/United States ; R01 ES021367/ES/NIEHS NIH HHS/United States ; R01ES021367/ES/NIEHS NIH HHS/United States ; T32 ES007141/ES/NIEHS NIH HHS/United States ; T32 ES103650/ES/NIEHS NIH HHS/United States ; T42OH008428/OH/NIOSH CDC HHS/United States ; UL1 TR001079/TR/NCATS NIH HHS/United States Less -
Place as Subject:
Arizona ; North Dakota ; Oklahoma ; South Dakota
Arizona ; North Dakota ; Oklahoma ; South Dakota Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:89a4876e60cd2a0183a893bfe437298fbd52dc113dd58ff27f8ed95e4921c190
File Type:

Supporting Files

• 	nihms764370f2.gif	gif
  	nihms764370f2.jpg	jpeg
  	nihms764370f3.gif	gif
  	nihms764370f3.jpg	jpeg
  	NIHMS764370-supplement-Supplement_1.docx	docx
  	NIHMS764370-supplement-Supplement_2.docx	docx
  	NIHMS764370-supplement-Supplement_3.docx	docx
  	NIHMS764370-supplement-Supplement_4.docx	docx
  	NIHMS764370-supplement-Supplement_5.docx	docx
  	nihms764370.nxml	bin
  	nihms764370f1.gif	gif
  	nihms764370f1.jpg	jpeg

More +