Associations of serum persistent organic pollutant concentrations with incident diabetes in midlife women: the Study of Women’s Health Across the Nation Multi-Pollutant Study

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Grant-Alfieri, Amelia ; Herman, William H. ; Watkins, Deborah J. ; Batterman, Stuart ; Karvonen-Gutierrez, Carrie ; Park, Sung Kyun
• Description:
  Background:
  
  Organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) that can negatively impact metabolic health through pathways including endocrine disruption. Few studies have evaluated diabetes risk associated with PBDEs. Little is known about the joint effect of exposure to POP mixtures on diabetes risk.
  
  Objectives:
  
  We investigated the relationship between POPs, individually and as mixtures, and diabetes development over 18 years (1999–2016) in midlife women.
  
  Methods:
  
  We measured lipid-standardized serum concentrations of 34 PCBs, 19 OCPs, and 14 PBDEs in 1,040 midlife women aged 45–56 years from the Study of Women’s Health Across the Nation. We tested the association between POPs measured in 1999/2000 and incident diabetes using Cox proportional hazards models. We evaluated diabetes risk associated with the overall POP mixture using Quantile-Based G-Computation (QBGC).
  
  Results:
  
  For most mixture components, single pollutant and mixtures analyses indicated null associations with diabetes risk, however results were inconsistent. After adjustment, hazard ratios (HRs) of developing diabetes (95% CI) associated with upper exposure tertiles (T2/T3) compared with the first tertile (T1), were 1.7 (1.0, 2.8) at T2 and 1.5 (0.84, 2.7) at T3 for hexachlorobenzene and 1.9 (1.1, 3.3) at T2 and 1.6 (0.88, 2.9) at T3 for PCB 123. A doubling of PBDE 47 was associated with 1.11 (1.00, 1.24) times the risk of T2D. QBGC identified no association for the overall joint effect of the POP mixture on diabetes (HR=1.04 [0.53, 2.07]).
  
  Conclusion:
  
  Exposure to a mixture of PCBs, OCPs, and PBDEs was not associated with incident diabetes in midlife U.S. women, although some individual POPs demonstrated significant yet inconsistent associations with diabetes. Non-linear and non-monotonic dose-response dynamics deserve further exploration. More research is needed on the diabetogenic effects of PBDEs.
  
  
• Subjects:
  Diabetes Mellitus Environmental Exposure Environmental Pollutants Female Halogenated Diphenyl Ethers Humans Hydrocarbons, Chlorinated Incidence Middle Aged Persistent Organic Pollutants Pesticides Polychlorinated Biphenyls United States Women's Health

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• Keywords:
  Diabetes PBDEs PCBs Persistent Organic Pollutants Pesticides Women
• Source:
  Environ Res. 260:119582
• Pubmed ID:
  38992756
• Pubmed Central ID:
  PMC11656409
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; R01 ES035087/ES/NIEHS NIH HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; T32 ES007062/ES/NIEHS NIH HHSUnited States/ ; U01 AG012535/AG/NIA NIH HHSUnited States/ ; U01 AG012553/AG/NIA NIH HHSUnited States/ ; U01 NR004061/NR/NINR NIH HHSUnited States/ ; U01 AG012539/AG/NIA NIH HHSUnited States/ ; R01 ES026578/ES/NIEHS NIH HHSUnited States/ ; U01 AG012546/AG/NIA NIH HHSUnited States/ ; U19 AG063720/AG/NIA NIH HHSUnited States/ ; U01 AG012495/AG/NIA NIH HHSUnited States/ ; U01 AG012531/AG/NIA NIH HHSUnited States/ ; R01 ES026964/ES/NIEHS NIH HHSUnited States/ ; U01 AG017719/AG/NIA NIH HHSUnited States/
• Volume:
  260
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:241b72e60fde8a3685cb7a8ac308b471e812266f1c3fe8cb7725c212545d72cb7bad067e121b99f9a19847e050a164b3c06af77675bea5de28f648ebccbcccaa
• Download URL:
  https://stacks.cdc.gov/view/cdc/175082/cdc_175082_DS1.pdf
• File Type:
  [PDF - 408.76 KB ]