Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol a in polycystic ovary syndrome: a case–control study

Details

• Alternative Title:
  BMC Endocr Disord
• Personal Author:
  Vagi, Sara J ; Azziz-Baumgartner, Eduardo ; Sjödin, Andreas ; Calafat, Antonia M ; Dumesic, Daniel ; Gonzalez, Leonardo ; Kato, Kayoko ; Silva, Manori J ; Ye, Xiaoyun ; Azziz, Ricardo
• Description:
  Background
  
  Polycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder that affects approximately 6-10% of women of child-bearing age. Although preliminary studies suggest that certain pollutants may act as endocrine disruptors in animals, little is known about their potential association with PCOS. The objective of this case-control pilot study is to determine whether women with PCOS have higher concentrations of specific environmental contaminants compared to women who have not developed PCOS.
  
  Methods
  
  Fifty-two PCOS case-patients (diagnosed using the National Institutes of Health 1990 definition) and 50 controls were recruited in 2007–2008, from an urban academic medical center in Los Angeles, CA. Brominated diphenyl ethers, polychlorinated biphenyls (PCBs), organochlorine pesticides, and perfluorinated compounds (PFCs) were measured in serum, and phthalates metabolites and bisphenol A (BPA) in urine.
  
  Results
  
  PCOS case-patients had significantly higher geometric mean (GM) serum concentrations of two PFCs: perfluorooctanoate (PFOA) (GMcases = 4.1 μg/L, GMcontrols = 2.3 μg/L; p = 0.001) and perfluorooctane sulfonate (PFOS) (GMcases = 8.2 μg/L, GMcontrols = 4.9 μg/L; p = 0.01), and lower urinary concentrations of monobenzyl phthalate (mBzP) (GMcases = 7.5 μg/g creatinine, GMcontrols = 11.7 μg/g creatinine; p = 0.02). Logistic regression, controlling for body mass index, age and race, identified an increased likelihood of PCOS in subjects with higher serum concentrations of PFOA and PFOS (adjusted-ORs = 5.8–6.9, p < 0.05), and with lower urine concentrations of mBzP and mono-n-butyl phthalate (mBP) (aORs = 0.14–0.25, p < 0.05).
  
  Conclusions
  
  Our data suggest that PCOS case-patients may differ from controls in their environmental contaminant profile. PCOS subjects had higher serum concentrations of two PFCs, PFOA and PFOS, and lower urine concentrations of mBP and mBzP. Future studies are needed to confirm these preliminary findings and determine if these chemicals or their precursors may have a role in the pathogenesis of PCOS.
  
  Electronic supplementary material
  
  The online version of this article (doi:10.1186/1472-6823-14-86) contains supplementary material, which is available to authorized users.
  
  
• Subjects:
  Adolescent Adult Benzhydryl Compounds Caprylates Case-Control Studies Chromatography, Gas Endocrine Disruptors Environmental Monitoring Environmental Pollutants Female Fluorocarbons Halogenated Diphenyl Ethers Humans Hydrocarbons, Chlorinated Mass Spectrometry Middle Aged Pesticides Phenols Phthalic Acids Pilot Projects Polychlorinated Biphenyls Polycystic Ovary Syndrome Prevalence Solid Phase Extraction Specimen Handling

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• Source:
  BMC Endocr Disord. 14(1).
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  14
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7fac60a08dceadc865fd47e8fae5e27d4d4fbc9123c52a6405c6345d5bfc4bed
• Download URL:
  https://stacks.cdc.gov/view/cdc/26599/cdc_26599_DS1.pdf
• File Type:
  [PDF - 321.90 KB ]