Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children <5 years old: 2006–2019

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Burnett, Eleanor ; Parashar, Umesh D. ; Tate, Jacqueline E.
• Description:
  Since 2006, more than 100 countries have introduced rotavirus vaccine into their immunization programs. We reviewed published data on relative reductions of rotavirus hospitalizations, acute gastroenteritis (AGE) hospitalizations, and AGE deaths among children <5 years old.|Articles published from January 1, 2006 to December 31, 2019 with at least 12 months of data before and after rotavirus vaccine introduction were included. Relative reductions were abstracted into a standardized form. Descriptive statistics are presented as medians and interquartile ranges (IQRs).|We reviewed 1827 total records and included 105 articles from 49 countries. Among children <5 years old, there was a median reduction of 59% (IQR, 46-74) in rotavirus hospitalizations, 36% (IQR, 23-47) in AGE hospitalizations, and 36% (IQR, 28-46) AGE mortality. Reductions were larger in countries with low child mortality, among younger age groups, and in countries with higher coverage. The median percentage of specimens that tested positive for rotavirus among children <5 years old hospitalized for diarrhea was 40% (IQR, 28-45) before rotavirus vaccine introduction and 20% (IQR, 20-20) 4 years after introduction.|Overall, we found sustained impact on rotavirus and AGE hospitalizations and deaths. These results should encourage countries still considering rotavirus vaccine implementation.
• Subjects:
  Child, Preschool Databases, Factual Diarrhea Gastroenteritis Hospitalization Humans Immunization Programs Rotavirus Rotavirus Infections Rotavirus Vaccines Vaccination

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• Keywords:
  Acute Gastroenteritis Impact Literature Review Rotavirus Vaccine
• Source:
  J Infect Dis. 222(10):1731-1739
• Pubmed ID:
  32095831
• Pubmed Central ID:
  PMC7483971
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  222
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:402b202af7551c66698053d910452a48e2c92efaafb89fdbe1c488d88e4b747ef6f9f7f0651562180785641a15861889bc6839e66a1434eed914bc1d587235b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/93506/cdc_93506_DS1.pdf
• File Type:
  [PDF - 615.83 KB ]